Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate

Authors: Schaefer, Thorsten ^{1, 14, ∗}, Mittal, Nitish ², Wang, Hui ^{1, 3}, Ataman, Meric ², Candido, Silvia ¹, Lötscher, Jonas ¹, Velychko, Sergiy ^{4, 5}, Tintignac, Lionel ¹, Bock, Thomas ⁶, Börsch, Anastasiya ¹, Baßler, Jochen ⁷, Rao, Tata Nageswara ^{8, 9}, Zmajkovic, Jakub ^{1, 10}, Roffeis, Sarah ¹, Löliger, Jordan ¹, Jacob, Francis ¹, Dumlin, Alain ¹, Schürch, Christoph ¹, Schmidt, Alexander ⁶, Skoda, Radek C. ¹, Wymann, Matthias P. ¹, Hess, Christoph ^{1, 11}, Schöler, Hans R. ⁴, Zaehres, Holm ^{4, 12}, Hurt, Ed ⁷, Zavolan, Mihaela ², Lengerke, Claudia ^{1, 13}

Source: In Cell Reports 22 October 2024 43(10)

Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor

Authors: De Pascale, Martina, Bissegger, Lukas, Tarantelli, Chiara, Beaufils, Florent, Prescimone, Alessandro, Mohamed Seid Hedad, Hayget, Kayali, Omar, Orbegozo, Clara, Raguž, Luka, Schaefer, Thorsten, Hebeisen, Paul, Bertoni, Francesco, Wymann, Matthias P., Borsari, Chiara

Source: In European Journal of Medicinal Chemistry 15 February 2023 248

Chemical and Structural Strategies to Selectively Target mTOR Kinase

Authors: Borsari, Chiara, De Pascale, Martina, Wymann, Matthias P.

Source: ChemMedChem. 16(18):2744-2759

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138341726.0x000001&indx=1&recIds=ETOCvdc_100138341726.0x000001

Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood–brain barrier permeabilityElectronic supplementary information (ESI) available: Experimental procedures and characterisation for all new compounds. Experimental details and raw data for biological assays, 1H, 13C NMR, HRMS spectra and HPLC chromatograms for all novel compounds. See DOI: 10.1039/d0md00408a

Authors: Borsari, Chiara, Keles, Erhan, Treyer, Andrea, De Pascale, Martina, Hebeisen, Paul, Hamburger, Matthias, Wymann, Matthias P.

Source: RSC medicinal chemistry. 12(4):579-583

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Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.

Authors: Bissegger, Lukas, Constantin, Theodora A., Keles, Erhan, Raguη, Luka, Barlow-Busch, Isobel, Orbegozo, Clara, Schaefer, Thorsten, Borlandelli, Valentina, Bohnacker, Thomas, Sriramaratnam, Rohitha, Schäfer, Alexander, Gstaiger, Matthias, Burke, John E., Borsari, Chiara, Wymann, Matthias P.

Source: Chemical Science; 12/28/2024, Vol. 15 Issue 48, p20274-20291, 18p

Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs.

Authors: Koumantou, Despoina^1,2, Adiko, Aimé Cézaire^1,2, Bourdely, Pierre^1,3, Nugue, Mathilde^1,2, Boedec, Erwan^1,2, El‐Benna, Jamel^1,2, Monteiro, Renato^1,2, Saveanu, Cosmin⁴, Laffargue, Muriel⁵, Wymann, Matthias P.⁶, Dalod, Marc⁷, Guermonprez, Pierre^8,9, Saveanu, Loredana^1,2, loredana.saveanu@inserm.fr

Source: Advanced Science; Nov2024, Vol. 11 Issue 44, p1-16, 16p

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

Authors: Theilmann, Wiebke, Gericke, Birthe, Schidlitzki, Alina, Muneeb Anjum, Syed Muhammad, Borsdorf, Saskia, Harries, Timon, Roberds, Steven L., Aguiar, Dean J., Brunner, Daniela, Leiser, Steven C., Song, Dekun, Fabbro, Doriano, Hillmann, Petra, Wymann, Matthias P., Löscher, Wolfgang

Source: In Neuropharmacology 1 December 2020 180

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD

Authors: Singer, Elisabeth, Walter, Carolin, Fabbro, Doriano, Rageot, Denise, Beaufils, Florent, Wymann, Matthias P., Rischert, Nadine, Riess, Olaf, Hillmann, Petra, Nguyen, Huu Phuc

Source: In Neuropharmacology 1 January 2020 162

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Authors: Brandt, Claudia, Hillmann, Petra, Noack, Andreas, Römermann, Kerstin, Öhler, Leon A., Rageot, Denise, Beaufils, Florent, Melone, Anna, Sele, Alexander M., Wymann, Matthias P., Fabbro, Doriano, Löscher, Wolfgang

Source: In Neuropharmacology 15 September 2018 140:107-120

Scalable, Economical, and Practical Synthesis of 4-(Difluoromethyl)pyridin-2-amine, a Key Intermediate for Lipid Kinase Inhibitors

Authors: Rageot, Denise, Beaufils, Florent, Borsari, Chiara, Dall Asen, Alix, Neuburger, Markus, Hebeisen, Paul, Wymann, Matthias P.

Source: Organic process research & development. 23(11):2416-2424

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Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB

Authors: Stocker, Hugo, Andjelkovic, Mirjana, Oldham, Sean, Laffargue, Muriel, Wymann, Matthias P., Hemmings, Brian A., Hafen, Ernst

Source: Science, 2002 Mar . 295(5562), 2088-2091.

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Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

Authors: Hirsch, Emilio, Katanaev, Vladimir L., Garlanda, Cecilia, Azzolino, Ornella, Pirola, Luciano, Silengo, Lorenzo, Sozzani, Silvano, Mantovani, Alberto, Altruda, Fiorella, Wymann, Matthias P.

Source: Science, 2000 Feb 01. 287(5455), 1049-1053.

Access URL: https://www.jstor.org/stable/3074219

Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

Authors: Bondeva, Tzvetanka, Pirola, Luciano, Bulgarelli-Leva, Ginette, Rubio, Ignacio, Wetzker, Reinhard, Wymann, Matthias P.

Source: Science, 1998 Oct 01. 282(5387), 293-296.

Access URL: https://www.jstor.org/stable/2897674

PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells

Authors: Lanahan, Stephen M., Yang, Lucas, Jones, Kate M., Qi, Zhihong, Cabrera, Emylette Cruz, Cominsky, Lauren Y., Ramaswamy, Anjali, Barmada, Anis, Gabernet, Gisela, Uthaya Kumar, Dinesh Babu, Xu, Lan, Shan, Peiying, Wymann, Matthias P., Kleinstein, Steven H., Rao, V. Koneti, Mustillo, Peter, Romberg, Neil, Abraham, Roshini S., Lucas, Carrie L.

Source: Nature Immunology; 20240101, Issue: Preprints p1-10, 10p

Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy

Authors: Collmann, Emilie, Bohnacker, Thomas, Marone, Romina, Dawson, Janet, Rehberg, Markus, Stringer, Rowan, Krombach, Fritz, Burkhart, Christoph, Hirsch, Emilio, Hollingworth, Gregory J., Thomas, Matthew, Wymann, Matthias P.

Source: In The Journal of Allergy and Clinical Immunology October 2013 132(4):959-968

Chemical Development of Intracellular Protein Heterodimerizers

Authors: Erhart, Dominik, Zimmermann, Mirjam, Jacques, Olivier, Wittwer, Matthias B., Ernst, Beat, Constable, Edwin, Zvelebil, Marketa, Beaufils, Florent, Wymann, Matthias P.

Source: In Chemistry & Biology 18 April 2013 20(4):549-557

C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms

Authors: Reichel, Christoph A., Puhr-Westerheide, Daniel, Zuchtriegel, Gabriele, Uhl, Bernd, Berberich, Nina, Zahler, Stefan, Wymann, Matthias P., Luckow, Bruno, Krombach, Fritz

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Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL

Authors: Anzinger, Joshua J. ^*, Chang, Janet ^*, Xu, Qing ^*, Barthwal, Manoj K. ^*, Bohnacker, Thomas ^†, Wymann, Matthias P. ^†, Kruth, Howard S. ^{1, *}

Source: In Journal of Lipid Research January 2012 53(1):34-42

PIЗKγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Authors: Becattini, Barbara, Marone, Romina, Zani, Fabio, Arsenijevic, Denis, Seydoux, Josiane, Montani, Jean-Pierre, Dulloo, Abdul G., Thorens, Bernard, Preitner, Frédéric, Wymann, Matthias P., Solinas, Giovanni

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Oct . 108(42), 17251-17252.

Access URL: https://www.jstor.org/stable/41352488

Ras Is an Indispensable Coregulator of the Class ${\rm I}_{{\rm B}}$ Phosphoinositide 3-Kinase p87/p110γ

Authors: Kurig, Barbara, Shymanets, Aliaksei, Bohnacker, Thomas, Prajwal, Brock, Carsten, Ahmadian, Mohammad Reza, Schaefer, Michael, Gohla, Antje, Harteneck, Christian, Wymann, Matthias P., Jeanclos, Elisabeth, Nürnberg, Bernd

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Dec 01. 106(48), 20312-20317.

Access URL: https://www.jstor.org/stable/25593371