Structure-activity optimization of ryanodine receptor modulators for the treatment of catecholaminergic polymorphic ventricular tachycardia

Authors: Moore, Oliver M., Sibrian-Vazquez, Martha, Navarro-Garcia, Jose Alberto, Aguilar-Sanchez, Yuriana, Turkieltaub-Paredes, Mara R., Lahiri, Satadru K., Ni, Li, Word, Tarah A., Miyake, Christina Y., Strongin, Robert M., Wehrens, Xander H.T.

Source: In Heart Rhythm

Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia

Authors: Greer-Short, Amara, Musa, Hassan, Alsina, Katherina M., Ni, Li, Word, Tarah A., Reynolds, Julia O., Gratz, Daniel, Lane, Cemantha, El-Refaey, Mona, Unudurthi, Sathya, Skaf, Michel, Li, Ning, Fedorov, Vadim V., Wehrens, Xander H.T., Mohler, Peter J., Hund, Thomas J.

Source: In Heart Rhythm March 2020 17(3):503-511

Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure

Authors: Connell, Patrick, Word, Tarah A., Wehrens, Xander H. T.

Source: Expert opinion on therapeutic targets. 24(1):25-36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096858230.0x000001&indx=1&recIds=ETOCvdc_100096858230.0x000001

Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation

Authors: Campbell, Hannah M., Quick, Ann P., Abu-Taha, Issam, Chiang, David Y., Kramm, Carlos F., Word, Tarah A., Brandenburg, Sören, Hulsurkar, Mohit, Alsina, Katherina M., Liu, Hui-Bin, Martin, Brian, Uhlenkamp, Dennis, Moore, Oliver M., Lahiri, Satadru K., Corradini, Eleonora, Kamler, Markus, Heck, Albert J.R., Lehnart, Stephan E., Dobrev, Dobromir, Wehrens, Xander H.T.

Source: Circulation. 142(12):1159-1172

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150444000.0x000001&indx=1&recIds=ETOCvdc_100150444000.0x000001

EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2

Authors: Klipp, Robert C., Li, Na, Wang, Qiongling, Word, Tarah A., Sibrian-Vazquez, Martha, Strongin, Robert M., Wehrens, Xander H.T., Abramson, Jonathan J.

Source: In Heart Rhythm April 2018 15(4):578-586

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation

Authors: Alsina, Katherina M., Hulsurkar, Mohit, Brandenburg, Sören, Kownatzki-Danger, Daniel, Lenz, Christof, Urlaub, Henning, Abu-Taha, Issam, Kamler, Markus, Chiang, David Y., Lahiri, Satadru K., Reynolds, Julia O., Quick, Ann P., Scott, Larry, Word, Tarah A., Gelves, Maria D., Heck, Albert J.R., Li, Na, Dobrev, Dobromir, Lehnart, Stephan E., Wehrens, Xander H.T.

Source: Circulation. 140(8):681-693

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100086912700.0x000001&indx=1&recIds=ETOCvdc_100086912700.0x000001

Time resolved calorimetry of photo-induced folding in horse heart cytochrome c at high pH

Authors: Word, Tarah A., Larsen, Randy W.

Source: In Archives of Biochemistry and Biophysics 1 February 2017 615:10-14

Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs

Authors: Li, Na, Wang, Qiongling, Sibrian-Vazquez, Martha, Klipp, Robert C., Reynolds, Julia O., Word, Tarah A., Scott, Larry, Jr., Salama, Guy, Strongin, Robert M., Abramson, Jonathan J., Wehrens, Xander H.T.

Source: In International Journal of Cardiology 15 January 2017 227:668-673

In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia

Authors: Pan, Xiaolu, Philippen, Leonne, Lahiri, Satadru K., Lee, Ciaran, Park, So Hyun, Word, Tarah A., Li, Na, Jarrett, Kelsey E., Gupta, Rajat, Reynolds, Julia O., Lin, Jean, Bao, Gang, Lagor, William R., Wehrens, Xander H.T.

Source: Circulation research. 123(8):953-963

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100067910393.0x000001&indx=1&recIds=ETOCvdc_100067910393.0x000001

Photoacoustic calorimetry studies of CO photo-dissociation from chloramine-T modified horse heart cytochrome-c

Authors: Word, Tarah A., Larsen, Randy W.

Source: In Archives of Biochemistry and Biophysics 15 December 2016 612:17-21

Photoacoustic calorimetry study of ligand photorelease from the Ru(II)bis(2,2′-bipyridine)(6,6′-dimethyl-2,2′-bipyridine) complex in aqueous solution

Authors: Word, Tarah A., Whittington, Christi L., Karolak, Aleksandra, Kemp, M. Trent, Woodcock, H. Lee, van der Vaart, Arjan, Larsen, Randy W.

Source: In Chemical Physics Letters 5 January 2015 619:214-218

Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity

Authors: Landstrom, Andrew P., Yang, Qixin, Sun, Bo, Perelli, Robin M., Bidzimou, Minu-Tshyeto, Zhang, Zhushan, Aguilar-Sanchez, Yuriana, Alsina, Katherina M., Cao, Shuyi, Reynolds, Julia O., Word, Tarah A., van der Sangen, Niels M.R., Wells, Quinn, Kannankeril, Prince J., Ludwig, Andreas, Kim, Jeffrey J., Wehrens, Xander H.T.

Source: Circulation.Arrhythmia and electrophysiology. 16(2):e010858-e010858

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188937614.0x000001&indx=1&recIds=ETOCvdc_100188937614.0x000001

Removal of pain-relieving drugs from aqueous solutions using Octolig and selected metalloligs

Authors: Martin, Dean F., Sehgal, Tanya, Word, Tarah A.

Source: Journal of environmental science and health.Part A.Toxic/hazardous substances & environmental engineering. 50(8):788-793

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100027192695.0x000001&indx=1&recIds=ETOCETOCvdc_100027192695.0x000001

Using Photoacoustic Calorimetry to Study the cis- to trans- Photoisomerization of the [Ru(II)(2, 2'-bipyridine)2(H2O)2]2+ Complex in Aqueous Solution

Authors: Word, Tarah A., Karolak, Aleksandra, Cioce, Christian R., Van Der Vaart, Arjan, Larsen, Randy W.

Source: Comments on inorganic chemistry. 36(6):343-354

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100034757666.0x000001&indx=1&recIds=ETOCvdc_100034757666.0x000001

Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice.

Authors: Bo Sun, Rouzbehani, Omid M. T., Kramer, Ryan J., Ghosh, Rajeshwary, Perelli, Robin M., Atkins, Sage, Fatahian, Amir Nima, Davis, Kathryn, Szulik, Marta W., Goodman, Michael A., Hathaway, Marissa A., Chi, Ellenor, Word, Tarah A., Tunuguntla, Hari, Denfield, Susan W., Wehrens, Xander H. T., Whitehead, Kevin J., Abdelnasser, Hala Y., Warren, Junco S., Mingfu Wu

Source: Circulation: Heart Failure; Dec2023, Vol. 16 Issue 12, p1066-1082, 17p

Photoacoustic calorimetry study of ligand photorelease from the Ru(II)bis(2, 2′-bipyridine)(6, 6′-dimethyl-2, 2′-bipyridine) complex in aqueous solution

Authors: Word, Tarah A., Whittington, Christi L., Karolak, Aleksandra, Kemp, M. Trent, Woodcock, H. Lee, van der Vaart, Arjan, Larsen, Randy W.

Source: Chemical physics letters. 619:214-218

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100064086616.0x000001&indx=1&recIds=ETOCvdc_100064086616.0x000001

B-IN01-09 MULTIPLEX GENOME EDITING FOR THE TREATMENT OF CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA

Authors: Moore, Oliver, Davidson, Jayso'n, Copeland, Juwan, Campbell, Hannah, Word, Tarah, Lagor, William, Wehrens, Xander H.T.

Source: Heart rhythm. 18(S):S467-S467

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150878745.0x000001&indx=1&recIds=ETOCvdc_100150878745.0x000001

Using Photoacoustic Calorimetry to Study the cis- to trans- Photoisomerization of the [Ru(II)(2,2’-bipyridine)2(H2O)2]²⁺ Complex in Aqueous Solution.

Authors: Word, Tarah A.¹ (AUTHOR), Karolak, Aleksandra² (AUTHOR), Cioce, Christian R.³ (AUTHOR), Van Der Vaart, Arjan⁴ (AUTHOR), Larsen, Randy W.⁴ (AUTHOR) rwlarsen@usf.edu

Source: Comments on Inorganic Chemistry. 2016, Vol. 36 Issue 6, p343-354. 12p. 1 Color Photograph, 1 Diagram, 2 Charts, 3 Graphs.

Subject Terms: *CALORIMETRY, *PHOTOISOMERIZATION, *RUTHENIUM compounds, *PHOTOACOUSTIC effect, *DENSITY functional theory, *ISOMERIZATION, *PHOTOLYSIS (Chemistry)

Efficacy of RyR2 inhibitor EL20 in induced pluripotent stem cell-derived cardiomyocytes from a patient with catecholaminergic polymorphic ventricular tachycardia.

Authors: Word, Tarah A., Quick, Ann P., Miyake, Christina, Shak, Mayra K., Xiaolu Pan, Kim, Jean J., Allen, Hugh D., Sibrian-Vazquez, Martha, Strongin, Robert M., Landstrom, Andrew P., Wehrens, Xander H. T.

Source: Journal of Cellular & Molecular Medicine; Jul2021, Vol. 25 Issue 13, p6115-6124, 10p

Subject Terms: VENTRICULAR tachycardia, BRUGADA syndrome, ARRHYTHMIA, RYANODINE receptors, LABORATORY mice, CARDIAC arrest

In Vivo Ryr 2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.

Authors: Pan, Xiaolu, Philippen, Leonne, Lahiri, Satadru K., Lee, Ciaran, Park, So Hyun, Word, Tarah A., Li, Na, Jarrett, Kelsey E., Gupta, Rajat, Reynolds, Julia O., Lin, Jean, Bao, Gang, Lagor, William R., Wehrens, Xander H.T.

Source: Circulation Research; 9/28/2018, Vol. 123 Issue 8, p953-963, 11p