Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

Authors: Kemin Tan, Junjian Chen, Yu Kaku, Yi Wang, Luke Donius, Rafiq Ahmad Khan, Xiaolong Li, Hannah Richter, Michael S. Seaman, Thomas Walz, Wonmuk Hwang, Ellis L. Reinherz, Mikyung Kim

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/47bc63ae82264e1ca90081493607b6de

Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination

Authors: Ana C Chang-Gonzalez, Robert J Mallis, Matthew J Lang, Ellis L Reinherz, Wonmuk Hwang

Source: eLife, Vol 13 (2024)

Subject Terms: T-cell receptor, catch bond, mechanobiology, major histocompatibility complex, molecular dynamics, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/91881; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/8f049efe069f4a2bbef030ed71b32ca6

Building a three-dimensional model of early-stage zebrafish embryo brain

Authors: Ana C. Chang-Gonzalez, Holly C. Gibbs, Arne C. Lekven, Alvin T. Yeh, Wonmuk Hwang

Source: Biophysical Reports, Vol 1, Iss 1, Pp 100003- (2021)

Subject Terms: Physics, QC1-999, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667074721000033; https://doaj.org/toc/2667-0747

Access URL: https://doaj.org/article/f07c57a794fc478f8b10b404cd3b5db9

Kinesin motility is driven by subdomain dynamics

Authors: Wonmuk Hwang, Matthew J Lang, Martin Karplus

Source: eLife, Vol 6 (2017)

Subject Terms: ATP hydrolysis, kinesin-microtubule system, mechanochemistry, molecular dynamics simulation, motility cycle, motor protein, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/28948; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/54609733a60045418161075cda4cb866

Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling

Authors: Holly C. Gibbs, Ana Chang-Gonzalez, Wonmuk Hwang, Alvin T. Yeh, Arne C. Lekven

Source: Frontiers in Neuroanatomy, Vol 11 (2017)

Subject Terms: MHB, mes/r1, Wnt, Fgf, constriction morphogenesis, two-photon fluorescence, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Human anatomy, QM1-695

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fnana.2017.00064/full; https://doaj.org/toc/1662-5129

Access URL: https://doaj.org/article/da81ab6a1b3e4a7bab1874ccdf991d26

Thermodynamic selection of steric zipper patterns in the amyloid cross-beta spine.

Authors: Jiyong Park, Byungnam Kahng, Wonmuk Hwang

Source: PLoS Computational Biology, Vol 5, Iss 9, p e1000492 (2009)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2723932?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/61eaeef89eba4e699ab6122914e6e4b4

Computational analysis of viscoelastic properties of crosslinked actin networks.

Authors: Taeyoon Kim, Wonmuk Hwang, Hyungsuk Lee, Roger D Kamm

Source: PLoS Computational Biology, Vol 5, Iss 7, p e1000439 (2009)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2703781?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/77b6e4099adb4bff89bd6eab3acbf07d

Supramolecular structure of a helical ribbon peptide self-assembly

Authors: Wonmuk Hwang, Marini, D.M., Shuguang Zhang, Kamm, R.D.

Source: Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology Joint EMBS-BMES conference Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint. 1:612-613 vol.1 2002

Relation: Conference Proceedings. Second Joint EMBS-BMES Conference 2002 24th Annual International Conference of the Engineering in Medicine and Biology Society. Annual Fall Meeting of the Biomedical Engineering Society

Nanoscale helical ribbons from self-assembly of a /spl beta/-sheet peptide

Authors: Marini, D.M., Wonmuk Hwang, Lauffenburger, D., Shuguang Zhang, Kamm, R.D.

Source: Proceedings of the IEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering Molecular, cellular and tissue engineering Molecular, Cellular and Tissue Engineering, 2002. Proceedings of the IEEE-EMBS Special Topic Conference on. :108 2002

Relation: Proceedings of the IEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering

Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination.

Authors: Chang-Gonzalez, Ana C., Mallis, Robert J., Lang, Matthew J., Reinherz, Ellis L., Wonmuk Hwang

Source: eLife; 2/15/2024, p1-31, 31p

Harnessing αβ T cell receptor mechanobiology to achieve the promise of immuno- oncology.

Authors: Reinherz, Ellis L.^1,2,3 ellis_reinherz@dfci.harvard.edu, Wonmuk Hwang^4,5,6 hwm@tamu.edu, Lang, Matthew J.^7,8 matt.lang@vanderbilt.edu

Source: Proceedings of the National Academy of Sciences of the United States of America. 7/4/2023, Vol. 120 Issue 27, p1-10. 19p.

Subject Terms: *T cell receptors, *CELL transformation, *MAJOR histocompatibility complex, *PEPTIDES, *T cells

Antifouling Self-assembled Monolayers on Microelectrodes for Patterning Biomolecules

Authors: John Noel, author¹, Winfried Teizer, author¹, Wonmuk Hwang, author²

Source: Journal of Visualized Experiments. (30)

Availability: http://www.jove.com/video/1390

Electric field-induced reversible trapping of microtubules along metallic glass microwire electrodes.

Authors: Kyongwan Kim¹, Sikora, Aurélien¹, Nakayama, Koji S.¹, Mitsuo Umetsu^1,2, Wonmuk Hwang^3,4,5, Winfried Teizer^1,4,6, teizer@physics.tamu.edu

Source: Journal of Applied Physics; 2015, Vol. 117 Issue 14, p144701-1-144701-10, 10p, 3 Diagrams, 3 Graphs

Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.

Authors: Mallis, Robert J., Duke-Cohan, Jonathan S., Das, Dibyendu Kumar, Aoi Akitsu, Luoma, Adrienne M., Banik, Debasis, Stephens, Hannah M., Tetteh, Paul W., Castro, Caitlin D., Krahnke, Sophie, Hussey, Rebecca E., Lawney, Brian, Brazin, Kristine N., Reche, Pedro A., Wonmuk Hwang, Adams, Erin J., Lang, Matthew J., Reinherz, Ellis L.

Source: Proceedings of the National Academy of Sciences of the United States of America; 6/29/2021, Vol. 118 Issue 26, p1-12, 12p

Subject Terms: CELL receptors, MAJOR histocompatibility complex, MOLECULAR dynamics, T cell receptors, CELL communication

Calculation of conformation-dependent biomolecular forces.

Authors: Wonmuk Hwang¹ hwm@tamu.edu

Source: Journal of Chemical Physics. 11/7/2007, Vol. 127 Issue 17, p175104. 5p. 3 Graphs.

Subject Terms: *CONFORMATIONAL analysis, *MOLECULAR rotation, *ELASTICITY, *BIOMOLECULES, *BIOPOLYMERS, *FINITE size scaling (Statistical physics)

Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses.

Authors: Jae-Hyun Cho, Baoyu Zhao, Jie Shi, Savage, Nowlan, Qingliang Shen, Byrnes, James, Lin Yang, Wonmuk Hwang, Pingwei Li

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/24/2020, Vol. 117 Issue 12, p6550-6558, 9p

Subject Terms: MOLECULAR recognition, SEASONAL influenza, INFLUENZA A virus, MOLECULAR dynamics, X-ray crystallography

Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling.

Authors: Gibbs, Holly C., Chang-Gonzalez, Ana, Wonmuk Hwang, Yeh, Alvin T., Lekven, Arne C.

Source: Frontiers in Neuroanatomy; 8/3/2017, p1-17, 17p

Subject Terms: NEURAL tube, MESENCEPHALON, RHOMBENCEPHALON, VERTEBRATE embryology, GENE expression in fishes

Structural features of the αβTCR mechanotransduction apparatus that promote pMHC discrimination.

Authors: Brazin, Kristine N., Mallis, Robert J., Das, Dibyendu Kumar, Yinnian Feng, Wonmuk Hwang, Jia-huai Wang, Wagner, Gerhard, Lang, Matthew J., Reinherz, Ellis L., Dushek, Omer, Varma, Rajat

Source: Frontiers in Immunology; Sep2015, p1-13, 13p

Subject Terms: MECHANOTRANSDUCTION (Cytology), T cell receptors, MAJOR histocompatibility complex

Kinetic Signature of Fractal-like Filament Networks Formed by Orientational Linear Epitaxy.

Authors: Wonmuk Hwang¹ hwm@tamu.edu, Eryilmaz, Esma²

Source: Physical Review Letters. 7/11/2014, Vol. 113 Issue 2, p025502-1-025502-5. 5p.

Subject Terms: *FRACTALS, *FIBERS, *EPITAXY, *COLLAGEN, *COMPUTER software, *LATTICE dynamics

Role of Hydration Force in the Self-Assembly of Collagens and Amyloid Steric Zipper Filaments.

Authors: Ravikumar, Krishnakumar M.¹, Wonmuk Hwang^1,2 hwm@tamu.edu

Source: Journal of the American Chemical Society. 8/3/2011, Vol. 133 Issue 30, p11766-11773. 8p.

Subject Terms: *WATER of hydration, *COLLAGEN, *AMYLOID, *MOLECULAR dynamics, *AMINO acids