Aberrant neural activity in prefrontal pyramidal neurons lacking TDP-43 precedes neuron loss

Authors: Liang, Bo, Thapa, Rashmi, Zhang, Gracie, Moffitt, Casey, Zhang, Yan, Zhang, Lifeng, Johnston, Amanda, Ruby, Hyrum P., Barbera, Giovanni, Wong, Philip C., Zhang, Zhaojie, Chen, Rong, Lin, Da-Ting, Li, Yun

Source: In Progress in Neurobiology August 2022 215

Loss of TDP‐43 Splicing Repression Occurs in Myonuclei of Inclusion Body Myositis Patients.

Authors: Ikenaga, Chiseko, Wilson, Andrew B., Irwin, Katherine E., Peethambaran Mallika, Aswathy, Kilgore, Collin, Sinha, Irika R., Michelle, Elizabeth H., Ling, Jonathan P., Wong, Philip C., Lloyd, Thomas E.

Source: Annals of Neurology; Apr2025, Vol. 97 Issue 4, p629-641, 13p

Subject Terms: INCLUSION body myositis, BIOMARKERS, THERAPEUTICS, TDP-43 proteinopathies, GENETIC regulation, SKELETAL muscle, BIOPSY, PEPTIDES

Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease

Authors: Gonzalez-Gil, Anabel, Porell, Ryan N., Fernandes, Steve M., Maenpaa, Eila, Li, T. August, Li, Tong, Wong, Philip C., Aoki, Kazuhiro, Tiemeyer, Michael, Yu, Zaikuan J., Orsburn, Benjamin C., Bumpus, Namandjé N., Matthews, Russell T., Schnaar, Ronald L.

Source: In Journal of Biological Chemistry June 2022 298(6)

Donald Lowell Price, M.D. In memoriam.

Authors: Sisodia, Sangram¹ (AUTHOR) ssisodia@bsd.uchicago.edu, Wong, Philip C.² (AUTHOR) wong@jhmi.edu

Source: Molecular Neurodegeneration. 11/20/2023, Vol. 18 Issue 1, p1-8. 8p.

Subject Terms: *PRICES, *ALZHEIMER'S disease

Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice

Authors: Campbell, Kaitlyn M., Xu, Yiding, Patel, Chintan, Rayl, Jeremy M., Zomer, Helena D., Osuru, Hari Prasad, Pratt, Michael, Pramoonjago, Patcharin, Timken, Madeline, Miller, Lyndzi M., Ralph, Abigail, Storey, Kathryn M., Peng, Yiheng, Drnevich, Jenny, Lagier-Tourenne, Clotilde, Wong, Philip C., Qiao, Huanyu, Reddi, Prabhakara P.

Source: In Journal of Biological Chemistry November 2021 297(5)

Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging

Authors: Chen, Lin, van Zijl, Peter C.M., Wei, Zhiliang, Lu, Hanzhang, Duan, Wenzhen, Wong, Philip C., Li, Tong, Xu, Jiadi

Source: In NeuroImage 1 August 2021 236

Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice

Authors: Sieverding, Kirsten, Ulmer, Johannes, Bruno, Clara, Satoh, Takashi, Tsao, William, Freischmidt, Axel, Akira, Shizuo, Wong, Philip C., Ludolph, Albert C., Danzer, Karin M., Lobsiger, Christian S., Brenner, David, Weishaupt, Jochen H.

Source: In Experimental Neurology January 2021 335

Elevated PDGF‐BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes

Authors: Liu, Guanqiao, Wang, Jiekang, Wei, Zhiliang, Fang, Ching‐Lien, Shen, Ke, Qian, Cheng, Qi, Cheng, Li, Tong, Gao, Peisong, Wong, Philip C., Lu, Hanzhang, Cao, Xu, Wan, Mei

Source: Advanced science. 10(20)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189698859.0x000001&indx=1&recIds=ETOCvdc_100189698859.0x000001

Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43

Authors: Donde, Aneesh, Sun, Mingkuan, Jeong, Yun Ha, Wen, Xinrui, Ling, Jonathan, Lin, Sophie, Braunstein, Kerstin, Nie, Shuke, Wang, Sheng, Chen, Liam, Wong, Philip C.

Source: Autophagy. 16(4):672-682

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099737388.0x000001&indx=1&recIds=ETOCvdc_100099737388.0x000001

Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI

Authors: Chen, Lin, Wei, Zhiliang, Chan, Kannie W.Y., Cai, Shuhui, Liu, Guanshu, Lu, Hanzhang, Wong, Philip C., van Zijl, Peter C.M., Li, Tong, Xu, Jiadi

Source: In NeuroImage March 2019 188:380-390

Reversible induction of TDP-43 granules in cortical neurons after traumatic injury

Authors: Wiesner, Diana, Tar, Lilla, Linkus, Birgit, Chandrasekar, Akila, olde Heuvel, Florian, Dupuis, Luc, Tsao, William, Wong, Philip C., Ludolph, Albert, Roselli, Francesco

Source: In Experimental Neurology January 2018 299 Part A:15-25

Splicing repression is a major function of TDP-43 in motor neurons

Authors: Donde, Aneesh, Sun, Mingkuan, Ling, Jonathan P., Braunstein, Kerstin E., Pang, Bo, Wen, Xinrui, Cheng, Xueying, Chen, Liam, Wong, Philip C.

Source: Acta neuropathologica. 138(5):813-826

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141525776.0x000001&indx=1&recIds=ETOCvdc_100141525776.0x000001

Elevated nuclear TDP-43 induces constitutive exon skipping.

Authors: Carmen-Orozco, Rogger P., Tsao, William, Ye, Yingzhi, Sinha, Irika R., Chang, Koping, Trinh, Vickie T., Chung, William, Bowden, Kyra, Troncoso, Juan C., Blackshaw, Seth, Hayes, Lindsey R., Sun, Shuying, Wong, Philip C., Ling, Jonathan P.

Source: Molecular Neurodegeneration; 6/9/2024, Vol. 19 Issue 1, p1-17, 17p

Subject Terms: NUCLEAR proteins, NEURODEGENERATION, GENETIC overexpression, RNA sequencing

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Protective Effect of Neurofilament Heavy Gene Overexpression in Motor Neuron Disease Induced by Mutant Superoxide Dismutase

Authors: Couillard-Despres, Sebastien, Zhu, Qinzhang, Wong, Philip C., Price, Donald L., Cleveland, Don W., Julien, Jean-Pierre

Source: Proceedings of the National Academy of Sciences of the United States of America, 1998 Aug 01. 95(16), 9626-9630.

Access URL: https://www.jstor.org/stable/45525

Overexpression of Human Copper,Zinc-Superoxide Dismutase (SOD1) Prevents Postischemic Injury

Authors: Wang, Penghai, Chen, Hua, Qin, Honghua, Sankarapandi, Sornampillai, Becher, Mark W., Wong, Philip C., Zweier, Jay L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1998 Apr . 95(8), 4556-4560.

Access URL: https://www.jstor.org/stable/44935

Subunit Composition of Neurofilaments Specifies Axonal Diameter

Authors: Xu, Zuoshang, Marszalek, Joe R., Lee, Michael K., Wong, Philip C., Folmer, Janet, Crawford, Thomas O., Hsieh, Sung-Tsang, Griffin, John W., Cleveland, Don W.

Source: The Journal of Cell Biology, 1996 Jun 01. 133(5), 1061-1069.

Access URL: https://www.jstor.org/stable/1617484

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 mutations

Authors: Le, Nhat T. T., Chang, Lydia, Kovlyagina, Irina, Georgiou, Polymnia, Safren, Nathaniel, Braunstein, Kerstin E., Kvarta, Mark D., Van Dyke, Adam M., LeGates, Tara A., Philips, Thomas, Morrison, Brett M., Thompson, Scott M., Puche, Adam C., Gould, Todd D., Rothstein, Jeffrey D., Wong, Philip C., Monteiro, Mervyn J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Nov . 113(47), E7580-E7589.

Access URL: https://www.jstor.org/stable/26472618

TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD

Authors: Ling, Jonathan P., Pletnikova, Olga, Troncoso, Juan C., Wong, Philip C.

Source: Science, 2015 Aug 01. 349(6248), 650-655.

Access URL: http://www.jstor.org/stable/24748734

Challenges and Advances in Gene Therapy Approaches for Neurodegenerative Disorders

Authors: Donde, Aneesh, Wong, Philip C., Chen, Liam L.

Source: Current gene therapy. 17(3):187-193

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077932702.0x000001&indx=1&recIds=ETOCvdc_100077932702.0x000001