Anti-fibrotic effects of nintedanib on lung fibroblasts derived from patients with Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)

Authors: Joannes, Audrey, Voisin, Tom, Morzadec, Claudie, Letellier, Alice, Gutierrez, Francisco Llamas, Chiforeanu, Dan Cristian, Le Naoures, Cécile, Guillot, Stéphanie, De Latour, Bertrand Richard, Rouze, Simon, Jaillet, Madeleine, Crestani, Bruno, Wollin, Lutz, Jouneau, Stéphane, Vernhet, Laurent

Source: In Pulmonary Pharmacology & Therapeutics December 2023 83

Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis

Authors: Joannes, Audrey, Morzadec, Claudie, Duclos, Maëla, Gutierrez, Francisco Llamas, Chiforeanu, Dan Cristian, Le Naoures, Cécile, De Latour, Bertrand, Rouzé, Simon, Wollin, Lutz, Jouneau, Stéphane, Vernhet, Laurent

Source: In Toxicology and Applied Pharmacology 15 April 2022 441

PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells.

Authors: Reininger, Dennis, Fundel‐Clemens, Katrin, Mayr, Christoph H., Wollin, Lutz, Laemmle, Baerbel, Quast, Karsten, Nickolaus, Peter, Herrmann, Franziska Elena

Source: British Journal of Pharmacology; Dec2024, Vol. 181 Issue 23, p4766-4781, 16p

Subject Terms: CYCLIC nucleotide phosphodiesterases, IDIOPATHIC pulmonary fibrosis, PULMONARY fibrosis, LABORATORY rats, EPITHELIAL cell culture

Alteration of human macrophage phenotypes by the anti-fibrotic drug nintedanib

Authors: Bellamri, Nessrine, Morzadec, Claudie, Joannes, Audrey, Lecureur, Valérie, Wollin, Lutz, Jouneau, Stéphane, Vernhet, Laurent

Source: In International Immunopharmacology July 2019 72:112-123

TNF-α and IL-10 Control CXCL13 Expression in Human Macrophages

Authors: Bellamri, Nessrine, Viel, Roselyne, Morzadec, Claudie, Lecureur, Valérie, Joannes, Audrey, de Latour, Bertrand, Llamas-Gutierrez, Francisco, Wollin, Lutz, Jouneau, Stéphane, Vernhet, Laurent

Source: Journal of immunology. 204(9):2492-2502

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623957431&indx=1&recIds=ETOCRN623957431

Objective measurement of cough in pulmonary fibrosis: a cohort study - ImpaCT.

Authors: Kebbe, Jad, Hart, Simon P., Kaner, Robert J., Kulkarni, Tejaswini, Wollin, Lutz, Coeck, Carl, Vinisko, Richard, Patel, Nina, Wijsenbeek, Marlies S.

Source: ERJ Open Research; Sep2024, Vol. 10 Issue 5, p1-5, 5p

Therapeutic targets in idiopathic pulmonary fibrosis

Authors: Kolb, Martin, Bonella, Francesco, Wollin, Lutz

Source: In Respiratory Medicine October 2017 131:49-57

Nintedanib reduces radiation-induced microscopic lung fibrosis but this cannot be monitored by CT imaging: A preclinical study with a high precision image-guided irradiator

Authors: De Ruysscher, Dirk, Granton, Patrick Vincent, Lieuwes, Natasja Gaby, van Hoof, Stefan, Wollin, Lutz, Weynand, Birgit, Dingemans, Anne-Marie, Verhaegen, Frank, Dubois, Ludwig

Source: In Radiotherapy and Oncology September 2017 124(3):482-487

The activity of nintedanib in an animal model of allogenic left lung transplantation resembling aspects of allograft rejection

Authors: von Suesskind-Schwendi, Marietta, Boxhammer, Elke, Hirt, Stephan W., Schreml, Stephan, Schmid, Christof, Wollin, Lutz, Lehle, Karla

Source: Experimental lung research. 43(6-7):259-270

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105902149.0x000001&indx=1&recIds=ETOCvdc_100105902149.0x000001

Antifibrotic and Anti-inflammatory Activity of the Tyrosine Kinase Inhibitor Nintedanib in Experimental Models of Lung Fibrosis

Authors: Wollin, Lutz ^*, Maillet, Isabelle, Quesniaux, Valérie, Holweg, Alexander, Ryffel, Bernhard

Source: In The Journal of Pharmacology and Experimental Therapeutics May 2014 349(2):209-220

Effects of Nintedanib in an Animal Model of Liver Fibrosis.

Authors: Wollin, Lutz¹ (AUTHOR), Togbe, Dieudonnée² (AUTHOR), Ryffel, Bernhard³ (AUTHOR)

Source: BioMed Research International. 3/31/2020, p1-9. 9p.

Subject Terms: *ANIMAL experimentation, *BIOLOGICAL models, *HYDROCARBONS, *INFLAMMATION, *INTERLEUKINS, *LIVER diseases, *MICE, *NECROSIS, *FIBROSIS, *ALANINE aminotransferase, *PROTEIN kinase inhibitors, *DESCRIPTIVE statistics

Nintedanib Reduces Muscle Fibrosis and Improves Muscle Function of the Alpha-Sarcoglycan-Deficient Mice.

Authors: Alonso-Pérez, Jorge, Carrasco-Rozas, Ana, Borrell-Pages, Maria, Fernández-Simón, Esther, Piñol-Jurado, Patricia, Badimon, Lina, Wollin, Lutz, Lleixà, Cinta, Gallardo, Eduard, Olivé, Montse, Díaz-Manera, Jordi, Suárez-Calvet, Xavier

Source: Biomedicines; Oct2022, Vol. 10 Issue 10, pN.PAG-N.PAG, 17p

Subject Terms: LIMB-girdle muscular dystrophy, MUSCULAR dystrophy, MUSCLE weakness, GRIP strength, MICE

Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis.

Authors: Herrmann, Franziska Elena¹, Wollin, Lutz¹, Wirth, Johannes¹, Gantner, Florian², Lämmle, Bärbel³, Wex, Eva¹

Source: British Journal of Pharmacology. Nov2017, Vol. 174 Issue 21, p3848-3864. 17p.

Subject Terms: *IDIOPATHIC pulmonary fibrosis, *FIBROBLASTS, *ADRENERGIC receptors, *PREPROENDOTHELIN, *RESPIRATORY diseases

Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis.

Authors: Hesse, Christina, Beneke, Valerie, Konzok, Sebastian, Diefenbach, Claudia, Bülow Sand, Jannie Marie, Rønnow, Sarah Rank, Karsdal, Morten Asser, Jonigk, Danny, Sewald, Katherina, Braun, Armin, Leeming, Diana Julie, Wollin, Lutz

Source: Respiratory Research; 8/4/2022, Vol. 23 Issue 1, p1-9, 9p

BI 1015550 is a PDE4B Inhibitor and a Clinical Drug Candidate for the Oral Treatment of Idiopathic Pulmonary Fibrosis.

Authors: Herrmann, Franziska Elena, Hesslinger, Christian, Wollin, Lutz, Nickolaus, Peter

Source: Frontiers in Pharmacology; 4/20/2022, Vol. 13, p1-17, 17p

Subject Terms: IDIOPATHIC pulmonary fibrosis, FIBROBLAST growth factor 2, MONONUCLEAR leukocytes, ORAL drug administration, PHOSPHODIESTERASE inhibitors, EXTRACELLULAR matrix proteins, TRANSFORMING growth factors

Cyclooxygenase-inhibition enhances the effects of rSP-C surfactant therapy in a rat lavage model of Acute Respiratory Distress Syndrome (ARDS)

Authors: Häfner, Dietrich, Ibrahim, Merdol, Wollin, Lutz, Germann, Paul-Georg

Source: In Experimental and Toxicologic Pathology 2003 55(1):59-68

The Effect of Nintedanib on T-Cell Activation, Subsets and Functions.

Authors: Ubieta, Kenia, Thomas, Matthew James, Wollin, Lutz

Source: Drug Design, Development & Therapy; Mar2021, Vol. 15, p997-1011, 15p

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