Ex Vivo 13 C-Metabolic Flux Analysis of Porcine Circulating Immune Cells Reveals Cell Type-Specific Metabolic Patterns and Sex Differences in the Pentose Phosphate Pathway.

Authors: Hogg, Melanie¹ (AUTHOR) eva-maria.wolfschmitt@uni-ulm.de, Wolfschmitt, Eva-Maria¹ (AUTHOR), Wachter, Ulrich¹ (AUTHOR), Zink, Fabian¹ (AUTHOR), Radermacher, Peter¹ (AUTHOR), Vogt, Josef Albert¹ (AUTHOR)

Source: Biomolecules (2218-273X). Jan2024, Vol. 14 Issue 1, p98. 20p.

Subject Terms: *PENTOSE phosphate pathway, *MONONUCLEAR leukocytes, *KREBS cycle, *T helper cells, *GLYCOLYSIS, *ENERGY metabolism, *OXYGEN consumption

Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.

Authors: Kapapa, Thomas, Wernheimer, Vanida, Hoffmann, Andrea, Merz, Tamara, Zink, Fabia, Wolfschmitt, Eva-Maria, McCook, Oscar, Vogt, Josef, Wepler, Martin, Messerer, David Alexander Christian, Hartmann, Claire, Scheuerle, Angelika, Mathieu, René, Mayer, Simon, Gröger, Michael, Denoix, Nicole, Clazia, Enrico, Radermacher, Peter, Röhrer, Stefan, Datzmann, Thomas

Source: Cells (2073-4409); Jan2025, Vol. 14 Issue 1, p17, 33p

Subject Terms: BRAIN injuries, SUBDURAL hematoma, THERAPEUTICS, INTRACRANIAL pressure, BASAL ganglia

Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle

Authors: Stifel, Ulrich, Wolfschmitt, Eva-Maria, Vogt, Josef, Wachter, Ulrich, Vettorazzi, Sabine, Tews, Daniel, Hogg, Melanie, Zink, Fabian, Koll, Nora Maria, Winning, Sandra, Mounier, Rémi, Chazaud, Bénédicte, Radermacher, Peter, Fischer-Posovszky, Pamela, Caratti, Giorgio, Tuckermann, Jan

Source: In Molecular Metabolism March 2022 57

Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H 2 S Systems.

Authors: Münz, Franziska, Abele, Nadja, Zink, Fabian, Wolfschmitt, Eva-Maria, Hogg, Melanie, Barck, Claus, Anetzberger, Josef, Hoffmann, Andrea, Gröger, Michael, Calzia, Enrico, Waller, Christiane, Radermacher, Peter, Merz, Tamara

Source: Biomolecules (2218-273X); Nov2024, Vol. 14 Issue 11, p1385, 16p

Subject Terms: PREFRONTAL cortex, ANIMAL anesthesia, BRAIN injuries, OXYTOCIN, IMMUNOHISTOCHEMISTRY

The Effect of Targeted Hyperoxemia on Brain Immunohistochemistry after Long-Term, Resuscitated Porcine Acute Subdural Hematoma and Hemorrhagic Shock.

Authors: Münz, Franziska, Datzmann, Thomas, Hoffmann, Andrea, Gröger, Michael, Mathieu, René, Mayer, Simon, Zink, Fabian, Gässler, Holger, Wolfschmitt, Eva-Maria, Hogg, Melanie, Calzia, Enrico, Asfar, Pierre, Radermacher, Peter, Kapapa, Thomas, Merz, Tamara

Source: International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 12, p6574, 15p

Subject Terms: HEMORRHAGIC shock, SUBDURAL hematoma, BRAIN injuries, BLOOD-brain barrier, IMMUNOHISTOCHEMISTRY, OXYTOCIN receptors, BLOOD volume, CEREBRAL circulation, HOMEOSTASIS

¹³C-Metabolic flux analysis detected a hyperoxemia-induced reduction of tricarboxylic acid cycle metabolism in granulocytes during two models of porcine acute subdural hematoma and hemorrhagic shock.

Authors: Wolfschmitt, Eva-Maria, Vogt, Josef Albert, Hogg, Melanie, Wachter, Ulrich, Stadler, Nicole, Kapapa, Thomas, Datzmann, Thomas, Christian Messerer, David Alexander, Hoffmann, Andrea, Gröger, Michael, Münz, Franziska, Mathieu, René, Mayer, Simon, Merz, Tamara, Asfar, Pierre, Calzia, Enrico, Radermacher, Peter, Zink, Fabian

Source: Frontiers in Immunology; 2024, p1-15, 15p

Subject Terms: KREBS cycle, ELECTRON paramagnetic resonance spectroscopy, HEMORRHAGIC shock, SUBDURAL hematoma, GRANULOCYTES

Bayesian 13 C-Metabolic Flux Analysis of Parallel Tracer Experiments in Granulocytes: A Directional Shift within the Non-Oxidative Pentose Phosphate Pathway Supports Phagocytosis.

Authors: Hogg, Melanie, Wolfschmitt, Eva-Maria, Wachter, Ulrich, Zink, Fabian, Radermacher, Peter, Vogt, Josef Albert

Source: Metabolites (2218-1989); Jan2024, Vol. 14 Issue 1, p24, 26p

Subject Terms: PENTOSE phosphate pathway, GAS chromatography/Mass spectrometry (GC-MS), SUGAR phosphates, PRINCIPAL components analysis, GRANULOCYTES, GLUCOSE metabolism, PHAGOCYTOSIS

Relation of Plasma Catecholamine Concentrations and Myocardial Mitochondrial Respiratory Activity in Anesthetized and Mechanically Ventilated, Cardiovascular Healthy Swine.

Authors: Abele, Nadja, Münz, Franziska, Zink, Fabian, Gröger, Michael, Hoffmann, Andrea, Wolfschmitt, Eva-Maria, Hogg, Melanie, Calzia, Enrico, Waller, Christiane, Radermacher, Peter, Merz, Tamara

Source: International Journal of Molecular Sciences; Dec2023, Vol. 24 Issue 24, p17293, 16p

Subject Terms: ARTIFICIAL respiration, RESPIRATION, ELECTRON paramagnetic resonance, MITOCHONDRIA, SWINE, DNA damage

Autoreactive napsin A–specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade.

Authors: Berner, Fiamma, Bomze, David, Lichtensteiger, Christa, Walter, Vincent, Niederer, Rebekka, Hasan Ali, Omar, Wyss, Nina, Bauer, Jens, Freudenmann, Lena Katharina, Marcu, Ana, Wolfschmitt, Eva-Maria, Haen, Sebastian, Gross, Thorben, Abdou, Marie-Therese, Diem, Stefan, Knöpfli, Stella, Sinnberg, Tobias, Hofmeister, Kathrin, Cheng, Hung-Wei, Toma, Marieta

Source: Science Immunology; 2022, Vol. 7 Issue 75, p1-13, 13p

Subject Terms: T cells, IMMUNE checkpoint proteins, LUNG diseases, LUNG tumors, NON-small-cell lung carcinoma, AUTOIMMUNE diseases

Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine Gamma Lyase (CSE) Knockout Mice.

Authors: Gröger, Michael, Hogg, Melanie, Abdelsalam, Essam, Kress, Sandra, Hoffmann, Andrea, Stahl, Bettina, Saub, Veronique, Denoix, Nicole, McCook, Oscar, Calzia, Enrico, Wolfschmitt, Eva-Maria, Wachter, Ulrich, Vogt, Josef A., Wang, Rui, Radermacher, Peter, Merz, Tamara, Nussbaum, Benedikt L.

Source: Shock; Jan2022, Vol. 57 Issue 1, p131-139, 9p

Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival.

Authors: Berner, Fiamma, Niederer, Rebekka, Luimstra, Jolien J., Pop, Oltin Tiberiu, Jochum, Ann-Kristin, Purde, Mette-Triin, Ali, Omar Hasan, Bomze, David, Bauer, Jens, Freudenmann, Lena Katharina, Marcu, Ana, Wolfschmitt, Eva-Maria, Haen, Sebastian, Gross, Thorben, Dubbelaar, Marissa Lisa, Abdou, Marie-Therese, Baumgaertner, Petra, Appenzeller, Christina, Cicin-Sain, Caroline, Lenz, Tobias

Source: OncoImmunology; 2021, Vol. 10 Issue 1, p1-8, 8p

Subject Terms: T cell differentiation, KERATINOCYTE differentiation, IMMUNE checkpoint proteins, ANTIGENS, T cell receptors, HLA histocompatibility antigens, NON-small-cell lung carcinoma