Predicting anxiety and depression in systemic lupus erythematosus: the role of inflammation, sociodemographic variables and clinical factors

Authors: Sigel, Margot ^a, Muñoz-Grajales, Carolina ^{b, c}, Barraclough, Michelle L. ^{a, d}, Diaz-Martinez, Juan P ^{b, c}, Kakvan, Mahta ^{b, c}, Kretzmann, Roberta Pozzi ^{b, c}, Tartaglia, M Carmela ^e, Ruttan, Lesley ^f, Choi, May Y ^g, Appenzeller, Simone ^h, Bonilla, Dennisse ^{b, c}, Katz, Patricia ⁱ, Beaton, Dorcas E. ^j, Green, Robin ^f, Gladman, Dafna D. ^{b, c}, Wither, Joan E. ^{b, k}, Flint, Alastair J. ^{a, l}, Touma, Zahi ^{b, c}, Bingham, Kathleen S. ^{a, l, ⁎}

Source: In Seminars in Arthritis and Rheumatism August 2025 73

Longitudinal relationships between cognitive domains and depression and anxiety symptoms in systemic lupus erythematosus

Authors: Bingham, Kathleen S., DiazMartinez, JuanPablo, Green, Robin, Tartaglia, Maria C., Ruttan, Lesley, Su, Jiandong, Wither, Joan E., Kakvan, Mahta, Anderson, Nicole, Bonilla, Dennisse, Choi, May Y., Fritzler, Marvin J., Beaton, Dorcas E., Katz, Patti, Touma, Zahi

Source: In Seminars in Arthritis and Rheumatism December 2021 51(6):1186-1192

Metrics and definitions used in the assessment of cognitive impairment in systemic lupus erythematosus: A systematic review

Authors: Yuen, Kimberley, Green, Robin, Bingham, Kathleen, Ruttan, Lesley, Lee-Kim, Victoria, Tartaglia, Maria Carmela, Anderson, Melanie, Zandy, Moe, Choi, May Y., Fritzler, Marvin J., Wither, Joan E., Beaton, Dorcas E., Katz, Patricia, Touma, Zahi

Source: In Seminars in Arthritis and Rheumatism August 2021 51(4):819-830

Evaluation of Progression From Preclinical to Systemic Autoimmune Rheumatic Disease: Novel Use of the European Alliance of Associations for Rheumatology/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria as an Outcome Measure

Authors: Johnson, Sindhu R., Alahmari, Hana, Bonilla, Dennisse, Ahmad, Zareen, Bookman, Arthur, Hiraki, Linda T., Silverman, Earl, Touma, Zahi, Movahedi, Mohammad, Wither, Joan E.

Source: ACR Open Rheumatology; Dec2024, Vol. 6 Issue 12, p871-877, 7p

Subject Terms: NEPHRITIS, RHEUMATOID arthritis, SYSTEMIC lupus erythematosus, FLUORESCENT antibody technique, DESCRIPTIVE statistics, LONGITUDINAL method, AUTOIMMUNE diseases, SYSTEMIC scleroderma, DELIRIUM, SJOGREN'S syndrome, CONFIDENCE intervals, DISEASE progression, SENSITIVITY & specificity (Statistics)

Prevalence and metric of depression and anxiety in systemic lupus erythematosus: A systematic review and meta-analysis

Authors: Moustafa, Ahmed T., Moazzami, Mitra, Engel, Lisa, Bangert, Elvira, Hassanein, Mohamed, Marzouk, Sherief, Kravtsenyuk, Maryana, Fung, William, Eder, Lihi, Su, Jiandong, Wither, Joan E., Touma, Zahi

Source: In Seminars in Arthritis and Rheumatism February 2020 50(1):84-94

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins

Authors: Wu, Chung-An M., Roth, Theodore L., Baglaenko, Yuriy, Ferri, Dario M., Brauer, Patrick, Zuniga-Pflucker, Juan Carlos, Rosbe, Kristina W., Wither, Joan E., Marson, Alexander, Allen, Christopher D.C.

Source: In Journal of Immunological Methods June 2018 457:33-40

Different Immunologic Profiles Are Associated With Distinct Clinical Phenotypes in Longitudinally Observed Patients With Systemic Lupus Erythematosus.

Authors: Manion, Kieran, Muñoz‐Grajales, Carolina, Kim, Michael, Atenafu, Eshetu, Faheem, Zoha, Gladman, Dafna D., Urowitz, Murray, Touma, Zahi, Wither, Joan E.

Source: Arthritis & Rheumatology; May2024, Vol. 76 Issue 5, p726-738, 13p

Subject Terms: SYSTEMIC lupus erythematosus treatment, FLOW cytometry, PARAMETERS (Statistics), SYSTEMIC lupus erythematosus, DECISION making in clinical medicine, LONGITUDINAL method, MATHEMATICAL statistics, T helper cells, PHENOTYPES, NONPARAMETRIC statistics, B cells, SYMPTOMS

Interferon-α induces altered transitional B cell signaling and function in Systemic Lupus Erythematosus

Authors: Chang, Nan-Hua, Li, Timothy T., Kim, Julie J., Landolt-Marticorena, Carolina, Fortin, Paul R., Gladman, Dafna D., Urowitz, Murray B., Wither, Joan E.

Source: In Journal of Autoimmunity April 2015 58:100-110

Experimental evidence that mutated-self peptides derived from mitochondrial DNA somatic mutations have the potential to trigger autoimmunity

Authors: Chen, Lina, Duvvuri, Bhargavi, Grigull, Jörg, Jamnik, Roni, Wither, Joan E., Wu, Gillian E.

Source: In Human Immunology August 2014 75(8):873-879

Elevated Levels of Interferon‐α Act Directly on B Cells to Breach Multiple Tolerance Mechanisms Promoting Autoantibody Production.

Authors: Ferri, Dario M., Nassar, Carol, Manion, Kieran P., Kim, Michael, Baglaenko, Yuriy, Muñoz‐Grajales, Carolina, Wither, Joan E.

Source: Arthritis & Rheumatology; Sep2023, Vol. 75 Issue 9, p1542-1555, 14p

Subject Terms: AUTOANTIBODIES, IMMUNOLOGICAL tolerance, FLOW cytometry, B cells, IN vivo studies, CELL culture, ANIMAL experimentation, INTERFERONS, CELLULAR signal transduction, GENE expression, ENZYME-linked immunosorbent assay, SYSTEMIC lupus erythematosus, POLYMERASE chain reaction, CARRIER proteins

Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice

Authors: Pau, Evelyn, Chang, Nan-Hua, Loh, Christina, Lajoie, Ginette, Wither, Joan E.

Source: In Clinical Immunology 2011 139(2):215-227

Association of mycophenolate and azathioprine use with cognitive function in systemic lupus.

Authors: Dobrowolski, Chrisanna, McGinley, John, Fazzari, Melissa, Su, Jiandong, Bingham, Kathleen S, Anderson, Nicole, Ruttan, Lesley, Beaton, Dorcas E, Wither, Joan E, Tartaglia, Maria Carmela, Kakvan, Mahta, Bonilla, Dennisse, Choi, May Y, Fritzler, Marvin J, Martinez, Juan Pablo Diaz, Katz, Patricia, Green, Robin, Putterman, Chaim, Touma, Zahi

Source: Rheumatology; May2023, Vol. 62 Issue 5, p1860-1869, 10p

Subject Terms: COGNITION disorders, AZATHIOPRINE, COMBINATION drug therapy, CONFIDENCE intervals, AGE distribution, MYCOPHENOLIC acid, SEX distribution, TREATMENT effectiveness, NEUROPROTECTIVE agents, RESEARCH funding, SYSTEMIC lupus erythematosus, LOGISTIC regression analysis, ODDS ratio, PHARMACODYNAMICS

Assessing the Utility of the Montreal Cognitive Assessment in Screening for Cognitive Impairment in Patients With Systemic Lupus Erythematosus.

Authors: Tayer‐Shifman, Oshrat E., Yuen, Kimberley, Green, Robin, Kakvan, Mahta, Katz, Patricia, Bingham, Kathleen S., Diaz‐Martinez, Juan Pablo, Ruttan, Lesley, Wither, Joan E., Tartaglia, Maria Carmela, Su, Jiandong, Bonilla, Dennisse, Choi, May Y., Appenzeller, Simone, Barraclough, Michelle, Beaton, Dorcas E., Touma, Zahi

Source: Arthritis Care & Research; Mar2023, Vol. 75 Issue 3, p569-577, 9p

Subject Terms: SYSTEMIC lupus erythematosus, MEDICAL screening, FISHER discriminant analysis, COGNITION disorders, MONTREAL Cognitive Assessment, NEUROPSYCHOLOGICAL tests

Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms.

Authors: Wither, Joan E.^1,2,3 jwither@uhnres.utoronto.ca, Prokopec, Stephenie D.⁴, Noamani, Babak¹, Chang, Nan-Hua¹, Bonilla, Dennisse¹, Touma, Zahi^2,3, Avila-Casado, Carmen⁵, Reich, Heather N.^3,6, Scholey, James^3,6, Fortin, Paul R.⁷, Boutros, Paul C.^4,8,9, Landolt-Marticorena, Carolina¹

Source: PLoS ONE. 5/9/2018, Vol. 13 Issue 5, p1-19. 19p.

Subject Terms: *NEUTROPHILS, *SYSTEMIC lupus erythematosus, *NEPHRITIS, *LINEAR statistical models, *DATA analysis, *GENETICS

Altered Balance of Pro-Inflammatory Immune Cells to T Regulatory Cells Differentiates Symptomatic From Asymptomatic Individuals With Anti-Nuclear Antibodies.

Authors: Gupta, Rashi, Vanlieshout, Emma, Manion, Kieran, Bonilla, Dennisse, Kim, Michael, Muñoz-Grajales, Carolina, Nassar, Carol, Johnson, Sindhu R., Hiraki, Linda T., Ahmad, Zareen, Touma, Zahi, Bookman, Arthur, Wither, Joan E.

Source: Frontiers in Immunology; 6/30/2022, Vol. 13, p1-13, 13p

Subject Terms: REGULATORY T cells, ANTINUCLEAR factors, IMMUNOGLOBULIN producing cells, TH2 cells, MYELOID cells, AUTOIMMUNE diseases

Molecular basis of antigen recognition by insulin specific T cell receptor

Authors: Sugiyama, Shigeru, Kohyama, Masako, Oda, Masayuki, Azuma, Takachika, Wither, Joan E, Hozumi, Nobumichi

Source: In Immunology Letters 15 February 2004 91(2-3):133-139

Validation of the automated neuropsychological assessment metrics for assessing cognitive impairment in systemic lupus erythematosus.

Authors: Yuen, Kimberley, Beaton, Dorcas, Bingham, Kathleen, Katz, Patricia, Su, Jiandong, Diaz Martinez, Juan Pablo, Tartaglia, Maria Carmela, Ruttan, Lesley, Wither, Joan E., Kakvan, Mahta, Anderson, Nicole, Bonilla, Dennisse, Choi, May Y., Fritzler, Marvin J., Green, Robin, Touma, Zahi

Source: Lupus; Jan2022, Vol. 31 Issue 1, p45-54, 10p, 4 Charts, 2 Graphs

Subject Terms: SYSTEMIC lupus erythematosus, NEUROPSYCHOLOGICAL tests, COGNITION disorders, DECISION trees, MEDICAL screening

Activated B Cells Express Increased Levels of Costimulatory Molecules in Young Autoimmune NZB and (NZB × NZW)F1 Mice

Authors: Wither, Joan E., Roy, Valerie, Brennan, Laurie A.

Source: In Clinical Immunology January 2000 94(1):51-63

Validity Evidence for the Use of Automated Neuropsychologic Assessment Metrics As a Screening Tool for Cognitive Impairment in Systemic Lupus Erythematosus.

Authors: Tayer‐Shifman, Oshrat E., Green, Robin, Beaton, Dorcas E., Ruttan, Lesley, Wither, Joan E., Tartaglia, Maria Carmela, Kakvan, Mahta, Lombardi, Sabrina, Anderson, Nicole, Su, Jiandong, Bonilla, Dennisse, Zandy, Moe, Choi, May Y., Fritzler, Marvin J., Touma, Zahi

Source: Arthritis Care & Research; Dec2020, Vol. 72 Issue 12, p1809-1819, 11p

Subject Terms: COGNITION disorders, SYSTEMIC lupus erythematosus, REGRESSION analysis, PATIENTS, FEMALES

Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in Vκ8/3H9 lupus-prone mice.

Authors: Manion, Kieran P., Baglaenko, Yuriy, Chang, Nan-Hua, Talaei, Nafiseh, Wither, Joan E.

Source: PLoS ONE; 7/28/2020, Vol. 15 Issue 7, p1-21, 21p

Subject Terms: B cells, AUTOANTIBODIES, T helper cells, CELL populations, T cells, SYSTEMIC lupus erythematosus