Fundamentals and recent advances in the evaluation and management of medullary thyroid carcinoma

Authors: Gigliotti, Benjamin J., Brooks, Jennifer A., Wirth, Lori J.

Source: In Molecular and Cellular Endocrinology 1 October 2024 592

Return of Vocal Fold Motion and Surgical Preservation of Invaded Recurrent Laryngeal Nerves After the Use of Neoadjuvant Therapy in Patients Presenting with Advanced Thyroid Cancer and Vocal Fold Paralysis: The Lazarus Effect

Authors: Silver Karcioglu, Amanda, Abdelhamid Ahmed, Amr H., Feng, Zipei, Russell, Marika, Shonka, David C., Iwata, Ayaka, Cabanillas, Maria, Shin, Jennifer J., Kyriazidis, Natalia, Park, Jong Chul, Wirth, Lori J., Zafereo, Mark E., Randolph, Gregory W.

Source: Thyroid. 33(10):1259-1263

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Biomarkers predictive of response to pembrolizumab in head and neck cancer

Authors: Pfister, David G., Haddad, Robert I., Worden, Francis P., Weiss, Jared, Mehra, Ranee, Chow, Laura Q. M., Liu, Stephen V., Kang, Hyunseok, Saba, Nabil F., Wirth, Lori J., Sukari, Ammar, Massarelli, Erminia, Ayers, Mark, Albright, Andrew, Webber, Andrea L., Mogg, Robin, Lunceford, Jared, Huang, Lingkang, Cristescu, Razvan, Cheng, Jonathan, Seiwert, Tanguy Y., Bauml, Joshua M.

Source: Cancer medicine. 12(6):6603-6614

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185281798.0x000001&indx=1&recIds=ETOCvdc_100185281798.0x000001

Challenges and Strategies to Combat Resistance Mechanisms in Thyroid Cancer Therapeutics

Authors: Gild, Matti L., Bullock, Martyn, Tsang, Venessa, Clifton-Bligh, Roderick J., Robinson, Bruce G., Wirth, Lori J.

Source: Thyroid. 33(6):682-690

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Does Current Training in Radiation Oncology Prepare Radiation Oncologists to Optimally Manage Patients With Head and Neck Cancer?

Authors: Richmon, Jeremy D., Chan, Annie W., Sadow, Peter M., Wirth, Lori J., Goldsmith, Tessa, Juliano, Amy F., Wallner, Paul, Quon, Harry

Source: American journal of clinical oncology. 46(7):281-283

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LIBRETTO-531: a phase III study of selpercatinib in multikinase inhibitor-naïve RET-mutant medullary thyroid cancer

Authors: Wirth, Lori J, Brose, Marcia S, Elisei, Rossella, Capdevila, Jaume, Hoff, Ana O, Hu, Mimi I, Tahara, Makoto, Robinson, Bruce, Gao, Ming, Xia, Meng, Maeda, Patricia, Sherman, Eric

Source: Future oncology. 18(28):3143-3150

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191695697.0x000001&indx=1&recIds=ETOCvdc_100191695697.0x000001

Case Report of CCDC149–ALK Fusion: A Novel Genetic Alteration and a Clinically Relevant Target in Metastatic Papillary Thyroid Carcinoma

Authors: Lee, Hannah, Krishnan, Vimal, Wirth, Lori J., Nucera, Carmelo, Venturina, Mariza, Sadow, Peter M., Mita, Alain, Sacks, Wendy

Source: Thyroid. 32(12):1580-1585

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Dabrafenib Versus Dabrafenib + Trametinib in BRAF-Mutated Radioactive Iodine Refractory Differentiated Thyroid Cancer: Results of a Randomized, Phase 2, Open-Label Multicenter Trial

Authors: Busaidy, Naifa L., Konda, Bhavana, Wei, Lai, Wirth, Lori J., Devine, Catherine, Daniels, Gregory A., DeSouza, Jonas A., Poi, Ming, Seligson, Nathan D., Cabanillas, Maria E., Sipos, Jennifer A., Ringel, Matthew D., Eisfeld, Ann-Kathrin, Timmers, Cynthia, Shah, Manisha H.

Source: Thyroid. 32(10):1184-1192

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Selumetinib Plus Adjuvant Radioactive Iodine in Patients With High-Risk Differentiated Thyroid Cancer: A Phase III, Randomized, Placebo-Controlled Trial (ASTRA)

Authors: Ho, Alan L., Dedecjus, Marek, Wirth, Lori J., Tuttle, R. Michael, Inabnet, William B., Tennvall, Jan, Vaisman, Fernanda, Bastholt, Lars, Gianoukakis, Andrew G., Rodien, Patrice, Paschke, Ralf, Elisei, Rossella, Viola, David, So, Karen, Carroll, Danielle, Hovey, Tina, Thakre, Bhavana, Fagin, James A.

Source: Journal of clinical oncology. 40(17):1870-1878

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American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer: Defining advanced thyroid cancer and its targeted treatment

Authors: Shonka, David C., Ho, Alan, Chintakuntlawar, Ashish V., Geiger, Jessica L., Park, Jong C., Seetharamu, Nagashree, Jasim, Sina, Abdelhamid Ahmed, Amr H., Bible, Keith C., Brose, Marcia S., Cabanillas, Maria E., Dabekaussen, Kirsten, Davies, Louise, Dias‐Santagata, Dora, Fagin, James A., Faquin, William C., Ghossein, Ronald A., Gopal, Raj K., Miyauchi, Akira, Nikiforov, Yuri E., Ringel, Matthew D., Robinson, Bruce, Ryder, Mabel M., Sherman, Eric J., Sadow, Peter M., Shin, Jennifer J., Stack, Brendan C., Tuttle, R. Michael, Wirth, Lori J., Zafereo, Mark E., Randolph, Gregory W.

Source: Head & neck. 44(6):1277-1300

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150041861.0x000001&indx=1&recIds=ETOCvdc_100150041861.0x000001

Impact of baseline tumor burden on overall survival in patients with radioiodine‐refractory differentiated thyroid cancer treated with lenvatinib in the SELECT global phase 3 trial

Authors: Kiyota, Naomi, Tahara, Makoto, Robinson, Bruce, Schlumberger, Martin, Sherman, Steven I., Leboulleux, Sophie, Lee, Eun Kyung, Suzuki, Takuya, Ren, Min, Fushimi, Kazuma, Wirth, Lori J.

Source: Cancer. 128(12):2281-2287

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Cell‐free human papillomavirus DNA kinetics after surgery for human papillomavirus–associated oropharyngeal cancer

Authors: O'Boyle, Connor J., Siravegna, Giulia, Varmeh, Shohreh, Queenan, Natalia, Michel, Alexa, Pang, Kim Chang Sing, Stein, Jarrod, Thierauf, Julia C., Sadow, Peter M., Faquin, William C., Wang, Wei, Deschler, Daniel G., Emerick, Kevin S., Varvares, Mark A., Park, Jong C., Clark, John R., Chan, Annie W., Busse, Paul M., Corcoran, Ryan B., Wirth, Lori J., Lin, Derrick T., Iafrate, A. John, Richmon, Jeremy D., Faden, Daniel L.

Source: Cancer. 128(11):2193-2204

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149772411.0x000001&indx=1&recIds=ETOCvdc_100149772411.0x000001

Clinical Activity of Selpercatinib in RET-mutant Pheochromocytoma.

Authors: Deschler-Baier, Barbara, Konda, Bhavana, Massarelli, Erminia, Hu, Mimi I, Wirth, Lori J, Xu, Xiaojian, Wright, Jennifer, Clifton-Bligh, Roderick J

Source: Journal of Clinical Endocrinology & Metabolism; Mar2025, Vol. 110 Issue 3, pe600-e606, 7p

Subject Terms: PHEOCHROMOCYTOMA, KINASE inhibitors, SMALL molecules, ANTINEOPLASTIC agents, REVIEW committees

Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study

Authors: Subbiah, Vivek ^*, Hu, Mimi I, Wirth, Lori J, Schuler, Martin, Mansfield, Aaron S, Curigliano, Giuseppe, Brose, Marcia S, Zhu, Viola W, Leboulleux, Sophie, Bowles, Daniel W, Baik, Christina S, Adkins, Douglas, Keam, Bhumsuk, Matos, Ignacio, Garralda, Elena, Gainor, Justin F, Lopes, Gilberto, Lin, Chia-Chi, Godbert, Yann, Sarker, Debashis, Miller, Stephen G, Clifford, Corinne, Zhang, Hui, Turner, Christopher D, Taylor, Matthew H

Source: In The Lancet Diabetes & Endocrinology August 2021 9(8):491-501

A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma

Authors: Hanna, Glenn J., ONeill, Anne, Cutler, Jennifer M., Flynn, Michelle, Vijaykumar, Tushara, Clark, John R., Wirth, Lori J., Lorch, Jochen H., Park, Jong C., Mito, Jeffrey K., Lohr, Jens G., Kaufman, Jeffrey, Burr, Nicole Spardy, Zon, Leonard I., Haddad, Robert I.

Source: In Oral Oncology August 2021 119

Intraductal carcinoma of the salivary gland with NCOA4-RET: expanding the morphologic spectrum and an algorithmic diagnostic approach

Authors: Fisch, Adam S., Laklouk, Israa, Nakaguro, Masato, Nosé, Vânia, Wirth, Lori J., Deschler, Daniel G., Faquin, William C., Dias-Santagata, Dora, Sadow, Peter M.

Source: In Human Pathology August 2021 114:74-89

Impact of lung metastases on overall survival in the phase 3 SELECT study of lenvatinib in patients with radioiodine-refractory differentiated thyroid cancer

Authors: Tahara, Makoto, Kiyota, Naomi, Hoff, Ana O., Badiu, Corin, Owonikoko, Taofeek K., Dutcus, Corina E., Suzuki, Takuya, Ren, Min, Wirth, Lori J.

Source: In European Journal of Cancer April 2021 147:51-57

Afirma Genomic Sequencing Classifier and Xpression Atlas Molecular Findings in Consecutive Bethesda III-VI Thyroid Nodules

Authors: Hu, Mimi I, Waguespack, Steven G, Dosiou, Chrysoula, Ladenson, Paul W, Livhits, Masha J, Wirth, Lori J, Sadow, Peter M, Krane, Jeffrey F, Stack, Brendan C, Zafereo, Mark E, Ali, Syed Z, Weitzman, Steven P, Hao, Yangyang, Babiarz, Joshua E, Kennedy, Giulia C, Kloos, Richard T

Source: Journal of clinical endocrinology & metabolism. 106(8):2198-2207

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A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma

Authors: Mahmood, Umair, Bang, Andrew, Chen, Yu-Hui, Mak, Raymond H., Lorch, Jochen H., Hanna, Glenn J., Nishino, Mizuki, Manuszak, Claire, Thrash, Emily M., Severgnini, Mariano, Sanborn, Matthew, Sridharan, Vishwajith, Margalit, Danielle N., Tishler, Roy B., Busse, Paul M., Willers, Henning, Mamon, Harvey J., Yoo, Hyung-Jin, Pai, Sara I., Wirth, Lori J., Haddad, Robert I., Chau, Nicole G., Schoenfeld, Jonathan D.

Source: International journal of radiation oncology, biology, physics. 109(1):134-144

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133093930.0x000001&indx=1&recIds=ETOCvdc_100133093930.0x000001

Correlation of Performance Status and Neutrophil-Lymphocyte Ratio with Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated with Lenvatinib

Authors: Taylor, Matthew H., Takahashi, Shunji, Capdevila, Jaume, Tahara, Makoto, Leboulleux, Sophie, Kiyota, Naomi, Dutcus, Corina E., Xie, Ran, Robinson, Bruce, Sherman, Steven, Habra, Mouhammed Amir, Elisei, Rossella, Wirth, Lori J.

Source: Thyroid. 31(8):1226-1234

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124781695.0x000001&indx=1&recIds=ETOCvdc_100124781695.0x000001