Restless Legs Syndrome: A Comprehensive Review of Current Treatment Methods and the Disease's Impact on Quality of Life

Authors: Natalie Papachristoforou, Natalia Tekiela, Daria Michałka, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Emilia Bąk, Justyna Głowacka, Aleksandra Kocjan, Radosław Chmiel

Source: Quality in Sport, Vol 37 (2025)

Subject Terms: Restless leg syndrome, Willis-Ekbom disease, sensorimotor disorder, neurotransmitter dysfunction, Sports, GV557-1198.995, Sports medicine, RC1200-1245

File Description: electronic resource

Relation: https://apcz.umk.pl/QS/article/view/57723; https://doaj.org/toc/2450-3118

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Efficacy and safety of intravenous ferric carboxymaltose in the treatment of Restless Legs Syndrome: a systematic review and meta-analysis

Authors: Ayesha Khan, Harsh Kumar, Kuldeep Dalpat Rai, Anzel Saeed, Jawad Ishtiaq, Muhammad Tanveer Alam, Sakshi Chawla, Md Ariful Haque

Source: Frontiers in Neurology, Vol 15 (2025)

Subject Terms: Restless Legs Syndrome, Willis-Ekbom Disease, ferric carboxymaltose, iron therapy, neuromuscular disorder, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2024.1503342/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/c40d99dea41a450a9c2fd821a6d32830

Clinical efficacy and safety of IV ferric carboxymaltose in restless legs syndrome: A meta-analysis of 537 patients

Authors: Qadri, Syeda Nimra ^{a, ⁎}, Jamil, Saifullah ^a, Zahid, Subhan ^a, Asghar, Tehreem ^b, Gillani, Syeda Muzna ^c, Qasim, Soban Ali ^d, Kambar, Tilyan ^e, Abideen, Zain Ul ^f, Brohi, Usama ^g, Tareen, Sammon Khan ^h, Tareen, Palay Khan ^h, Kumari, Sandhya ^e, Kumar, Satesh ⁱ, Khatri, Mahima ^a

Source: In Sleep Medicine December 2024 124:244-253

Experiences of facilitators and barriers for fulfilment of human needs when living with restless legs syndrome: a qualitative study

Authors: Elzana Odzakovic, Monika Allgurin, Lise-Lotte Jonasson, Sandra Öberg, Bengt Fridlund, Martin Ulander, Jonas Lind, Anders Broström

Source: International Journal of Qualitative Studies on Health & Well-Being, Vol 19, Iss 1 (2024)

Subject Terms: human needs, patient-centred, qualitative content analysis, restless legs syndrome, willis ekbom disease, wittmaack ekbom syndrome, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1748-2623; https://doaj.org/toc/1748-2631

Access URL: https://doaj.org/article/85ae1310359b4233a7aa2c862e6f4785

Use of Integrative Medicine Practices by Pregnant Women with Restless Legs Syndrome

Authors: Fulya Çağli, Mürüvvet Başer, Özlem Kaplan

Source: Journal of Nursology, Vol 27, Iss 1, Pp 29-37 (2024)

Subject Terms: integrative medicine practices, nursing, pregnant, restless legs syndrome, willis-ekbom disease., bütünleşik tıp uygulamaları, gebe, hemşirelik, huzursuz bacak sendromu, willis-ekbom hastalığı, Nursing, RT1-120

File Description: electronic resource

Relation: https://dergipark.org.tr/tr/download/article-file/3817428; https://doaj.org/toc/2822-2954

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Aripiprazole, a Novel Option in the Management of Restless Legs Syndrome (RLS) Patients with Augmentation and/or Severe RLS Symptoms: A Report of 4 Cases

Authors: Lee EK, Spitale N, Robillard R

Source: Nature and Science of Sleep, Vol Volume 15, Pp 779-784 (2023)

Subject Terms: partial dopamine agonist, willis ekbom disease, dopamine treatment, dopamine receptor partial agonist, augmentation, restless legs syndrome, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495

File Description: electronic resource

Relation: https://www.dovepress.com/aripiprazole-a-novel-option-in-the-management-of-restless-legs-syndrom-peer-reviewed-fulltext-article-NSS; https://doaj.org/toc/1179-1608

Access URL: https://doaj.org/article/a274a5d68d0147b383e0e04ef68bf08c

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial

Authors: Ali Jadidi, Alireza Rezaei Ashtiani, Ali Khanmohamadi Hezaveh, Seyed Mohamad Aghaepour

Source: BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-6 (2022)

Subject Terms: Restless legs syndrome, Willis-Ekbom Disease, Magnesium, Vitamin B6, Pramipexole, Sleep disorders, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://doaj.org/toc/2662-7671

Access URL: https://doaj.org/article/743746281429400e8b33a5da0d949515

Evaluation of Restless Leg Syndrome in Patients with Non-Dialysis Dependent Chronic Kidney Disease at Fatima Memorial Hospital Lahore: A Cross-sectional Study

Authors: Bilal Basit, Omer Sabir, Adnan Hussain Shahid, Andleeb Kanwal, Ghulam Abass Qadri, Nabiha Rizvi

Source: Life and Science, Vol 5, Iss 1, Pp 06-06 (2024)

Subject Terms: chronic kidney disease, restless leg syndrome, willis-ekbom disease., Science

File Description: electronic resource

Relation: https://ojs.lifenscience.org/index.php/life-and-science/article/view/516; https://doaj.org/toc/2521-0475; https://doaj.org/toc/2708-2970

Access URL: https://doaj.org/article/61883c2553114edda2c366c3d5c7ad2d

Restless Legs Syndrome and Iron

Authors: Josipa Pulić

Source: Southeastern European Medical Journal, Vol 4, Iss 1, Pp 55-62 (2020)

Subject Terms: restless legs syndrome, willis-ekbom disease, iron metabolism, serum ferritin levels, treatment, Medicine

File Description: electronic resource

Relation: http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/127/72; https://doaj.org/toc/2459-9484

Access URL: https://doaj.org/article/ff3d1adee955461088bf85c2d68e735e

Restless Legs Syndrome, and symptoms of Restless Syndrome in patients with Graves’ disease: a cross-sectional survey

Authors: Pradella-Hallinan, Marcia, Pereira Jr., José Carlos, Martins, João Roberto Maciel

Source: Clinics. January 2020 75

Subject Terms: Restless Legs Syndrome, Willis-Ekbom Disease, Graves’ Disease

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100302

Characteristics of sleep/wake problems and delivery outcomes among pregnant Japanese women without gestational complications

Authors: Shiho Umeno, Chiho Kato, Yuki Nagaura, Hideaki Kondo, Hiromi Eto

Source: BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-10 (2020)

Subject Terms: Excessive daytime sleepiness, Insomnia, Sleep disordered breathing, Sleep quality, Restless legs syndrome/Willis-Ekbom disease, Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12884-020-02868-1; https://doaj.org/toc/1471-2393

Access URL: https://doaj.org/article/8fa5288e7e914c7893f307f8ec47786e

Restless arms syndrome: prevalence, impact, and management strategies

Authors: Ruppert E

Source: Neuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1737-1750 (2019)

Subject Terms: RLS variant, RLS equivalent, restless upper limb, restless of upper extremities, Willis-Ekbom disease, periodic arm movements, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.dovepress.com/restless-arms-syndrome-prevalence-impact-and-management-strategies-peer-reviewed-article-NDT; https://doaj.org/toc/1178-2021

Access URL: https://doaj.org/article/e4b3825840974104bebe14f4c3f24930

Reporting Quality of Randomized Controlled Trials in Restless Legs Syndrome Based on the CONSORT Statement

Authors: Dimitrios Rikos, Efthimios Dardiotis, Athina-Maria Aloizou, Vasileios Siokas, Elias Zintzaras, Georgios M. Hadjigeorgiou

Source: Tremor and Other Hyperkinetic Movements, Vol 9, Iss 0, Pp 1-6 (2019)

Subject Terms: RLS, CONSORT, Randomized controlled trials, Willis-Ekbom Disease, RCTs, Diseases of the musculoskeletal system, RC925-935, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://tremorjournal.org/index.php/tremor/article/view/637/2291; https://doaj.org/toc/2160-8288

Access URL: https://doaj.org/article/f9e28b097c054bafb7f31d32cf406e90

Exclusion of mimics does not influence Willis-Ekbom disease diagnosis among recent medical graduates

Authors: Carlos, Karla, Prado, Gilmar Fernandes do

Source: Arquivos de Neuro-Psiquiatria. December 2018 76(12)

Subject Terms: Restless legs syndrome, Willis-Ekbom disease, diagnosis

File Description: text/html

Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001200816

Correlation of Anaemia and Restless Legs Syndrome in Elderly: A Cross-sectional Study

Authors: Abhijit Agrawal, Jahnabi Bhagawati, Sunil Kumar

Source: Journal of Clinical and Diagnostic Research, Vol 14, Iss 12, Pp OC14-OC17 (2020)

Subject Terms: ferritin, geriatric, iron deficiency, severity, willis ekbom disease, Medicine

File Description: electronic resource

Relation: https://jcdr.net/articles/PDF/14368/45715_CE[Ra1]_F(SL)_PF1(ShG_KM)_PN(SL).pdf; https://doaj.org/toc/2249-782X; https://doaj.org/toc/0973-709X

Access URL: https://doaj.org/article/6f457e18b1504ee589e45a30b7a9be89

Restless Legs Syndrome, and symptoms of Restless Syndrome in patients with Graves’ disease: a cross-sectional survey

Authors: Marcia Pradella-Hallinan, José Carlos Pereira Jr., João Roberto Maciel Martins

Source: Clinics, Vol 75 (2020)

Subject Terms: Restless Legs Syndrome, Willis-Ekbom Disease, Graves’ Disease, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100302&tlng=en; http://www.scielo.br/pdf/clin/v75/1807-5932-clin-75-e2140.pdf; https://doaj.org/toc/1980-5322

Access URL: https://doaj.org/article/9d939c8d9cf642baaf259751f572c35b

Impact of different stages of chronic kidney disease on the severity of Willis–Ekbom disease

Authors: Jahnabi Bhagawati, Sunil Kumar, Abhijeet Kumar Agrawal, Sourya Acharya, Anil K Wanjari, Tarachand K Kamble

Source: Journal of Family Medicine and Primary Care, Vol 8, Iss 2, Pp 432-436 (2019)

Subject Terms: Chronic kidney disease, restless legs syndrome, severity, Willis–Ekbom disease prevalence, Medicine

File Description: electronic resource

Relation: http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=2;spage=432;epage=436;aulast=Bhagawati; https://doaj.org/toc/2249-4863

Access URL: https://doaj.org/article/ecbf8065fc2b4d39a1d915c51ede57b6

Improvement of Restless Legs Syndrome Under Treatment of Cancer Pain With Morphine and Fentanyl

Authors: Jan Gärtner, Karin Jaroslawski, Gerhild Becker, Christopher Boehlke

Source: Frontiers in Neurology, Vol 10 (2019)

Subject Terms: restless-legs-syndrome, Willis-Ekbom disease, treatment, morphine, oxycodone, transdermal fentanyl, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2019.00457/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/92de1964848941e9b75c1b6b26cce12c

Depression and Sleep Quality in Patients with Restless Legs Syndrome

Authors: Selma Topaloglu Tuaç, Serkan Özben, Mesrure Köseoglu Bitnel, Sevim Baybas

Source: Türk Uyku Tıbbı Dergisi, Vol 4, Iss 1, Pp 1-5 (2017)

Subject Terms: Restless Legs Syndrome, Willis-Ekbom disease, depression, sleep disorder, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://jtsm.org/archives/archive-detail/article-preview/depression-and-sleep-quality-in-patients-with-rest/16001; https://doaj.org/toc/2148-1504

Access URL: https://doaj.org/article/4f7c06852ebd4d33bdb176aa2b28aeea

Sleep and Tibialis Anterior Muscle Activity in Mice With Mild Hypoxia and Iron Deficiency: Implications for the Restless Legs Syndrome

Authors: Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Alice Valli, Mauro Manconi, Giovanna Zoccoli, Alessandro Silvani

Source: Frontiers in Physiology, Vol 9 (2018)

Subject Terms: hypoxia, iron, mice, restless legs syndrome, Willis-Ekbom disease, sleep, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2018.01818/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/4c7e792cfc6d46479dadc9126923c892