Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

Authors: Mittmann, Gesa, Laiouar-Pedari, Sara, Mehrtens, Hendrik A., Haggenmüller, Sarah, Bucher, Tabea-Clara, Chanda, Tirtha, Gaisa, Nadine T., Wagner, Mathias, Klamminger, Gilbert Georg, Rau, Tilman T., Neppl, Christina, Compérat, Eva Maria, Gocht, Andreas, Hämmerle, Monika, Rupp, Niels J., Westhoff, Jula, Krücken, Irene, Seidl, Maximillian, Schürch, Christian M., Bauer, Marcus, Solass, Wiebke, Tam, Yu Chun, Weber, Florian, Grobholz, Rainer, Augustyniak, Jaroslaw, Kalinski, Thomas, Hörner, Christian, Mertz, Kirsten D., Döring, Constanze, Erbersdobler, Andreas, Deubler, Gabriele, Bremmer, Felix, Sommer, Ulrich, Brodhun, Michael, Griffin, Jon, Lenon, Maria Sarah L., Trpkov, Kiril, Cheng, Liang, Chen, Fei, Levi, Angelique, Cai, Guoping, Nguyen, Tri Q., Amin, Ali, Cimadamore, Alessia, Shabaik, Ahmed, Manucha, Varsha, Ahmad, Nazeel, Messias, Nidia, Sanguedolce, Francesca, Taheri, Diana, Baraban, Ezra, Jia, Liwei, Shah, Rajal B., Siadat, Farshid, Swarbrick, Nicole, Park, Kyung, Hassan, Oudai, Sakhaie, Siamak, Downes, Michelle R., Miyamoto, Hiroshi, Williamson, Sean R., Holland-Letz, Tim, Schneider, Carolin V., Kather, Jakob Nikolas, Tolkach, Yuri, Brinker, Titus J.

Subject Terms: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition

Access URL: http://arxiv.org/abs/2410.15012

What Is New in Pathologic Diagnosis and Classification of the Common Renal Cell Neoplasms?

Authors: Zalles, Nicole, Williamson, Sean R. ^∗

Source: In Surgical Pathology Clinics March 2025 18(1):133-155

Gamna-Gandy bodies in renal neoplasms: A multi-institutional clinicopathologic study of 350 consecutive nephrectomies

Authors: Mubeen, Aysha ^{a, ⁎}, Pacheco, Richard ^b, Akgul, Mahmut ^b, Williamson, Sean R. ^c, Collins, Katrina ^d, Chan, Emily ^e, Sangoi, Ankur R. ^e

Source: In Annals of Diagnostic Pathology April 2025 75

Primary intrarenal hemangioma – A series of 39 cases

Authors: Faraz, Maria ^{a, 1}, Rosenzweig, Andrew ^{b, 1}, Panizo, Angel ^c, Hajiyeva, Sabina ^d, Subasi, Nusret B. ^a, Alghamdi, Mohammed A. ^a, Lightle, Andrea A. ^a, Kuthi, Levente ^e, Kelemen, Dora ^f, Sangoi, Ankur R. ^g, Nova-Camacho, Luiz M. ^h, Martos, María Garcia ⁱ, Movassaghi, Mehrnaz ^j, Lobo, Anandi ^k, Jha, Shilpy ^l, Yörükoğlu, Kutsal ^m, Bayrak, Busra Yaprak ⁿ, Williamson, Sean R. ^o, Bhardwaj, Swati ^p, Kandukuri, Shivani ^q, Kaushal, Seema ^r, Mohanty, Sambit K. ^s, Akgul, Mahmut ^{t, ⁎}

Source: In Annals of Diagnostic Pathology April 2025 75

Genetic validation of a TSC2 immunohistochemistry assay in TSC/mTOR-pathway altered renal tumors

Authors: Akbari, Amir ^{a, b, ∗}, Villanueva, Clarence Rachel ^a, Hes, Ondrej ^c, Williamson, Sean R. ^d, Kandukuri, Shivani ^b, Sharma, Shivani ^e, Aditi, Aggarwal ^e, Pivovarcikova, Kristyna ^c, Argani, Pedram ^a, Mohanty, Sambit K. ^f, Asrani, Kaushal ^a, Lotan, Tamara L. ^{a, g, h}

Source: In Human Pathology December 2024 154

Pure intertubular seminoma (PITS) of the testis: A multi-institutional cohort of a rare growth pattern of seminoma

Authors: Kaushal, Seema, Jain, Ekta, Acosta, Andres M., Sangoi, Ankur R., Lobo, Anandi, Jha, Shilpy, Sharma, Shivani, Arora, Samriti, Beg, Arshi, Akgul, Mahmut, Williamson, Sean R., Baisakh, Manas R., Pattnaik, Niharika, Satturwar, Swati, Parwani, Anil V., Dixit, Mallika, Malik, Vipra, Osunkoya, Adeboye O., Cheng, Liang, Amin, Mahul B., Dhillon, Jasreman, Mishra, Sourav K., Biswas, Ghanashyam, Panda, Soumya Surath, Mohanty, Sambit K.

Source: In Human Pathology November 2024 153

Acquired cystic disease associated renal cell carcinoma: A clinicopathologic and molecular study of 31 tumors

Authors: Palathingal Bava, Ejas, Sanfrancesco, Joseph M., Alkashash, Ahmed, Favazza, Laura, Aldilami, Akram, Williamson, Sean R., Cheng, Liang, Idrees, Mohammed T., Al-Obaidy, Khaleel I.

Source: In Human Pathology July 2024 149:48-54

Molecular Characterization of Juxtaglomerular Cell Tumors: Evidence of Alterations in MAPK–RAS Pathway

Authors: Lobo, João, Canete-Portillo, Sofia, Pena, Maria Del Carmen Rodriguez, McKenney, Jesse K., Aron, Manju, Massicano, Felipe, Wilk, Brandon M., Gajapathy, Manavalan, Brown, Donna M., Baydar, Dilek E., Matoso, Andres, Rioux-Leclerq, Nathalie, Pan, Chin-Chen, Tretiakova, Maria S., Trpkov, Kiril, Williamson, Sean R., Rais-Bahrami, Soroush, Mackinnon, Alexander C., Harada, Shuko, Worthey, Elizabeth A., Magi-Galluzzi, Cristina

Source: In Modern Pathology June 2024 37(6)

Metastatic solid tumors to the testis: a clinicopathologic evaluation of 157 cases from an international collaboration

Authors: Nova-Camacho, Luiz M., Acosta, Andres M., Trpkov, Kiril, Sangoi, Ankur R., Pierre, Allaume, Chou, Angela, Yilmaz, Asli, Morini, Aurélien, Rodrigues, Ângelo, Fletcher, Christopher D.M., Perez-Montiel, Delia, Maclean, Fiona, Contreras, Félix, Queipo, Francisco Javier, Muñiz Unamunzaga, Gorka, Mesa, Hector, de Torres, Inés, Ruiz, Irune, Alvarado-Cabrero, Isabel, Lobo, João, Schwartz, Lauren, Cheng, Liang, Akgul, Mahmut, García-Martos, María, Palmer, Matthew B., Aron, Manju, Raspollini, Maria Rosaria, Manrique Celada, Manuel, Hwang, Michael, Idrees, Muhammad T., Rioux-Leclercq, Nathalie, Zalles, Nicole, Vergara, Norge, Lal, Priti, Wobker, Sara, Kammerer-Jacquet, Solène-Florence, Prendeville, Susan, Tilmant, Théau, Ulbright, Thomas M., Verkarre, Virginie, Collins, Katrina, Williamson, Sean R., Panizo, Angel

Source: Human pathology. 139:37-46

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196153377.0x000001&indx=1&recIds=ETOCvdc_100196153377.0x000001

Metastatic solid tumours to the penis: a clinicopathologic evaluation of 109 cases from an international collaboration

Authors: Nova‐Camacho, Luiz M., Collins, Katrina, Trpkov, Kiril, Acosta, Andres M., Sangoi, Ankur R., Akgul, Mahmut, Chou, Angela, Polonia, Antonio, Rodrigues, Ângelo, Yilmaz, Asli, Perez‐Montiel, Delia, Maclean, Fiona, Queipo Gutiérrez, Francisco Javier, Contreras, Félix, Wu, Howard H., Alvarado‐Cabrero, Isabel, Torres, Inés, Ruiz, Irune, Lobo, João, Prendeville, Susan, Manrique Celada, Manuel, Cheng, Liang, Galea, Laurence A., Hwang, Michael, Aron, Manju, García‐Martos, María, Zalles, Nicole, Raspollini, Maria Rosaria, Williamson, Sean R., Ulbright, Thomas M., Panizo, Angel

Source: Histopathology. 83(1):31-39

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191010939.0x000001&indx=1&recIds=ETOCvdc_100191010939.0x000001

Histopathologic approaches to the infiltrative renal mass

Authors: Zalles, Nicole, Nguyen, Jane K., Williamson, Sean R.

Source: Diagnostic histopathology. 29(6):269-275

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190948149.0x000001&indx=1&recIds=ETOCvdc_100190948149.0x000001

Characterization of protein S-(2-succino)-cysteine (2SC) succination as a biomarker for fumarate hydratase–deficient renal cell carcinoma

Authors: Mannan, Rahul, Wang, Xiaoming, Bawa, Pushpinder S., Chugh, Seema, Chinnaiyan, Anya K., Rangaswamy, Roshni, Zhang, Yuping, Cao, Xuhong, Smith, Steven C., Trpkov, Kiril, Williamson, Sean R., Sangoi, Ankur R., Mohanty, Sambit, McKenney, Jesse K., Gupta, Sounak, Magi-Galluzzi, Cristina, Argani, Pedram, Osunkoya, Adeboye O., Chinnaiyan, Arul M., Dhanasekaran, Saravana M., Mehra, Rohit

Source: Human pathology. 134:102-113

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189637704.0x000001&indx=1&recIds=ETOCvdc_100189637704.0x000001

Fibromyxoid Nephrogenic Adenoma

Authors: Li, Lin, Williamson, Sean R., Castillo, Rosa P., Delma, Katiana S., Gonzalgo, Mark L., Epstein, Jonathan I., Kryvenko, Oleksandr N.

Source: American journal of surgical pathology. 47(1):37-46

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186832444.0x000001&indx=1&recIds=ETOCvdc_100186832444.0x000001

Nephrogenic Adenoma Intermixed With Urothelial Carcinoma: A Potential Mimic of Divergent Glandular Differentiation, Variant Morphology, or Invasion

Authors: Kryvenko, Oleksandr N., Wasco, Matthew J., Williamson, Sean R.

Source: Archives of pathology & laboratory medicine. 147(5):552-558

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632111677&indx=1&recIds=ETOCRN632111677

Clear Cell Renal Cell Carcinoma with Immunotherapy Effect Mimicking Xanthogranulomatous Pyelonephritis

Authors: Wang, Yan, Ganesan, Santhi, Williamson, Sean R., Rayes-Danan, Rania

Source: International journal of surgical pathology. 31(3):316-320

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632099403&indx=1&recIds=ETOCRN632099403

Clear cell renal cell carcinoma with focal psammomatous calcifications: a rare occurrence mimicking translocation carcinoma

Authors: Sangoi, Ankur R, Al‐Obaidy, Khaleel I, Cheng, Liang, Kao, Chia‐Sui, Chan, Emily, Sadasivan, Sudha, Levin, Albert M, Alvarado‐Cabrero, Isabel, Kunju, Lakshmi P, Mehra, Rohit, Mannan, Rahul, Wang, Xioming, Dhillon, Jasreman, Tretiakova, Maria, Smith, Steven C, Hes, Ondrej, Williamson, Sean R

Source: Histopathology. 82(5):684-690

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176473240.0x000001&indx=1&recIds=ETOCvdc_100176473240.0x000001

Low‐grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity

Authors: Williamson, Sean R, Hes, Ondrej, Trpkov, Kiril, Aggarwal, Aditi, Satapathy, Abhishek, Mishra, Sourav, Sharma, Shivani, Sangoi, Ankur, Cheng, Liang, Akgul, Mahmut, Idrees, Muhammad, Levin, Albert, Sadasivan, Sudha, San Miguel Fraile, Pilar, Rogala, Joanna, Comperat, Eva, Berney, Daniel M, Bulimbasic, Stela, McKenney, Jesse K, Jha, Shilpy, Sampat, Nakul Y, Mohanty, Sambit K

Source: Histopathology. 82(2):296-304

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169487444.0x000001&indx=1&recIds=ETOCvdc_100169487444.0x000001

Nested and Large Nested Subtypes of Urothelial Carcinoma of the Upper Urinary Tract: A Multi-institutional Study

Authors: Aron, Manju, Chandrashekar, Darshan S., Canete-Portillo, Sofia, Brimo, Fadi, Williamson, Sean R., Osunkoya, Adeboye O., Raspollini, Maria Rosaria, Kunju, Lakshmi P., Varambally, Sooryanarayana, Mackinnon, Alexander C., Harada, Shuko, Netto, George J.

Source: In Modern Pathology December 2023 36(12)

Convolutional Neural Network Quantification of Gleason Pattern 4 and Association With Biochemical Recurrence in Intermediate-Grade Prostate Tumors

Authors: Chen, Yalei, Loveless, Ian M., Nakai, Tiffany, Newaz, Rehnuma, Abdollah, Firas F., Rogers, Craig G., Hassan, Oudai, Chitale, Dhananjay, Arora, Kanika, Williamson, Sean R., Gupta, Nilesh S., Rybicki, Benjamin A., Sadasivan, Sudha M., Levin, Albert M.

Source: In Modern Pathology July 2023 36(7)

International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members

Authors: Beijert, Irene J., Cheng, Liang, Liedberg, Fredrik, Plass, Karin, Williamson, Sean R., Gontero, Paolo, Ribal, Maria J., Babjuk, Marko, Black, Peter C., Kamat, Ashish M., Algaba, Ferran, Berman, David M., Hartmann, Arndt, Masson-Lecomte, Alexandra, Rouprêt, Morgan, Lopez-Beltran, Antonio, Samaratunga, Hemamali, Shariat, Shahrokh F., Mostafid, A. Hugh, Varma, Murali, Shen, Steven, Burger, Maximilian, Tsuzuki, Toyonori, Palou, Joan, Compérat, Eva M., Sylvester, Richard J., van der Kwast, Theo H., van Rhijn, Bas W.G., Downes, Michelle R.

Source: In European Urology Open Science June 2023 52:154-165