Updating the study protocol: Insight 46 – a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development – phases 2 and 3

Authors: Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M. Brown, Gabriella Captur, Molly R.E.Cartlidge, David M. Cash, William Coath, Daniel Davis, John C. Dickson, James Groves, Alun D. Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E. Keuss, Josh King-Robson, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Alicja Rapala, Catherine J. Scott, Rebecca Street, Carole H. Sudre, David L. Thomas, Andrew Wong, Selina Wray, Henrik Zetterberg, Nishi Chaturvedi, Nick C. Fox, Sebastian J. Crutch, Marcus Richards, Jonathan M. Schott

Source: BMC Neurology, Vol 24, Iss 1, Pp 1-21 (2024)

Subject Terms: Epidemiology, Life course, Genetics, Alzheimer’s disease, Ageing, Magnetic resonance imaging, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2377

Access URL: https://doaj.org/article/9fdd7c07f6e74bf4bc709c0fc60fb7cd

Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease

Authors: Rebecca E. Green, Jodie Lord, Marzia A. Scelsi, Jin Xu, Andrew Wong, Sarah Naomi-James, Alex Handy, Lachlan Gilchrist, Dylan M. Williams, Thomas D. Parker, Christopher A. Lane, Ian B. Malone, David M. Cash, Carole H. Sudre, William Coath, David L. Thomas, Sarah Keuss, Richard Dobson, Cristina Legido-Quigley, Nick C. Fox, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, The Insight 46 study team

Source: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)

Subject Terms: Metabolites, Dementia, Brain imaging, Ageing, Polygenic scores, Birth cohort, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/f5a5b80764c34bc1b3fd5049c6dcb527

Evaluation of novel data-driven metrics of amyloid β deposition for longitudinal PET studies

Authors: Ariane Bollack, Pawel J Markiewicz, Alle Meije Wink, Lloyd Prosser, Johan Lilja, Pierrick Bourgeat, Jonathan M Schott, William Coath, Lyduine E Collij, Hugh G Pemberton, Gill Farrar, Frederik Barkhof, David M Cash

Source: NeuroImage, Vol 280, Iss , Pp 120313- (2023)

Subject Terms: Quantification, Longitudinal, Machine learning, Amyloid, PET, Alzheimer's, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1053811923004640; https://doaj.org/toc/1095-9572

Access URL: https://doaj.org/article/31a4b313a057412299854b162b868a65

Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI

Authors: William Coath, Marc Modat, M. Jorge Cardoso, Pawel J. Markiewicz, Christopher A. Lane, Thomas D. Parker, Ashvini Keshavan, Sarah M. Buchanan, Sarah E. Keuss, Matthew J. Harris, Ninon Burgos, John Dickson, Anna Barnes, David L. Thomas, Daniel Beasley, Ian B. Malone, Andrew Wong, Kjell Erlandsson, Benjamin A. Thomas, Michael Schöll, Sebastien Ourselin, Marcus Richards, Nick C. Fox, Jonathan M. Schott, David M. Cash, for the Alzheimer's Disease Neuroimaging Initiative

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023)

Subject Terms: Alzheimer's disease, amyloid beta, centiloid, florbetapir, positron emission tomography/magnetic resonance imaging, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/89fc878da77c45b0abc21824ecd8a625

Investigating the relationship between BMI across adulthood and late life brain pathologies

Authors: Christopher A. Lane, Josephine Barnes, Jennifer M. Nicholas, John W. Baker, Carole H. Sudre, David M. Cash, Thomas D. Parker, Ian B. Malone, Kirsty Lu, Sarah-Naomi James, Ashvini Keshavan, Sarah Buchanan, Sarah Keuss, Heidi Murray-Smith, Andrew Wong, Elizabeth Gordon, William Coath, Marc Modat, David Thomas, Rebecca Hardy, Marcus Richards, Nick C. Fox, Jonathan M. Schott

Source: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)

Subject Terms: Cohort studies, Epidemiology, MRI, PET, Alzheimer’s disease, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/10e2a7dba0b142c4a8c65a142938d773

A population‐based study of head injury, cognitive function and pathological markers

Authors: Sarah‐Naomi James, Jennifer M. Nicholas, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Ashvini Keshavan, Sarah M. Buchanan, Sarah E. Keuss, Heidi Murray‐Smith, Andrew Wong, David M. Cash, Ian B. Malone, Josephine Barnes, Carole H. Sudre, William Coath, Lloyd Prosser, Sebastien Ourselin, Marc Modat, David L. Thomas, Jorge Cardoso, Amanda Heslegrave, Henrik Zetterberg, Sebastian J. Crutch, Jonathan M. Schott, Marcus Richards, Nick C. Fox

Source: Annals of Clinical and Translational Neurology, Vol 8, Iss 4, Pp 842-856 (2021)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/f1db91f3d9084dcca21faecff35979d1

Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays

Authors: Ashvini Keshavan, Henrietta Wellington, Zhongbo Chen, Ayesha Khatun, Miles Chapman, Melanie Hart, David M. Cash, William Coath, Thomas D. Parker, Sarah M. Buchanan, Sarah E. Keuss, Matthew J. Harris, Heidi Murray‐Smith, Amanda Heslegrave, Nick C. Fox, Henrik Zetterberg, Jonathan M Schott

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)

Subject Terms: amyloid, cerebrospinal fluid, Lumipulse, positron emission tomography, tau, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/6d192a34b4fb4435b96b930df6feef2f

Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays

Authors: Ashvini Keshavan, Henrietta Wellington, Zhongbo Chen, Ayesha Khatun, Miles Chapman, Melanie Hart, David M. Cash, William Coath, Thomas D. Parker, Sarah M. Buchanan, Sarah E. Keuss, Matthew J. Harris, Heidi Murray‐Smith, Amanda Heslegrave, Nick C. Fox, Henrik Zetterberg, Jonathan M. Schott

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)

Subject Terms: amyloid, CSF, Lumipulse, PET, tau, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/e0d2b395b65f4dd1afd1a7baf34097a2

Increased variability in reaction time is associated with amyloid beta pathology at age 70

Authors: Kirsty Lu, Jennifer M. Nicholas, Sarah‐Naomi James, Christopher A. Lane, Thomas D. Parker, Ashvini Keshavan, Sarah E. Keuss, Sarah M. Buchanan, Heidi Murray‐Smith, David M. Cash, Carole H. Sudre, Ian B. Malone, William Coath, Andrew Wong, Susie M.D. Henley, Nick C. Fox, Marcus Richards, Jonathan M. Schott, Sebastian J. Crutch

Source: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)

Subject Terms: amyloid‐positron emission tomography imaging, birth cohort, cognition, cognitive decline, dementia, healthy aging, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8729

Access URL: https://doaj.org/article/581b7ddff37a46509cc58782170ae19f

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