Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes

Authors: Wilfried Le Goff, Olivier Bourron, Clément Materne, Sophie Galier, Franck Phan, Sophie Tan-Chen, Isabelle Guillas, Agnès Hartemann, Joe-Elie Salem, Alban Redheuil, Fabienne Foufelle, Hervé Le Stunff, Eric Hajduch, Maryse Guerin

Source: Cardiovascular Diabetology, Vol 24, Iss 1, Pp 1-16 (2025)

Subject Terms: Sphingosine-1-phosphate, High-density lipoprotein, Type 2 diabetes, Atherosclerosis, Cardiovascular diseases, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/13d8fb85d2cf4146836208945ad179fc

Reduced Capacity of High‐Density Lipoprotein to Acquire Free Cholesterol From Triglyceride‐Rich Lipoproteins Is Associated With Elevated Postprandial Hypertriglyceridemia in Healthy Men

Authors: Sophie Galier, Maryam Darabi, Feng Ma, Clément Materne, Isabelle Guillas, Wilfried Le Goff, Anatol Kontush, Maryse Guerin

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 15 (2024)

Subject Terms: free cholesterol, CETP, high‐density lipoprotein, postprandial metabolism, remants, triglyceride‐rich lipoprotein, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/f0a013750bc54352b6131324bd5114af

Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Authors: Yujiao Zhang, Marie Vandestienne, Jean-Rémi Lavillegrand, Jeremie Joffre, Icia Santos-Zas, Aonghus Lavelle, Xiaodan Zhong, Wilfried Le Goff, Maryse Guérin, Rida Al-Rifai, Ludivine Laurans, Patrick Bruneval, Coralie Guérin, Marc Diedisheim, Melanie Migaud, Anne Puel, Fanny Lanternier, Jean-Laurent Casanova, Clément Cochain, Alma Zernecke, Antoine-Emmanuel Saliba, Michal Mokry, Jean-Sebastien Silvestre, Alain Tedgui, Ziad Mallat, Soraya Taleb, Olivia Lenoir, Cécile Vindis, Stéphane M. Camus, Harry Sokol, Hafid Ait-Oufella

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b269b498eb06438890385181c12ba8bb

Editorial: Cardiometabolic diseases and inflammatory responses

Authors: Nadine Suffee, Wilfried Le Goff, Jianmin Chen

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: systemic inflammation, heart failure, coronary artery disease, stroke, autoimmune diseases, ascending thoracic aortic aneurysm, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1384022/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/610f98e2fae8456b9a69ae0d9fc744ab

An obesogenic diet increases atherosclerosis through promoting microbiota dysbiosis-induced gut lymphocyte trafficking into the periphery

Authors: Ludivine Laurans, Nirmala Mouttoulingam, Mouna Chajadine, Aonghus Lavelle, Marc Diedisheim, Emilie Bacquer, Laura Creusot, Nadine Suffee, Bruno Esposito, Nada Joe Melhem, Wilfried Le Goff, Yacine Haddad, Jean-Louis Paul, Dominique Rainteau, Alain Tedgui, Hafid Ait-Oufella, Laurence Zitvogel, Harry Sokol, Soraya Taleb

Source: Cell Reports, Vol 42, Iss 11, Pp 113350- (2023)

Subject Terms: CP: Metabolism, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723013621; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/dc302500baab428b8478bd6724febd13

Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosusResearch in context

Authors: Fanny Urbain, Maharajah Ponnaiah, Farid Ichou, Marie Lhomme, Clément Materne, Sophie Galier, Julien Haroche, Eric Frisdal, Alexis Mathian, Herve Durand, Micheline Pha, Miguel Hie, Anatol Kontush, Philippe Cluzel, Philippe Lesnik, Zahir Amoura, Maryse Guerin, Fleur Cohen Aubart, Wilfried Le Goff

Source: EBioMedicine, Vol 96, Iss , Pp 104802- (2023)

Subject Terms: Cardiovascular diseases, Systemic lupus erythematosus, Lipidomics, Metabolomics, Ceramides, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423003687; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/67b692d094b74532be90a95d53d9c822

Enhancer/gene relationships: Need for more reliable genome-wide reference sets

Authors: Tristan Hoellinger, Camille Mestre, Hugues Aschard, Wilfried Le Goff, Sylvain Foissac, Thomas Faraut, Sarah Djebali

Source: Frontiers in Bioinformatics, Vol 3 (2023)

Subject Terms: gene expression regulation, identification of enhancer/gene relationships, method evaluation, chromatin structure, eQTL, functional genomic data, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbinf.2023.1092853/full; https://doaj.org/toc/2673-7647

Access URL: https://doaj.org/article/73a3910a12624bcdb92d4c98d5247f4d

Abnormal Lipoproteins Trigger Oxidative Stress-Mediated Apoptosis of Renal Cells in LCAT Deficiency

Authors: Monica Gomaraschi, Marta Turri, Arianna Strazzella, Marie Lhomme, Chiara Pavanello, Wilfried Le Goff, Anatol Kontush, Laura Calabresi, Alice Ossoli

Source: Antioxidants, Vol 12, Iss 8, p 1498 (2023)

Subject Terms: LCAT deficiency, renal disease, LpX, preβ-HDL, lipoprotein toxicity, nephrotoxicity, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/8/1498; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/c16b3f1222f641988ef0199d86d7d1c1

LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients

Authors: Auguste Dargent, Jean-Paul Pais de Barros, Samir Saheb, Randa Bittar, Wilfried Le Goff, Alain Carrié, Thomas Gautier, Isabelle Fournel, Anne Laure Rerole, Hélène Choubley, David Masson, Laurent Lagrost, Jean-Pierre Quenot

Source: Journal of Lipid Research, Vol 61, Iss 12, Pp 1776-1783 (2020)

Subject Terms: lipoproteins, low density lipoprotein, tandem mass spectroscopy, human and clinical research, inflammation, sepsis, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520600359; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/4750f967e5824c6684367f41a6b58339

Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim-Chester disease in 78 patients from a single center

Authors: Fleur Cohen Aubart, Lucie Poupel, Flora Saint-Charles, Frederic Charlotte, Youssef Arsafi, Eric Frisdal, Damien Roos-Weil, Jean-Francois Emile, Zahir Amoura, Maryse Guerin, Philippe Lesnik, Julien Haroche, Wilfried Le Goff

Source: Haematologica, Vol 107, Iss 6 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10426; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/47622669fba24abab9f8d8d31e7a77a3

Multitrait GWAS to connect disease variants and biological mechanisms.

Authors: Hanna Julienne, Vincent Laville, Zachary R McCaw, Zihuai He, Vincent Guillemot, Carla Lasry, Andrey Ziyatdinov, Cyril Nerin, Amaury Vaysse, Pierre Lechat, Hervé Ménager, Wilfried Le Goff, Marie-Pierre Dube, Peter Kraft, Iuliana Ionita-Laza, Bjarni J Vilhjálmsson, Hugues Aschard

Source: PLoS Genetics, Vol 17, Iss 8, p e1009713 (2021)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/5c9ea5db0c81433a97c3f01fff044602

Mathematical Modelling of Material Transfer to High-Density Lipoprotein (HDL) upon Triglyceride Lipolysis by Lipoprotein Lipase: Relevance to Cardioprotective Role of HDL

Authors: Svetlana Schekatolina, Viktoriia Lahovska, Aleksandr Bekshaev, Sergey Kontush, Wilfried Le Goff, Anatol Kontush

Source: Metabolites, Vol 12, Iss 7, p 623 (2022)

Subject Terms: mathematical modelling, lipolysis, triglyceride-rich lipoproteins, high-density lipoprotein, free cholesterol, lipoprotein lipase, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/12/7/623; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/77400269147144f6b4c7d80b544dd447

Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 1

Authors: Serena Barilla, Ning Liang, Enrichetta Mileti, Raphaëlle Ballaire, Marie Lhomme, Maharajah Ponnaiah, Sophie Lemoine, Antoine Soprani, Jean-Francois Gautier, Ez-Zoubir Amri, Wilfried Le Goff, Nicolas Venteclef, Eckardt Treuter

Source: Molecular Metabolism, Vol 42, Iss , Pp 101066- (2020)

Subject Terms: Adipocytes, Adipogenesis, Hypertrophy, Obesity, Type 2 diabetes, GPS2, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221287782030140X; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/f460bff5fd63430e99e9c9d70a40b52d

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages

Authors: Louise Ménégaut, Charles Thomas, Antoine Jalil, Jean Baptiste Julla, Charlène Magnani, Adam Ceroi, Louise Basmaciyan, Adélie Dumont, Wilfried Le Goff, Mano Joseph Mathew, Cédric Rébé, Valentin Dérangère, Aline Laubriet, Valentin Crespy, Jean-Paul Pais de Barros, Eric Steinmetz, Nicolas Venteclef, Philippe Saas, Laurent Lagrost, David Masson

Source: Cell Reports, Vol 31, Iss 7, Pp - (2020)

Subject Terms: liver X receptors, interleukin-1 beta, hypoxia inducible factor 1 alpha, macrophages, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720306185; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/3db0334021a940558885f0366630bc79

Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

Authors: Lynda Aoudjehane, Jérémie Gautheron, Wilfried Le Goff, Claire Goumard, Julia Gilaizeau, Chan Sonavine Nget, Eric Savier, Muhammad Atif, Philippe Lesnik, Romain Morichon, Yves Chrétien, Yvon Calmus, Olivier Scatton, Chantal Housset, Filomena Conti

Source: Disease Models & Mechanisms, Vol 13, Iss 4 (2020)

Subject Terms: defatting, human hepatocytes, human precision-cut liver slices, liver transplantation, steatosis, triglycerides, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/13/4/dmm042663; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/eff1e63a2c874e1f9e36d2804419bb84

Transcriptomic and Lipidomic Mapping of Macrophages in the Hub of Chronic Beta-Adrenergic-Stimulation Unravels Hypertrophy-, Proliferation-, and Lipid Metabolism-Related Genes as Novel Potential Markers of Early Hypertrophy or Heart Failure

Authors: Sophie Nadaud, Mathilde Flamant, Wilfried Le Goff, Elise Balse, Catherine Pavoine

Source: Biomedicines, Vol 10, Iss 2, p 221 (2022)

Subject Terms: cardiac hypertrophy and heart failure, sympathetic nervous system and chronic beta-adrenergic signaling, temporal cardiac-resident macrophage plasticity, RNA sequencing and lipidomic analysis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/2/221; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/cb657b3f3e7648bc92c00e5981b6e3e5

The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus

Authors: Isabella Bonilha, Eric Hajduch, Beatriz Luchiari, Wilson Nadruz, Wilfried Le Goff, Andrei C. Sposito

Source: Metabolites, Vol 11, Iss 12, p 807 (2021)

Subject Terms: type 2 diabetes mellitus, low-density lipoprotein, oxidation, glycation, modified LDL, small and dense LDL, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/11/12/807; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/084af1e369064e1a92e3f32dc3b4935f

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

Authors: Veronica Codoni, Yuna Blum, Mete Civelek, Carole Proust, Oscar Franzén, Cardiogenics Consortium, IDEM Leducq Consortium CADGenomics, Johan L. M. Björkegren, Wilfried Le Goff, Francois Cambien, Aldons J. Lusis, David-Alexandre Trégouët

Source: G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3361-3371 (2016)

Subject Terms: gene expression network analysis, eQTL analysis, macrophages, cross-species comparison, trans genetic effects, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2160-1836

Access URL: https://doaj.org/article/6400e4b80771417f88d84779bd8eaf01

Reduced Reverse Cholesterol Transport Efficacy in Healthy Men with Undesirable Postprandial Triglyceride Response

Authors: Alexandre Motte, Julie Gall, Joe-Elie Salem, Eric Dasque, Martine Lebot, Eric Frisdal, Sophie Galier, Elise F. Villard, Elodie Bouaziz-Amar, Jean-Marc Lacorte, Beny Charbit, Wilfried Le Goff, Philippe Lesnik, Maryse Guerin

Source: Biomolecules, Vol 10, Iss 5, p 810 (2020)

Subject Terms: postprandial, hypertriglyceridemia, reverse cholesterol transport, high-density lipoprotein, CETP, cholesterol efflux, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/10/5/810; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/17aec6421bbe4fca9d8a76453aeffa05

Plasma cholesterol efflux capacity from human THP-1 macrophages is reduced in HIV-infected patients: impact of HAART[S]

Authors: Petra El Khoury, Mathilde Ghislain, Elise F. Villard, Wilfried Le Goff, Caroline Lascoux-Combe, Patrick Yeni, Laurence Meyer, Corinne Vigouroux, Cécile Goujard, Maryse Guerin

Source: Journal of Lipid Research, Vol 56, Iss 3, Pp 692-702 (2015)

Subject Terms: high density lipoprotein function, macrophage cholesterol efflux, reverse cholesterol transport, antiretroviral therapy, human immunodeficiency virus, highly active antiretroviral therapy, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520355978; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/b5ea46c104c2444c8f0711982caf1362