Gut microbiome alterations precede graft rejection in kidney transplantation patients

Authors: Holle, Johannes ^{1, 2, 3, 4, 5, †, ⁎}, Reitmeir, Rosa ^{1, 2, 3, 4, †}, Behrens, Felix ^{1, 2, 3, 4}, Singh, Dharmesh ^{6, 7}, Schindler, Daniela ⁸, Potapenko, Olena ^{2, 4, 9}, McParland, Victoria ^{2, 4, 9}, Anandakumar, Harithaa ^{2, 3, 4, 9}, Kanzelmeyer, Nele ^{10, 11}, Sommerer, Claudia ^{12, 13}, Hartleif, Steffen ^{14, 15}, Andrassy, Joachim ^{7, 16}, Heemann, Uwe ^{7, 17}, Neuenhahn, Michael ^{6, 7}, Forslund-Startceva, Sofia K. ^{2, 3, 4}, Gerhard, Markus ^{6, 7}, Oh, Jun ¹⁸, Wilck, Nicola ^{2, 3, 4, 9, ‡}, Löber, Ulrike ^{2, 3, 4, ‡}, Bartolomaeus, Hendrik ^{3, 4, 19, ‡}

Source: In American Journal of Transplantation February 2025

Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Authors: Al-Aly, Ziyad, Ashuntantang, Gloria E., Boor, Peter, Calice da Silva, Viviane, Coleman, Jill, Coresh, Josef, Delanaye, Pierre, Ebert, Natalie, Enghard, Philipp, Feldman, Harold I., Fisher, Lori, Flythe, Jennifer E., Fukui, Akira, Grams, Morgan E., Ix, Joseph H., Jardine, Meg J., Jha, Vivek, Ju, Wenjun, Jurish, Robert, Kalyesubula, Robert, Kashihara, Naoki, Levey, Andrew S., Levin, Adeera, Luyckx, Valerie, Małyszko, Jolanta, Manski-Nankervis, Jo-Anne, Navaneethan, Sankar D., Obrador, Greg, Ortiz, Alberto, Ortiz, John, Cardoso Dos Santos, Bento Fortunato, Sarnak, Mark J., Schaeffner, Elke, Selby, Nick M., Simpson, David M., Solá, Laura, St. Peter, Wendy L., Stevens, Paul E., Tangri, Navdeep, Tannor, Elliot Koranteng, Tchokhonelidze, Irma, Wilck, Nicola, Wong, Michelle M.Y., Eckardt, Kai-Uwe, Delgado, Cynthia, Heerspink, Hiddo J.L., Pecoits-Filho, Roberto, Ricardo, Ana C., Stengel, Bénédicte, Tonelli, Marcello, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., Kramer, Holly

Source: In Kidney International November 2023 104(5):888-903

Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration.

Authors: Stürzbecher, Lucas, Bartolomaeus, Hendrik, Bartolomaeus, Theda U. P., Bolz, Sylvia, Sekulic, Andjela, Ueffing, Marius, Clark, Simon J., Reichhart, Nadine, Crespo-Garcia, Sergio, Wilck, Nicola, Strauß, Olaf

Source: Frontiers in Immunology; 2025, p1-13, 13p

Subject Terms: MACULAR degeneration, T cells, RHODOPSIN, RETINAL degeneration, IMMUNOLOGIC memory

Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity

Authors: Maifeld, András, Wild, Johannes, Karlsen, Tine V., Rakova, Natalia, Wistorf, Elisa, Linz, Peter, Jung, Rebecca, Birukov, Anna, Gimenez-Rivera, Vladimir-Andrey, Wilck, Nicola, Bartolomaeus, Theda, Dechend, Ralf, Kleinewietfeld, Markus, Forslund, Sofia K., Krause, Andreas, Kokolakis, Georgios, Philipp, Sandra, Clausen, Björn E., Brand, Anna, Waisman, Ari, Kurschus, Florian C., Wegner, Joanna, Schultheis, Michael, Luft, Friedrich C., Boschmann, Michael, Kelm, Marcus, Wiig, Helge, Kuehne, Titus, Müller, Dominik N., Karbach, Susanne, Markó, Lajos

Source: In Journal of Investigative Dermatology January 2022 142(1):166-178

The Gut Microbiome in Hypertension

Authors: Avery, Ellen G., Bartolomaeus, Hendrik, Maifeld, Andras, Marko, Lajos, Wiig, Helge, Wilck, Nicola, Rosshart, Stephan P., Forslund, Sofia K., Müller, Dominik N.

Source: Circulation research. 128(7):934-950

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190154483.0x000001&indx=1&recIds=ETOCvdc_100190154483.0x000001

Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes

Authors: Geisberger, Sabrina, Bartolomaeus, Hendrik, Neubert, Patrick, Willebrand, Ralf, Zasada, Christin, Bartolomaeus, Thomas, McParland, Victoria, Swinnen, Dries, Geuzens, Anneleen, Maifeld, András, Krampert, Luka, Vogl, Marion, Mähler, Anja, Wilck, Nicola, Markó, Lajos, Tilic, Ekin, Forslund, Sofia K., Binger, Katrina J., Stegbauer, Johannes, Dechend, Ralf, Kleinewietfeld, Markus, Jantsch, Jonathan, Kempa, Stefan, Müller, Dominik N.

Source: Circulation. 144(2):144-158

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189137100.0x000001&indx=1&recIds=ETOCvdc_100189137100.0x000001

Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage

Authors: Thiele, Arne, Luettges, Katja, Ritter, Daniel, Beyhoff, Niklas, Smeir, Elia, Grune, Jana, Steinhoff, Julia S, Schupp, Michael, Klopfleisch, Robert, Rothe, Michael, Wilck, Nicola, Bartolomaeus, Hendrik, Migglautsch, Anna K, Breinbauer, Rolf, Kershaw, Erin E, Grabner, Gernot F, Zechner, Rudolf, Kintscher, Ulrich, Foryst-Ludwig, Anna

Source: Cardiovascular research. 118(11):2488-2505

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164406635.0x000001&indx=1&recIds=ETOCvdc_100164406635.0x000001

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Authors: Gawałko, Monika, Agbaedeng, Thomas A, Saljic, Arnela, Müller, Dominik N, Wilck, Nicola, Schnabel, Renate, Penders, John, Rienstra, Michiel, van Gelder, Isabelle, Jespersen, Thomas, Schotten, Ulrich, Crijns, Harry J G M, Kalman, Jonathan M, Sanders, Prashanthan, Nattel, Stanley, Dobrev, Dobromir, Linz, Dominik

Source: Cardiovascular research. 118(11):2415-2427

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164406614.0x000001&indx=1&recIds=ETOCvdc_100164406614.0x000001

Gut dysbiosis contributes to TMAO accumulation in CKD.

Authors: Holle, Johannes, McParland, Victoria, Anandakumar, Harithaa, Gerritzmann, Frederick, Behrens, Felix, Schumacher, Fabian, Thumfart, Julia, Eckardt, Kai-Uwe, Kleuser, Burkhard, Bartolomaeus, Hendrik, Wilck, Nicola

Source: Nephrology Dialysis Transplantation; Nov2024, Vol. 39 Issue 11, p1923-1926, 4p

Subject Terms: FECAL microbiota transplantation, BACTERIAL enzymes, DISEASE risk factors, DIETARY patterns, ACUTE kidney failure, PEDIATRIC nursing

Sodium chloride triggers Th17 mediated autoimmunity

Authors: Haase, Stefanie, Wilck, Nicola, Kleinewietfeld, Markus, Müller, Dominik N., Linker, Ralf A.

Source: In Journal of Neuroimmunology 15 April 2019 329:9-13

The role of the gut microbiota and microbial metabolites in neuroinflammation

Authors: Haase, Stefanie, Wilck, Nicola, Haghikia, Aiden, Gold, Ralf, Mueller, Dominik N., Linker, Ralf A.

Source: European journal of immunology. 50(12):1863-1870

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114625087.0x000001&indx=1&recIds=ETOCvdc_100114625087.0x000001

Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction

Authors: Schimmel, Katharina, Jung, Mira, Foinquinos, Ariana, José, Gorka San, Beaumont, Javier, Bock, Katharina, Grote-Levi, Lea, Xiao, Ke, Bär, Christian, Pfanne, Angelika, Just, Annette, Zimmer, Karina, Ngoy, Soeun, López, Begoña, Ravassa, Susana, Samolovac, Sabine, Janssen-Peters, Heike, Remke, Janet, Scherf, Kristian, Dangwal, Seema, Piccoli, Maria-Teresa, Kleemiss, Felix, Kreutzer, Fabian Philipp, Kenneweg, Franziska, Leonardy, Julia, Hobuß, Lisa, Santer, Laura, Do, Quoc-Tuan, Geffers, Robert, Braesen, Jan Hinrich, Schmitz, Jessica, Brandenberger, Christina, Müller, Dominik N., Wilck, Nicola, Kaever, Volkhard, Bähre, Heike, Batkai, Sandor, Fiedler, Jan, Alexander, Kevin M., Wertheim, Bradley M., Fisch, Sudeshna, Liao, Ronglih, Diez, Javier, González, Arantxa, Thum, Thomas

Source: Circulation. 141(9):751-767

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188863604.0x000001&indx=1&recIds=ETOCvdc_100188863604.0x000001

Darm-Herz-Achse

Authors: Bartolomaeus, Hendrik, McParland, Victoria, Wilck, Nicola

Source: Herz. 45(2):134-141

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167892139.0x000001&indx=1&recIds=ETOCvdc_100167892139.0x000001

Quantifying technical confounders in microbiome studies

Authors: Bartolomaeus, Theda U P, Birkner, Till, Bartolomaeus, Hendrik, Löber, Ulrike, Avery, Ellen G, Mähler, Anja, Weber, Daniela, Kochlik, Bastian, Balogh, András, Wilck, Nicola, Boschmann, Michael, Müller, Dominik N, Markó, Lajos, Forslund, Sofia K

Source: Cardiovascular research. 117(3):863-875

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130286685.0x000001&indx=1&recIds=ETOCvdc_100130286685.0x000001

Sodium in the microenvironment regulates immune responses and tissue homeostasis

Authors: Müller, Dominik, Wilck, Nicola, Haase, Stefanie, Kleinewietfeld, Markus, Linker, Ralf

Source: Nature reviews.Immunology. 19(4):243-254

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129125684.0x000001&indx=1&recIds=ETOCvdc_100129125684.0x000001

The role of sodium in modulating immune cell function

Authors: Wilck, Nicola, Balogh, András, Markó, Lajos, Bartolomaeus, Hendrik, Müller, Dominik

Source: Nature reviews.Nephrology. 15(9):546-558

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191723860.0x000001&indx=1&recIds=ETOCvdc_100191723860.0x000001

Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage

Authors: Bartolomaeus, Hendrik, Balogh, András, Yakoub, Mina, Homann, Susanne, Markó, Lajos, Höges, Sascha, Tsvetkov, Dmitry, Krannich, Alexander, Wundersitz, Sebastian, Avery, Ellen G., Haase, Nadine, Kräker, Kristin, Hering, Lydia, Maase, Martina, Kusche-Vihrog, Kristina, Grandoch, Maria, Fielitz, Jens, Kempa, Stefan, Gollasch, Maik, Zhumadilov, Zhaxybay, Kozhakhmetov, Samat, Kushugulova, Almagul, Eckardt, Kai-Uwe, Dechend, Ralf, Rump, Lars Christian, Forslund, Sofia K., Müller, Dominik N., Stegbauer, Johannes, Wilck, Nicola

Source: Circulation. 139(11):1407-1421

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188861544.0x000001&indx=1&recIds=ETOCvdc_100188861544.0x000001

Deletion in mice of X‐linked, Brugada syndrome–and atrial fibrillation–associated Kcne5 augments ventricular Kv currents and predisposes to ventricular arrhythmia

Authors: David, Jens-Peter, Lisewski, Ulrike, Crump, Shawn M., Jepps, Thomas A., Bocksteins, Elke, Wilck, Nicola, Lossie, Janine, Roepke, Torsten K., Schmitt, Nicole, Abbott, Geoffrey W.

Source: FASEB journal. 33(2):2537-2552

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103324924.0x000001&indx=1&recIds=ETOCvdc_100103324924.0x000001

Precarious Symbiosis Between Host and Microbiome in Cardiovascular Health

Authors: Bartolomaeus, Hendrik, Markó, Lajos, Wilck, Nicola, Luft, Friedrich C., Forslund, Sofia K., Muller, Dominik N.

Source: Hypertension. 73(5):926-935

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176812306.0x000001&indx=1&recIds=ETOCvdc_100176812306.0x000001

Myocardial Evaluation of Post-Preeclamptic Women by CMR

Authors: Birukov, Anna, Wiesemann, Stephanie, Golic, Michaela, Balogh, Andras, Marko, Lajos, Rakova, Natalia, Wilck, Nicola, Blaszczyk, Edyta, Lim, Carolin, Weiss, Sara, Kräker, Kristin, Haase, Nadine, Frolova, Alina, Jørgensen, Jan Stener, Daub, Steffen, Müller, Dominik N., Herse, Florian, Schulz-Menger, Jeanette, Dechend, Ralf

Source: JACC.Cardiovascular imaging. 13(5):1291-1293

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112442348.0x000001&indx=1&recIds=ETOCvdc_100112442348.0x000001