Evaluation of the distribution and excretion of [14C]-inclisiran following single subcutaneous administration in cynomolgus monkeys

Authors: Lehoux, Dario, Far, Adel Rafai, Kallend, David, Wijngaard, Peter L.J., Zerler, Brad

Source: In Toxicology and Applied Pharmacology 15 May 2022 443

Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis

Authors: Wright, R. Scott, Ray, Kausik K., Raal, Frederick J., Kallend, David G., Jaros, Mark, Koenig, Wolfgang, Leiter, Lawrence A., Landmesser, Ulf, Schwartz, Gregory G., Friedman, Andrew, Wijngaard, Peter L.J., Garcia Conde, Lorena, Kastelein, John J.P.

Source: Journal of the American College of Cardiology. 77(9):1182-1193

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136650545.0x000001&indx=1&recIds=ETOCvdc_100136650545.0x000001

Effects of Renal Impairment on the Pharmacokinetics, Efficacy, and Safety of Inclisiran: An Analysis of the ORION-7 and ORION-1 Studies

Authors: Wright, R. Scott, Collins, Michael G., Stoekenbroek, Robert M., Robson, Richard, Wijngaard, Peter L.J., Landmesser, Ulf, Leiter, Lawrence A., Kastelein, John J.P., Ray, Kausik K., Kallend, David

Source: In Mayo Clinic Proceedings January 2020 95(1):77-89

Inclisiran Durably Lowers Low-Density Lipoprotein Cholesterol and Proprotein Convertase Subtilisin/Kexin Type 9 Expression in Homozygous Familial Hypercholesterolemia

Authors: Hovingh, G. Kees, Lepor, Norman E., Kallend, David, Stoekenbroek, Robert M., Wijngaard, Peter L.J., Raal, Frederick J.

Source: Circulation. 141(22):1829-1831

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188866305.0x000001&indx=1&recIds=ETOCvdc_100188866305.0x000001

Persistent changes in lipoprotein lipids after a single infusion of ascending doses of MDCO-216 (apoA-IMilano/POPC) in healthy volunteers and stable coronary artery disease patients

Authors: Kempen, Herman J., Gomaraschi, Monica, Simonelli, Sara, Calabresi, Laura, Moerland, Matthijs, Otvos, James, Jeyarajah, Elias, Kallend, David, Wijngaard, Peter L.J.

Source: In Atherosclerosis December 2016 255:17-24

High-Density Lipoprotein Subfractions and Cholesterol Efflux Capacities After Infusion of MDCO-216 (Apolipoprotein A-IMilano/Palmitoyl-Oleoyl-Phosphatidylcholine) in Healthy Volunteers and Stable Coronary Artery Disease Patients

Authors: Kempen, Herman J., Asztalos, Bela F., Moerland, Matthijs, Jeyarajah, Elias, Otvos, James, Kallend, David G., Bellibas, S. Eralp, Wijngaard, Peter L.J.

Source: Arteriosclerosis, thrombosis, and vascular biology. 36(4):736-742

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100032630450.0x000001&indx=1&recIds=ETOCvdc_100032630450.0x000001

Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys

Authors: Kempen, Herman J. ^*, Gomaraschi, Monica ^†, Bellibas, S. Eralp ^§, Plassmann, Stephanie ^**, Zerler, Brad ^§, Collins, Heidi L. ^††, Adelman, Steven J. ^††, Calabresi, Laura ^†, Wijngaard, Peter L.J. ^*

Source: In Journal of Lipid Research September 2013 54(9):2341-2353

Corrigendum to “Evaluation of the distribution and excretion of [14C]-inclisiran following single subcutaneous administration in cynomolgus monkeys” [Toxicology and Applied Pharmacology 443 (2022) 115978]

Authors: Lehoux, Dario, Far, Adel Rafai, Kallend, David, Wijngaard, Peter L.J., Zerler, Brad

Source: In Toxicology and Applied Pharmacology 15 September 2022 451

The drug resistance-related protein LRP is the human major vault protein

Authors: Scheffer, George L., Wijngaard, Peter L.J., Flens, Marcel J., Izquierdo, Miguel A., Slovak, Marilyn L., Pinedo, Herbert M., Meijer, Chris J.L.M., Clevers, Hans C., Scheper, Rik J.

Source: Nature medicine. 1(6):578-582

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191246628.0x000001&indx=1&recIds=ETOCvdc_100191246628.0x000001

SiRNA to PCSK9 in patients with high cardiovascular risk and elevated LDL-C: the ORION 1 trial

Authors: Ray, Kausik K., Landmesser, Ulf, Leiter, Lawrence A., Kallend, David, Wijngaard, Peter L.J., Wright, R.Scott, Kastelein, John J.P.

Source: Atherosclerosis. 263:e9-e10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063630716.0x000001&indx=1&recIds=ETOCvdc_100063630716.0x000001

Cytoimmunologic monitoring for rejection and infection after lung transplantation

Authors: Schuurman, Henk-Jan, Wijngaard, Peter L.J., Jansen, Erik W.L., der Meulen, Ankje van, Slootweg, Pieter J., Gmelig Meyling, Frits H.J.

Source: Journal of Thoracic and Cardiovascular Surgery; January 1993, Vol. 105 Issue: 1 p178-180, 3p

Breaking of transplantation tolerance after reduction of immunosuppression

Authors: Wijngaard, Peter L.J., Schuurman, Henk-Jan, Gmelig Meyling, Frits H.J., Jambroes, George, Borleffs, Jan C.C.

Source: Journal of Thoracic and Cardiovascular Surgery; January 1993, Vol. 105 Issue: 1 p183-184, 2p

Transplantation tolerance in heart transplant recipients as demonstrated by unresponsiveness in cell-mediated lympholysis

Authors: Wijngaard, Peter L.J., Schuurman, Henk-Jan, Gmelig Meyling, Frits H.J., Jambroes, George, Borleffs, Jan C.C.

Source: In Human Immunology 1992 34(3):167-172

Invited letter concerning: Transplantation tolerance and transplantation: Reply to the Editor

Authors: Wijngaard, Peter L.J., Gmelig Meyling, Frits H.J., Schuurman, Henk-Jan

Source: Journal of Thoracic and Cardiovascular Surgery; January 1993, Vol. 105 Issue: 1 p185-185, 1p