Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer

Authors: Whatcott, Clifford J., Han, Haiyong, Von Hoff, Daniel D.

Source: cancer journal. 21(4):299-306

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037128220.0x000001&indx=1&recIds=ETOCvdc_100037128220.0x000001

A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence

Authors: Whatcott, Clifford J., Meyer-Ficca, Mirella L., Meyer, Ralph G., Jacobson, Myron K. ^⁎

Source: In Experimental Cell Research 2009 315(20):3477-3485

Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity

Authors: Meyer, Ralph G., Meyer-Ficca, Mirella L., Whatcott, Clifford J., Jacobson, Elaine L., Jacobson, Myron K.

Source: In Experimental Cell Research 1 August 2007 313(13):2920-2936

Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.

Authors: Whatcott, Clifford J.¹, Ng, Serina¹, Barrett, Michael T.², Hostetter, Galen³, Von Hoff, Daniel D.¹, Han, Haiyong¹ hhan@tgen.org

Source: PLoS ONE. 8/25/2017, Vol. 12 Issue 8, p1-18. 18p.

Subject Terms: *PANCREATIC cancer treatment, *FIBROBLASTS, *KINASES, *CANCER cells, *RHO GTPases

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry protocol for monitoring the progress of enzymatic 13C/ 15N-labeled DNA syntheses

Authors: Ambrus, Attila, Chen, Ding, Whatcott, Clifford, Somogyi, Árpád, Yang, Danzhou

Source: In Analytical Biochemistry 2005 342(2):246-253

Activity of the multikinase inhibitor TP‐0903 in RAS mutant acute myeloid leukemia

Authors: Jeon, Jae Yoon, Eisenmann, Eric, Niu, Mingshan, Garrison, Dominique, Buelow, Daelynn, Thomas, Megan Zavorka, Whatcott, Clifford, Warner, Steven, Orwick, Shelley, Hertlein, Erin, Byrd, John, Bhatnagar, Bhavana, Baker, Sharyn D.

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140399531.0x000001&indx=1&recIds=ETOCvdc_100140399531.0x000001

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.

Authors: Chan, Tsz-Yin, Egbert, Christina M., Maxson, Julia E., Siddiqui, Adam, Larsen, Logan J., Kohler, Kristina, Balasooriya, Eranga Roshan, Pennington, Katie L., Tsang, Tsz-Ming, Frey, Madison, Soderblom, Erik J., Geng, Huimin, Müschen, Markus, Forostyan, Tetyana V., Free, Savannah, Mercenne, Gaelle, Banks, Courtney J., Valdoz, Jonard, Whatcott, Clifford J., Foulks, Jason M.

Source: Nature Communications; 9/9/2021, Vol. 12 Issue 1, p1-17, 17p

Subject Terms: TUMOR growth, LABORATORY mice, CELL proliferation, UBIQUITIN, CELL culture, PROTEIN-tyrosine kinases

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

The CDK9 Inhibitor, Alvocidib, Potentiates the Non-Clinical Activity of Azacytidine or Decitabine in an MCL-1-Dependent Fashion, Supporting Clinical Exploration of a Decitabine and Alvocidib Combination

Authors: Kim, Wontak ^*, Whatcott, Clifford ^*, Siddiqui-Jain, Adam ^*, Anthony, Stephen, Bearss, David J., Warner, Steven L.

Source: In Blood 29 November 2018 132 Supplement 1:4355-4355

The Oral CDK9 Inhibitor, TP-1287, Is Active in Non-Clinical Models of Multiple Myeloma

Authors: Tyagi, Ethika ^*, Whatcott, Clifford ^*, Foulks, Jason M ^*, Siddiqui-Jain, Adam ^*, Bearss, David J., Warner, Steven L.

Source: In Blood 29 November 2018 132 Supplement 1:3269-3269

The PIM Kinase Inhibitor TP-3654 in Combination with Ruxolitinib Exhibits Marked Improvement of Myelofibrosis in Murine Models

Authors: Nath, Dipmoy ^*, Dutta, Avik ^*, Yang, Yue ^*, Whatcott, Clifford ^*, Warner, Steven L., Mohi, Golam

Source: In Blood 29 November 2018 132 Supplement 1:54-54

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

TP-0903, a Novel Axl Inhibitor with Activity in Drug Resistant FLT3-ITD+ AML through a Mechanism That Includes FLT3 Inhibition

Authors: Jeon, Jae Yoon, Park, Il-Kyoo, Buelow, Daelynn R ^*, Whatcott, Clifford ^*, Warner, Steven L., Blum, William, Baker, Sharyn

Source: In Blood 8 December 2017 130 Supplement 1:2522-2522

TP-0184 Inhibits ALK2/ACVR1, Decreases Hepcidin Levels, and Demonstrates Activity in Preclinical Mouse Models of Functional Iron Deficiency

Authors: Peterson, Peter ^*, K, W ^*, Whatcott, Clifford ^*, Siddiqui-Jain, Adam ^*, Weitman, Steven ^*, Kieran, Mark ^*, Bearss, David J. ^*, Warner, Steven L.

Source: In Blood 8 December 2017 130 Supplement 1:937-937

This result is not displayed to guests.
Login for full access.