Learning From Evidence: Changes in Real-World Use of Second Androgen Receptor Targeted Treatments in Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Authors: Bosch, Dianne ^{1, ⁎}, van der Velden, Kim J.M. ¹, Belleman, Tom ², van Deen, Welmoed K. ², Bergman, André M. ³, van der Doelen, Maarten J. ^{1, 7}, van den Eertwegh, Alfons J.M. ⁴, Gerritsen, Winald R. ⁵, van Moorselaar, Reindert J.A. ⁶, Somford, Diederik M. ⁷, Tascilar, Metin ⁸, Westgeest, Hans M. ⁹, Uyl-de Groot, Carin A. ², Mulders, Peter F.A. ¹, Kuppen, Malou C.P. ¹⁰, van Oort, Inge M. ¹

Source: In Clinical Genitourinary Cancer February 2025

Lessons learned from postmarketing withdrawals of expedited approvals for oncology drug indications

Authors: Koole, Simone N ^*, Huisman, Atse H, Timmers, Lonneke, Westgeest, Hans M, van Breugel, Edwin, Sonke, Gabe S, van Waalwijk van Doorn-Khosrovani, Sahar Barjesteh

Source: In The Lancet Oncology March 2024 25(3):e126-e135

Phenotype-guided targeted therapy based on functional signal transduction pathway activity in recurrent ovarian cancer patients: The STAPOVER study protocol

Authors: van der Ploeg, Phyllis ^{a, b, 1}, Hendrikse, Cynthia SE. ^{a, b, ∗, 1}, Thijs, Anna MJ. ^c, Westgeest, Hans M. ^d, Smedts, Huberdina PM. ^e, Vos, M Caroline ^f, Jalving, Mathilde ^g, Lok, Christianne AR. ^h, Boere, Ingrid A. ⁱ, van Ham, Maaike APC. ^j, Ottevanger, Petronella B. ^k, Westermann, Anneke M. ^l, Mom, Constantijne H. ^m, Lalisang, Roy I. ⁿ, Lambrechts, Sandrina ^o, Bekkers, Ruud LM. ^{a, b}, Piek, Jurgen MJ. ^a

Source: In Heliyon 15 January 2024 10(1)

CT radiomics compared to a clinical model for predicting checkpoint inhibitor treatment outcomes in patients with advanced melanoma

Authors: ter Maat, Laurens S., van Duin, Isabella A.J., Elias, Sjoerd G., Leiner, Tim, Verhoeff, Joost J.C., Arntz, Eran R.A.N., Troenokarso, Max F., Blokx, Willeke A.M., Isgum, Ivana, de Wit, Geraldine A., van den Berkmortel, Franchette W.P.J., Boers-Sonderen, Marye J., Boomsma, Martijn F., van den Eertwegh, Fons J.M., de Groot, Jan Willem B., Piersma, Djura, Vreugdenhil, Art, Westgeest, Hans M., Kapiteijn, Ellen, van Diest, Paul J., Pluim, Josien P.W., de Jong, Pim A., Suijkerbuijk, Karijn P.M., Veta, Mitko

Source: European journal of cancer. 185:167-177

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Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma

Authors: Nakauma-González, J. Alberto, Rijnders, Maud, van Riet, Job, van der Heijden, Michiel S., Voortman, Jens, Cuppen, Edwin, Mehra, Niven, van Wilpe, Sandra, Oosting, Sjoukje F., Rijstenberg, L. Lucia, Westgeest, Hans M., Zwarthoff, Ellen C., de Wit, Ronald, van der Veldt, Astrid A.M., van de Werken, Harmen J.G., Lolkema, Martijn P.J., Boormans, Joost L.

Source: European urology. 81(4):331-336

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169445441.0x000001&indx=1&recIds=ETOCvdc_100169445441.0x000001

Symptomatic Skeletal Events and the Use of Bone Health Agents in a Real-World Treated Metastatic Castration Resistant Prostate Cancer Population: Results From the CAPRI-Study in the Netherlands

Authors: Kuppen, Malou C.P., Westgeest, Hans M., van den Eertwegh, Alfons J.M., van Moorselaar, Reindert J.A., van Oort, Inge M., Tascilar, Metin, Mehra, Niven, Lavalaye, Jules, Somford, Diederik M., Aben, Katja K.H., Bergman, Andre M., de Wit, Ronald, van den Bergh, A.C.M. (Fons), de Groot, Carin A. Uyl-, Gerritsen, Winald R.

Source: Clinical genitourinary cancer. 20(1):43-52

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167674751.0x000001&indx=1&recIds=ETOCvdc_100167674751.0x000001

Evidence or Prejudice? Critical Re-Analysis of Randomized Controlled Trials Comparing Overall Survival After Cisplatin Versus Carboplatin-Based Regimens in Advanced Urothelial Carcinoma

Authors: Richters, Anke, Kiemeney, Lambertus A.L.M., Mehra, Niven, Westgeest, Hans M., Birtle, Alison, Bryan, Richard T., Aben, Katja K.H.

Source: Clinical genitourinary cancer. 20(4):e346-e352

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167392540.0x000001&indx=1&recIds=ETOCvdc_100167392540.0x000001

Life-prolonging treatment restrictions and outcomes in patients with cancer and COVID-19: an update from the Dutch Oncology COVID-19 Consortium

Authors: de Joode, Karlijn, Tol, Jolien, Hamberg, Paul, Cloos, Marissa, Kastelijn, Elisabeth A., Borgers, Jessica S.W., Nuij, Veerle J.A.A., Klaver, Yarne, Herder, Gerarda J.M., Mutsaers, Pim G.N.J., Dumoulin, Daphne W., Oomen-de Hoop, Esther, van Diemen, Nico G.J., Libourel, Eduard J., Geraedts, Erica J., Bootsma, Gerben P., van der Leest, Cor H., Peerdeman, Anne L., Herbschleb, Karin H., Visser, Otto J., Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., de Vries, Elisabeth G.E., Hendriks, Lizza E.L., Beerepoot, Laurens V., Westgeest, Hans M., van den Berkmortel, Franchette W.P.J., Haanen, John B.A.G., Dingemans, Anne-Marie C., van der Veldt, Astrid A.M.

Source: European journal of cancer. 160:261-272

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Genome‐wide aneuploidy detected by mFast‐SeqS in circulating cell‐free DNA is associated with poor response to pembrolizumab in patients with advanced urothelial cancer

Authors: Mendelaar, Pauline A. J., Robbrecht, Debbie G. J., Rijnders, Maud, Wit, Ronald, Weerd, Vanja, Deger, Teoman, Westgeest, Hans M., Aarts, Maureen J. B., Voortman, Jens, Martens, John W. M., Veldt, Astrid A. M., Nakauma‐González, José Alberto, Wilting, Saskia M., Lolkema, Martijn

Source: Molecular oncology. 16(10):2086-2097

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150328889.0x000001&indx=1&recIds=ETOCvdc_100150328889.0x000001

De toekomst van de uro-oncologische zorg: minder is meer? (Dutch/Flemish)

Alternate Title: The future of uro-oncological care: less is more? (English)

Authors: Rutten, Vera C., Penninx, Bart M. F., Westgeest, Hans M., Boormans, Joost L.

Source: Tijdschrift voor Urologie; Mar2025, Vol. 15 Issue 2, p32-37, 6p

Subject Terms: WATCHFUL waiting, PROSTATE cancer, PREVENTIVE medicine, DOSE fractionation, OVERALL survival, HOSPITAL administration, RESOURCE allocation

Adjuvant treatment for melanoma in clinical practice – Trial versus reality

Authors: de Meza, Melissa M., Ismail, Rawa K., Rauwerdink, Daan, van Not, Olivier J., van Breeschoten, Jesper, Blokx, Willeke A.M., de Boer, Anthonius, van Dartel, Maaike, Hilarius, Doranne L., Ellebaek, Eva, Bonenkamp, Han J., Blank, Christian U., Aarts, Maureen J.B., van Akkooi, Alexander C.J., van den Berkmortel, Franchette W.P.J., Boers-Sonderen, Marye J., de Groot, Jan Willem B., Haanen, John B., Hospers, Geke A.P., Kapiteijn, Ellen W., Piersma, Djura, van Rijn, Roos S., van der Veldt, Astrid A.M., Vreugdenhil, Art, Westgeest, Hans M., van den Eertwegh, Alfons J.M., Suijkerbuijk, Karijn P.M., Wouters, Michel W.J.M.

Source: In European Journal of Cancer November 2021 158:234-245

The effectiveness of monotherapy with PI3K/AKT/mTOR pathway inhibitors in ovarian cancer: A meta-analysis

Authors: van der Ploeg, Phyllis, Uittenboogaard, Aniek, Thijs, Anna M.J., Westgeest, Hans M., Boere, Ingrid A., Lambrechts, Sandrina, van de Stolpe, Anja, Bekkers, Ruud L.M., Piek, Jurgen M.J.

Source: In Gynecologic Oncology November 2021 163(2):433-444

Impact of DNA damage repair defects and aggressive variant features on response to carboplatin‐based chemotherapy in metastatic castration‐resistant prostate cancer

Authors: Slootbeek, Peter H. J., Duizer, Marleen L., Doelen, Maarten J., Kloots, Iris S. H., Kuppen, Malou C. P., Westgeest, Hans M., Uyl‐de Groot, Carin A., Pamidimarri Naga, Samhita, Ligtenberg, Marjolijn J. L., Oort, Inge M., Gerritsen, Winald R., Schalken, Jack A., Kroeze, Leonie I., Bloemendal, Haiko J., Mehra, Niven

Source: International journal of cancer. 148(2):385-395

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110343701.0x000001&indx=1&recIds=ETOCvdc_100110343701.0x000001

High-Intensity Care in the End-of-Life Phase of Castration-Resistant Prostate Cancer Patients: Results from the Dutch CAPRI-Registry

Authors: Westgeest, Hans M., Kuppen, Malou C.P., van den Eertwegh, Fons A.J.M., van Oort, Inge M., Coenen, Juleon L.L.M., van Moorselaar, Jeroen R.J.A., Aben, Katja K.H., Bergman, Andre M., Huinink, Daan ten Bokkel, van den Bosch, Joan, Hendriks, Mathijs P., Lampe, Menuhin I., Lavalaye, Jules, Mehra, Niven, Smilde, Tineke J., Somford, Rik D.M., Tick, Lidwine, Weijl, Nir I., van de Wouw, Yes A.J., Gerritsen, Winald R., Groot, Carin A. Uyl-de

Source: Journal of palliative medicine. 24(12):1789-1797

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135512908.0x000001&indx=1&recIds=ETOCvdc_100135512908.0x000001

Deep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma.

Authors: Ter Maat, Laurens S., De Mooij, Rob A. J., Van Duin, Isabella A. J., Verhoeff, Joost J. C., Elias, Sjoerd G., Leiner, Tim, van Amsterdam, Wouter A. C., Troenokarso, Max F., Arntz, Eran R. A. N., Van den Berkmortel, Franchette W. P. J., Boers-Sonderen, Marye J., Boomsma, Martijn F., Van den Eertwegh, Fons J. M., de Groot, Jan Willem, Hospers, Geke A. P., Piersma, Djura, Vreugdenhil, Art, Westgeest, Hans M., Kapiteijn, Ellen, De Wit, Ardine A.

Source: Scientific Reports; 12/30/2024, Vol. 14 Issue 1, p1-11, 11p

Subject Terms: RECEIVER operating characteristic curves, IMMUNE checkpoint inhibitors, DEEP learning, LACTATE dehydrogenase, COMPUTED tomography

Dutch Oncology COVID-19 consortium: Outcome of COVID-19 in patients with cancer in a nationwide cohort study

Authors: van Loenhout, C.J., van der Leest, C.H., Becker-Commissaris, A., Borgers, J.S.W., Terhegggen, F., van den Borne, B.E.E.M., van Warmerdam, L.J.C., van Leeuwen, L., van der Meer, F.S., Tiemessen, M.A., van Diepen, D.M., Klaver, Y., Hamberg, A.P., Libourel, E.J., Strobbe, L., Cloos, M., Geraedts, E.J., Drooger, J.C., Heller, R., de Groot, J.W.B., Stigt, J.A., Nuij, V.J.A.A., Pitz, C.C.M., Slingerland, M., Borm, F.J., Haberkorn, B.C.M., Westeinde, S.C. van 't, Aarts, M.J.B., van Putten, J.W.G., Youssef, M., Cirkel, G.A., Herder, G.J.M., van Rooijen, C.R., Citgez, E., Barlo, N.P., Scholtes, B.M.J., Koornstra, R.H.T., Claessens, N.J.M., Faber, L.M., Rikers, C.H., van de Wetering, R.A.W., Veurink, G.L., Bouter, B.W., Houtenbos, I., Bard, M.P.L., Herbschleb, K.H., Kastelijn, E.A., Brocken, P., Douma, G., Jalving, M., Hiltermann, T.J.N., Schuurbiers-Siebers, O.C.J., Suijkerbuijk, K.P.M., van Lindert, A.S.R., van de Wouw, A.J., van den Boogaart, V.E.M., Bakker, S.D., Looysen, E., Peerdeman, A.L., de Jong, W.K., Siemerink, E.J.M., Staal, A.J., Franken, B., van Geffen, W.H., Bootsma, G.P., de Joode, Karlijn, Dumoulin, Daphne W., Tol, Jolien, Westgeest, Hans M., Beerepoot, Laurens V., van den Berkmortel, Franchette W.P.J., Mutsaers, Pim G.N.J., van Diemen, Nico G.J., Visser, Otto J., Oomen-de Hoop, Esther, Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., Hendriks, Lizza E.L., Haanen, John B.A.G., de Vries, Elisabeth G.E., Dingemans, Anne-Marie C., van der Veldt, Astrid A.M.

Source: In European Journal of Cancer December 2020 141:171-184

Health-related Quality of Life and Pain in a Real-world Castration-resistant Prostate Cancer Population: Results From the PRO-CAPRI Study in the Netherlands

Authors: Kuppen, Malou C.P., Westgeest, Hans M., van den Eertwegh, Alphonsus J.M., Coenen, Jules L.L.M., van Moorselaar, Reindert J.A., van den Berg, Pieter, Geenen, Maud M., Mehra, Niven, Hendriks, Mathijs P., Lampe, Menuhin I., van de Luijtgaarden, Addy C.M., Peters, Frank P.J., Roeleveld, Ton A., Smilde, Tineke J., de Wit, Ronald, van Oort, Inge M., Gerritsen, Winald R., Uyl-de Groot, Carin A.

Source: In Clinical Genitourinary Cancer June 2020 18(3):e233-e253

Second-Line Cabazitaxel Treatment in Castration-Resistant Prostate Cancer Clinical Trials Compared to Standard of Care in CAPRI: Observational Study in the Netherlands

Authors: Westgeest, Hans M., Kuppen, Malou C.P., van den Eertwegh, Alphonsus J.M., de Wit, Ronald, Coenen, Juleon L.L.M., van den Berg, H.P. (Pieter), Mehra, Niven, van Oort, Inge M., Fossion, Laurent M.C.L., Hendriks, Mathijs P., Bloemendal, Haiko J., van de Luijtgaarden, Addy C.M., ten Bokkel Huinink, Daan, van den Bergh, A.C.M. (Fons), van den Bosch, Joan, Polee, Marco B., Weijl, Nir, Bergman, Andre M., Uyl-de Groot, Carin A., Gerritsen, Winald R.

Source: In Clinical Genitourinary Cancer October 2019 17(5):e946-e956

Dutch Oncology COVID-19 consortium: Outcome of COVID-19 in patients with cancer in a nationwide cohort study

Authors: de Joode, Karlijn, Dumoulin, Daphne W., Tol, Jolien, Westgeest, Hans M., Beerepoot, Laurens V., van den Berkmortel, Franchette W.P.J., Mutsaers, Pim G.N.J., van Diemen, Nico G.J., Visser, Otto J., Oomen-de Hoop, Esther, Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., Hendriks, Lizza E.L., Haanen, John B.A.G., de Vries, Elisabeth G.E., Dingemans, Anne-Marie C., van der Veldt, Astrid A.M.

Source: European journal of cancer. 141:171-184

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Real-world outcomes of radium-223 dichloride for metastatic castration resistant prostate cancer

Authors: Kuppen, Malou CP, Westgeest, Hans M, van der Doelen, Maarten J, van den Eertwegh, Alphonsus JM, Coenen, Jules LLM, Aben, Katja KH, van den Bergh, Alphons CM, Bergman, Andries M, den Bosch, Joan van, Celik, Filiz, Hendriks, Mathijs P, Lavalaye, Jules, der Meer, Saskia van, Polee, Marco B, Somford, Diederik M, van Oort, Inge M, Uyl-de Groot, Carin A, Gerritsen, Winald R

Source: Future oncology. 16(19):1371-1384

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186983761.0x000001&indx=1&recIds=ETOCvdc_100186983761.0x000001