Creeping Fat–Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn’s Disease

Authors: Liu, Weiwei ¹, Mao, Ren ^{1, 2}, Nga Le, Thi Hong ¹, West, Gail ¹, Varadharajan, Venkateshwari ³, Banerjee, Rakhee ³, Doyon, Genevieve ¹, Mukherjee, Pranab ¹, Nguyen, Quang Tam ¹, Mulya, Anny ¹, Rennison, Julie H. ³, Gordon, Ilyssa O. ⁴, Cruise, Michael ⁴, Hu, Shaomin ⁴, Czarnecki, Doug ¹, Plesec, Thomas ⁴, Chandra, Jyotsna ¹, Banerjee, Suhanti ¹, Wang, Jie ^{1, 5}, Massey, William J. ¹, Goren, Idan ¹, Lin, Si-Nan ¹, Kurada, Satya ⁶, Cohen, Benjamin L. ⁷, Qazi, Taha ⁷, Holubar, Stefan D. ⁸, Lipman, Jeremy ⁸, Kanters, Arielle ⁸, Gliniak, Christy M. ⁹, Scherer, Philipp E. ⁹, Chen, Min-Hu ², Siegmund, Britta ¹⁰, Ivanov, Andrei I. ¹, Fiocchi, Claudio ^{1, 7}, Van Wagoner, David R. ³, Brown, J. Mark ³, Rieder, Florian ^{1, 7, 11, ∗}

Source: In Gastroenterology March 2025 168(3):508-524

Hyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan (∼35 kDa) protects via a layilin dependent mechanism

Authors: Jatana, Samreen, Abbadi, Amina, West, Gail A., Ponti, András K., Braga-Neto, Manuel B., Smith, Jordyn L., Marino-Melendez, Armando, Willard, Belinda, Nagy, Laura E., Motte, Carol de la

Source: In Matrix Biology November 2024 133:116-133

Stricturing Crohn’s Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions

Authors: Mukherjee, Pranab K., Nguyen, Quang Tam, Li, Jiannan, Zhao, Shuai, Christensen, Stephen M., West, Gail A., Chandra, Jyotsna, Gordon, Ilyssa O., Lin, Sinan, Wang, Jie, Mao, Ren, Czarnecki, Douglas, Rayan, Carla, Goren, Idan, Banerjee, Suhanti, Kotak, Prerna, Plesec, Thomas, Lal, Samir, Fabre, Thomas, Asano, Shoh, Bound, Kathryn, Hart, Kevin, Park, Chanyoung, Martinez, Robert, Dower, Ken, Wynn, Thomas A., Hu, Shaomin, Naydenov, Nayden, Decaris, Martin, Turner, Scott, Holubar, Stefan D., Steele, Scott R., Fiocchi, Claudio, Ivanov, Andrei I., Kravarik, Kellie M., Rieder, Florian

Source: In Gastroenterology November 2023 165(5):1180-1196

35kDa hyaluronan ameliorates ethanol driven loss of anti-microbial defense and intestinal barrier integrity in a TLR4-dependent manner

Authors: Ray, Semanti, Huang, Emily, West, Gail A, Mrdjen, Marko, McMullen, Megan R, de la Motte, Carol, Nagy, Laura E

Source: MATRIX BIOLOGY. 115:71-80

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Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation

Authors: Lin, Si-Nan, Musso, Alessandro, Wang, Jie, Mukherjee, Pranab K., West, Gail A., Mao, Ren, Lyu, Ruishen, Li, Jiannan, Zhao, Shuai, Elias, Michael, Haberman, Yael, Denson, Lee A., Kugathasan, Subra, Chen, Min-Hu, Czarnecki, Doug, Dejanovic, Dina, Le, Hongnga T., Chandra, Jyotsna, Lipman, Jeremy, Steele, Scott R., Nguyen, Quang Tam, Fiocchi, Claudio, Rieder, Florian

Source: In Matrix Biology November 2022 113:1-21

Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation

Authors: Zhao, Shuai ^*, Dejanovic, Dina ^*, Yao, Peng, Bhilocha, Shardul, Sadler, Tammy, Schirbel, Anja, West, Gail, Doyon, Genevieve, Lopez, Rocio, Mao, Ren, Kurada, Satya, El Ouali, Sara, Grassl, Guntram, Fox, Paul L., Cruise, Michael, Worthley, Daniel L., de la Motte, Carol, Fiocchi, Claudio, Rieder, Florian

Source: In Mucosal Immunology July 2020 13(4):665-678

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Layilin is critical for mediating hyaluronan 35 kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo

Authors: Kim, Yeojung, West, Gail A., Ray, Greeshma, Kessler, Sean P., Petrey, Aaron C., Fiocchi, Claudio, McDonald, Christine, Longworth, Michelle S., Nagy, Laura E., de la Motte, Carol A.

Source: In Matrix Biology March 2018 66:93-109

Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy

Authors: Schirbel, Anja, Rebert, Nancy, Sadler, Tammy, West, Gail, Rieder, Florian, Wagener, Christoph, Horst, Andrea, Sturm, Andreas, de la Motte, Carol, Fiocchi, Claudio

Source: Inflammatory bowel diseases. 25(2):294-305

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Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis.

Authors: Sinan Lin, Jie Wang, Mukherjee, Pranab K., Mao, Ren, West, Gail, Czarnecki, Doug, Shuai Zhao, Nguyen, Quang Tam, Elias, Michael, Massey, William J., Wei Wei Liu, Yan Wang, Prasad, Ankita, Banerjee, Suhanti, Goren, Idan, Chandra, Jyotsna, Le, Hongnga T., Dejanovic, Dina, Jiannan Li, Minhu Chen

Source: Gut; Jul2024, Vol. 73 Issue 7, p1110-1123, 14p

Subject Terms: MILKFAT, FIBROSIS, BLOOD coagulation factor VIII, CELL receptors, INTESTINES, LYSYL oxidase, KERATIN, FIBRONECTINS

951 CREEPING FAT-DERIVED LONG CHAIN FREE FATTY ACIDS DRIVE INTESTINAL MUSCULARIS PROPRIA MUSCLE CELL PROLIFERATION VIA LIPID METABOLISM AND CARNITINE PALMITOYLTRANSFERASE 1 (CPT-1) - A RELEVANT MECHANISM FOR STRICTURING CROHN'S DISEASE

Authors: Liu, Weiwei, Mao, Ren, Le, Thi Hong Nga, Czarnecki, Doug, Chandra, Jyotsna, Gordon, Ilyssa O., Plesec, Thomas, Wang, Jie, Lin, Sinan, Zhao, Shuai, Dejanovic, Dina, Mukherjee, Pranab, West, Gail A., Fiocchi, Claudio, Brown, Jonathan Mark, Rieder, Florian

Source: Gastroenterology. 164(6):S-208-S-209

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194425067.0x000001&indx=1&recIds=ETOCvdc_100194425067.0x000001

Tu1246 CROHN'S DISEASE STRICTURE MATRISOME ANALYSIS REVEALS THE ANTI-FIBROTIC ACTIVITY OF MILK-FAT GLOBULE-EPIDERMAL GROWTH FACTOR 8 (MFGE8)

Authors: Lin, Sinan, Wang, Jie, Mukherjee, Pranab, Mao, Ren, West, Gail A., Czarnecki, Doug, Zhao, Shuai, Nguyen, Quang Tam, Chandra, Jyotsna, Le, Thi Hong Nga, Dejanovic, Dina, Chen, Minhu, Holubar, Stefan D., Olman, Mitch, Southern, Brian D., Hu, Shaomin, Gordon, Ilyssa O., Atabai, Kamran, Fiocchi, Claudio, Rieder, Florian

Source: Gastroenterology. 164(6):S-1006-S-1007

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194461524.0x000001&indx=1&recIds=ETOCvdc_100194461524.0x000001

Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo

Authors: Kim, Yeojung, West, Gail A., Ray, Greeshma, Kessler, Sean P., Petrey, Aaron C., Fiocchi, Claudio, McDonald, Christine, Longworth, Michelle S., Nagy, Laura E., de la Motte, Carol A.

Source: MATRIX BIOLOGY. 66:93-109

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063794553.0x000001&indx=1&recIds=ETOCvdc_100063794553.0x000001

Crohn’s Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments

Authors: Soroosh, Artin, Albeiroti, Sami, West, Gail A., Willard, Belinda, Fiocchi, Claudio, de la Motte, Carol A.

Source: In Cellular and Molecular Gastroenterology and Hepatology May 2016 2(3):358-368

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The Postbiotic Butyrate Mitigates Gut Mucosal Disruption Caused by Acute Ethanol Exposure.

Authors: Siddiqui, Mohamed Tausif, Han, Yingchun, Shapiro, David, West, Gail, Fiocchi, Claudio, Cresci, Gail A. M.

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 3, p1665, 16p

Subject Terms: BUTYRATES, ENDOTOXINS, SODIUM butyrate, ULCERATIVE colitis, ETHANOL, TRIBUTYRIN, DENDRITIC cells

Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis

Authors: Mintet, Elodie, Rannou, Emilie, Buard, Valérie, West, Gail, Guipaud, Olivier, Tarlet, Georges, Sabourin, Jean-Christophe, Benderitter, Marc, Fiocchi, Claudio, Milliat, Fabien, François, Agnès

Source: In The American Journal of Pathology September 2015 185(9):2550-2562

Chromosome-Associated Protein D3 Promotes Bacterial Clearance in Human Intestinal Epithelial Cells by Repressing Expression of Amino Acid Transporters

Authors: Schuster, Andrew T., Homer, Craig R., Kemp, Jacqueline R., Nickerson, Kourtney P., Deutschman, Emily, Kim, Yeojung, West, Gail, Sadler, Tammy, Stylianou, Eleni, Krokowski, Dawid, Hatzoglou, Maria, de la Motte, Carol, Rubin, Brian P., Fiocchi, Claudio, McDonald, Christine, Longworth, Michelle S.

Source: In Gastroenterology June 2015 148(7):1405-1416

The Epithelial Danger Signal IL-1α Is a Potent Activator of Fibroblasts and Reactivator of Intestinal Inflammation

Authors: Scarpa, Melania, Kessler, Sean, Sadler, Tammy, West, Gail, Homer, Craig, McDonald, Christine, de la Motte, Carol, Fiocchi, Claudio, Stylianou, Eleni

Source: In The American Journal of Pathology June 2015 185(6):1624-1637

30 A NOVEL MECHANISM OF SPHINGOSINE-1-PHOSPHATE RECEPTOR (S1PR) MODULATORS IN INFLAMMATORY BOWEL DISEASES

Authors: Wang, Jie, West, Gail A., Li, Jiannan, Dines, Kevin, Harris, Sarah, Gordon, Ilyssa O., Mao, Ren, Lin, Sinan, Zhao, Shuai, Dejanovic, Dina, Fiocchi, Claudio, Rieder, Florian

Source: Gastroenterology. 160(6):S-7-S-7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140884380.0x000001&indx=1&recIds=ETOCvdc_100140884380.0x000001