Aspirin prevents metastasis by limiting platelet TXA2suppression of T cell immunity

Authors: Yang, Jie, Yamashita-Kanemaru, Yumi, Morris, Benjamin I., Contursi, Annalisa, Trajkovski, Daniel, Xu, Jingru, Patrascan, Ilinca, Benson, Jayme, Evans, Alexander C., Conti, Alberto G., Al-Deka, Aws, Dahmani, Layla, Avdic-Belltheus, Adnan, Zhang, Baojie, Okkenhaug, Hanneke, Whiteside, Sarah K., Imianowski, Charlotte J., Wesolowski, Alexander J., Webb, Louise V., Puccio, Simone, Tacconelli, Stefania, Bruno, Annalisa, Di Berardino, Sara, De Michele, Alessandra, Welch, Heidi C. E., Yu, I-Shing, Lin, Shu-Wha, Mitra, Suman, Lugli, Enrico, van der Weyden, Louise, Okkenhaug, Klaus, Saeb-Parsy, Kourosh, Patrignani, Paola, Adams, David J., Roychoudhuri, Rahul

Source: Nature; 20250101, Issue: Preprints p1-10, 10p

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion.

Authors: Whiteside, Sarah K., Grant, Francis M., Alvisi, Giorgia, Clarke, James, Tang, Leqi, Imianowski, Charlotte J., Zhang, Baojie, Evans, Alexander C., Wesolowski, Alexander J., Conti, Alberto G., Yang, Jie, Lauder, Sarah N., Clement, Mathew, Humphreys, Ian R., Dooley, James, Burton, Oliver, Liston, Adrian, Alloisio, Marco, Voulaz, Emanuele, Langhorne, Jean

Source: Science Immunology; 2023, Vol. 8 Issue 90, p1-16, 16p

Subject Terms: T cells, IMMUNITY, IMMUNOTHERAPY, IMMUNE response, IMMUNOSUPPRESSION, TREATMENT failure, TREATMENT effectiveness