Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries

Authors: Simone Bohnert, Christoph Reinert, Stefanie Trella, Andrea Cattaneo, Ulrich Preiß, Michael Bohnert, Johann Zwirner, Andreas Büttner, Werner Schmitz, Benjamin Ondruschka

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Biomarker, Cerebrospinal fluid, Post mortem biochemistry, Forensic neuropathology, Traumatic brain injury, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/7252679f5bfa4c0b971ccabdcbe627a7

Structural enzymology studies with the substrate 3S‐hydroxybutanoyl‐CoA: bifunctional MFE1 is a less efficient dehydrogenase than monofunctional HAD

Authors: Shruthi Sridhar, Tiila‐Riikka Kiema, Werner Schmitz, Mikael Widersten, Rik K. Wierenga

Source: FEBS Open Bio, Vol 14, Iss 4, Pp 655-674 (2024)

Subject Terms: crotonase, crystal structure, dehydrogenase, dynamical properties, stopped‐flow, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/333c3c615e614729a5c9efb7d149d074

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

Authors: Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela F. Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Remi Doucet-Ladevèze, Werner Schmitz, Bart Ghesquière, Sebastian Theurich, Jan Dudek, Georg Gasteiger, Alma Zernecke, Sebastian Kobold, Wolfgang Kastenmüller, Martin Vaeth

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8569ec630ff141898b05f8e21eb43d82

Thiol starvation triggers melanoma state switching in an ATF4 and NRF2-dependent manner

Authors: Madlen Meinert, Christina Jessen, Anita Hufnagel, Julia Katharina Charlotte Kreß, Mychal Burnworth, Theo Däubler, Till Gallasch, Thamara Nishida Xavier da Silva, Ancély Ferreira dos Santos, Carsten Patrick Ade, Werner Schmitz, Susanne Kneitz, José Pedro Friedmann Angeli, Svenja Meierjohann

Source: Redox Biology, Vol 70, Iss , Pp 103011- (2024)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231723004123; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/3fd2a9cca6cd42a59ae9cc508320c0e7

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Authors: Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti‐Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli

Source: EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-17 (2023)

Subject Terms: ferroptosis, neuroblastoma, selenocysteine, selenoprotein, synthetic lethality, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/f738f088a5b24d4d84df76ffa09916f9

Platelet‐derived lipids promote insulin secretion of pancreatic β cells

Authors: Till Karwen, Katarzyna Kolczynska‐Matysiak, Carina Gross, Mona C Löffler, Mike Friedrich, Angel Loza‐Valdes, Werner Schmitz, Magdalena Wit, Filip Dziaczkowski, Andrei Belykh, Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Carsten Deppermann, Sameena Nawaz, Benoit Hastoy, Agnieszka Demczuk, Manuela Erk, Mariusz R Wieckowski, Patrik Rorsman, Katrin G Heinze, David Stegner, Bernhard Nieswandt, Grzegorz Sumara

Source: EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-23 (2023)

Subject Terms: 20‐HETE, diabetes, insulin secretion, platelet, β cell, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/974cd37e10194d4682e8df439ae20f8d

An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration

Authors: M. Tanvir Rahman, M. Kristian Koski, Joanna Panecka-Hofman, Werner Schmitz, Alexander J. Kastaniotis, Rebecca C. Wade, Rik K. Wierenga, J. Kalervo Hiltunen, Kaija J. Autio

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d16d0b2bf48f43899654c6293ec0c770

Glycolytic flux control by drugging phosphoglycolate phosphatase

Authors: Elisabeth Jeanclos, Jan Schlötzer, Kerstin Hadamek, Natalia Yuan-Chen, Mohammad Alwahsh, Robert Hollmann, Stefanie Fratz, Dilan Yesilyurt-Gerhards, Tina Frankenbach, Daria Engelmann, Angelika Keller, Alexandra Kaestner, Werner Schmitz, Martin Neuenschwander, Roland Hergenröder, Christoph Sotriffer, Jens Peter von Kries, Hermann Schindelin, Antje Gohla

Source: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fece9c1dab514555a6b20fa9b7dd7974

The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2

Authors: Julia Katharina Charlotte Kreß, Christina Jessen, Anita Hufnagel, Werner Schmitz, Thamara Nishida Xavier da Silva, Ancély Ferreira dos Santos, Laura Mosteo, Colin R. Goding, José Pedro Friedmann Angeli, Svenja Meierjohann

Source: Cell Reports, Vol 42, Iss 7, Pp 112724- (2023)

Subject Terms: CP: Cell biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723007350; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/e9c771ed6d1c4e52a0f3a51015e08aa6

c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

Authors: Nadine Vollmuth, Lisa Schlicker, Yongxia Guo, Pargev Hovhannisyan, Sudha Janaki-Raman, Naziia Kurmasheva, Werner Schmitz, Almut Schulze, Kathrin Stelzner, Karthika Rajeeve, Thomas Rudel

Source: eLife, Vol 11 (2022)

Subject Terms: Chlamydia trachomatis, persistence, c-Myc, interferon-gamma, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/76721; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/b5901aba18994e7e8ed2c8f6ada5ed36

Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease

Authors: Oliver Hartmann, Michaela Reissland, Carina R. Maier, Thomas Fischer, Cristian Prieto-Garcia, Apoorva Baluapuri, Jessica Schwarz, Werner Schmitz, Martin Garrido-Rodriguez, Nikolett Pahor, Clare C. Davies, Florian Bassermann, Amir Orian, Elmar Wolf, Almut Schulze, Marco A. Calzado, Mathias T. Rosenfeldt, Markus E. Diefenbacher

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: non-small cell lung cancer, CRISPR-Cas9, mouse model, lung cancer, MYC, JUN, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.641618/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/25bb6c9a9e3b4539a37791d85b52657e

Low Energy Status under Methionine Restriction Is Essentially Independent of Proliferation or Cell Contact Inhibition

Authors: Corinna Koderer, Werner Schmitz, Anna Chiara Wünsch, Julia Balint, Mohamed El-Mesery, Julian Manuel Volland, Stefan Hartmann, Christian Linz, Alexander Christian Kübler, Axel Seher

Source: Cells, Vol 11, Iss 3, p 551 (2022)

Subject Terms: methionine restriction, caloric restriction, mass spectrometry, LC/MS, liquid chromatography/mass spectrometry, metabolomics, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/3/551; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/ed68f6be026747a5acf9e628ff8907c8

Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

Authors: Stefanie Peter, Jennyfer Bultinck, Kevin Myant, Laura A Jaenicke, Susanne Walz, Judith Müller, Michael Gmachl, Matthias Treu, Guido Boehmelt, Carsten P Ade, Werner Schmitz, Armin Wiegering, Christoph Otto, Nikita Popov, Owen Sansom, Norbert Kraut, Martin Eilers

Source: EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1525-1541 (2014)

Subject Terms: colorectal cancer, HUWE1, MIZ1, MYC, ubiquitination, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/285765620d5f424582909a71e1e55870

Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis.

Authors: Ilkka J Miinalainen, Werner Schmitz, Anne Huotari, Kaija J Autio, Raija Soininen, Emiel Ver Loren van Themaat, Myriam Baes, Karl-Heinz Herzig, Ernst Conzelmann, J Kalervo Hiltunen

Source: PLoS Genetics, Vol 5, Iss 7, p e1000543 (2009)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2697383?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/e20224d2fbbb4044b32004e8e1b2516b

Site-Specific PEGylation of Bone Morphogenetic Protein-2 Cysteine Analogues.

Authors: Junli Hu, Viswanadham Duppatla, Stefan Harth, Werner Schmitz, Walter Sebald

Source: Bioconjugate Chemistry; Oct2010, Vol. 21 Issue 10, p1762-1772, 11p

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