Toll-like receptor 4 deficiency in Purkinje neurons drives cerebellar ataxia by impairing the BK channel-mediated after-hyperpolarization and cytosolic calcium homeostasis

Authors: Jianwei Zhu, Wenqiao Qiu, Fan Wei, Jin Zhang, Ying Yuan, Ling Liu, Meixiong Cheng, Huan Xiong, Ruxiang Xu

Source: Cell Death and Disease, Vol 15, Iss 8, Pp 1-15 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/18602dd3ea8a4a48914879e78e262b82

Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1‐mediated microglia underlies a therapy for intracerebral hemorrhage

Authors: Wenqiao Qiu, Jie Tian, Gao Mou, Lili Guo, Tao Xu, Wei Liu, Jianwei Zhu, Yi Zhang, Xiaolin Hou, Yao Xie, Huan Xiong, Xinda Li, Yangyang Wang, Mingjun Gao, Anguo Wu, Longyi Chen, Jie Mei, Lulin Huang, Ruxiang Xu

Source: Clinical and Translational Medicine, Vol 14, Iss 12, Pp n/a-n/a (2024)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/7c94cded279a49dab06893f41189c138

Machine-learning-based risk stratification for probability of dying in patients with basal ganglia hemorrhage

Authors: Lili Guo, Nuoyangfan Lei, Mou Gao, Wenqiao Qiu, Yunsen He, Qijun Zhao, Ruxiang Xu

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/56edaadfc8de406e8fe2dab7cfb34040

High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS

Authors: Minsong Guo, Fengdan Zhu, Wenqiao Qiu, Gan Qiao, Betty Yuen-Kwan Law, Lu Yu, Jianming Wu, Yong Tang, Chonglin Yu, Dalian Qin, Xiaogang Zhou, Anguo Wu

Source: Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1723-1739 (2022)

Subject Terms: Alzheimer's disease, High-throughput screening, Biolayer interferometry, UHPLC−DAD-Q/TOF-MS/MS, Kai-Xin-San, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383521003403; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/be053c1fb28047ccb0c66f356830e655

Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies

Authors: Liang Yue, Nan Jiang, Anguo Wu, Wenqiao Qiu, Xin Shen, Dalian Qin, Hong Li, Jing Lin, Sicheng Liang, Jianming Wu

Source: BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)

Subject Terms: Xanthine oxidase, Plumbagin, Uric acid, Enzymatic reaction kinetics, Toxic metabolism, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://doaj.org/toc/2050-6511

Access URL: https://doaj.org/article/d1e5950807d04db6a395f555ea6e80c4

Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

Authors: Yueshan Sun, Xueqin Jiang, Rong Pan, Xiaogang Zhou, Dalian Qin, Rui Xiong, Yiling Wang, Wenqiao Qiu, Anguo Wu, Jianming Wu

Source: Frontiers in Pharmacology, Vol 11 (2020)

Subject Terms: Huntington’s disease, autophagy, mHtt, Aesculus chinensis Bge., HT22 cells, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.00116/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/ce92a33ce18d4a5c8bf27bcbe27bd73e

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