YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies

Authors: Chen, Zhenhua ^{1, 2, 15, ∗}, Zeng, Chengwu ^{1, 2, 3, 15}, Yang, Lu ^{1, 2, 15}, Che, Yuan ^{1, 2, 15}, Chen, Meiling ^{1, 2, 4}, Sau, Lillian ^{1, 2}, Wang, Bintao ^{1, 2}, Zhou, Keren ^{1, 2}, Chen, Yu ⁵, Qing, Ying ^{1, 2}, Shen, Chao ^{1, 2}, Zhang, Tingjian ⁶, Wunderlich, Mark ⁷, Wu, Dong ^{1, 2}, Li, Wei ^{1, 2}, Wang, Kitty ^{1, 2}, Leung, Keith ^{1, 2}, Sun, Miao ⁸, Tang, Tingting ^{1, 2}, He, Xin ⁹, Zhang, Lianjun ⁹, Swaminathan, Srividya ¹, Mulloy, James C. ⁷, Müschen, Markus ¹⁰, Huang, Huilin ¹¹, Weng, Hengyou ¹², Xiao, Gang ^{13, 14}, Deng, Xiaolan ^{1, 2, ∗∗}, Chen, Jianjun ^{1, 2, 16, ∗∗∗}

Source: In Cell 23 January 2025 188(2):331-351

Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification

Authors: Wang, Yushuai ^*, Huang, Huilin ^*, Chen, Jianjun, Weng, Hengyou

Source: In Current Opinion in Genetics & Development June 2024 86

RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Authors: Zhang, Zheng, Zhou, Keren, Han, Li, Small, Andrew, Xue, Jianhuang, Huang, Huilin, Weng, Hengyou, Su, Rui, Tan, Brandon, Shen, Chao, Li, Wei, Zhao, Zhicong, Qing, Ying, Qin, Xi, Wang, Kitty, Leung, Keith, Boldin, Mark, Chen, Chun-Wei, Ann, David, Qian, Zhijian, Deng, Xiaolan, Chen, Jianjun, Chen, Zhenhua

Source: In Genes & Diseases January 2024 11(1):382-396

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

Authors: Weng, Hengyou, Huang, Feng, Yu, Zhaojin, Chen, Zhenhua, Prince, Emily, Kang, Yalin, Zhou, Keren, Li, Wei, Hu, Jiacheng, Fu, Chen, Aziz, Tursunjan, Li, Hongzhi, Li, Jingwen, Yang, Ying, Han, Li, Zhang, Subo, Ma, Yuelong, Sun, Mingli, Wu, Huizhe, Zhang, Zheng, Wunderlich, Mark, Robinson, Sean, Braas, Daniel, Hoeve, Johanna ten, Zhang, Bin, Marcucci, Guido, Mulloy, James C., Zhou, Keda, Tao, Hong-Fang, Deng, Xiaolan, Horne, David, Wei, Minjie, Huang, Huilin, Chen, Jianjun

Source: In Cancer Cell 12 December 2022 40(12):1566-1582

N6‐methyladenosine Steers RNA Metabolism and Regulation in Cancer

Authors: Dong, Shenghua, Wu, Yutong, Liu, Yadi, Weng, Hengyou, Huang, Huilin

Source: Cancer communications. 41(7):538-559

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123602264.0x000001&indx=1&recIds=ETOCvdc_100123602264.0x000001

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Authors: Su, Rui, Dong, Lei, Li, Yangchan, Gao, Min, Han, Li, Wunderlich, Mark, Deng, Xiaolan, Li, Hongzhi, Huang, Yue, Gao, Lei, Li, Chenying, Zhao, Zhicong, Robinson, Sean, Tan, Brandon, Qing, Ying, Qin, Xi, Prince, Emily, Xie, Jun, Qin, Hanjun, Li, Wei, Shen, Chao, Sun, Jie, Kulkarni, Prakash, Weng, Hengyou, Huang, Huilin, Chen, Zhenhua, Zhang, Bin, Wu, Xiwei, Olsen, Mark J., Müschen, Markus, Marcucci, Guido, Salgia, Ravi, Li, Ling, Fathi, Amir T., Li, Zejuan, Mulloy, James C., Wei, Minjie, Horne, David, Chen, Jianjun

Source: In Cancer Cell 13 July 2020 38(1):79-96

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

Authors: Shen, Chao, Sheng, Yue, Zhu, Allen C., Robinson, Sean, Jiang, Xi, Dong, Lei, Chen, Huiying, Su, Rui, Yin, Zhe, Li, Wei, Deng, Xiaolan, Chen, Yinhuai, Hu, Yueh-Chiang, Weng, Hengyou, Huang, Huilin, Prince, Emily, Cogle, Christopher R., Sun, Miao, Zhang, Bin, Chen, Chun-Wei, Marcucci, Guido, He, Chuan, Qian, Zhijian, Chen, Jianjun

Source: In Cell Stem Cell 2 July 2020 27(1):64-80

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Authors: Huang, Huilin, Weng, Hengyou, Chen, Jianjun

Source: In Cancer Cell 16 March 2020 37(3):270-288

The Biogenesis and Precise Control of RNA m6A Methylation

Authors: Huang, Huilin, Weng, Hengyou, Chen, Jianjun

Source: In Trends in Genetics January 2020 36(1):44-52

NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia

Authors: Zhang, Subo, Huang, Feng, Wang, Yushuai, Long, Yifei, Li, Yuanpei, Kang, Yalin, Gao, Weiwei, Zhang, Xiuxin, Wen, Yueting, Wang, Yun, Pan, Lili, Xia, Youmei, Yang, Zhoutian, Yang, Ying, Mo, Hongjie, Li, Baiqing, Hu, Jiacheng, Song, Yunda, Zhang, Shilin, Dong, Shenghua, Du, Xiao, Li, Yingmin, Liu, Yadi, Liao, Wenting, Gao, Yijun, Zhang, Yaojun, Chen, Hongming, Liang, Yang, Chen, Jianjun, Weng, Hengyou, Huang, Huilin

Source: Nature Cell Biology; December 2024, Vol. 26 Issue: 12 p2168-2182, 15p

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Authors: Weng, Hengyou, Huang, Huilin, Wu, Huizhe, Qin, Xi, Zhao, Boxuan Simen, Dong, Lei, Shi, Hailing, Skibbe, Jennifer, Shen, Chao, Hu, Chao, Sheng, Yue, Wang, Yungui, Wunderlich, Mark, Zhang, Bin, Dore, Louis C., Su, Rui, Deng, Xiaolan, Ferchen, Kyle, Li, Chenying, Sun, Miao, Lu, Zhike, Jiang, Xi, Marcucci, Guido, Mulloy, James C., Yang, Jianhua, Qian, Zhijian, Wei, Minjie, He, Chuan, Chen, Jianjun

Source: In Cell Stem Cell 1 February 2018 22(2):191-205

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Authors: Su, Rui, Dong, Lei, Li, Chenying, Nachtergaele, Sigrid, Wunderlich, Mark, Qing, Ying, Deng, Xiaolan, Wang, Yungui, Weng, Xiaocheng, Hu, Chao, Yu, Mengxia, Skibbe, Jennifer, Dai, Qing, Zou, Dongling, Wu, Tong, Yu, Kangkang, Weng, Hengyou, Huang, Huilin, Ferchen, Kyle, Qin, Xi, Zhang, Bin, Qi, Jun, Sasaki, Atsuo T., Plas, David R., Bradner, James E., Wei, Minjie, Marcucci, Guido, Jiang, Xi, Mulloy, James C., Jin, Jie, He, Chuan, Chen, Jianjun

Source: In Cell 11 January 2018 172(1-2):90-105

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Authors: Huang, Huilin, Weng, Hengyou, Zhou, Keren, Wu, Tong, Zhao, Boxuan, Sun, Mingli, Chen, Zhenhua, Deng, Xiaolan, Xiao, Gang, Auer, Franziska, Klemm, Lars, Wu, Huizhe, Zuo, Zhixiang, Qin, Xi, Dong, Yunzhu, Zhou, Yile, Qin, Hanjun, Tao, Shu, Du, Juan, Liu, Jun, Lu, Zhike, Yin, Hang, Mesquita, Ana, Yuan, Celvie, Hu, Yueh-Chiang, Sun, Wenju, Su, Rui, Dong, Lei, Shen, Chao, Li, Chenying, Qing, Ying, Jiang, Xi, Wu, Xiwei, Sun, Miao, Guan, Jun-Lin, Qu, Lianghu, Wei, Minjie, Müschen, Markus, Huang, Gang, He, Chuan, Yang, Jianhua, Chen, Jianjun

Source: Nature. 567(7748):414-419

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128020143.0x000001&indx=1&recIds=ETOCvdc_100128020143.0x000001

RNA N^6-Methyladenosine Modification in Normal and Malignant Hematopoiesis

Authors: Weng, Hengyou, Huang, Huilin, Chen, Jianjun

Source: Advances in experimental medicine and biology. 1143:75-94

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621046753&indx=1&recIds=ETOCRN621046753

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase

Authors: Li, Zejuan, Weng, Hengyou, Su, Rui, Weng, Xiaocheng, Zuo, Zhixiang, Li, Chenying, Huang, Huilin, Nachtergaele, Sigrid, Dong, Lei, Hu, Chao, Qin, Xi, Tang, Lichun, Wang, Yungui, Hong, Gia-Ming, Huang, Hao, Wang, Xiao, Chen, Ping, Gurbuxani, Sandeep, Arnovitz, Stephen, Li, Yuanyuan, Li, Shenglai, Strong, Jennifer, Neilly, Mary Beth, Larson, Richard A., Jiang, Xi, Zhang, Pumin, Jin, Jie, He, Chuan, Chen, Jianjun

Source: In Cancer Cell 9 January 2017 31(1):127-141

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Authors: Huang, Huilin, Weng, Hengyou, Sun, Wenju, Qin, Xi, Shi, Hailing, Wu, Huizhe, Zhao, Boxuan, Mesquita, Ana, Liu, Chang, Yuan, Celvie, Hu, Yueh-Chiang, Hüttelmaier, Stefan, Skibbe, Jennifer, Su, Rui, Deng, Xiaolan, Dong, Lei, Sun, Miao, Li, Chenying, Nachtergaele, Sigrid, Wang, Yungui, Hu, Chao, Ferchen, Kyle, Greis, Kenneth, Jiang, Xi, Wei, Minjie, Qu, Lianghu, Guan, Jun-Lin, He, Chuan, Yang, Jianhua, Chen, Jianjun

Source: Nature cell biology. 20(3):285-295

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117610928.0x000001&indx=1&recIds=ETOCvdc_100117610928.0x000001

RNA N6-methyladenosine modification in cancers: current status and perspectives

Authors: Deng, Xiaolan, Su, Rui, Weng, Hengyou, Huang, Huilin, Li, Zejuan, Chen, Jianjun

Source: Cell research. 28(5):507-517

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133339716.0x000001&indx=1&recIds=ETOCvdc_100133339716.0x000001

Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia

Authors: Huang, Hao, Jiang, Xi, Wang, Jinhua, Li, Yuanyuan, Song, Chun-Xiao, Chen, Ping, Li, Shenglai, Gurbuxani, Sandeep, Arnovitz, Stephen, Wang, Yungui, Weng, Hengyou, Neilly, Mary Beth, He, Chuan, Li, Zejuan, Chen, Jianjun ^*

Source: In Cancer Letters 28 March 2016 372(2):157-165

Overexpression and knockout of miR-126 both promote leukemogenesis

Authors: Li, Zejuan ^*, Chen, Ping ^*, Su, Rui ^*, Li, Yuanyuan ^*, Hu, Chao, Wang, Yungui, Arnovitz, Stephen, He, Miao, Gurbuxani, Sandeep, Zuo, Zhixiang, Elkahloun, Abdel G., Li, Shenglai ^*, Weng, Hengyou, Huang, Hao, Neilly, Mary Beth, Wang, Shusheng, Olson, Eric N., Larson, Richard A., Le Beau, Michelle M., Zhang, Jiwang, Jiang, Xi, Wei, Minjie, Jin, Jie, Liu, Paul P., Chen, Jianjun ^*

Source: In Blood 22 October 2015 126(17):2005-2015

The pathological role and prognostic impact of miR-181 in acute myeloid leukemia

Authors: Weng, Hengyou, Lal, Kumar, Yang, Frank F., Chen, Jianjun

Source: In Cancer Genetics May 2015 208(5):225-229