The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment

Authors: Ledvin, Leya, Gassaway, Brandon M., Tawil, Jonathan, Urso, Olivia, Pizzo, Donald, Welsh, Kaeli A., Bolhuis, Derek L., Fisher, Daniel, Bonni, Azad, Gygi, Steven P., Brown, Nicholas G., Ferguson, Cole J.

Source: In Developmental Cell 4 December 2023 58(23):2666-2683

APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.

Authors: Skrajna, Aleksandra, Bodrug, Tatyana, Martinez-Chacin, Raquel C., Fisher, Caleb B., Welsh, Kaeli A., Simmons, Holly C., Arteaga, Eyla C., Simmons, Jake M., Nasr, Mohamed A., LaPak, Kyle M., Nguyen, Anh, Huynh, Mai T., Fargo, Isabel, Welfare, Joshua G., Zhao, Yani, Lawrence, David S., Goldfarb, Dennis, Brown, Nicholas G., McGinty, Robert K.

Source: Nature Communications; 3/15/2025, Vol. 15 Issue 1, p1-16, 16p

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

Authors: Welsh, Kaeli A, Bolhuis, Derek L, Nederstigt, Anneroos E, Boyer, Joshua, Temple, Brenda R S, Bonacci, Thomas, Gu, Li, Ordureau, Alban, Harper, J Wade, Steimel, Joshua P, Zhang, Qi, Emanuele, Michael J, Harrison, Joseph S, Brown, Nicholas G

Source: EMBO journal. 41(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139820575.0x000001&indx=1&recIds=ETOCvdc_100139820575.0x000001

Examining the mechanistic relationship of APC/CCDH1 and its interphase inhibitor EMI1

Authors: Bolhuis, Derek L., Martinez‐Chacin, Raquel C., Welsh, Kaeli A., Bodrug, Tatyana, Cui, Liying, Emanuele, Michael J., Brown, Nicholas G.

Source: Protein science. 31(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151896180.0x000001&indx=1&recIds=ETOCvdc_100151896180.0x000001

Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)

Authors: Bodrug, Tatyana, Welsh, Kaeli A., Bolhuis, Derek L., Paulаkonis, Ethan, Martinez-Chacin, Raquel C., Liu, Bei, Pinkin, Nicholas, Bonacci, Thomas, Cui, Liying, Xu, Pengning, Roscow, Olivia, Amann, Sascha Josef, Grishkovskaya, Irina, Emanuele, Michael J., Harrison, Joseph S., Steimel, Joshua P., Hahn, Klaus M., Zhang, Wei, Zhong, Ellen D., Haselbach, David, Brown, Nicholas G.

Source: Nature Structural and Molecular Biology; November 2023, Vol. 30 Issue: 11 p1663-1674, 12p

Examining the mechanistic relationship of APC/C^CDH1 and its interphase inhibitor EMI1.

Authors: Bolhuis, Derek L., Martinez‐Chacin, Raquel C., Welsh, Kaeli A., Bodrug, Tatyana, Cui, Liying, Emanuele, Michael J., Brown, Nicholas G.

Source: Protein Science: A Publication of the Protein Society; Jun2022, Vol. 31 Issue 6, p1-12, 12p