Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases

Authors: Zheng, Xiaozhang, Ji, Nan, Campbell, Veronica, Slavin, Anthony, Zhu, Xiao, Chen, Dapeng, Rong, Haojing, Enerson, Brad, Mayo, Michele, Sharma, Kirti, Browne, Chris M., Klaus, Christine R., Li, Haoran, Massa, Ginny, McDonald, Alice A., Shi, Yatao, Sintchak, Mike, Skouras, Stephanie, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Kelleher, Joe, Liu, Guang, Luo, Xinbo, Mainolfi, Nello, Weiss, Matthew M.

Source: Journal of Medicinal Chemistry; October 2024, Vol. 67 Issue: 20 p18022-18037, 16p

Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma.

Authors: Weiss, Matthew M., Zheng, Xiaozhang, Ji, Nan, Browne, Chris M., Campbell, Veronica, Chen, Dapeng, Enerson, Brad, Fei, Xue, Huang, Xin, Klaus, Christine R., Li, Haoran, Mayo, Michele, McDonald, Alice A., Paul, Atanu, Rong, Haojing, Sharma, Kirti, Shi, Yatao, Slavin, Anthony, Walther, Dirk M., Yuan, Karen

Source: Journal of Medicinal Chemistry; 7/11/2024, Vol. 67 Issue 13, p10548-10566, 19p

Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7

Authors: Kornecook, Thomas J., Yin, Ruoyuan, Altmann, Stephen ¹, Be, Xuhai, Berry, Virginia, Ilch, Christopher P., Jarosh, Michael, Johnson, Danielle, Lee, Josie H., Lehto, Sonya G., Ligutti, Joseph, Liu, Dong, Luther, Jason, Matson, David, Ortuno, Danny ², Roberts, John, Taborn, Kristin, Wang, Jinti, Weiss, Matthew M., Yu, Violeta, Zhu, Dawn X.D., Fremeau, Robert T., Jr. ³, Moyer, Bryan D. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics July 2017 362(1):146-160

Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors

Authors: Schenkel, Laurie B., DiMauro, Erin F., Nguyen, Hanh N., Chakka, Nagasree, Du, Bingfan, Foti, Robert S., Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S., Ligutti, Joseph, Milgram, Benjamin C., Moyer, Bryan D., Peterson, Emily A., Roberts, John, Yu, Violeta L., Weiss, Matthew M.

Source: Bioorganic & medicinal chemistry letters. 27(16):3817-3824

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082112848.0x000001&indx=1&recIds=ETOCvdc_100082112848.0x000001

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

Authors: La, Daniel S., Peterson, Emily A., Bode, Christiane, Boezio, Alessandro A., Bregman, Howard, Chu-Moyer, Margaret Y., Coats, James, DiMauro, Erin F., Dineen, Thomas A., Du, Bingfan, Gao, Hua, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Fremeau, Robert, Huang, Xin, Ilch, Christopher, Kornecook, Thomas J., Kreiman, Charles, Ligutti, Joseph, Jasmine Lin, Min-Hwa, McDermott, Jeff S., Marx, Isaac, Matson, David J., McDonough, Stefan I., Moyer, Bryan D., Nho Nguyen, Hanh, Taborn, Kristin, Yu, Violeta, Weiss, Matthew M.

Source: Bioorganic & medicinal chemistry letters. 27(15):3477-3485

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049670042.0x000001&indx=1&recIds=ETOCvdc_100049670042.0x000001

Chapter 11 Interest Rates After Till.

Authors: Marsh, Gary W., Weiss, Matthew M.

Source: American Bankruptcy Law Journal; Spring2010, Vol. 84 Issue 2, p209-232, 24p

Where Do We Draw the Line?: The Justiciability of Political Gerrymandering Claims in Light of League of United Latin American Citizens v. Perry.

Authors: Weiss, Matthew M., student author

Source: Georgia Law Review; Spring 2007, Vol. 41 Issue 3, p1053-1098, 46p

Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders.

Authors: Gadiyar, Varsha, Patel, Gopi, Chen, Jesse, Vigil, Dominico, Nan Ji, Campbell, Veronica, Sharma, Kirti, Yatao Shi, Weiss, Matthew M., Birge, Raymond B., Davra, Viralkumar

Source: Frontiers in Immunology; 2023, p1-14, 14p

Subject Terms: MEMBRANE proteins, UBIQUITIN ligases, SMALL molecules, PROTEIN-tyrosine kinase inhibitors, PROTEINS

Establishing the Relationship between In Vitro Potency, Pharmacokinetic, and Pharmacodynamic Parameters in a Series of Orally Available, Hydroxyethylamine-Derived β-Secretase Inhibitors

Authors: Wood, Stephen ^*, Wen, Paul H., Zhang, Jianhua, Zhu, Li, Luo, Yi, Babu-Khan, Safura ¹, Chen, Kui, Pham, Roger, Esmay, Joel, Dineen, Thomas A., Kaller, Matthew R., Weiss, Matthew M., Hitchcock, Stephen A. ², Citron, Martin ³, Zhong, Wenge, Hickman, Dean, Williamson, Toni ⁴

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2012 343(2):460-467

Total syntheses of (+)- and (−)-syringolides 3 and of (+)- and (−)-syributins 1, 2 and 3

Authors: Navarro Villalobos, Mauricio, Wood, John L., Jeong, Susan, Benson, Cristy Lindberg, Zeman, Steven M., McCarty, Catherine, Weiss, Matthew M., Salcedo, Analee, Jenkins, Jonathan

Source: In Tetrahedron 26 September 2009 65(39):8091-8098

Evolution of a Synthetic Strategy: Total Synthesis of (±)-Welwitindolinone A Isonitrile.

Authors: Reisman, Sarah E., Ready, Joseph M., Weiss, Matthew M.

Source: Journal of the American Chemical Society; February 13 2008, Vol. 130 Issue 6, p2087-2100, 14p

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Authors: Boezio, Alessandro A., Andrews, Kristin, Boezio, Christiane, Chu-Moyer, Margaret, Copeland, Katrina W., DiMauro, Erin F., Foti, Robert S., Fremeau, Robert T., Jr., Gao, Hua, Geuns-Meyer, Stephanie, Graceffa, Russell F., Gunaydin, Hakan, Huang, Hongbing, La, Daniel S., Ligutti, Joseph, Moyer, Bryan D., Peterson, Emily A., Yu, Violeta, Weiss, Matthew M.

Source: In Bioorganic & Medicinal Chemistry Letters 15 June 2018 28(11):2103-2108

Third Circuit’s Warning Shot to Senior Creditors in In re Tribune.

Authors: Dorsey, Rufus T.¹, Weiss, Matthew M.²

Source: ABI Journal. Dec2020, Vol. 39 Issue 12, p14-52. 4p.

Subject Terms: *Debtor & creditor, *Long-term debt, Constitutional law, Appellate courts, Legal judgments

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

Authors: Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., II, Wood, Stephen, Fremeau, Robert T., Jr., White, Ryan D., Patel, Vinod F.

Source: In Bioorganic & Medicinal Chemistry Letters 15 February 2015 25(4):767-774

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities.

Authors: Weiss, Matthew M., Dineen, Thomas A., Marx, Isaac E., Altmann, Steven, Boezio, Alessandro, Bregman, Howard, Chu-Moyer, Margaret, DiMauro, Erin F., Feric Bojic, Elma, Foti, Robert S., Hua Gao, Graceffa, Russell, Gunaydin, Hakan, Guzman-Perez, Angel, Hongbing Huang, Liyue Huang, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R., Ligutti, Joseph

Source: Journal of Medicinal Chemistry; 7/27/2017, Vol. 60 Issue 14, p5969-5989, 21p

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