SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

Authors: Chang, Yu-Hsuan ^{1, 2}, Yamamoto, Keita ¹, Fujino, Takeshi ¹, Wang, Teh-Wei ³, Sugimoto, Emi ¹, Zhang, Wenyu ¹, Yabushita, Tomohiro ², Suzaki, Ken ¹, Pietsch, E. Christine ⁴, Weir, Barbara A. ⁵, Crescenzo, Ramona ⁶, Cowley, Glenn S. ⁴, Attar, Ricardo ⁴, Philippar, Ulrike ⁶, Wunderlich, Mark ⁷, Mizukawa, Benjamin ⁷, Zheng, Yi ⁷, Enomoto, Yutaka ², Imai, Yoichi ⁸, Kitamura, Toshio ^{2, 9}, Goyama, Susumu ^{1, 10, ∗}

Source: In Cell Reports 27 August 2024 43(8)

Comprehensive genomic dependency landscape of a human colon cancer organoid.

Authors: Khalili, Sana, Mohseninia, Atefeh, Liu, Changlong, Banister, Carolyn E., Heine, Paige, Khazan, Minou, Morrison, Sidney E., Gokare, Prashanth, Cowley, Glenn S., Weir, Barbara A., Pocalyko, David, Bachman, Kurtis E., Buckhaults, Phillip J.

Source: Communications Biology; 3/14/2025, Vol. 8 Issue 1, p1-11, 11p

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

Authors: Oberlick, Elaine M., Rees, Matthew G., Seashore-Ludlow, Brinton, Vazquez, Francisca, Nelson, Geoffrey M., Dharia, Neekesh V., Weir, Barbara A., Tsherniak, Aviad, Ghandi, Mahmoud, Krill-Burger, John M., Meyers, Robin M., Wang, Xiaofeng, Montgomery, Phil, Root, David E., Bieber, Jake M., Radko, Sandi, Cheah, Jaime H., Hon, C. Suk-Yee, Shamji, Alykhan F., Clemons, Paul A., Park, Peter J., Dyer, Michael A., Golub, Todd R., Stegmaier, Kimberly, Hahn, William C., Stewart, Elizabeth A., Schreiber, Stuart L., Roberts, Charles W.M.

Source: In Cell Reports 27 August 2019 28(9):2331-2344

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

Authors: Pan, Joshua, Meyers, Robin M., Michel, Brittany C., Mashtalir, Nazar, Sizemore, Ann E., Wells, Jonathan N., Cassel, Seth H., Vazquez, Francisca, Weir, Barbara A., Hahn, William C., Marsh, Joseph A., Tsherniak, Aviad, Kadoch, Cigall

Source: In Cell Systems 23 May 2018 6(5):555-568

Small-molecule targeting of brachyury transcription factor addiction in chordoma

Authors: Sharifnia, Tanaz, Wawer, Mathias, Chen, Ting, Huang, Qing-Yuan, Weir, Barbara, Sizemore, Ann, Lawlor, Matthew, Goodale, Amy, Cowley, Glenn, Vazquez, Francisca, Ott, Christopher, Francis, Joshua, Sassi, Slim, Cogswell, Patricia, Sheppard, Hadley, Zhang, Tinghu, Gray, Nathanael, Clarke, Paul, Blagg, Julian, Workman, Paul, Sommer, Josh, Hornicek, Francis, Root, David, Hahn, William, Bradner, James, Wong, Kwok, Clemons, Paul, Lin, Charles, Kotz, Joanne, Schreiber, Stuart

Source: Nature medicine. 25(2):292-300

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112262576.0x000001&indx=1&recIds=ETOCvdc_100112262576.0x000001

Next-generation characterization of the Cancer Cell Line Encyclopedia

Authors: Ghandi, Mahmoud, Huang, Franklin, Jané-Valbuena, Judit, Kryukov, Gregory, Lo, Christopher, McDonald, E., Barretina, Jordi, Gelfand, Ellen, Bielski, Craig, Li, Haoxin, Hu, Kevin, Andreev-Drakhlin, Alexander, Kim, Jaegil, Hess, Julian, Haas, Brian, Aguet, François, Weir, Barbara, Rothberg, Michael, Paolella, Brenton, Lawrence, Michael, Akbani, Rehan, Lu, Yiling, Tiv, Hong, Gokhale, Prafulla, de Weck, Antoine, Mansour, Ali, Oh, Coyin, Shih, Juliann, Hadi, Kevin, Rosen, Yanay, Bistline, Jonathan, Venkatesan, Kavitha, Reddy, Anupama, Sonkin, Dmitriy, Liu, Manway, Lehar, Joseph, Korn, Joshua, Porter, Dale, Jones, Michael, Golji, Javad, Caponigro, Giordano, Taylor, Jordan, Dunning, Caitlin, Creech, Amanda, Warren, Allison, McFarland, James, Zamanighomi, Mahdi, Kauffmann, Audrey, Stransky, Nicolas, Imielinski, Marcin, Maruvka, Yosef, Cherniack, Andrew, Tsherniak, Aviad, Vazquez, Francisca, Jaffe, Jacob, Lane, Andrew, Weinstock, David, Johannessen, Cory, Morrissey, Michael, Stegmeier, Frank, Schlegel, Robert, Hahn, William, Getz, Gad, Mills, Gordon, Boehm, Jesse, Golub, Todd, Garraway, Levi, Sellers, William

Source: Nature. 569(7757):503-508

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153411474.0x000001&indx=1&recIds=ETOCvdc_100153411474.0x000001

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

Authors: Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Kory, Nora, Pacold, Michael E., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Sabatini, David M., Hahn, William C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Apr . 114(17), E3434-E3443.

Access URL: https://www.jstor.org/stable/26480790

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

Authors: Afsari, Bahman, Airola, Antti, Aittokallio, Tero, Bivol, Adrian, Boehm, Jesse S., Bunte, Kerstin, Carlin, Daniel, Chang, Yu-Chuan, Chen, Tenghui, Chong, Zechen, Chopra, Sahil, Cowley, Glenn S., Deran, Alden, Ellrott, Kyle, Elmarakeby, Haitham, Fertig, Elana J., Gonçalves, Emanuel, Gönen, Mehmet, Gong, Pinghua, Gopalacharyulu, Peddinti, Graim, Kiley, Guan, Yuanfang, Hafemeister, Christoph, Hahn, William C., Heath, Lenwood, Hoff, Bruce, Howell, Sara, Jaiswal, Alok, Karasuyama, Masayuki, Kaski, Samuel, Kędziorski, Łukasz, Khan, Suleiman A., Khemka, Niraj, King, Erh-kan, Lauria, Mario, Liu, Mark, Machado, Daniel, Mamitsuka, Hiroshi, Marbach, Daniel, Margolin, Adam A., Mazurkiewicz, Mateusz, Menden, Michael P., Migacz, Szymon, Newton, Yulia, Ng, Sam, Nie, Zhi, Norman, Thea C., Pahikkala, Tapio, Paull, Evan, Praveen, Paurush, Priami, Corrado, Rizzetto, Simone, Rocha, Miguel, Root, David E., Rudd, Cameron, Rudnicki, Witold R., Saez-Rodriguez, Julio, Sokolov, Artem, Song, Lei, Stolovitzky, Gustavo, Stuart, Joshua M., Sun, Duanchen, Szalai, Bence, Tang, Hao, Tang, Jing, Tsherniak, Aviad, Uzunangelov, Vladislav, Vazquez, Francisca, Wang, Tao, Wang, Difei, Weir, Barbara A., Wennerberg, Krister, Wu, Ling-yun, Xiao, Guanghua, Xie, Yang, Ye, Jieping, Ye, Yuting, Zhan, Xiaowei, Zhou, Wanding, Zhu, Fan

Source: In Cell Systems 22 November 2017 5(5):485-497

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States

Authors: Kim, Jong Wook, Abudayyeh, Omar O., Yeerna, Huwate, Yeang, Chen-Hsiang, Stewart, Michelle, Jenkins, Russell W., Kitajima, Shunsuke, Konieczkowski, David J., Medetgul-Ernar, Kate, Cavazos, Taylor, Mah, Clarence, Ting, Stephanie, Van Allen, Eliezer M., Cohen, Ofir, Mcdermott, John, Damato, Emily, Aguirre, Andrew J., Liang, Jonathan, Liberzon, Arthur, Alexe, Gabriella, Doench, John, Ghandi, Mahmoud, Vazquez, Francisca, Weir, Barbara A., Tsherniak, Aviad, Subramanian, Aravind, Meneses-Cime, Karina, Park, Jason, Clemons, Paul, Garraway, Levi A., Thomas, David, Boehm, Jesse S., Barbie, David A., Hahn, William C., Mesirov, Jill P., Tamayo, Pablo

Source: In Cell Systems 23 August 2017 5(2):105-118

Defining a Cancer Dependency Map

Authors: Tsherniak, Aviad, Vazquez, Francisca, Montgomery, Phil G., Weir, Barbara A., Kryukov, Gregory, Cowley, Glenn S., Gill, Stanley, Harrington, William F., Pantel, Sasha, Krill-Burger, John M., Meyers, Robin M., Ali, Levi, Goodale, Amy, Lee, Yenarae, Jiang, Guozhi, Hsiao, Jessica, Gerath, William F.J., Howell, Sara, Merkel, Erin, Ghandi, Mahmoud, Garraway, Levi A., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C.

Source: In Cell 27 July 2017 170(3):564-576

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia

Authors: Li, Hubo ^*, Mar, Brenton G. ^*, Zhang, Huadi, Puram, Rishi V., Vazquez, Francisca, Weir, Barbara A., Hahn, William C., Ebert, Benjamin, Pellman, David

Source: In Blood 26 January 2017 129(4):497-508

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Authors: Kryukov, Gregory V., Wilson, Frederick H., Ruth, Jason R., Paulk, Joshiawa, Tsherniak, Aviad, Marlow, Sara E., Vazquez, Francisca, Weir, Barbara A., Fitzgerald, Mark E., Tanaka, Minoru, Bielski, Craig M., Scott, Justin M., Dennis, Courtney, Cowley, Glenn S., Boehm, Jesse S., Root, David E., Golub, Todd R., Clish, Clary B., Bradner, James E., Hahn, William C., Garraway, Levi A.

Source: Science, 2016 Mar 01. 351(6278), 1214-1218.

Access URL: http://www.jstor.org/stable/24743195

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

Authors: Dunn, Gavin P., Cheung, Hiu Wing, Agarwalla, Pankaj K., Thomas, Sapana, Zektser, Yulia, Karst, Alison M., Boehm, Jesse S., Weir, Barbara A., Berlin, Aaron M., Zou, Lihua, Getz, Gad, Liu, Joyce F., Hirsch, Michelle, Vazquez, Francisca, Root, David E., Beroukhim, Rameen, Drapkin, Ronny, Hahn, William C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jan . 111(3), 1102-1107.

Access URL: https://www.jstor.org/stable/23770435

Synthetic lethality between CCNE1 amplification and loss of BRCA1

Authors: Australian Ovarian Cancer Study Group, Etemadmoghadam, Dariush, Weir, Barbara A., Au-Yeung, George, Alsop, Kathryn, Mitchell, Gillian, George, Joshy, Davis, Sally, D'Andrea, Alan D., Simpson, Kaylene, Hahn, William C., Bowtell, David D. L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Nov . 110(48), 19489-19494.

Access URL: https://www.jstor.org/stable/23757286

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Authors: Rosenbluh, Joseph, Nijhawan, Deepak, Cox, Andrew G., Li, Xingnan, Neal, James T., Schafer, Eric J., Zack, Travis I., Wang, Xiaoxing, Tsherniak, Aviad, Schinzel, Anna C., Shao, Diane D., Schumacher, Steven E., Weir, Barbara A., Vazquez, Francisca, Cowley, Glenn S., Root, David E., Mesirov, Jill P., Beroukhim, Rameen, Kuo, Calvin J., Goessling, Wolfram, Hahn, William C.

Source: In Cell 21 December 2012 151(7):1457-1473

Cancer Vulnerabilities Unveiled by Genomic Loss

Authors: Nijhawan, Deepak, Zack, Travis I., Ren, Yin, Strickland, Matthew R., Lamothe, Rebecca, Schumacher, Steven E., Tsherniak, Aviad, Besche, Henrike C., Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A., Goldberg, Alfred L., Mesirov, Jill P., Root, David E., Bhatia, Sangeeta N., Beroukhim, Rameen, Hahn, William C.

Source: In Cell 17 August 2012 150(4):842-854

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

Authors: Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Rusin, Scott, Scott, Justine A., East, Alexandra, Ali, Levi D., Lizotte, Patrick H., Wong, Terence C., Jiang, Guozhi, Hsiao, Jessica, Mermel, Craig H., Getz, Gad, Barretina, Jordi, Gopal, Shuba, Tamayo, Pablo, Gould, Joshua, Tsherniak, Aviad, Stransky, Nicolas, Luo, Biao, Ren, Yin, Drapkin, Ronny, Bhatia, Sangeeta N., Mesirov, Jill P., Garraway, Levi A., Meyerson, Matthew, Lander, Eric S., Root, David E., Hahn, William C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Jul . 108(30), 12372-12377.

Access URL: https://www.jstor.org/stable/27979009

Highly Parallel Identification of Essential Genes in Cancer Cells

Authors: Luo, Biao, Cheung, Hiu Wing, Subramanian, Aravind, Sharifnia, Tanaz, Okamoto, Michael, Yang, Xiaoping, Hinkle, Greg, Boehm, Jesse S., Beroukhim, Rameen, Weir, Barbara A., Mermel, Craig, Barbie, David A., Awad, Tarif, Zhou, Xiaochuan, Nguyen, Tuyen, Piqani, Bruno, Li, Cheng, Golub, Todd R., Meyerson, Matthew, Hacohen, Nir, Hahn, William C., Lander, Eric S., Sabatini, David M., Root, David E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2008 Dec . 105(51), 20380-20385.

Access URL: https://www.jstor.org/stable/25465833

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Authors: Verhaak, Roel G.W., Hoadley, Katherine A., Purdom, Elizabeth, Wang, Victoria, Qi, Yuan, Wilkerson, Matthew D., Miller, C. Ryan, Ding, Li, Golub, Todd, Mesirov, Jill P., Alexe, Gabriele, Lawrence, Michael, O'Kelly, Michael, Tamayo, Pablo, Weir, Barbara A., Gabriel, Stacey, Winckler, Wendy, Gupta, Supriya, Jakkula, Lakshmi, Feiler, Heidi S., Hodgson, J. Graeme, James, C. David, Sarkaria, Jann N., Brennan, Cameron, Kahn, Ari, Spellman, Paul T., Wilson, Richard K., Speed, Terence P., Gray, Joe W., Meyerson, Matthew, Getz, Gad, Perou, Charles M., Hayes, D. Neil

Source: In Cancer Cell 2010 17(1):98-110

Clinical significance of TTF‐1 protein expression and TTF‐1 gene amplification in lung adenocarcinoma

Authors: Barletta, Justine A., Perner, Sven, Iafrate, A. John, Yeap, Beow Y., Weir, Barbara A., Johnson, Laura A., Johnson, Bruce E., Meyerson, Matthew, Rubin, Mark A., Travis, William D., Loda, Massimo, Chirieac, Lucian R.

Source: Journal of cellular and molecular medicine. 13(8b):1977-1986

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119708791.0x000001&indx=1&recIds=ETOCvdc_100119708791.0x000001