HIF1α controls steroidogenesis under acute hypoxic stress.

Authors: Ariyeloye, Stephen¹ (AUTHOR), Watts, Deepika¹ (AUTHOR), Jaykar, Mangesh T.¹ (AUTHOR), Ermis, Cagdas¹ (AUTHOR), Krüger, Anja¹ (AUTHOR), Kaden, Denise¹ (AUTHOR), Stepien, Barbara K.¹ (AUTHOR), Alexaki, Vasileia Ismini¹ (AUTHOR), Peitzsch, Mirko¹ (AUTHOR), Bechmann, Nicole¹ (AUTHOR), Mirtschink, Peter¹ (AUTHOR), El-Armouche, Ali² (AUTHOR), Wielockx, Ben^1,3 (AUTHOR) Ben.Wielockx@tu-dresden.de

Source: Cell Communication & Signaling. 2/13/2025, Vol. 23 Issue 1, p1-12. 12p.

Subject Terms: *GENE expression, *HYPOXIA-inducible factors, *ADRENAL cortex, *OXYGEN detectors, *ADRENAL glands

Adrenal Hormone Interactions and Metabolism: A Single Sample Multi-Omics Approach

Authors: Bechmann, Nicole, Watts, Deepika, Steenblock, Charlotte, Wallace, Paal, Schürmann, Annette, Bornstein, Stefan, Wielockx, Ben, Eisenhofer, Graeme, Peitzsch, Mirko

Source: Hormone and metabolic research. 53(5):326-334

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191752495.0x000001&indx=1&recIds=ETOCvdc_100191752495.0x000001

Reprogramming of glucocorticoid receptor function by hypoxia

Authors: Vanderhaeghen, Tineke, Timmermans, Steven, Watts, Deepika, Paakinaho, Ville, Eggermont, Melanie, Vandewalle, Jolien, Wallaeys, Charlotte, Van Wyngene, Lise, Van Looveren, Kelly, Nuyttens, Louise, Dewaele, Sylviane, Vanden Berghe, Joke, Lemeire, Kelly, De Backer, Joey, Dirkx, Laura, Vanden Berghe, Wim, Caljon, Guy, Ghesquière, Bart, De Bosscher, Karolien, Wielockx, Ben, Palvimo, Jorma J, Beyaert, Rudi, Libert, Claude

Source: EMBO reports. 23(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138809112.0x000001&indx=1&recIds=ETOCvdc_100138809112.0x000001

Targeting DEC-205−DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis

Authors: Tabansky, Inna, Keskin, Derin, Watts, Deepika, Petzold, Cathleen, Funaro, Michael, Sands, Warren, Wright, Paul, Yunis, Edmond, Najjar, Souhel, Diamond, Betty, Cao, Yonghao, Mooney, David, Kretschmer, Karsten, Stern, Joel

Source: Molecular medicine. 24(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164844091.0x000001&indx=1&recIds=ETOCvdc_100164844091.0x000001

PPARG dysregulation as a potential molecular target in adrenal Cushing's syndrome.

Authors: Vetrivel, Sharmilee, Tamburello, Mariangela, Oßwald, Andrea, Ru Zhang, Khan, Ali, Sara Jung, Baker, Jessica E., Rainey, William E., Nowak, Elisabeth, Altieri, Barbara, Detomas, Mario, Watts, Deepika, Williams, Tracy Ann, Wielockx, Ben, Beuschlein, Felix, Reincke, Martin, Sbiera, Silviu, Riester, Anna

Source: Frontiers in Endocrinology; 2023, p1-14, 14p

Subject Terms: CUSHING'S syndrome, DRUG target, PEROXISOME proliferator-activated receptors, CORTISONE, NUCLEOTIDE sequencing, ADENOMATOUS polyps

The impact of hepatocytespecific deletion of hypoxiainducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function.

Authors: Vanderhaeghen, Tineke, Timmermans, Steven, Eggermont, Melanie, Watts, Deepika, Vandewalle, Jolien, Wallaeys, Charlotte, Nuyttens, Louise, De Temmerman, Joyca, Hochepied, Tino, Dewaele, Sylviane, Berghe, Joke Vanden, Sanders, Niek, Wielockx, Ben, Beyaert, Rudi, Libert, Claude

Source: Frontiers in Immunology; 3/16/2023, Vol. 14, p1-18, 18p

Subject Terms: KNOCKOUT mice, SEPSIS, WHITE adipose tissue, PEROXISOME proliferator-activated receptors, FREE fatty acids

Hypoxia signaling pathway: A central mediator in endocrine tumors.

Authors: Watts, Deepika, Jaykar, Mangesh T., Bechmann, Nicole, Wielockx, Ben

Source: Frontiers in Endocrinology; 1/9/2023, Vol. 13, p1-13, 13p

Subject Terms: CELLULAR signal transduction, HYPOXEMIA, PARAGANGLIOMA, OXYGEN detectors, ADRENAL tumors, ADRENAL glands, ENDOCRINE system

Characterization of Adrenal miRNA-Based Dysregulations in Cushing's Syndrome.

Authors: Vetrivel, Sharmilee, Zhang, Ru, Engel, Mareen, Oßwald, Andrea, Watts, Deepika, Chen, Alon, Wielockx, Ben, Sbiera, Silviu, Reincke, Martin, Riester, Anna

Source: International Journal of Molecular Sciences; Jul2022, Vol. 23 Issue 14, p7676-7676, 17p

Subject Terms: CUSHING'S syndrome, ADRENAL glands, WNT genes, WNT signal transduction, NUCLEOTIDE sequencing, ADRENOCORTICOTROPIC hormone

HIF2α regulates the synthesis and release of epinephrine in the adrenal medulla.

Authors: Watts, Deepika¹ (AUTHOR), Bechmann, Nicole^1,2,3 (AUTHOR), Meneses, Ana¹ (AUTHOR), Poutakidou, Ioanna K.¹ (AUTHOR), Kaden, Denise¹ (AUTHOR), Conrad, Catleen¹ (AUTHOR), Krüger, Anja¹ (AUTHOR), Stein, Johanna¹ (AUTHOR), El-Armouche, Ali⁴ (AUTHOR), Chavakis, Triantafyllos¹ (AUTHOR), Eisenhofer, Graeme^1,5 (AUTHOR), Peitzsch, Mirko¹ (AUTHOR), Wielockx, Ben¹ (AUTHOR) Ben.Wielockx@tu-dresden.de

Source: Journal of Molecular Medicine. Nov2021, Vol. 99 Issue 11, p1655-1666. 12p.

Subject Terms: *ADRENALINE, *CHROMAFFIN cells, *ERYTHROPOIETIN receptors, *ADRENAL glands, *SMALL molecules, *POLYCYTHEMIA

Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss.

Authors: Rauner, Martina, Murray, Marta, Thiele, Sylvia, Watts, Deepika, Neumann, Drorit, Gabet, Yankel, Hofbauer, Lorenz C., Wielockx, Ben

Source: Bone Research; 9/13/2021, Vol. 9 Issue 1, p1-8, 8p

Subject Terms: HOMEOSTASIS, OSTEOPENIA, ERYTHROPOIETIN, PROGENITOR cells, BONE resorption

Transient Depletion of Foxp3⁺ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice.

Authors: Watts, Deepika, Janßen, Marthe, Jaykar, Mangesh, Palmucci, Francesco, Weigelt, Marc, Petzold, Cathleen, Hommel, Angela, Sparwasser, Tim, Bonifacio, Ezio, Kretschmer, Karsten

Source: Frontiers in Immunology; 8/10/2021, Vol. 12, p1-11, 11p

Subject Terms: REGULATORY T cells, AUTOIMMUNE diseases, T cell receptors, TYPE 1 diabetes, DIPHTHERIA toxin, AUTOIMMUNITY

HIF1α is a direct regulator of steroidogenesis in the adrenal gland.

Authors: Watts, Deepika¹ (AUTHOR), Stein, Johanna¹ (AUTHOR), Meneses, Ana¹ (AUTHOR), Bechmann, Nicole^1,2,3 (AUTHOR), Neuwirth, Ales¹ (AUTHOR), Kaden, Denise¹ (AUTHOR), Krüger, Anja¹ (AUTHOR), Sinha, Anupam¹ (AUTHOR), Alexaki, Vasileia Ismini¹ (AUTHOR), Luis Gustavo Perez-Rivas⁴ (AUTHOR), Kircher, Stefan⁵ (AUTHOR), Martinez, Antoine⁶ (AUTHOR), Theodoropoulou, Marily⁴ (AUTHOR), Eisenhofer, Graeme¹ (AUTHOR), Peitzsch, Mirko¹ (AUTHOR), El-Armouche, Ali⁷ (AUTHOR), Chavakis, Triantafyllos¹ (AUTHOR), Wielockx, Ben¹ (AUTHOR) Ben.Wielockx@tu-dresden.de

Source: Cellular & Molecular Life Sciences. Apr2021, Vol. 78 Issue 7, p3577-3590. 14p.

Subject Terms: *ADRENAL glands, *HYPOXIA-inducible factors, *ADRENAL cortex, *HORMONE synthesis, *STEROID hormones

This result is not displayed to guests.
Login for full access.

Hypoxia Pathway Proteins and Their Impact on the Blood Vasculature.

Authors: Rodriguez, Diego¹ (AUTHOR) diego.rodriguez@mailbox.tu-dresden.de, Watts, Deepika¹ (AUTHOR), Gaete, Diana¹ (AUTHOR), Sormendi, Sundary¹ (AUTHOR), Wielockx, Ben¹ (AUTHOR) Ben.Wielockx@tu-dresden.de

Source: International Journal of Molecular Sciences. Sep2021, Vol. 22 Issue 17, p9191. 1p.

Subject Terms: *BLOOD proteins, *PERICYTES, *HYPOXEMIA, *DRUG target, *OXYGEN detectors, *OXYGEN in the body

Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis.

Authors: Watts, Deepika¹ (AUTHOR) deepika.watts@ukdd.de, Gaete, Diana¹ (AUTHOR) Diana.Gaete@ukdd.de, Rodriguez, Diego¹ (AUTHOR) diego.rodriguez@mailbox.tu-dresden.de, Hoogewijs, David² (AUTHOR) david.hoogewijs@unifr.ch, Rauner, Martina³ (AUTHOR) Martina.Rauner@uniklinikum-dresden.de, Sormendi, Sundary¹ (AUTHOR) sundary.sormendi@ukdd.de, Wielockx, Ben¹ (AUTHOR) ben.wielockx@tu-dresden.de

Source: International Journal of Molecular Sciences. Nov2020, Vol. 21 Issue 21, p8131. 1p.

Subject Terms: *ERYTHROPOIESIS, *HYPOXIA-inducible factors, *HYPOXEMIA, *ERYTHROCYTES, *CHRONIC kidney failure

This result is not displayed to guests.
Login for full access.

Advantages of Foxp3⁺ regulatory T cell depletion using DEREG mice.

Authors: Mayer, Christian T., Lahl, Katharina, Milanez‐Almeida, Pedro, Watts, Deepika, Dittmer, Ulf, Fyhrquist, Nanna, Huehn, Jochen, Kopf, Manfred, Kretschmer, Karsten, Rouse, Barry, Sparwasser, Tim

Source: Immunity, Inflammation & Disease; Nov2014, Vol. 2 Issue 3, p162-165, 4p

Subject Terms: T cells, AUTOIMMUNITY, TYPE 1 diabetes, LABORATORY mice, IMMUNE response

Foxp3⁺ Regulatory T Cells in Mouse Models of Type 1 Diabetes.

Authors: Petzold, Cathleen, Riewaldt, Julia, Watts, Deepika, Sparwasser, Tim, Schallenberg, Sonja, Kretschmer, Karsten

Source: Journal of Diabetes Research; 2013, p1-10, 10p

Subject Terms: TYPE 1 diabetes, T cells, LABORATORY mice, DIABETES complications, DIABETES, HOMEOSTASIS, AUTOIMMUNITY

HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?

Authors: Gaete, Diana, Rodriguez, Diego, Watts, Deepika, Sormendi, Sundary, Chavakis, Triantafyllos, Wielockx, Ben, Simos, George, Mylonis, Ilias, Chachami, Georgia, Carraro, Fabio

Source: Cancers; Mar2021, Vol. 13 Issue 5, p988-988, 1p

Subject Terms: THERAPEUTIC use of antineoplastic agents, IMMUNOLOGICAL tolerance, HEMATOPOIETIC agents, CARCINOGENESIS, GENE expression, OXIDOREDUCTASES, CELL lines, TUMORS, TRANSCRIPTION factors, HYPOXEMIA, CHEMICAL inhibitors