Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein

Authors: Nguyen, William ^{a, b}, Boulet, Coralie ^c, Dans, Madeline G. ^{a, b}, Loi, Katie ^{a, b}, Jarman, Kate E. ^{a, b}, Watson, Gabrielle M. ^{a, b}, Tham, Wai-Hong ^{a, b}, Fairhurst, Kate J. ^d, Yeo, Tomas ^d, Fidock, David A. ^{d, e}, Wittlin, Sergio ^{f, g}, Chowdury, Mrittika ^{h, i}, de Koning-Ward, Tania F. ^{h, i}, Chen, Gong ^j, Yan, Dandan ^j, Charman, Susan A. ^j, Baud, Delphine ^k, Brand, Stephen ^k, Jackson, Paul F. ^l, Cowman, Alan F. ^{a, b}, Gilson, Paul R. ^c, Sleebs, Brad E. ^{a, b, ⁎}

Source: In European Journal of Medicinal Chemistry 15 April 2024 270

Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1

Alternate Title: Immune recognition of nectin adhesion molecules (English)

Authors: Deuss, Felix A., Watson, Gabrielle M., Goodall, Katharine J., Leece, Isobel, Chatterjee, Sayantani, Fu, Zhihui, Thaysen-Andersen, Morten, Andrews, Daniel M., Rossjohn, Jamie ^**, Berry, Richard

Source: In Journal of Biological Chemistry 16 August 2019 294(33):12534-12546

Structural Basis for CD96 Immune Receptor Recognition of Nectin-like Protein-5, CD155

Authors: Deuss, Felix A., Watson, Gabrielle M., Fu, Zhihui, Rossjohn, Jamie, Berry, Richard

Source: In Structure 5 February 2019 27(2):219-228

Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids.

Authors: Zimmermann, Cosima¹, Watson, Gabrielle M.², Bauersfeld, Liane¹, Berry, Richard², Ciblis, Barbara¹, Huan Lan³, Gerke, Carolin^1,4, Oberhardt, Valerie⁵, Fuchs, Jonas¹, Hofmann, Maike⁵, Freund, Christian³, Rossjohn, Jamie^2,6, Momburg, Frank⁷, Hengel, Hartmut¹, Halenius, Anne¹ anne.halenius@uniklinik-freiburg.de

Source: Proceedings of the National Academy of Sciences of the United States of America. 2/27/2024, Vol. 121 Issue 9, p1-12. 32p.

Subject Terms: *ARMS race, *HOMINIDS, *COEVOLUTION, *CYTOMEGALOVIRUSES, *PEPTIDES, *HUMAN cytomegalovirus

Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability.

Authors: Sturre, Natasha P., Colson, Rhys N., Shah, Neelam, Watson, Gabrielle M., Yang, Xue, Wilce, Matthew C. J., Price, John T., Wilce, Jacqueline A.

Source: Biomedicines; May2022, Vol. 10 Issue 5, p1145, 12p

Subject Terms: CELL permeability, CANCER cell migration, TRYPTOPHAN, PEPTIDES, AMINO acids, X-ray crystallography

Author Correction: Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.

Authors: Dans, Madeline G., Boulet, Coralie, Watson, Gabrielle M., Nguyen, William, Dziekan, Jerzy M., Evelyn, Cindy, Reaksudsan, Kitsanapong, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Mlodzianoski, Michael J., Goodman, Christopher Dean, Ling, Dawson B., Jonsdottir, Thorey K., Tong, Joshua, Famodimu, Mufuliat Toyin, Kristan, Mojca, Pollard, Harry, Stewart, Lindsay B., Brandner-Garrod, Luke

Source: Nature Communications; 9/30/2024, Vol. 15 Issue 1, p1-1, 1p

Subject Terms: PLASMODIUM falciparum, INTERNET publishing, PROTEINS

A pocket guide on how to structure SARS-CoV-2 drugs and therapies.

Authors: Littler, Dene R., MacLachlan, Bruce J., Watson, Gabrielle M., Vivian, Julian P., Gully, Benjamin S.

Source: Biochemical Society Transactions; Dec2020, Vol. 48 Issue 6, p2625-2641, 17p

Subject Terms: SARS-CoV-2, COVID-19, DRUG therapy, SARS virus, VIRAL replication, ANTIVIRAL agents, MERS coronavirus

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

Modulation of innate and adaptive immunity by cytomegaloviruses

Authors: Berry, Richard, Watson, Gabrielle M., Jonjic, Stipan, Degli-Esposti, Mariapia A., Rossjohn, Jamie

Source: Nature Reviews Immunology; February 2020, Vol. 20 Issue: 2 p113-127, 15p

This result is not displayed to guests.
Login for full access.

Direct Interaction between Calmodulin and the Grb7 RA-PH Domain.

Authors: Watson, Gabrielle M.¹ (AUTHOR) gabrielle.watson@monash.edu, Wilce, Jacqueline A.¹ (AUTHOR) jackie.wilce@monash.edu

Source: International Journal of Molecular Sciences. Feb2020, Vol. 21 Issue 4, p1336. 1p.

Subject Terms: *CALMODULIN, *ADAPTOR proteins, *SURFACE plasmon resonance, *CARRIER proteins, *CELL migration

This result is not displayed to guests.
Login for full access.

Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity.

Authors: Sang, Jianrong, Kulkarni, Ketav, Watson, Gabrielle M., Ma, Xiuquan, Craik, David J., Henriques, Sónia T., Poth, Aaron G., Benfield, Aurélie H., Wilce, Jacqueline A., Miyata, Yasuyoshi

Source: Molecules; Oct2019, Vol. 24 Issue 20, p3739, 1p

Subject Terms: BREAST cancer, ADAPTOR proteins, MASS spectrometry, STERIC hindrance

This result is not displayed to guests.
Login for full access.