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Application of Single Cell Type-Derived Spheroids Generated by Using a Hanging Drop Culture Technique in Various In Vitro Disease Models: A Narrow Review.

Authors: Ohguro, Hiroshi¹ (AUTHOR) ooguro@sapmed.ac.jp, Watanabe, Megumi¹ (AUTHOR) nami076@yahoo.co.jp, Sato, Tatsuya^2,3 (AUTHOR) satatsu.bear@gmail.com, Nishikiori, Nami¹ (AUTHOR) araya.umetsu@sapmed.ac.jp, Umetsu, Araya¹ (AUTHOR) megumi.h@sapmed.ac.jp, Higashide, Megumi¹ (AUTHOR), Yano, Toshiyuki² (AUTHOR) oltomwaits55@gmail.com, Suzuki, Hiromu⁴ (AUTHOR) hsuzuki@sapmed.ac.jp, Miyazaki, Akihiro⁵ (AUTHOR) amiyazak@sapmed.ac.jp, Takada, Kohichi⁶ (AUTHOR) ktakada@sapmed.ac.jp, Uhara, Hisashi⁷ (AUTHOR) uhara3@yahoo.co.jp, Furuhashi, Masato² (AUTHOR) furuhasi@sapmed.ac.jp, Hikage, Fumihito¹ (AUTHOR) ooguro@sapmed.ac.jp

Source: Cells (2073-4409). Sep2024, Vol. 13 Issue 18, p1549. 21p.

Subject Terms: *DRUG discovery, *CENTRIFUGAL force, *DRUG efficacy, *MAGNETISM, *LIFE sciences, *CELL culture

FABP5 Is a Possible Factor for the Maintenance of Functions of Human Non-Pigmented Ciliary Epithelium Cells.

Authors: Higashide, Megumi¹ (AUTHOR), Watanabe, Megumi¹ (AUTHOR), Sato, Tatsuya^2,3 (AUTHOR), Umetsu, Araya¹ (AUTHOR), Nishikiori, Nami¹ (AUTHOR), Ogawa, Toshifumi^2,3 (AUTHOR), Furuhashi, Masato² (AUTHOR), Ohguro, Hiroshi¹ (AUTHOR) ooguro@sapmed.ac.jp

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9285. 15p.

Subject Terms: *RNA sequencing, *UNFOLDED protein response, *FATTY acid-binding proteins, *GENE expression, *CELL survival

Fatty Acid-Binding Protein 4-Mediated Regulation Is Pivotally Involved in Retinal Pathophysiology: A Review.

Authors: Ohguro, Hiroshi¹ (AUTHOR) ooguro@sapmed.ac.jp, Watanabe, Megumi¹ (AUTHOR) fuhika@gmail.com, Hikage, Fumihito¹ (AUTHOR) nami076@yahoo.co.jp, Sato, Tatsuya^2,3 (AUTHOR) satatsu.bear@gmail.com, Nishikiori, Nami¹ (AUTHOR) araya.umetsu@sapmed.ac.jp, Umetsu, Araya¹ (AUTHOR) megumi.h@sapmed.ac.jp, Higashide, Megumi¹ (AUTHOR), Ogawa, Toshifumi^2,3 (AUTHOR) a08m024@yahoo.co.jp, Furuhashi, Masato² (AUTHOR) ooguro@sapmed.ac.jp

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7717. 20p.

Subject Terms: *FATTY acid-binding proteins, *RETINAL vein occlusion, *PATHOLOGICAL physiology, *RETINAL diseases, *DIABETIC retinopathy

Intraocular fatty acids induce reinforcement of barrier functions on the outer blood-retinal barrier

Authors: Nishikiori, Nami, Watanabe, Megumi, Sato, Tatsuya, Umetsu, Araya, Higashide, Megumi, Furuhashi, Masato, Ohguro, Hiroshi

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids March 2024 202

Simultaneous Effects of a Selective EP2 Agonist, Omidenepag, and a Rho-Associated Coiled-Coil Containing Protein Kinase Inhibitor, Ripasudil, on Human Orbital Fibroblasts

Authors: Hikage, Fumihito, Watanabe, Megumi, Sato, Tatsuya, Umetsu, Araya, Tsugeno, Yuri, Furuhashi, Masato, Ohguro, Hiroshi

Source: Journal of ocular pharmacology and therapeutics. 39(7):439-448

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192796258.0x000001&indx=1&recIds=ETOCvdc_100192796258.0x000001

Prostanoid FP and EP2 Receptor Agonists Induce Epithelial and Subepithelial Fibrogenetic Changes in Human Conjunctival Fibroblasts in Different Manners

Authors: Tsugeno, Yuri, Sato, Tatsuya, Watanabe, Megumi, Furuhashi, Masato, Ohguro, Hiroshi

Source: Journal of ocular pharmacology and therapeutics. 39(6):404-414

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187258728.0x000001&indx=1&recIds=ETOCvdc_100187258728.0x000001

3D culture induction of adipogenic differentiation in 3T3-L1 preadipocytes exhibits adipocyte-specific molecular expression patterns and metabolic functions

Authors: Endo, Keisuke ^{a, 1}, Sato, Tatsuya ^{a, b, 1}, Umetsu, Araya ^c, Watanabe, Megumi ^c, Hikage, Fumihito ^c, Ida, Yosuke ^c, Ohguro, Hiroshi ^c, Furuhashi, Masato ^{a, ∗}

Source: In Heliyon October 2023 9(10)

Lysophosphatidic Acid Modulates TGF-β2-Induced Biological Phenotype in Human Conjunctival Fibroblasts.

Authors: Watanabe, Megumi¹ (AUTHOR) watanabe@sapmed.ac.jp, Tsugeno, Yuri¹ (AUTHOR) yuri.tsugeno@gmail.com, Sato, Tatsuya^2,3 (AUTHOR) satatsu.bear@gmail.com, Higashide, Megumi¹ (AUTHOR) megumi.h@sapmed.ac.jp, Nishikiori, Nami¹ (AUTHOR) nami076@yahoo.co.jp, Umetsu, Araya¹ (AUTHOR) araya.umetsu@sapmed.ac.jp, Ogawa, Toshifumi^2,3 (AUTHOR) a08m024@yahoo.co.jp, Furuhashi, Masato² (AUTHOR) furuhasi@sapmed.ac.jp, Ohguro, Hiroshi¹ (AUTHOR) ooguro@sapmed.ac.jp

Source: Life (2075-1729). Jun2024, Vol. 14 Issue 6, p770. 14p.

Subject Terms: *LYSOPHOSPHOLIPIDS, *HUMAN phenotype, *FIBROBLASTS, *EXTRACELLULAR matrix, *FLUORESCEIN isothiocyanate, *DEXTRAN, *TRANSFORMING growth factors

Significant and Various Effects of ML329-Induced MITF Suppression in the Melanoma Cell Line.

Authors: Nishikiori, Nami¹ (AUTHOR) nami076@yahoo.co.jp, Watanabe, Megumi¹ (AUTHOR) watanabe@sapmed.ac.jp, Sato, Tatsuya^2,3 (AUTHOR) satatsu.bear@gmail.com, Furuhashi, Masato² (AUTHOR) mfuruhas@gmail.com, Okura, Masae⁴ (AUTHOR) haiyingj@sapmed.ac.jp, Hida, Tokimasa⁴ (AUTHOR) hidat@sapmed.ac.jp, Uhara, Hisashi⁴ (AUTHOR) uharah@sapmed.ac.jp, Ohguro, Hiroshi¹ (AUTHOR) ooguro@sapmed.ac.jp

Source: Cancers. Jan2024, Vol. 16 Issue 2, p263. 12p.

Subject Terms: *STATISTICS, *CELL culture, *MELANOMA, *ONCOGENES, *MICROSCOPY, *CYTOMETRY, *ONE-way analysis of variance, *CELL survival, *GENE expression, *T-test (Statistics), *DESCRIPTIVE statistics, *TRANSCRIPTION factors, *CELL lines, *POLYMERASE chain reaction, *DATA analysis software, *DATA analysis, *DRUG resistance in cancer cells

Short-Term Postoperative Outcomes between Ahmed Glaucoma Valve Implant and Baerveldt Glaucoma Implant Surgery for Neovascular Glaucoma

Authors: Neriai, Kanoko, Ida, Yosuke, Suzuki, Soma, Watanabe, Megumi, Hikage, Fumihito, Ohguro, Hiroshi

Source: Atarashii ganka. 39(11):1534-1538

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631165744&indx=1&recIds=ETOCRN631165744

Gender, type of higher education institution, and faculty work-life integration in the United States

Authors: Berheide, Catherine White, Watanabe, Megumi, Falci, Christina, Borland, Elizabeth, Bates, Diane C., Anderson-Hanley, Cay

Source: Community, work & family. 25(4):444-463

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161236021.0x000001&indx=1&recIds=ETOCvdc_100161236021.0x000001

Fatty acid metabolism is involved in both retinal physiology and the pathology of retinal vascular diseases

Authors: Umetsu, Araya, Furuhashi, Masato, Watanabe, Megumi, Ohkawa, Ei, Tsugeno, Yuri, Suzuki, Soma, Itoh, Kaku, Ida, Yosuke, Hikage, Fumihito, Ohguro, Hiroshi

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids August 2022 183

Expression and Secretion of Intraocular Fatty Acid-Binding Protein 4 (ioFABP4) and 5 (ioFABP5) Are Regulated by Glucose Levels and Fatty Acids.

Authors: Ohguro, Hiroshi, Higashide, Megumi, Ishiwata, Erika, Hikage, Fumihito, Watanabe, Megumi, Nishikiori, Nami, Sato, Tatsuya, Furuhashi, Masato

Source: International Journal of Molecular Sciences; Mar2025, Vol. 26 Issue 5, p1791, 13p

High-Glucose-Induced Metabolic and Redox Alterations Are Distinctly Modulated by Various Antidiabetic Agents and Interventions Against FABP5/7, MITF and ANGPTL4 in Melanoma A375 Cells.

Authors: Nishikiori, Nami, Ohguro, Hiroshi, Watanabe, Megumi, Higashide, Megumi, Ogawa, Toshifumi, Furuhashi, Masato, Sato, Tatsuya

Source: International Journal of Molecular Sciences; Feb2025, Vol. 26 Issue 3, p1014, 15p

Subject Terms: MICROPHTHALMIA-associated transcription factor, FATTY acid-binding proteins, ANGIOPOIETIN-like proteins, HYPOGLYCEMIC agents, REACTIVE oxygen species

Distinct Infection Mechanisms of Rhizoctonia solani AG-1 IA and AG-4 HG-I+II in Brachypodium distachyon and Barley.

Authors: Mahadevan, Niranjan, Fernanda, Rozi, Kouzai, Yusuke, Kohno, Natsuka, Nagao, Reiko, Nyein, Khin Thida, Watanabe, Megumi, Sakata, Nanami, Matsui, Hidenori, Toyoda, Kazuhiro, Ichinose, Yuki, Mochida, Keiichi, Hisano, Hiroshi, Noutoshi, Yoshiteru

Source: Life (2075-1729); Feb2025, Vol. 15 Issue 2, p235, 20p

Subject Terms: RICE sheath blight, SALICYLIC acid, AGRICULTURE, RHIZOCTONIA solani, FOLIAGE plants, BRACHYPODIUM

Inhibition of mTOR differently modulates planar and subepithelial fibrogenesis in human conjunctival fibroblasts.

Authors: Watanabe, Megumi¹ (AUTHOR) watanabe@sapmed.ac.jp, Tsugeno, Yuri¹ (AUTHOR), Sato, Tatsuya^2,3 (AUTHOR), Higashide, Megumi¹ (AUTHOR), Umetsu, Araya¹ (AUTHOR), Furuhashi, Masato² (AUTHOR), Ohguro, Hiroshi¹ (AUTHOR) ooguro@sapmed.ac.jp

Source: Graefe's Archive of Clinical & Experimental Ophthalmology. Jan2025, Vol. 263 Issue 1, p33-46. 14p.

Subject Terms: *MTOR inhibitors, *GENE expression, *CELL proliferation, *FIBROBLASTS, *PROTEIN expression

Gender Inequality in International Research Engagement Amid Transformation to Global and Neoliberal Academia: The Case of Japan.

Authors: Watanabe, Megumi¹ (AUTHOR) megumiw@hiroshima-u.ac.jp

Source: Gender, Work & Organization. Dec2024, p1. 11p.

Subject Terms: Women's roles, Gender inequality, Social norms, Family roles, Academia

Addition of EP2 agonists to an FP agonist additively and synergistically modulates adipogenesis and the physical properties of 3D 3T3-L1 sphenoids

Authors: Ida, Yosuke, Watanabe, Megumi, Umetsu, Araya, Ohguro, Hiroshi, Hikage, Fumihito

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids August 2021 171

Diagnostic Delays and Quality of Life in Japanese Patients with Pulmonary Hypertension: A Nationwide Survey

Authors: Murakami, Noriko, Asano, Daiki, Tokushige, Natsuko, Omura, Junichi, Watanabe, Megumi, Nomura, Seitaro, Kitaoka, Hiroaki, Tamura, Yuichi

Source: Pulmonary Therapy; 20250101, Issue: Preprints p1-20, 20p