Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations

Authors: Zhu, Jie, Message, Simon D., Mallia, Patrick, Kebadze, Tatiana, Contoli, Marco, Ward, Christine K., Barnathan, Elliot S., Mascelli, Mary Ann, Kon, Onn M., Papi, Alberto, Stanciu, Luminita A., Edwards, Michael R., Jeffery, Peter K., Johnston, Sebastian L.

Source: In The Journal of Allergy and Clinical Immunology January 2019 143(1):114-125

Treatment of lung and pulmonary diseases and disorders

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

Authors: Kearley, Jennifer, Silver, Jonathan S., Sanden, Caroline, Liu, Zheng, Berlin, Aaron A., White, Natalie, Mori, Michiko, Pham, Tuyet-Hang, Ward, Christine K., Criner, Gerard J., Marchetti, Nathaniel, Mustelin, Tomas, Erjefalt, Jonas S., Kolbeck, Roland, Humbles, Alison A.

Source: In Immunity 17 March 2015 42(3):566-579

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

Authors: Castro, Mario, Wenzel, Sally E, Bleecker, Eugene R, Pizzichini, Emilio, Kuna, Piotr, Busse, William W, Gossage, David L, Ward, Christine K, Wu, Yanping, Wang, Bing, Khatry, Deepak B, van der Merwe, René, Kolbeck, Roland, Molfino, Nestor A, Raible, Donald G

Source: In The Lancet Respiratory Medicine November 2014 2(11):879-890

Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study

Authors: Brightling, Christopher E, Bleecker, Eugene R, Panettieri, Reynold A, Jr, Bafadhel, Mona, She, Dewei, Ward, Christine K, Xu, Xiao, Birrell, Claire, van der Merwe, René

Source: In The Lancet Respiratory Medicine November 2014 2(11):891-901

High blood eosinophil count is associated with more frequent asthma attacks in asthma patients

Authors: Tran, Trung N., Khatry, Deepak B., Ke, Xiongkan, Ward, Christine K., Gossage, David

Source: In Annals of Allergy, Asthma & Immunology July 2014 113(1):19-24

Airway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma

Authors: Zhu, Jie, Message, Simon D., Qiu, Yusheng, Mallia, Patrick, Kebadze, Tatiana, Contoli, Marco, Ward, Christine K., Barnathan, Elliot S., Mascelli, Mary Ann, Kon, Onn M., Papi, Alberto, Stanciu, Luminita A., Jeffery, Peter K., Johnston, Sebastian L.

Source: In Chest June 2014 145(6):1219-1229

Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice

Authors: Wu, Linda H., Huang, C. Chris, Adhikarakunnathu, Sree, San Mateo, Lani R., Duffy, Karen E., Rafferty, Patricia, Bugelski, Peter, Raymond, Holly, Deutsch, Heather, Picha, Kristen, Ward, Christine K., Alexoupolou, Lena, Flavell, Richard A., Mbow, M. Lamine, Susulic, Vedrana S.

Source: In Metabolism November 2012 61(11):1633-1645

Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro

Authors: Bunting, Rachel A., Duffy, Karen E., Lamb, Roberta J., San Mateo, Lani R., Smalley, Karen, Raymond, Holly, Liu, Xuesong, Petley, Ted, Fisher, Jamie, Beck, Heena, Flavell, Richard A., Alexopoulou, Lena, Ward, Christine K.

Source: In Cellular Immunology 2011 267(1):9-16

TREATMENT OF LUNG AND PULMONARY DISEASES AND DISORDERS

Modeling of systemic inflammatory response to infection

Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein.

Authors: Ward, Christine K., Lumbley, Sheryl R., Latimer, Jo L.

Source: Journal of Bacteriology; November 1998, Vol. 180 Issue 22, p6013-6022, 10p

Phase 1b/2 Study of the First-in-Class SUMO-Activating Enzyme Inhibitor TAK-981 in Combination with Monoclonal Antibodies in Patients with Triple-Class Refractory Multiple Myeloma

Authors: Lonial, Sagar, Tarantolo, Stefano R., Boccia, Ralph V., Yimer, Habte, Levy, Moshe Y., Abonour, Rafat, Mohan, Meera, Roy, Vivek, Larsen, Jeremy T., Girnius, Saulius K., Rosenbaum, Cara A., Nadeem, Omar, Berg, Deborah, Chao, Bo, Berger, Allison J, Nakamura, Akito, Zhang, Yuhong, Song, Keli, Ward, Christine K., Proscurshim, Igor, Kumar, Shaji

Source: In Blood 23 November 2021 138 Supplement 1:2742-2742

TAK-981, a First-in-Class SUMO-Activating Enzyme Inhibitor, Combined with Rituximab in Adult Patients (Pts) with CD20-Positive Relapsed/Refractory (R/R) Non-Hodgkin Lymphoma (NHL): Phase 1 Data

Authors: Assouline, Sarit, Mehta, Amitkumar, Phillips, Tycel, Alinari, Lapo, Danilov, Alexey V., Doucet, Stéphane, Park, Steven I., Berg, Deborah, Gomez-Pinillos, Alejandro, Martinez, Alonzo, Chao, Bo, Berger, Allison J, Gibbs, John, Friedlander, Sharon, Ward, Christine K., Proscurshim, Igor, Cooper, Brenda W., Caimi, Paolo F

Source: In Blood 23 November 2021 138 Supplement 1:2488-2488

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IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.

Authors: Briend, Emmanuel, Ferguson, G. John, Mori, Michiko, Damera, Gautam, Stephenson, Katherine, Karp, Natasha A., Sethi, Sanjay, Ward, Christine K., Sleeman, Matthew A., Erjefält, Jonas S., Finch, Donna K.

Source: Respiratory Research; 8/22/2017, Vol. 18, p1-14, 14p, 2 Charts, 6 Graphs

Subject Terms: INTERFERON gamma release tests, OBSTRUCTIVE lung diseases, INTERLEUKIN-1, LYMPH nodes, GENE expression, LYMPHOCYTE metabolism, INTERFERONS, INTERLEUKINS, LONGITUDINAL method, LUNGS, LYMPHOCYTES, SPUTUM, SEVERITY of illness index, MONONUCLEAR leukocytes

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Airway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma.

Authors: Jie Zhu, Message, Simon D., Yusheng Qiu, Mallia, Patrick, Kebadze, Tatiana, Contoli, Marco, Ward, Christine K., Barnathan, Elliot S., Mascelli, Mary Ann, Onn M. Kon, Papi, Alberto, Stanciu, Luminita A., Jeffery, Peter K., Johnston, Sebastian L.

Source: CHEST; Jun2014, Vol. 145 Issue 6, p1219-1229, 11p

Subject Terms: MUCOUS membrane diseases, INFLAMMATION, RHINOVIRUSES, PICORNAVIRUSES, ASTHMA