Immunological approaches to HIV cure

Authors: Ward, Adam R., Mota, Talia M., Jones, R. Brad ^*

Source: In Seminars in Immunology January 2021 51

The Index of Attitudes Toward Homosexuals: Factor Analysis in a National Sample of Oncology Clinicians.

Authors: Pratt-Chapman, Mandi L.¹ (AUTHOR) mandi@gwu.edu, Ward, Adam R.^2,3 (AUTHOR)

Source: Journal of Homosexuality. 2022, Vol. 69 Issue 7, p1238-1251. 14p. 1 Diagram, 5 Charts, 1 Graph.

OP 1.9 – 00042 Measuring the impact of early 3BNC117 intervention at ART initiation on the productive reservoir in a cohort of diverse viral subtypes: results from the VIP-SPOT assay in the eCLEAR trial

Authors: Puertas, M.C., Gunst, J.D., Pahus, M.H., Kinloch, N.N., Copertino, D.C., Ward, Adam R., Brumme, Z.L., Jones, R. Brad, Tolstrup, M., Fidler, S., Søgaard, O.S., Martinez-Picado, J.

Source: In Journal of Virus Eradication December 2022 8 Supplement

Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1.

Authors: Sanz, Marta, Weideman, Ann Marie K., Ward, Adam R., Clohosey, Matthew L., Garcia-Recio, Susana, Selitsky, Sara R., Mann, Brendan T., Iannone, Marie Anne, Whitworth, Chloe P., Chitrakar, Alisha, Garrido, Carolina, Kirchherr, Jennifer, Coffey, Alisha R., Yi-Hsuan Tsai, Samir, Shahryar, Yinyan Xu, Copertino, Dennis, Bosque, Alberto, Jones, Brad R., Parker, Joel S.

Source: Frontiers in Immunology; 2023, p01-14, 14p

Subject Terms: URINARY urge incontinence, HIV, AP-1 transcription factor, BONE density, RNA sequencing, T cells

No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART.

Authors: Ward, Adam R., Thomas, Allison S., Stevenson, Eva M., Huang, Szu-Han, Keating, Sheila M., Gandhi, Rajesh T., McMahon, Deborah K., Bosch, Ronald J., Macatangay, Bernard J., Cyktor, Joshua C., Eron, Joseph J., Mellors, John W., Jones, R. Brad, ACTG A5321 Team

Source: AIDS (02699370); Oct2022, Vol. 36 Issue 12, p1617-1628, 12p

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8⁺ T-cells.

Authors: Stevenson, Eva M., Terry, Sandra, Copertino, Dennis, Leyre, Louise, Danesh, Ali, Weiler, Jared, Ward, Adam R., Khadka, Pragya, McNeil, Evan, Bernard, Kevin, Miller, Itzayana G., Ellsworth, Grant B., Johnston, Carrie D., Finkelsztein, Eli J., Zumbo, Paul, Betel, Doron, Dündar, Friederike, Duncan, Maggie C., Lapointe, Hope R., Speckmaier, Sarah

Source: Nature Communications; 8/19/2022, Vol. 13 Issue 1, p1-15, 15p

Subject Terms: SARS-CoV-2, HIV, COVID-19 vaccines, CYTOTOXIC T cells, MESSENGER RNA, T cells, VACCINATION

Provider Recommendations Are Associated with Cancer Screening of Transgender and Gender-Nonconforming People: A Cross-Sectional Urban Survey.

Authors: Pratt-Chapman, Mandi L., Ward, Adam R.

Source: Transgender Health; Jun2020, Vol. 5 Issue 2, p80-85, 6p

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OP 4.6 - Dynamics of HIV-specific T cells on long-term ART differ by antigen recognised and by sex

Authors: Stevenson, Eva M., Ward, Adam R., Dilling, Thomas R., Bui, John K., Mellors, John, Gandhi, Rajesh, McMahon, Deborah, Eron, Joseph, Bosch, Ronald, Lalama, Christina, Cyktor, Joshua, Jones, Brad

Source: In Journal of Virus Eradication December 2019 5 Supplement 3:32-32

KIR+RA+CD8 T CELLS EXHIBIT ANTIGEN INDEPENDENCE AND CORRELATE WITH HIV RESERVOIR SIZE.

Authors: Mota, Talia, Weiler, Jared, Zumbo, Paul, Copertino, Dennis C., Linden, Noemi L., Gramatica, Andrea, Ward, Adam R., Terry, Sandra, Benko, Erika, Kovacs, Colin, Safrit, Jeffrey, Paiardini, Mirko, Kulpa, Deanna A., Silvestri, Guido, Jones, R. Brad

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p163-163, 1/3p

CTL RESPONSES ARE NOT ASSOCIATED WITH DECAY OF INTACT PROVIRUSES OR HIV RNA ON ART.

Authors: Ward, Adam R., Copertino, Dennis C., Stevenson, Eva M., McNeil, Evan, Chukwukere, Uchenna, Gandhi, Rajesh T., McMahon, Deborah K., Bosch, Ronald J., Macatangay, Bernard, Cyktor, Joshua C., Eron, Joseph J., Mellors, John W., Jones, R. Brad

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p158-158, 1/3p

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The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary TCM Cell Model of Latency.

Authors: Sarabia, Indra¹, Szu-Han Huang², Ward, Adam R.^1,2, Jones, R. Brad^1,2, Bosque, Alberto¹ abosque@gwu.edu

Source: Journal of Virology. Apr2021, Vol. 95 Issue 7, p1-16. 16p.

Subject Terms: *HIV, *PROTEIN kinase C, *T cell receptors, *PRIMARY cell culture, *HISTONE deacetylase

Relationships between Neutralization, Binding, and ADCC of Broadly Neutralizing Antibodies against Reservoir HIV.

Authors: Yanqin Ren¹, Korom, Maria², Ward, Adam R.^1,2, Truong, Ronald², Chan, Dora², Szu-Han Huang^1,2, Kovacs, Colin M.³, Benko, Erika³, Safrit, Jeffrey T.⁴, John Lee⁴, Garbán, Hermes⁵, Lynch, Rebecca², Jones, R. Brad¹ rbjones@med.cornell.edu

Source: Journal of Virology. 2021, Vol. 95 Issue 2, p1-4. 4p.

Subject Terms: *HIV, *IMMUNOGLOBULINS, *ANTIBODY-dependent cell cytotoxicity, *RESERVOIRS, *SIMIAN immunodeficiency virus

Selective BCL-XL Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs.

Authors: Yanqin Ren¹, Szu Han Huang¹, Macedo, Amanda B.², Ward, Adam R.^1,2, Alberto, Winiffer D. Conce¹, Klevorn, Thais¹, Leyre, Louise¹, Copertino, Dennis C.¹, Mota, Talia M.¹, Dora Chan², Truong, Ronald², Rohwetter, Thomas², Zumbo, Paul^3,4, Dündar, Friederike^3,4, Betel, Doron^3,4,5, Kovacs, Colin⁶, Benko, Erika⁶, Bosque, Alberto², Jones, R. Brad^1,2

Source: Journal of Virology. Aug2021, Vol. 95 Issue 15, p1-20. 20p.

Subject Terms: *HIV, *T cells, *BCL-2 proteins, *CELL survival, *CELL death, *ANTIRETROVIRAL agents, *HIV infections