Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

Authors: Chan, Chris Chun-Yiu, Guo, Qian, Chan, Jasper Fuk-Woo, Tang, Kaiming, Cai, Jian-Piao, Chik, Kenn Ka-Heng, Huang, Yixin, Dai, Mei, Qin, Bo, Ong, Chon Phin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Wen, Lei, Tsang, Jessica Oi-Ling, Wang, Tong-Yun, Xie, Yubin, Qin, Zhenzhi, Cao, Jianli, Ye, Zi-Wei, Chu, Hin, To, Kelvin Kai-Wang, Ge, Xing-Yi, Ni, Tao, Jin, Dong-Yan, Cui, Sheng, Yuen, Kwok-Yung, Yuan, Shuofeng

Source: In Acta Pharmaceutica Sinica B September 2024 14(9):4028-4044

SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike–mediated cell-to-cell fusion

Authors: Zhang, Yu-Yuan, Liang, Ronghui, Wang, Shu-Jie, Ye, Zi-Wei, Wang, Tong-Yun, Chen, Meng, Liu, Jianbo, Na, Lei, Yang, Yue-Lin, Yang, Yong-Bo, Yuan, Shuofeng, Yin, Xin, Cai, Xue-Hui, Tang, Yan-Dong

Source: In Journal of Biological Chemistry November 2022 298(11)

Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species

Authors: Zhang, Hong-Liang, Li, Yu-Ming, Sun, Jing, Zhang, Yu-Yuan, Wang, Tong-Yun, Sun, Ming-Xia, Wang, Meng-Hang, Yang, Yue-Lin, Hu, Xiao-Liang, Tang, Yan-Dong, Zhao, Jincun, Cai, Xuehui

Source: In Journal of Biological Chemistry January-June 2021 296

A novel viral vaccine platform based on engineered transfer RNA

Authors: Wang, Tong-Yun, Meng, Fan-Dan, Sang, Guo-Ju, Zhang, Hong-Liang, Tian, Zhi-Jun, Zheng, Hao, Cai, Xue-Hui, Tang, Yan-Dong

Source: Emerging microbes & infections. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193509778.0x000001&indx=1&recIds=ETOCvdc_100193509778.0x000001

Comparative analysis of SARS‐CoV‐2 Omicron BA.2.12.1 and BA.5.2 variants

Authors: Ong, Chon Phin, Ye, Zi‐Wei, Tang, Kaiming, Liang, Ronghui, Xie, Yubin, Zhang, Hongzhuo, Qin, Zhenzhi, Sun, Haoran, Wang, Tong‐Yun, Cheng, Yun, Chu, Hin, Chan, Jasper F.‐W., Jin, Dong‐Yan, Yuan, Shuofeng

Source: Journal of medical virology. 95(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173011640.0x000001&indx=1&recIds=ETOCvdc_100173011640.0x000001

The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis

Authors: Wang, Tong-Yun, Fang, Qiong-Qiong, Cong, Feng, Liu, Yong-Gang, Wang, Hai-Ming, Zhang, Hong-Liang, Tian, Zhi-Jun, Tang, Yan-Dong, Cai, Xue-Hui

Source: Emerging microbes & infections. 8(1):1501-1510

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094548319.0x000001&indx=1&recIds=ETOCvdc_100094548319.0x000001

Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology.

Authors: Wang, Tong-Yun¹ (AUTHOR) sdndwty@163.com, Sang, Guo-Ju² (AUTHOR) 18438615167@139.com, Wang, Qian¹ (AUTHOR) wangqian@caas.cn, Leng, Chao-Liang³ (AUTHOR) lenghan1223@126.com, Tian, Zhi-Jun¹ (AUTHOR) tianzhijun@caas.cn, Peng, Jin-Mei¹ (AUTHOR) pengjinmei@caas.cn, Wang, Shu-Jie¹ (AUTHOR) wangshujie@caas.cn, Sun, Ming-Xia¹ (AUTHOR) sunmingxia@caas.cn, Meng, Fan-Dan¹ (AUTHOR) mengfandan@caas.cn, Zheng, Hao² (AUTHOR) haozheng@shvri.ac.cn, Cai, Xue-Hui¹ (AUTHOR) haozheng@shvri.ac.cn, Tang, Yan-Dong¹ (AUTHOR) haozheng@shvri.ac.cn

Source: Viruses (1999-4915). Mar2022, Vol. 14 Issue 3, p572-572. 12p.

Subject Terms: *GENETIC code, *AUJESZKY'S disease virus, *ORTHOGONAL systems, *AUTOMATIC control systems, *VACCINE effectiveness, *TRANSFER RNA

Isobavachalcone inhibits post-entry stages of the porcine reproductive and respiratory syndrome virus life cycle

Authors: Wang, Hai-Ming, Liu, Tian-Xin, Wang, Tong-Yun, Wang, Gang, Liu, Yong-Gang, Liu, Si-Guo, Tang, Yan-Dong, Cai, Xue-Hui

Source: Archives of virology. 163(5):1263-1270

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118405774.0x000001&indx=1&recIds=ETOCvdc_100118405774.0x000001

CRISPR/Cas9‐mediated 2‐sgRNA cleavage facilitates Pseudorabies virus editing

Authors: Tang, Yan‐Dong, Guo, Jin‐Chao, Wang, Tong‐Yun, Zhao, Kuan, Liu, Ji‐Ting, Gao, Jia‐Cong, Tian, Zhi‐Jun, An, Tong‐Qing, Cai, Xue‐Hui

Source: FASEB journal. 32(8):4293-4301

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103531891.0x000001&indx=1&recIds=ETOCvdc_100103531891.0x000001

Live attenuated pseudorabies virus developed using the CRISPR/Cas9 system

Authors: Tang, Yan-Dong, Liu, Ji-Ting, Wang, Tong-Yun, An, Tong-Qing, Sun, Ming-Xia, Wang, Shu-Jie, Fang, Qiong-Qiong, Hou, Lin-lin, Tian, Zhi-Jun, Cai, Xue-Hui

Source: In Virus Research 2 October 2016 225:33-39

Genomic analyses reveal that partial sequence of an earlier pseudorabies virus in China is originated from a Bartha-vaccine-like strain

Authors: Ye, Chao, Guo, Jin-Chao, Gao, Jia-Cong, Wang, Tong-Yun, Zhao, Kuan, Chang, Xiao-Bo, Wang, Qian, Peng, Jin-Mei, Tian, Zhi-Jun, Cai, Xue-Hui, Tong, Guang-Zhi, An, Tong-Qing

Source: In Virology April 2016 491:56-63

Comparison of Pathogenicity-Related Genes in the Current Pseudorabies Virus Outbreak in China

Authors: Tang, Yan-Dong, Liu, Ji-Ting, Wang, Tong-Yun, Sun, Ming-Xia, Tian, Zhi-Jun, Cai, Xue-Hui

Source: Scientific reports. 7(1):1-6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174881381.0x000001&indx=1&recIds=ETOCvdc_100174881381.0x000001

Open reading frames 1a and 1b of the porcine reproductive and respiratory syndrome virus (PRRSV) collaboratively initiate viral minus-strand RNA synthesis

Authors: Tang, Yan-Dong, Fang, Qiong-Qiong, Liu, Ji-Ting, Wang, Tong-Yun, Wang, Yu, Tao, Ye, Liu, Yong-gang, Cai, Xue-Hui

Source: Biochemical and biophysical research communications. 477(4):927-931

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100066165559.0x000001&indx=1&recIds=ETOCvdc_100066165559.0x000001

Isobavachalcone inhibits Pseudorabies virus by impairing virus-induced cell-to-cell fusion

Authors: Wang, Yu, Liu, Tian-Xin, Wang, Tong-Yun, Tang, Yan-Dong, Wei, Ping

Source: Virology journal. 17(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164913351.0x000001&indx=1&recIds=ETOCvdc_100164913351.0x000001

CRISPR-Cas13d Exhibits Robust Antiviral Activity Against Seneca Valley Virus.

Authors: Zhang, Yu-Yuan, Sun, Ming-Xia, Lian, Yuexiao, Wang, Tong-Yun, Jia, Mei-Yu, Leng, Chaoliang, Chen, Meng, Bai, Yuan-Zhe, Meng, Fandan, Cai, Xue-Hui, Tang, Yan-Dong

Source: Frontiers in Microbiology; 2/14/2022, Vol. 13, p1-6, 6p

Subject Terms: ANTIVIRAL agents, INFECTIOUS disease transmission, SWINE industry, ACTINOBACILLUS pleuropneumoniae, VIRUSES, INFECTION control, EPIDEMICS

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Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65.

Authors: Wang, Tong-Yun¹ (AUTHOR) sdndwty@163.com, Yang, Yue-Lin¹ (AUTHOR) 15663830363@163.com, Feng, Cong² (AUTHOR) congfeng521@126.com, Sun, Ming-Xia¹ (AUTHOR) qzsmx122@163.com, Peng, Jin-Mei¹ (AUTHOR) peng_jinmei@126.com, Tian, Zhi-Jun¹ (AUTHOR) tianzhijun@caas.cn, Tang, Yan-Dong¹ (AUTHOR) tianzhijun@caas.cn, Cai, Xue-Hui¹ (AUTHOR) tianzhijun@caas.cn

Source: Viruses (1999-4915). Jan2020, Vol. 12 Issue 1, p51-51. 1p.

Subject Terms: *AUJESZKY'S disease virus, *TRANSCRIPTION factors, *NATURAL immunity, *PROTEASOMES

Experimental Investigation on the Behavior of Hollow GFRP Pipes Subjected to Transverse Impact

Authors: Xiong, De Xin, Wang, Tong Yun, Liew, Jat Yuen Richard

Source: Advanced Materials Research; June 2015, Vol. 1110 Issue: 1 p36-39, 4p