Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials.

Authors: Norton, Hillary, Sliwinska-Stanczyk, Paula, Hala, Tomas, El-Zorkany, Bassel, Stockert, Lori, Mundayat, Rajiv, Wang, Lisy, Ritchlin, Christopher T.

Source: Rheumatology & Therapy; Feb2025, Vol. 12 Issue 1, p67-84, 18p

Subject Terms: ANKYLOSING spondylitis, BODY mass index, TUMOR necrosis factors, JOINT diseases, C-reactive protein

Determinants of tofacitinib discontinuation in adult patients with rheumatoid arthritis during long-term extension studies up to 9.5 years.

Authors: Curtis, Jeffrey R, Wollenhaupt, Jürgen, Tas, Sander W, Chatzidionysiou, Katerina, Wang, Lisy, Roberts, Kevin, Tsekouras, Vassilis

Source: Rheumatology Advances in Practice; 2024, Vol. 8 Issue 2, p1-10, 10p

Subject Terms: RHEUMATOID arthritis, INFLAMMATION, PHARMACOLOGY

Tofacitinib Efficacy in Patients with Rheumatoid Arthritis and Probable Depression/Anxiety: Post Hoc Analysis of Phase 3 and 3b/4 Randomized Controlled Trials.

Authors: Citera, Gustavo, Jain, Rakesh, Irazoque, Fedra, Madariaga, Hugo, Gruben, David, Wang, Lisy, Stockert, Lori, Santana, Karina, Ebrahim, Abbas, Ponce de Leon, Dario

Source: Rheumatology & Therapy; Feb2024, Vol. 11 Issue 1, p35-50, 16p

Subject Terms: GENERALIZED anxiety disorder, RHEUMATOID arthritis, ANXIETY disorders, JOINT pain, MENTAL depression, BLOOD sedimentation, ANXIETY

Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start.

Authors: Ciurea, Adrian, Distler, Oliver, Kwok, Kenneth, Jo, Hyejin, Wang, Lisy, Killeen, Tim, Ospelt, Caroline, Frank Bertoncelj, Mojca

Source: Arthritis Research & Therapy; 9/29/2023, Vol. 25 Issue 1, p1-11, 11p

The effect of tofacitinib on residual pain in patients with rheumatoid arthritis and psoriatic arthritis.

Authors: Dougados, Maxime, Taylor, Peter C., Bingham III, Clifton O., Fallon, Lara, Brault, Yves, Roychoudhury, Satrajit, Wang, Lisy, Kessouri, Meriem

Source: RMD Open; Dec2022, Vol. 8 Issue 2, p1-11, 11p

Effect of tofacitinib on pain, fatigue, health-related quality of life and work productivity in patients with active ankylosing spondylitis: results from a phase III, randomised, double-blind, placebo-controlled trial.

Authors: Navarro-Compán, Victoria, Cheng-Chung Wei, James, Van den Bosch, Filip, Magrey, Marina, Wang, Lisy, Fleishaker, Dona, Cappelleri, Joseph C., Cunshan Wang, Wu, Joseph, Dina, Oluwaseyi, Fallon, Lara, Strand, Vibeke

Source: RMD Open; Dec2022, Vol. 8 Issue 2, p1-13, 13p

Functional Assessment of Chronic Illness Therapy-Fatigue is a reliable and valid measure in patients with active ankylosing spondylitis.

Authors: Cella, David, Lenderking, William R., Chongpinitchai, Peter, Bushmakin, Andrew G., Dina, Oluwaseyi, Wang, Lisy, Cappelleri, Joseph C., Navarro-Compán, Victoria

Source: Journal of Patient-Reported Outcomes; 9/23/2022, Vol. 6 Issue 1, p1-10, 10p

Subject Terms: WELL-being, RESEARCH evaluation, STATISTICAL reliability, ANKYLOSING spondylitis, RANDOMIZED controlled trials, CRONBACH'S alpha, PSYCHOMETRICS, RESEARCH funding, QUESTIONNAIRES, DESCRIPTIVE statistics, QUALITY of life, BLIND experiment, INTRACLASS correlation, REPEATED measures design, FATIGUE (Physiology), STATISTICAL sampling, STATISTICAL correlation, LONGITUDINAL method

Frequency and Duration of Early Non-serious Adverse Events in Patients with Rheumatoid Arthritis and Psoriatic Arthritis Treated with Tofacitinib.

Authors: Dikranian, Ara, Gold, David, Bessette, Louis, Nash, Peter, Azevedo, Valderilio F., Wang, Lisy, Woolcott, John, Shapiro, Andrea B., Szumski, Annette, Fleishaker, Dona, Wollenhaupt, Jürgen

Source: Rheumatology & Therapy; Apr2022, Vol. 9 Issue 2, p411-433, 23p

Subject Terms: PSORIATIC arthritis, RHEUMATOID arthritis, TERMINATION of treatment, ABDOMINAL pain, KINASE inhibitors, ANTIRHEUMATIC agents

Effect of dose adjustments on the efficacy and safety of tofacitinib in patients with rheumatoid arthritis: a post hoc analysis of an open-label, long-term extension study (ORAL Sequel).

Authors: Mueller, Ruediger B., Schulze-Koops, Hendrik, Furst, Daniel E., Cohen, Stanley B., Kwok, Kenneth, Wang, Lisy, Killeen, Tim, von Kempis, Johannes

Source: Clinical Rheumatology; Apr2022, Vol. 41 Issue 4, p1045-1055, 11p

Subject Terms: RHEUMATOID arthritis, PATIENT safety, BLOOD sedimentation

Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Authors: Wang, Ellen Q., Le, Vu, Winton, Jennifer A., Tripathy, Sakambari, Raje, Sangeeta, Wang, Lisy, Dowty, Martin E., Malhotra, Bimal K.

Source: Journal of Clinical Pharmacology; Apr2022, Vol. 62 Issue 4, p505-519, 15p

Subject Terms: DRUG efficacy, EXPERIMENTAL design, CLINICAL trials, KIDNEY function tests, CONFIDENCE intervals, ORAL drug administration, KIDNEY failure, JANUS kinases, COMPARATIVE studies, ATOPIC dermatitis, DESCRIPTIVE statistics, NEUROTRANSMITTER uptake inhibitors, METABOLITES, EVALUATION

Incidence Rates of Interstitial Lung Disease Events in Tofacitinib-Treated Rheumatoid Arthritis Patients: Post Hoc Analysis From 21 Clinical Trials.

Authors: Citera, Gustavo, Mysler, Eduardo, Madariaga, Hugo, Cardiel, Mario H., Castañeda, Oswaldo, Fischer, Aryeh, Richette, Pascal, Chartrand, Sandra, Park, Jin Kyun, Strengholt, Sander, Rivas, Jose L., Thorat, Amit V., Girard, Tanya, Kwok, Kenneth, Wang, Lisy, Ponce de Leon, Dario

Source: JRC: Journal of Clinical Rheumatology; Dec2021, Vol. 27 Issue 8, pe482-e490, 9p

Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Authors: Wang, Ellen Q., Le, Vu, O'Gorman, Melissa, Tripathy, Sakambari, Dowty, Martin E., Wang, Lisy, Malhotra, Bimal K.

Source: Journal of Clinical Pharmacology; Oct2021, Vol. 61 Issue 10, p1311-1323, 13p

Subject Terms: EXPERIMENTAL design, CONFIDENCE intervals, DRUG tolerance, CLINICAL trials, JANUS kinases, LIVER diseases, DESCRIPTIVE statistics, NEUROTRANSMITTER uptake inhibitors, ODDS ratio, PATIENT safety, METABOLITES, LONGITUDINAL method

Geographic Terms: UNITED States

Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study.

Authors: Deodhar, Atul, Sliwinska-Stanczyk, Paula, Huji X, Baraliakos, Xenofon, Gensler, Lianne S., Fleishaker, Dona, Wang, Lisy, Wu, Joseph, Menon, Sujatha, Cunshan Wang, Dina, Oluwaseyi, Fallon, Lara, Kanik, Keith S., van der Heijde, Désirée, Xu, Huji, Wang, Cunshan

Source: Annals of the Rheumatic Diseases; Aug2021, Vol. 80 Issue 8, p1004-1013, 10p

Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials.

Authors: Panaccione, Remo, Isaacs, John D., Chen, Lea Ann, Wang, Wenjin, Marren, Amy, Kwok, Kenneth, Wang, Lisy, Chan, Gary, Su, Chinyu

Source: Digestive Diseases & Sciences; Aug2021, Vol. 66 Issue 8, p2732-2743, 12p

Subject Terms: CREATINE kinase, ULCERATIVE colitis, CLINICAL trials, PSORIATIC arthritis, INFLAMMATORY bowel diseases, MESALAMINE

Assessment of radiographic progression in patients with rheumatoid arthritis treated with tofacitinib in long-term studies.

Authors: Heijde, Désirée van der, Landewé, Robert B M, Wollenhaupt, Jürgen, Strengholt, Sander, Terry, Ketti, Kwok, Kenneth, Wang, Lisy, Cohen, Stanley

Source: Rheumatology; Apr2021, Vol. 60 Issue 4, p1708-1716, 9p

Subject Terms: DISEASE progression, COMBINATION drug therapy, JANUS kinases, ANTIRHEUMATIC agents, RHEUMATOID arthritis, DESCRIPTIVE statistics, QUESTIONNAIRES, NEUROTRANSMITTER uptake inhibitors

Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme.

Authors: Cohen, Stanley B., Yoshiya Tanaka, Mariette, Xavier, Curtis, Jeffrey R., Eun Bong Lee, Nash, Peter, Winthrop, Kevin L., Charles-Schoeman, Christina, Wang, Lisy, Chen, Connie, Kwok, Kenneth, Biswas, Pinaki, Shapiro, Andrea, Madsen, Ann, Wollenhaupt, Jürgen

Source: RMD Open; 10/30/2020, p1-15, 15p

Re-establishment of efficacy of tofacitinib, an oral JAK inhibitor, after temporary discontinuation in patients with rheumatoid arthritis.

Authors: Kaine, Jeffrey, Tesser, John, Takiya, Liza, DeMasi, Ryan, Wang, Lisy, Snyder, Mark, Soma, Koshika, Fan, Haiyun, Bandi, Vara, Wollenhaupt, Jürgen

Source: Clinical Rheumatology; Jul2020, Vol. 39 Issue 7, p2127-2137, 11p, 4 Charts, 2 Graphs

Subject Terms: RHEUMATOID arthritis, CLINICAL trial registries, ABATACEPT, BLOOD sedimentation, TERMINATION of treatment, PATIENT safety

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