A Randomized Phase 2 Trial of Nivolumab Versus Nivolumab-Ipilimumab Combination in EGFR-Mutant NSCLC

Authors: Gillianne G.Y. Lai, MBBS, Jia Chi Yeo, PhD, Amit Jain, MBBS, PhD, Siqin Zhou, MSc, Mengyuan Pang, MSc, Jacob J.S. Alvarez, BSc, Ngak Leng Sim, BCS, Aaron C. Tan, MBBS, FRACP, PhD, Lisda Suteja, BSc, Tze Wei Lim, BSc, Yu Amanda Guo, PhD, Meixin Shen, PhD, Stephanie P.L. Saw, MBBS, Neha Rohatgi, BSc, Joe P.S. Yeong, MBBS, PhD, Angela Takano, MBBS, Kiat Hon Lim, MBBS, Apoorva Gogna, MBBS, Chow Wei Too, MBBS, Kun Da Zhuang, MBBS, Wan Ling Tan, MBBS, Ravindran Kanesvaran, MBBS, Quan Sing Ng, MBBS, Mei Kim Ang, MBBS, Tanujaa Rajasekaran, MBBS, Lanying Wang, MBBS, Chee Keong Toh, MBBS, Wan-Teck Lim, MBBS, Wai Leong Tam, PhD, Sze Huey Tan, PhD, Anders M.J. Skanderup, PhD, Eng-Huat Tan, MBBS, Daniel S.W. Tan, BSc, MBBS, MRCP, PhD

Source: JTO Clinical and Research Reports, Vol 3, Iss 12, Pp 100416- (2022)

Subject Terms: Lung cancer, Epidermal growth factor receptor, Immunotherapy, Biomarkers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666364322001400; https://doaj.org/toc/2666-3643

Access URL: https://doaj.org/article/7d3ef7d52e0641cbadf717aeaf522b4b

Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer

Authors: Say Li Kong, Xingliang Liu, Swee Jin Tan, Joyce A. Tai, Ler Yee Phua, Huay Mei Poh, Trifanny Yeo, Yong Wei Chua, Yu Xuan Haw, Wen Huan Ling, Raymond Chee Hui Ng, Tira J. Tan, Kiley Wei Jen Loh, Daniel Shao-Weng Tan, Quan Sing Ng, Mei Kim Ang, Chee Keong Toh, Yi Fang Lee, Chwee Teck Lim, Tony Kiat Hon Lim, Axel M. Hillmer, Yoon Sim Yap, Wan-Teck Lim

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: circulating tumor cells, cell-free tumor DNA, amplicon-sequencing, metastatic signatures, genomic heterogeneity, evolving alterations, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.698551/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/b70ad78864ef47c3b413d596470674f7

Cost effectiveness analysis of afatinib versus pemetrexed-cisplatin for first-line treatment of locally advanced or metastatic EGFR mutation positive non-small-cell lung cancer from the Singapore healthcare payer’s perspective

Authors: Ping-Tee Tan, Mohamed Ismail Abdul Aziz, Fiona Pearce, Wan-Teck Lim, David Bin-Chia Wu, Kwong Ng

Source: BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-018-4223-y; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/a648f17157914f9e908b6b4c5c736c8c

Primary pulmonary lymphoepithelioma-like carcinoma in Singapore

Authors: Chee Kiang Tay, Yang Chong Chua, Angela Takano, Madeline Yen Min Chee, Wan-Teck Lim, Cindy Lim, Mariko Siyue Koh

Source: Annals of Thoracic Medicine, Vol 13, Iss 1, Pp 30-35 (2018)

Subject Terms: Lung, lymphoepithelioma-like cancer, prognosis, stage, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2018;volume=13;issue=1;spage=30;epage=35;aulast=Tay; https://doaj.org/toc/1817-1737; https://doaj.org/toc/1998-3557

Access URL: https://doaj.org/article/9c4010aa7e4d44249b34b529c52d5961

Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing

Authors: Rahul Nahar, Weiwei Zhai, Tong Zhang, Angela Takano, Alexis J. Khng, Yin Yeng Lee, Xingliang Liu, Chong Hee Lim, Tina P. T. Koh, Zaw Win Aung, Tony Kiat Hon Lim, Lavanya Veeravalli, Ju Yuan, Audrey S. M. Teo, Cheryl X. Chan, Huay Mei Poh, Ivan M. L. Chua, Audrey Ann Liew, Dawn Ping Xi Lau, Xue Lin Kwang, Chee Keong Toh, Wan-Teck Lim, Bing Lim, Wai Leong Tam, Eng-Huat Tan, Axel M. Hillmer, Daniel S. W. Tan

Source: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/358b10958e814ff3ae9b2917b6e35d5b

An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer

Authors: Su Bin LIM, Swee Jin TAN, Wan-Teck LIM, Chwee Teck LIM

Source: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1415769e294f48ad9e9ce5914015f9ba

HepScope: CNN-based single-cell discrimination of malignant hepatocytes

Authors: Yunjin Go, Jestlin Tianthing Ng, Darren Wan-Teck Lim, Su Bin Lim

Source: Journal of Big Data, Vol 11, Iss 1, Pp 1-28 (2024)

Subject Terms: Hepatocellular carcinoma, Biomarkers, Artificial intelligence, Single cell RNA-seq, Spatial transcriptomics, Convolution neural network, Computer engineering. Computer hardware, TK7885-7895, Information technology, T58.5-58.64, Electronic computers. Computer science, QA75.5-76.95

File Description: electronic resource

Relation: https://doaj.org/toc/2196-1115

Access URL: https://doaj.org/article/49d4a783d21542e4a48efc9d79727e60

Phase I Study of Oral Vinorelbine in Combination with Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Using Two Different Schedules.

Authors: Natalia Sutiman, Zhenxian Zhang, Eng Huat Tan, Mei Kim Ang, Shao-Weng Daniel Tan, Chee Keong Toh, Quan Sing Ng, Balram Chowbay, Wan-Teck Lim

Source: PLoS ONE, Vol 11, Iss 5, p e0154316 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4852941?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/150bd87ff00e4b54bbb6e78a4be7f732

Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers

Authors: Yuan Chen, Li Zhang, Xingjie Wu, Xuecheng Sun, Noah R. Sundah, Chi Yan Wong, Auginia Natalia, John K. C. Tam, Darren Wan-Teck Lim, Balram Chowbay, Beng Ti Ang, Carol Tang, Tze Ping Loh, Huilin Shao

Source: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1205fa90508243ea8bd82a8fd32f8525

Assessment of Quality of Life in Advanced-Stage Lung Cancer Patients Using EORTC QLQ-C30 Questionnaire

Authors: Ariantika Ariantika, Rahayu Lubis, Asfriyati Asfriyati, Taufik Ashar, Nurmaini Nurmaini, Noni Novisari Soeroso, Kamal Basri Siregar, Darren Wan-Teck Lim

Source: Jurnal Respirasi, Vol 10, Iss 3, Pp 228-235 (2024)

Subject Terms: cancer, eortc qlq-c30, lung cancer, prognostic factors, quality of life, Medicine

File Description: electronic resource

Relation: https://e-journal.unair.ac.id/JR/article/view/59360; https://doaj.org/toc/2407-0831; https://doaj.org/toc/2621-8372

Access URL: https://doaj.org/article/8f66a92efbff4e15929efc126e9227e9

Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.

Authors: Bee Luan Khoo, Majid Ebrahimi Warkiani, Daniel Shao-Weng Tan, Ali Asgar S Bhagat, Darryl Irwin, Dawn Pingxi Lau, Alvin S T Lim, Kiat Hon Lim, Sai Sakktee Krisna, Wan-Teck Lim, Yoon Sim Yap, Soo Chin Lee, Ross A Soo, Jongyoon Han, Chwee Teck Lim

Source: PLoS ONE, Vol 9, Iss 7, p e99409 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24999991/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/03951ce56787415fbd46f96bac1202e5

CYP2A6 Genetic Polymorphism and Nicotine Metabolism of Male Smokers in Indonesia

Authors: Chaliza Soliha, Noni Novisari Soeroso, Fannie Rizki Ananda, Rozaimah Zain-Hamid, Syamsul Bihar, Darren Wan-Teck Lim

Source: Jurnal Respirasi, Vol 10, Iss 2, Pp 93-98 (2024)

Subject Terms: cyp2a6, hplc, human & health, nicotine metabolism, pcr-rflp, Medicine

File Description: electronic resource

Relation: https://e-journal.unair.ac.id/JR/issue/view/2644; https://doaj.org/toc/2407-0831; https://doaj.org/toc/2621-8372

Access URL: https://doaj.org/article/6f2fcfb93ac14d968b6b71b2938af08a

Combinatorial hypofractionated radiotherapy and pembrolizumab in anaplastic thyroid cancer

Authors: Janice Ser Huey Tan, Timothy Kwang Yong Tay, Enya Hui Wen Ong, Michael Fehlings, Daniel Shao-Weng Tan, Nadiah Binte Sukma, Eileen Xueqin Chen, Jen-Hwei Sng, Connie Siew Poh Yip, Kok Hing Lim, Darren Wan-Teck Lim, Narayanan Gopalakrishna Iyer, Jacqueline Siok Gek Hwang, Melvin Lee Kiang Chua, Mei-Kim Ang

Source: European Thyroid Journal, Vol 13, Iss 1, Pp 1-10 (2024)

Subject Terms: hypofractionated radiotherapy, immunotherapy, anaplastic thyroid cancer, quad-shot, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://etj.bioscientifica.com/view/journals/etj/13/1/ETJ-23-0144.xml; https://doaj.org/toc/2235-0802

Access URL: https://doaj.org/article/bcbd473df09d426dac1f9589976fe55d

Canakinumab in combination with docetaxel compared with docetaxel alone for the treatment of advanced non-small cell lung cancer following platinum-based doublet chemotherapy and immunotherapy (CANOPY-2): A multicenter, randomized, double-blind, phase 3 trial

Authors: Paz-Ares, Luis, Goto, Yasushi, Wan-Teck Lim, Darren, Halmos, Balazs, Chul Cho, Byoung, Cobo, Manuel, Luis González Larriba, José, Zhou, Caicun, Demedts, Ingel, Atmaca, Akin, Baka, Sofia, Mookerjee, Bijoyesh, Portella, Socorro, Zhu, Zewen, Wu, Jincheng, Demanse, David, Dharan, Bharani, Reck, Martin

Source: In Lung Cancer March 2024 189

Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer

Authors: Ning-Yuan Lee, Melissa Hum, Sabna Zihara, Lanying Wang, Matthew K. Myint, Darren Wan-Teck Lim, Chee-Keong Toh, Anders Skanderup, Jens Samol, Min-Han Tan, Peter Ang, Soo-Chin Lee, Eng-Huat Tan, Gillianne G. Y. Lai, Daniel S. W. Tan, Yoon-Sim Yap, Ann S. G. Lee

Source: Human Genomics, Vol 17, Iss 1, Pp 1-15 (2023)

Subject Terms: Multiple primary cancers, Breast cancer, Lung cancer, Whole-exome sequencing, Germline variants, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1479-7364

Access URL: https://doaj.org/article/606c22b537b34d029e0606d233c3a1b7

Correction: Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer

Authors: Ning-Yuan Lee, Melissa Hum, Sabna Zihara, Lanying Wang, Matthew K. Myint, Darren Wan-Teck Lim, Chee-Keong Toh, Anders Skanderup, Jens Samol, Min-Han Tan, Peter Ang, Soo-Chin Lee, Eng-Huat Tan, Gillianne G. Y. Lai, Daniel S. W. Tan, Yoon-Sim Yap, Ann S. G. Lee

Source: Human Genomics, Vol 17, Iss 1, Pp 1-3 (2023)

Subject Terms: Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1479-7364

Access URL: https://doaj.org/article/e9e788a2a8014f09833d11de0c9d51dd

IMpower150 Final Exploratory Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in Key NSCLC Patient Subgroups With EGFR Mutations or Metastases in the Liver or Brain

Authors: Nogami, Naoyuki, Barlesi, Fabrice, Socinski, Mark A., Reck, Martin, Thomas, Christian A., Cappuzzo, Federico, Mok, Tony S.K., Finley, Gene, Aerts, Joachim G., Orlandi, Francisco, Moro-Sibilot, Denis, Jotte, Robert M., Stroyakovskiy, Daniil, Villaruz, Liza C., Rodríguez-Abreu, Delvys, Wan-Teck Lim, Darren, Merritt, David, Coleman, Shelley, Lee, Anthony, Shankar, Geetha, Yu, Wei, Bara, Ilze, Nishio, Makoto

Source: In Journal of Thoracic Oncology February 2022 17(2):309-323

Circulating Biomarkers for Prediction of Immunotherapy Response in NSCLC

Authors: Kah Yee Goh, Terence You De Cheng, Su Chin Tham, Darren Wan-Teck Lim

Source: Biomedicines, Vol 11, Iss 2, p 508 (2023)

Subject Terms: liquid biopsy, biomarkers, immunotherapy, checkpoint inhibition, lung cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/2/508; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/633940801cbf47fbaec9f11f67913c24

Detection of circulating tumor DNA with ultradeep sequencing of plasma cell-free DNA for monitoring minimal residual disease and early detection of recurrence in earlystage lung cancer.

Authors: Tan, Aaron C., Lai, Gillianne G. Y., Saw, Stephanie P. L., Chua, Kevin L. M., Takano, Angela, Ong, Boon-Hean, Koh, Tina P. T., Jain, Amit, Wan Ling Tan, Quan Sing Ng, Kanesvaran, Ravindran, Rajasekaran, Tanujaa, Kalashnikova, Ekaterina, Renner, Derrick, Sudhaman, Sumedha, Malhotra, Meenakshi, Sethi, Himanshu, Liu, Minetta C., Aleshin, Alexey, Wan-Teck Lim

Source: Cancer (0008543X); 5/15/2024, Vol. 130 Issue 10, p1758-1765, 8p

Subject Terms: CIRCULATING tumor DNA, CELL-free DNA, EARLY diagnosis, LUNG cancer, DNA sequencing

P31-4 Differentiated omental-derived adipose stem cells-conditioned medium promotes ovarian cancer migration and angiogenesis

Authors: Tham, Su chin, De Cheng, Terence You, Goh, Kah Yee, Lau, Kah Weng, Wan-Teck Lim, Darren, Lim, Elaine Hsuen

Source: In Annals of Oncology July 2022 33 Supplement 6:S525-S525