Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial

Authors: David Cipolla, Jimin Zhang, Brice Korkmaz, James D. Chalmers, Jessica Basso, Daniel Lasala, Carlos Fernandez, Ariel Teper, Kevin C. Mange, Walter R. Perkins, Eugene J. Sullivan

Source: Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)

Subject Terms: Non-cystic fibrosis bronchiectasis, Brensocatib, Dipeptidyl peptidase-1 inhibitor, Neutrophil serine protease, Sputum biomarkers, Neutrophil elastase, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/85f654da54af4f9a8406df384ca1cca2

Brensocatib (an oral, reversible inhibitor of dipeptidyl peptidase-1) attenuates disease progression in two animal models of rheumatoid arthritis

Authors: Patrick P. McDonald, Franziska Graf Leifer, Jessica Basso, Dan Lasala, Dedong Li, Kuan-Ju Chen, Jimin Zhang, Walter R. Perkins, David C. Cipolla

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: DPP-1, cathepsin C, neutrophil serine proteases, inflammation, neutrophils, migration, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231047/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8bdd637f3aad40d9abb74d1bb722c196

Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice

Authors: Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, Yuchen Zhou, Patrick P. McDonald, Walter R. Perkins, David C. Cipolla

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: brensocatib, neutrophil serine proteases (NSP), lupus nephritis (LN), interferon-alpha (IFNα), systemic lupus erythematosus (SLE), DPP1 inhibitor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185727/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/39068ea155094654afda96d63a8b6583

Preclinical Investigation of a Lipoglycopeptide Dry Powder Inhalation Therapy for the Treatment of Pulmonary MRSA Infection

Authors: Donna M. Konicek, Adam J. Plaunt, Sachin Gharse, Sasha J. Rose, Arielle Dorfman, Amruta Sabnis, Thomas Baker, Helena Gauani, Donald Chun, Zhili Li, Walter R. Perkins, David Cipolla, Vladimir S. Malinin

Source: Pharmaceutics, Vol 15, Iss 9, p 2250 (2023)

Subject Terms: DPI, antibiotics, cystic fibrosis, MRSA, lipoglycopeptide, inhalation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/9/2250; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/489479d94ae3433599532bcbf80b551d

Effect of Inhalation Profile on Delivery of Treprostinil Palmitil Inhalation Powder

Authors: Helena Gauani, Thomas Baker, Zhili Li, Vladimir S. Malinin, Walter R. Perkins, Eugene J. Sullivan, David Cipolla

Source: Pharmaceutics, Vol 15, Iss 3, p 934 (2023)

Subject Terms: device performance, dry powder inhaler (DPI), fine particle dose (FPD), aerosol delivery, inhalation, treprostinil palmitil (TP), Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/3/934; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/901785b5f5b0470397f70a9f2a5e4176

Amikacin Liposome Inhalation Suspension (ALIS) Penetrates Non-tuberculous Mycobacterial Biofilms and Enhances Amikacin Uptake Into Macrophages

Authors: Jimin Zhang, Franziska Leifer, Sasha Rose, Dung Yu Chun, Jill Thaisz, Tracey Herr, Mary Nashed, Jayanthi Joseph, Walter R. Perkins, Keith DiPetrillo

Source: Frontiers in Microbiology, Vol 9 (2018)

Subject Terms: non-tuberculous mycobacteria, amikacin, biofilm, macrophage uptake, ALIS, LAI, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fmicb.2018.00915/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/813bad059d1045a89a6f173e71af11f6

Characterization of Nebulized Liposomal Amikacin (Arikace™) as a Function of Droplet Size.

Authors: Zhili Li, Yanling Zhang, William Wurtz, Jin K. Lee, Vladimir S. Malinin, Sripriya Durwas-Krishnan, Paul Meers, Walter R. Perkins

Source: Journal of Aerosol Medicine & Pulmonary Drug Delivery; Vol. 21 Issue 3, p245-254, 10p

Assessing a System to Capture Stray Aerosol duringInhalation of Nebulized Liposomal Cisplatin.

Authors: Bart P.H. Wittgen, Peter W.A. Kunst, Walter R. Perkins, Jin K. Lee, Pieter E. Postmus

Source: Journal of Aerosol Medicine; Fall2006, Vol. 19 Issue 3, p385-391, 7p