Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

Authors: Schmidt, Sven H., Weng, Jui-Hung, Aoto, Phillip C., Boassa, Daniela, Mathea, Sebastian, Silletti, Steve, Hu, Junru, Wallbott, Maximilian, Komives, Elizabeth A., Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jun 01. 118(23), 1-12.

Access URL: https://www.jstor.org/stable/27040869

PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies.

Authors: Taylor, Susan S.^1,2 staylor@ucsd.edu, Wallbott, Maximilian³, Machal, Erik M. F.³, Søberg, Kristoffer⁴, Ahmed, Faihaa⁵, Bruystens, Jessica², Lily Vu¹, Baker, Blaine¹, Jian Wu², Raimondi, Francesco⁶, Ongeri, Elimelda M.⁵, Herberg, Friedrich W.³, Skålhegg, Bjørn S.⁷

Source: Biochemical Journal. Jun2021, Vol. 478 Issue 11, p2101-2119. 19p.

Subject Terms: *CYCLIC-AMP-dependent protein kinase, *PATHOLOGY, *ADENOSINE monophosphate, *PROTEIN kinases, *EUKARYOTIC cells, *CELLULAR signal transduction

Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2.

Authors: Manschwetus, Jascha T., Wallbott, Maximilian, Fachinger, Alexandra, Obergruber, Claudia, Pautz, Sabine, Bertinetti, Daniela, Schmidt, Sven H., Herberg, Friedrich W.

Source: Frontiers in Neuroscience; 4/7/2020, p1-11, 11p

Subject Terms: DARDARIN, BINDING sites

Molecular Basis for Ser/Thr Specificity in PKA Signaling.

Authors: Knape, Matthias J.¹ (AUTHOR), Wallbott, Maximilian¹ (AUTHOR) maknape@googlemail.com, Burghardt, Nicole C. G.¹ (AUTHOR), Bertinetti, Daniela¹ (AUTHOR), Hornung, Jan¹ (AUTHOR), Schmidt, Sven H.¹ (AUTHOR), Lorenz, Robin¹ (AUTHOR) robin.lorenz@uni-kassel.de, Herberg, Friedrich W.¹ (AUTHOR) robin.lorenz@uni-kassel.de

Source: Cells (2073-4409). Jun2020, Vol. 9 Issue 6, p1548-1548. 1p.

Subject Terms: *CYCLIC-AMP-dependent protein kinase, *ADENINE, *SURFACE plasmon resonance, *PROTEIN kinases, *ADENINE nucleotides, *THREONINE, *PROTEIN kinase inhibitors

The Forgotten PKAs: New Insights Revealed by the First Crystal Structure of a PKA C Beta Splice Variant, Cβ4ab.

Authors: Bruystens, Jessica H., Wu, Jian, Wallbott, Maximilian, Bertinetti, Daniela, Herberg, Friedrich W., Taylor, Susan S.

Source: FASEB Journal; May2022 Supplement, Vol. 36, pN.PAG-N.PAG, 1p