Type 1 diabetes

Authors: Quattrin, Teresa, Mastrandrea, Lucy D, Walker, Lucy S K

Source: Lancet. 401(10394):2149-2162

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193631844.0x000001&indx=1&recIds=ETOCvdc_100193631844.0x000001

Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B–deficient mice

Authors: Mazharian, Alexandra, Maître, Blandine, Bornert, Alicia, Hennequin, Desline, Lourenco-Rodrigues, Marc, Geer, Mitchell J., Smith, Christopher W., Heising, Silke, Walter, Michaela, Montel, Florian, Walker, Lucy S. K., de la Salle, Henri, Watson, Steve P., Gachet, Christian, Senis, Yotis A.

Source: In Blood Advances 10 January 2023 7(1):46-59

CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner.

Authors: Lo, Jonathan W., Schroeder, Jan-Hendrik, Roberts, Luke B., Mohamed, Rami, Cozzetto, Domenico, Beattie, Gordon, Omer, Omer S., Ross, Ellen M., Heuts, Frank, Jowett, Geraldine M., Read, Emily, Madgwick, Matthew, Neves, Joana F., Korcsmaros, Tamas, Jenner, Richard G., Walker, Lucy S. K., Powell, Nick, Lord, Graham M.

Source: Nature Communications; 11/4/2024, Vol. 15 Issue 1, p1-17, 17p

Subject Terms: INNATE lymphoid cells, INFLAMMATORY bowel diseases, IMMUNE checkpoint proteins, GUT microbiome, CYTOTOXIC T lymphocyte-associated molecule-4

TIGIT⁺ Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre.

Authors: Edner, Natalie M., Houghton, Luke P., Ntavli, Elisavet, Rees-Spear, Chloe, Petersone, Lina, Chunjing Wang, Fabri, Astrid, Elfaki, Yassin, Gonzalez, Andrea Rueda, Brown, Rachel, Kisand, Kai, Peterson, Pärt, McCoy, Laura E., Walker, Lucy S. K.

Source: Frontiers in Immunology; 2024, p01-14, 14p

Subject Terms: ANTIBODY titer, T helper cells, B cells, ANTIBODY formation, PHENOTYPIC plasticity

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

Authors: Zhang, Yang, Tech, Laura, George, Laura A., Acs, Andreas, Durrett, Russell E., Hess, Henry, Walker, Lucy S. K., Tarlinton, David M., Fletcher, Anne L., Hauser, Anja Erika

Source: Journal of experimental medicine. 215(4):1227-1244

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615456352&indx=1&recIds=ETOCRN615456352

The immunology of type 1 diabetes

Authors: Herold, Kevan C., Delong, Thomas, Perdigoto, Ana Luisa, Biru, Noah, Brusko, Todd M., Walker, Lucy S. K.

Source: Nature Reviews Immunology; June 2024, Vol. 24 Issue: 6 p435-451, 17p

T-cell help in the germinal center: homing in on the role of IL-21.

Authors: Petersone, Lina¹ (AUTHOR) lina.petersone.15@ucl.ac.uk, Walker, Lucy S K¹ (AUTHOR) lucy.walker@ucl.ac.uk

Source: International Immunology. Mar2024, Vol. 36 Issue 3, p89-98. 10p.

Subject Terms: *GERMINAL centers, *T helper cells, *T cells, *HOME improvement centers, *OPTICAL polarization

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

Authors: Wang, Chun Jing, Heuts, Frank, Ovcinnikovs, Vitalijs, Wardzinski, Lukasz, Bowers, Chantelle, Schmidt, Emily M., Kogimtzis, Alexandros, Kenefeck, Rupert, Sansom, David M., Walker, Lucy S. K.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Jan . 112(2), 524-529.

Access URL: https://www.jstor.org/stable/26460469

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

Authors: Penaranda, Cristina, Kuswanto, Wilson, Hofmann, Jerry, Kenefeck, Rupert, Narendran, Parth, Walker, Lucy S. K., Blueston, Jeffrey A., Abbas, Abul K., Dooms, Hans

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Jul . 109(31), 12668-12673.

Access URL: https://www.jstor.org/stable/41685456

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity.

Authors: Wang, Chun Jing, Petersone, Lina, Edner, Natalie M., Heuts, Frank, Ovcinnikovs, Vitalijs, Ntavli, Elisavet, Kogimtzis, Alexandros, Fabri, Astrid, Elfaki, Yassin, Houghton, Luke P., Hosse, Ralf J., Schubert, David A., Frei, Andreas P., Ross, Ellen M., Walker, Lucy S. K.

Source: Nature Communications; 11/9/2022, Vol. 13 Issue 1, p1-12, 12p

Subject Terms: REGULATORY T cells, T cells, IMMUNOREGULATION, AUTOIMMUNITY, CD28 antigen

The link between circulating follicular helper T cells and autoimmunity

Authors: Walker, Lucy S. K.

Source: Nature Reviews Immunology; September 2022, Vol. 22 Issue: 9 p567-575, 9p

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Authors: Kennedy, Alan, Waters, Erin, Rowshanravan, Behzad, Hinze, Claudia, Williams, Cayman, Janman, Daniel, Fox, Thomas A., Booth, Claire, Pesenacker, Anne M., Halliday, Neil, Soskic, Blagoje, Kaur, Satdip, Qureshi, Omar S., Morris, Emma C., Ikemizu, Shinji, Paluch, Christopher, Huo, Jiandong, Davis, Simon J., Boucrot, Emmanuel, Walker, Lucy S. K., Sansom, David M.

Source: Nature Immunology; September 2022, Vol. 23 Issue: 9 p1365-1378, 14p

Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.

Authors: Attridge, Kesley¹, Walker, Lucy S. K.²

Source: Immunological Reviews. May2014, Vol. 259 Issue 1, p23-39. 17p.

Subject Terms: *HOMEOSTASIS, *T cells, *CD25 antigen, *CELL populations, *T cell receptors, *FORKHEAD transcription factors, *BIOMARKERS, *IMMUNE response

Targeting TFHcells in human diseases and vaccination: rationale and practice

Authors: Yu, Di, Walker, Lucy S. K., Liu, Zheng, Linterman, Michelle A., Li, Zhanguo

Source: Nature Immunology; 20220101, Issue: Preprints p1-12, 12p

CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4.

Authors: Halliday, Neil, Williams, Cayman, Kennedy, Alan, Waters, Erin, Pesenacker, Anne M., Soskic, Blagoje, Hinze, Claudia, Hou, Tie Zheng, Rowshanravan, Behzad, Janman, Daniel, Walker, Lucy S. K., Sansom, David M.

Source: Frontiers in Immunology; 12/8/2020, Vol. 11, pN.PAG-N.PAG, 13p

Subject Terms: SUPPRESSOR cells, CYTOTOXIC T lymphocyte-associated molecule-4, ANTIGEN presenting cells, HOMEOSTASIS, T cells

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.

Authors: Walker, Lucy S. K.¹, Sansom, David M.¹

Source: Nature Reviews Immunology. Dec2011, Vol. 11 Issue 12, p852-863. 12p. 5 Diagrams.

Subject Terms: *T cell receptors, *HOMEOSTASIS, *ANTIGEN presenting cells, *RECEPTOR-ligand complexes, *TYROSINE, *PHOSPHORYLATION

Regulatory T cells overturned: the effectors fight back.

Authors: Walker, Lucy S. K.¹ L.S.Walker@bham.ac.uk

Source: Immunology. Apr2009, Vol. 126 Issue 4, p466-474. 9p. 1 Diagram, 1 Chart.

Subject Terms: *T cells, *CELLULAR control mechanisms, *CELL populations, *IMMUNOSUPPRESSION, *AUTOIMMUNE diseases

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology.

Authors: Sansom, David M.¹ D.M.Sansom@bham.ac.uk, Walker, Lucy S. K.¹

Source: Immunological Reviews. Aug2006, Vol. 212 Issue 1, p131-148. 18p. 1 Diagram, 2 Graphs.

Subject Terms: *T cells, *LYMPHOCYTES, *ANTIGENS, *IMMUNITY, *IMMUNOLOGY

CTLA4 gene polymorphism and autoimmunity.

Authors: Gough, Stephen C. L.¹ s.c.gough@bham.ac.uk, Walker, Lucy S. K.², Sansom, David M.²

Source: Immunological Reviews. Apr2005, Vol. 204 Issue 1, p102-115. 14p. 2 Diagrams.

Subject Terms: *GENETIC polymorphisms, *AUTOIMMUNITY, *T cells, *CELL receptors, *IMMUNOLOGY

CD4⁺ CD25⁺ Treg: divide and rule?

Authors: Walker, Lucy S. K.¹ L.S.Walker@bham.ac.uk

Source: Immunology. Feb2004, Vol. 111 Issue 2, p129-137. 9p.

Subject Terms: *T cells, *CD4 antigen, *T cell receptors, *IMMUNOLOGY