β-catenin mediates endodermal commitment of human ES cells via distinct transactivation functions

Authors: Xun Ma, Liujiang Dai, Chunlai Tan, Jiangchuan Li, Xiangjun He, Yaofeng Wang, Junyi Xue, Min Huang, Jianwei Ren, Yin Xia, Qiang Wu, Hui Zhao, Wai-Yee Chan, Bo Feng

Source: Cell & Bioscience, Vol 14, Iss 1, Pp 1-17 (2024)

Subject Terms: Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/88ef720812b14d30a280410d06740151

The single-cell chromatin landscape in gonadal cell lineage specification

Authors: Hoi Ching Suen, Fanghong Ou, Kai-kei Miu, Zhangting Wang, Wai-yee Chan, Jinyue Liao

Source: BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)

Subject Terms: Gonad development, Sex determination, scATAC-seq, Chromatin accessibility, Regulatory genomics, Single-cell biology, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2164

Access URL: https://doaj.org/article/d05caea8691042928d918408755731b5

CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing

Authors: Shiyu Wang, Yuling Cai, Tongtong Li, Yan Wang, Ziyou Bao, Renxue Wang, Junchao Qin, Ziqi Wang, Yining Liu, Zhaojian Liu, Wai‐Yee Chan, Xiangfeng Chen, Gang Lu, Zi‐Jiang Chen, Tao Huang, Hongbin Liu

Source: Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)

Subject Terms: CWF19L2, fertility, spermatogenesis, spermatogonial differentiation, splicing factor, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/580dd51ab47e4e0b925cda24115a03f0

WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome

Authors: Yuyao Tian, Sofie Lautrup, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Wai-Yee Chan

Source: Cell & Bioscience, Vol 14, Iss 1, Pp 1-19 (2024)

Subject Terms: Werner syndrome, WRN, Abnormal metabolism, SMARCA5, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/590e422dd0744c8aa85d87446ce950c2

NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations

Authors: Liang Yang, Zifeng Ruan, Xiaobing Lin, Hao Wang, Yanmin Xin, Haite Tang, Zhijuan Hu, Yunhao Zhou, Yi Wu, Junwei Wang, Dajiang Qin, Gang Lu, Kerry M. Loomes, Wai-Yee Chan, Xingguo Liu

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b31222b4952b4cd8aa803588340aa940

Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling

Authors: Shang Li, Junyu Zhai, Weiwei Chu, Xueying Geng, Dongshuang Wang, Luwei Jiao, Gang Lu, Wai-Yee Chan, Kang Sun, Yun Sun, Zi-Jiang Chen, Yanzhi Du

Source: npj Biofilms and Microbiomes, Vol 9, Iss 1, Pp 1-18 (2023)

Subject Terms: Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://doaj.org/toc/2055-5008

Access URL: https://doaj.org/article/3a0ec04d0532463ab4a68fe065b41ac4

Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation

Authors: Wei Li, Qi Long, Hao Wu, Yanshuang Zhou, Lifan Duan, Hao Yuan, Yingzhe Ding, Yile Huang, Yi Wu, Jinyu Huang, Delong Liu, Baodan Chen, Jian Zhang, Juntao Qi, Shiwei Du, Linpeng Li, Yang Liu, Zifeng Ruan, Zihuang Liu, Zichao Liu, Yifan Zhao, Jianghuan Lu, Junwei Wang, Wai-Yee Chan, Xingguo Liu

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c53d76e31af847fdb1f261bf98cc7868

WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome

Authors: Yuyao Tian, Wuming Wang, Sofie Lautrup, Hui Zhao, Xiang Li, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Hoi Hung Cheung, Wai-Yee Chan

Source: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5cf95fd306b348f2bda0e4413752072d

IGF2 reduces meiotic defects in oocytes from obese mice and improves embryonic developmental competency

Authors: Yanling Wan, Tahir Muhammad, Tao Huang, Yue Lv, Qianqian Sha, Shuang Yang, Gang Lu, Wai-yee Chan, Jinlong Ma, Hongbin Liu

Source: Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-13 (2022)

Subject Terms: Maternal obesity, Oocyte quality, IGF2, Meiotic defects, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489

File Description: electronic resource

Relation: https://doaj.org/toc/1477-7827

Access URL: https://doaj.org/article/cb1d97ffdfd44cabb42523736b5ad709

The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice

Authors: Ke Xu, Xianwei Su, Kailun Fang, Yue Lv, Tao Huang, Mengjing Li, Ziqi Wang, Yingying Yin, Tahir Muhammad, Shangming Liu, Xiangfeng Chen, Jing Jiang, Jinsong Li, Wai-Yee Chan, Jinlong Ma, Gang Lu, Zi-Jiang Chen, Hongbin Liu

Source: eLife, Vol 12 (2023)

Subject Terms: spermatogenesis, Ssh2, actin remodeling, acrosome biogenesis, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/83129; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/9f23f9aed9b044e19ddedc1b8f2863d2

lncRNA DDGC participates in premature ovarian insufficiency through regulating RAD51 and WT1

Authors: Duan Li, Weiwei Xu, Xiaoyan Wang, Yujie Dang, Lan Xu, Gang Lu, Wai-Yee Chan, Peter C.K. Leung, Shidou Zhao, Yingying Qin

Source: Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1092-1106 (2021)

Subject Terms: premature ovarian insufficiency, granulosa cells, lncRNA, WT1, RAD51, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253121002584; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/5ad116309fca4af59cca967b3f6b123c

Genome-wide 5-hydroxymethylcytosine (5hmC) reassigned in Pten-depleted mESCs along neural differentiation

Authors: Zhangting Wang, Kai-Kei Miu, See-Wing Chan, Fanghong Ou, Patrick Wai-Nok Law, Wai-Yee Chan

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: midbrain/hindbrain progenitors, Pten, 5-hydroxymethylcytosine, nano-5hmC-seal, mitochondrial respiratory chain, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.956604/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/0823d2e6df08430a9c9a0b257908d4d3

Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction

Authors: Weiwei Chu, Shang Li, Xueying Geng, Dongshuang Wang, Junyu Zhai, Gang Lu, Wai-Yee Chan, Zi-Jiang Chen, Yanzhi Du

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: constant darkness, polycystic ovary syndrome, hyperandrogenism, melatonin receptor 1A, androgen receptor, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.954186/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/6e95df6fa12d49c59cc3796e79910f86

Neuroprotective Effects of Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Extracellular Vesicles in Ischemic Stroke Models

Authors: Gang Lu, Xianwei Su, Lihong Wang, Chi-Kwan Leung, Jingye Zhou, Zhiqiang Xiong, Wuming Wang, Hongbin Liu, Wai-Yee Chan

Source: Biomedicines, Vol 11, Iss 9, p 2550 (2023)

Subject Terms: hiPS-MSC-EV, middle cerebral artery occlusion, proliferation, angiogenesis, exosomes, ischemic stroke, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/9/2550; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/58ca144c529a47dcbcac469d35e7cc8e

lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1

Authors: Duan Li, Xiaoyan Wang, Yujie Dang, Xinyue Zhang, Shidou Zhao, Gang Lu, Wai-Yee Chan, Peter C.K. Leung, Yingying Qin

Source: Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 132-141 (2021)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S216225312030353X; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/e77baeccfcd24c5cad32873c9c2b1cd2

Dynamic Epigenetic Regulation of miR-10 Family Governs the Caudalization of Floor Plate Neural Progenitors

Authors: Zhangting Wang, Sin-Hang Fung, Chi-Lam Yu, Patrick Wai-Nok Law, Suyu Hao, Kai-Kei Miu, Wai-Yee Chan

Source: Re:GEN Open, Vol 1, Iss 1, Pp 117-129 (2021)

Subject Terms: Neural development, microRNA, caudalization, mitochondrial regulation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2766-2705

Access URL: https://doaj.org/article/eeb78b076ba54225adb6f8c10e90cd92

Changes in the vaginal microbiota associated with primary ovarian failure

Authors: Juan Wang, Jieying Xu, Qixin Han, Weiwei Chu, Gang Lu, Wai-Yee Chan, Yingying Qin, Yanzhi Du

Source: BMC Microbiology, Vol 20, Iss 1, Pp 1-13 (2020)

Subject Terms: Vaginal microbiota, Primary ovarian failure, 16S rRNA, Pathogenesis, Female reproductive tract, Microbiology, QR1-502

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12866-020-01918-0; https://doaj.org/toc/1471-2180

Access URL: https://doaj.org/article/ccec5bade2f14c158bab985a8bcbb90e

Deficiency of the Tmem232 Gene Causes Male Infertility with Morphological Abnormalities of the Sperm Flagellum in Mice

Authors: Xiuqing He, Wenyu Mu, Ziqi Wang, Ke Xu, Yingying Yin, Gang Lu, Wai-Yee Chan, Hongbin Liu, Yue Lv, Shangming Liu

Source: Cells, Vol 12, Iss 12, p 1614 (2023)

Subject Terms: TMEM232, ODF1, sperm, axoneme, cytoplasm removal, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/12/1614; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/7d449684d8964442a2bd653f7669dfa9

Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA

Authors: Jun-Yu Zhu, An-Qi Lyu, Zhang-Ting Wang, Wai-Yee Chan, Tao Qin, Kai-Kei Miu, He-Rui Yao

Source: Journal of Immunology Research, Vol 2022 (2022)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2314-7156

Access URL: https://doaj.org/article/b6cdf685c46d4b968e896077ca004065

Pten Regulates Cardiomyocyte Differentiation by Modulating Non‐CG Methylation via Dnmt3

Authors: Wuming Wang, Gang Lu, Hong‐Bin Liu, Zhiqiang Xiong, Ho‐Duen Leung, Ruican Cao, Alan Lap‐Yin Pang, Xianwei Su, Patrick Wai Nok Law, Zhiju Zhao, Zi‐Jiang Chen, Wai‐Yee Chan

Source: Advanced Science, Vol 8, Iss 17, Pp n/a-n/a (2021)

Subject Terms: cardiomyocytes, Dnmt3, embryonic stem cells, Igf2, non‐CG methylation, Pten, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/0ef56d9376984538b4d2b08ecbcfb5ab