GABA and GLP-1 receptor agonist combination therapy modifies diabetes and Langerhans islet cytoarchitecture in a rat model of Wolfram syndrome

Authors: Toomas Jagomäe, Sandra Velling, Tessa Britt Tikva, Varvara Maksimtšuk, Nayana Gaur, Riin Reimets, Allen Kaasik, Eero Vasar, Mario Plaas

Source: Diabetology & Metabolic Syndrome, Vol 17, Iss 1, Pp 1-15 (2025)

Subject Terms: Wolfram syndrome, Wfs1, GABA, GLP1-RA, Liraglutide, Langerhans islet, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1758-5996

Access URL: https://doaj.org/article/5c7e67b52dbe41cf8fc7bec7efdacc52

Evaluation of pathogenic variant in WFS1 in a patient with Wolfram syndrome

Authors: Marziyeh Hoseinzadeh, Mohammad Mehdi Jahani, Samane Nasrniya, Mohammad Amin Tabatabaiefar

Source: Egyptian Journal of Medical Human Genetics, Vol 26, Iss 1, Pp 1-8 (2025)

Subject Terms: Wolfram syndrome (WS), WFS1 gene, Wolframin, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2090-2441

Access URL: https://doaj.org/article/ff8cc27451854e0b9590318fb4385e17

Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy

Authors: Cansu de Muijnck, Lonneke Haer-Wigman, Judith A. M. van Everdingen, Tanya Lushchyk, Pam A. T. Heutinck, Marieke F. van Dooren, Anneke J. A. Kievit, Virginie J. M. Verhoeven, Marleen E. H. Simon, Rosemarie A. Wasmann, Irene C. Notting, Elfride De Baere, Sophie Walraedt, Julie De Zaeytijd, Filip Van den Broeck, Bart P. Leroy, Camiel J. F. Boon, Maria M. van Genderen

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: WFS1, Optic atrophy, OPA1, DOA, Inherited optic neuropathy, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/0c0b6eba7aa84c6fa61212f9ff5202a8

The WFS1‐ZnT3‐Zn2+ Axis Regulates the Vicious Cycle of Obesity and Depression

Authors: Mengting Gong, Yulin Fang, Kaijiang Yang, Fei Yuan, Rui Hu, Yajuan Su, Yiling Yang, Wenjun Xu, Qing Ma, Jiaxue Cha, Ru Zhang, Zhen‐Ning Zhang, Weida Li

Source: Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)

Subject Terms: cerebral organoid, depression, obesity, WFS1, ZnT3, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/7f82db8142a3446586146e23f15dfeec

The immunological and prognostic significance of the diabetes mellitus-related gene WFS1 in endometrial cancer

Authors: Wenzhe Li, Da Ke, Yi Xu, Ya Wang, Qian Wang, Jie Tan, Hongyan Wu, Xianglin Cheng

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: WFS1, endometrial cancer, molecular typing, diabetes mellitus, prognostic markers, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1464421/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9ce679a1a23f428c8a42b54f00c1780c

Insights from a Wolfram syndrome cohort: clinical and molecular findings from a specialized diabetes reference center

Authors: Carolina Paniago Lopes, Gentil Ferreira Gonçalves Neto, Maria Fernanda Vanti Macedo Paulino, Adriana Mangue Esquiaveto-Aun, Maricilda Palandi de Mello, Elizabeth João Pavin, Ikaro Soares Santos Breder, Mariana Zorron Mei Hsia Pu, Sofia Helena Valente de Lemos-Marini, Gil Guerra Junior

Source: Archives of Endocrinology and Metabolism, Vol 68 (2024)

Subject Terms: Wolfram syndrome, wolframin, WFS1, CISD2, diabetes mellitus, diabetes insipidus, Medicine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024000100365&lng=en&tlng=en; http://www.scielo.br/pdf/aem/v68/2359-4292-aem-68-e240091.pdf; https://doaj.org/toc/2359-4292

Access URL: https://doaj.org/article/cbf3da5adedf4723adfdf888d2ce1a13

Novel WFS1 variants are associated with different diabetes phenotypes

Authors: Lei Wu, Juan Zhang, Danjie Li, Zhongyun Zhang, Qicheng Ni, Rulai Han, Lei Ye, Yifei Zhang, Jie Hong, Weiqing Wang, Guang Ning, Weiqiong Gu

Source: Frontiers in Genetics, Vol 15 (2024)

Subject Terms: WFS1 gene, Wolfram syndrome-like disorders (WSLD), ACMG classification, functional analysis, whole-exome sequencing (WES), Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2024.1433060/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/ce5c793a14e54f4d9c3dc7a832237736

Beyond Wolfram Syndrome 1: The WFS1 Gene’s Role in Alzheimer’s Disease and Sleep Disorders

Authors: Valerio Caruso, Luciana Rigoli

Source: Biomolecules, Vol 14, Iss 11, p 1389 (2024)

Subject Terms: WFS1 gene, Wolfram syndrome 1, Alzheimer’s disease, neuropsychiatric disorders, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/11/1389; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/b2317c82db3840fa9e92ead7d50afc71

N6-Methyladenosine RNA Modification Regulates the Differential Muscle Development in Large White and Ningxiang Pigs

Authors: Hao Gu, Kang Xu, Zhao Yu, Zufeng Ren, Fan Chen, Changfan Zhou, Wei Zeng, Hongyan Ren, Yulong Yin, Yanzhen Bi

Source: Cells, Vol 13, Iss 20, p 1744 (2024)

Subject Terms: pig muscle, m6A, MeRIP-seq, WFS1, YTHDF2, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/20/1744; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/c5cdefb7b9cc415f8f713780e95131a1

Wolfram syndrome type 1: a case series

Authors: Danyang Du, Aihemaitijiang Tuhuti, Yanrong Ma, Munila Abuduniyimu, Suli Li, Guoying Ma, Jazyra Zynat, Yanying Guo

Source: Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-8 (2023)

Subject Terms: Wolfram syndrome, WFS1 gene, Diabetic mellitus, Genetic testing, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/409f2af6c2624686b6e701cc8648f312

Next generation sequencing identifies a pathogenic mutation of WFS1 gene in a Moroccan family with Wolfram syndrome: a case report

Authors: Maryem Sahli, Abdelali Zrhidri, Imad Boualaoui, Imane Cherkaoui Jaouad, Youssef El Kadiri, Yassine Nouini, Abdelaziz Sefiani

Source: Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-5 (2023)

Subject Terms: Wolfram syndrome, Next-generation sequencing, WFS1 gene, Moroccan family, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1752-1947

Access URL: https://doaj.org/article/cd5ca4b1105145bfab11db6f3f87770a

Selective proteasome degradation of C‐terminally‐truncated human WFS1 in pancreatic beta cells

Authors: Hiraku Tokuma, Daisuke Sakano, Katsuya Tanabe, Yukio Tanizawa, Nobuaki Shiraki, Shoen Kume

Source: FEBS Open Bio, Vol 13, Iss 8, Pp 1405-1414 (2023)

Subject Terms: beta cells, degradation, diabetes, endocrine, proteasome, WFS1, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/50d1e9465cc64119b0b5f9c148a15311

Clinical management and obstetric outcome in WFS1 Wolfram syndrome spectrum disorder: A case report and literature review

Authors: Kai Zhang, Xin Cui, Yan Long

Source: Taiwanese Journal of Obstetrics & Gynecology, Vol 62, Iss 3, Pp 440-443 (2023)

Subject Terms: Fetal outcome, Pregnancy, WFS1, Wolfram syndrome spectrum disorder, Gynecology and obstetrics, RG1-991

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1028455923000815; https://doaj.org/toc/1028-4559

Access URL: https://doaj.org/article/ed7a854d48b9426d8444de80058f68fc

WFS1 autosomal dominant variants linked with hearing loss: update on structural analysis and cochlear implant outcome

Authors: Hui Dong Lim, So Min Lee, Ye Jin Yun, Dae Hee Lee, Jun Ho Lee, Seung-Ha Oh, Sang-Yeon Lee

Source: BMC Medical Genomics, Vol 16, Iss 1, Pp 1-16 (2023)

Subject Terms: WFS1, DFNA6/14/38, Wolfram-like syndrome, Structure analysis, Cochlear implantation, Internal medicine, RC31-1245, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1755-8794

Access URL: https://doaj.org/article/8a790b9fabc94646ba6638964b516729

A p.Val412Serfs pathogenic variant associated with Wolfram-like syndrome and leukodystrophy

Authors: Ayca Kocaaga, Sevgi Yimenicioglu, Murat Bayav

Source: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 59, Iss 1, Pp 1-6 (2023)

Subject Terms: Dominant inheritance, Leukodystrophy, Optic atrophy, WFS1 (Wolframin) gene, Wolfram-like syndrome, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/1687-8329

Access URL: https://doaj.org/article/484b5aeee7fb45789317a32cb5760d27

The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians

Authors: Maha M. Hammad, Mohamed Abu-Farha, Prashantha Hebbar, Emil Anoop, Betty Chandy, Motasem Melhem, Arshad Channanath, Fahd Al-Mulla, Thangavel Alphonse Thanaraj, Jehad Abubaker

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: WFS1, ethnicity, obesity, triglycerides, polymorphism, waist circumference, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1185956/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/1ebbdead7c2c41bba24ec0edea49521c

Treatment with the dual-incretin agonist DA-CH5 demonstrates potent therapeutic effect in a rat model of Wolfram Syndrome

Authors: Toomas Jagomäe, Nayana Gaur, Kadri Seppa, Riin Reimets, Marko Pastak, Mihkel Plaas, Allen Kaasik, Eero Vasar, Mario Plaas

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: wolfram (DIDMOAD) syndrome, incretin mimetics, glucose intolerance, dual incretins, animal models - rodent, Wfs1, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1234925/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/837495d36ff5427582528fa2621ac92c

Combined effect of pancreatic lipid content and gene variants (TCF7L2, WFS1 and 11BHSD1) on B-cell function in Middle Aged Women in a Post Hoc Analysis

Authors: Ákos Nádasdi, Viktor Gál, Tamás Masszi, Attila Patócs, Peter Igaz, Anikó Somogyi, Gábor Firneisz

Source: Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-10 (2022)

Subject Terms: Pancreatic fat, Liver fat, PNPLA3, TCF7L2, WFS1, 11ΒHSD1, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://doaj.org/toc/1758-5996

Access URL: https://doaj.org/article/a79ce6ae946e49048d3aa3a19e918c7e

GLP-1 receptor agonists as promising disease-modifying agents in WFS1 spectrum disorder

Authors: Eleonora Panfili, Giulio Frontino, Maria Teresa Pallotta

Source: Frontiers in Clinical Diabetes and Healthcare, Vol 4 (2023)

Subject Terms: Wolfram syndrome type 1, wolframin (WFS1), GLP-1RAs, diabetes, neurodegeneration, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcdhc.2023.1171091/full; https://doaj.org/toc/2673-6616

Access URL: https://doaj.org/article/ef348fed53b94b11abcbe1893dbcce3e

Paediatric Wolfram syndrome Type 1: should gonadal dysfunction be part of the diagnostic criteria?

Authors: Giulio Frontino, Raffaella Di Tonno, Marianna Rita Stancampiano, Francesca Arrigoni, Andrea Rigamonti, Elisa Morotti, Daniele Canarutto, Riccardo Bonfanti, Gianni Russo, Graziano Barera, Lorenzo Piemonti

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: Wolfram syndrome, Wolfram syndrome 1 (WFS1), monogenic diabetes, gonadal dysfunction, hypogonadism, hypergonadotropic hypogonadism, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1155644/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/7ef22ef30a0c4d089676d73777b582f9