Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes

Authors: Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee

Source: OncoImmunology, Vol 13, Iss 1 (2024)

Subject Terms: Immune checkpoint therapy, T cells, T cell receptor (TCR) sequencing, tumour-infiltrating lymphocytes, immune repertoire, machine learning, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/f60545e051804f9796499b61db90824e

Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade

Authors: Francois Xavier Rwandamuriye, Tao Wang, Hanfu Zhang, Omar Elaskalani, Jorren Kuster, Xueting Ye, Breana Vitali, Juliët Schreurs, M. Lizeth Orozco Morales, Marck Norret, Cameron W. Evans, Rachael M. Zemek, K. Swaminathan Iyer, W. Joost Lesterhuis, Ben Wylie

Source: OncoImmunology, Vol 13, Iss 1 (2024)

Subject Terms: Cancer immunotherapy, combination therapy, hydrogel, innate immunity, surgery, TLR agonists, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/2a3718095d18493b9813cd62cb6972ec

Time-course RNAseq data of murine AB1 mesothelioma and Renca renal cancer following immune checkpoint therapy

Authors: Wee Loong Chin, Rachael M. Zemek, Caitlin M. Tilsed, Alistair R. R. Forrest, Vanessa S. Fear, Catherine Forbes, Louis Boon, Anthony Bosco, Belinda B. Guo, Michael J. Millward, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis, Timo Lassmann

Source: Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/a6b9ffd96f4e40b6b71f12cbc7e2efb8

Tretinoin improves the anti-cancer response to cyclophosphamide, in a model-selective manner

Authors: Caitlin M. Tilsed, M. Lizeth Orozco Morales, Rachael M. Zemek, Brianna A. Gordon, Matthew J. Piggott, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)

Subject Terms: Cyclophosphamide, Tretinoin, Interferon, Sensitisation, Combination treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/604f2ab58dbd40a8bc1286fd39a00ca8

The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop

Authors: Scott A. Fisher, Kimberley Patrick, Tracy Hoang, Elly Marcq, Kiarash Behrouzfar, Sylvia Young, Timothy J. Miller, Bruce W. S. Robinson, Raphael Bueno, Anna K. Nowak, W. Joost Lesterhuis, Grant Morahan, Richard A. Lake

Source: Frontiers in Toxicology, Vol 6 (2024)

Subject Terms: mesothelioma, collaborative cross, MexTAg, asbestos related disease, host genetics, mouse model, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2024.1373003/full; https://doaj.org/toc/2673-3080

Access URL: https://doaj.org/article/3d44dba5e34544bab7bb7980e494ea5c

Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice

Authors: Rachael M. Zemek, Wee Loong Chin, Vanessa S. Fear, Ben Wylie, Thomas H. Casey, Cath Forbes, Caitlin M. Tilsed, Louis Boon, Belinda B. Guo, Anthony Bosco, Alistair R. R. Forrest, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Timo Lassmann, W. Joost Lesterhuis

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/59cfc35dd0fb4aa0a34e44f36234b216

Cancer chemotherapy: insights into cellular and tumor microenvironmental mechanisms of action

Authors: Caitlin M. Tilsed, Scott A. Fisher, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: chemotherapy, tumor microenvironment, cell death, immune response, mechanism of action, cancer chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.960317/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e6d00f5ca20546b5b9b062d82fa200d8

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

Authors: M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis

Source: iScience, Vol 25, Iss 1, Pp 103571- (2022)

Subject Terms: Biological sciences, Metabolomics, Transcriptomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221015418; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/6d9c2a0cd5324c82ad3d7f092e5dbba3

A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

Authors: Wayne J. Aston, Danika E. Hope, Anna K. Nowak, Bruce W. Robinson, Richard A. Lake, W. Joost Lesterhuis

Source: BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)

Subject Terms: Chemotherapy, Mice, Dose optimization, Maximum tolerated dose, MTD, Supportive care, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-017-3677-7; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/23b7d93ee31743cab7a5c2ce88034ef9

Sensitizing the Tumor Microenvironment to Immune Checkpoint Therapy

Authors: Rachael M. Zemek, Wee Loong Chin, Anna K. Nowak, Michael J. Millward, Richard A. Lake, W. Joost Lesterhuis

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: cancer immunotherapy, immune checkpoints, sensitization, tumor microenvironment, PD-1, CTLA4, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.00223/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c0ab4303f2fa4686a1db0102b6c02049

Dexamethasone differentially depletes tumour and peripheral blood lymphocytes and can impact the efficacy of chemotherapy/checkpoint blockade combination treatment

Authors: Wayne J. Aston, Danika E. Hope, Alistair M. Cook, Louis Boon, Ian Dick, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis

Source: OncoImmunology, Vol 8, Iss 11 (2019)

Subject Terms: dexamethasone, chemotherapy, immunotherapy, cancer, supportive care, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/e187f26bebde410e85dfd1051a98ed1f

Programmed Death Ligand 2 in Cancer-Induced Immune Suppression

Authors: Esdy N. Rozali, Stanleyson V. Hato, Bruce W. Robinson, Richard A. Lake, W. Joost Lesterhuis

Source: Clinical and Developmental Immunology, Vol 2012 (2012)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1740-2522; https://doaj.org/toc/1740-2530

Access URL: https://doaj.org/article/15fed20b94284209a02ee500e5f625b6

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Authors: Francois X. Rwandamuriye, author^{1, 2}, Breana J. Weston, author^{2, 3}, Terrance G. Johns, author², W. Joost Lesterhuis, author^{1, 2}, Rachael M. Zemek, author²

Source: Journal of Visualized Experiments. (161)

Availability: http://www.jove.com/video/60882

Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade

Authors: Elly Marcq, Anna K Nowak, W Joost Lesterhuis, Caitlin M Tilsed, Nicola Principe, Amber-Lee Phung, Kofi L P Stevens, Omar Elaskalani, Ben Wylie, Fezaan Sheikh, M Lizeth Orozco Morales, Joel Kidman, Scott A Fisher, Alison M McDonnell, Jonathan Chee

Source: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/12/9/e008568.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/7f07a0c5e8004791ac4fe2312e89506b

Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.

Authors: M Lizeth Orozco Morales, Catherine A Rinaldi, Emma de Jong, Sally M Lansley, Y C Gary Lee, Rachael M Zemek, Anthony Bosco, Richard A Lake, W Joost Lesterhuis

Source: PLoS ONE, Vol 18, Iss 5, p e0274364 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2d135eaea4984e23b135b7a3cb4c24d4

A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery

Authors: Winald R Gerritsen, Johannes Textor, Niven Mehra, Jeroen H A Creemers, W Joost Lesterhuis, Carl G Figdor, I Jolanda M de Vries

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/5/e002032.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1f4bfd04544d4e08bbd18c182cc178b7

Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the induction of anti-tumor immunity.

Authors: W Joost Lesterhuis, Joanne Salmons, Anna K Nowak, Esdy N Rozali, Andrea Khong, Ian M Dick, Julie A Harken, Bruce W Robinson, Richard A Lake

Source: PLoS ONE, Vol 8, Iss 4, p e61895 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23626745/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/356226740b7c4b4bb74348ae13186b28