Identifying distinct prognostic and predictive contributions of tumor epithelium versus tumor microenvironment in colorectal cancer

Authors: Mingli Yang, Michael V. Nebozhyn, Michael J. Schell, Nishant Gandhi, Lance Pflieger, Andrey Loboda, W. Jack Pledger, Ramani Soundararajan, Michelle Maurin, Heiman Wang, Jetsen Rodriguez Silva, Ashley Alden, Domenico Coppola, Andrew Elliott, George Sledge, Moh’d Khushman, Emil Lou, Sanjay Goel, Timothy J. Yeatman

Source: BMC Cancer, Vol 25, Iss 1, Pp 1-21 (2025)

Subject Terms: Colorectal cancer, Consensus molecular subtype, Clinical outcome, Tumor epithelium, Tumor microenvironment, Gene expression signature, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/7ee01953a8ae4380964c4b8c5583c30c

An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy

Authors: Mingli Yang, Thomas B. Davis, Lance Pflieger, Michael V. Nebozhyn, Andrey Loboda, Heiman Wang, Michael J. Schell, Ramya Thota, W. Jack Pledger, Timothy J. Yeatman

Source: BMC Cancer, Vol 22, Iss 1, Pp 1-21 (2022)

Subject Terms: Colorectal cancer, MEK inhibitor, Targeted therapy, SRC, EMT, Cancer stem cell, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/b3ce1c0168df4f64b92380ac36065a83