Quantification of clesrovimab, an investigational, half-life extended, anti-respiratory syncytial virus protein F human monoclonal antibody in the nasal epithelial lining fluid of healthy adults

Authors: Phuah, Jia Yao, Maas, Brian M., Tang, Aimin, Zhang, Ying, Caro, Luzelena, Railkar, Radha A., Swanson, Michael D., Cao, Yu, Li, Hankun, Roadcap, Brad, Catchpole, Andrew P., Aliprantis, Antonios O., Vora, Kalpit A.

Source: In Biomedicine & Pharmacotherapy 31 December 2023 169

High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface

Authors: Datta, Suprama, Chen, Da-Yuan, Tavares, Alexander H., Reyes-Robles, Tamara, Ryu, Keun Ah, Khan, Nazimuddin, Bechtel, Tyler J., Bertoch, Jayde M., White, Cory H., Hazuda, Daria J., Vora, Kalpit A., Hett, Erik C., Fadeyi, Olugbeminiyi O., Oslund, Rob C., Emili, Andrew, Saeed, Mohsan

Source: In Cell Chemical Biology 19 October 2023 30(10):1313-1322

Development of High-Titer Antidrug Antibodies in a Phase 1b/2a Infant Clesrovimab Trial Are Associated With RSV Exposure Beyond Day 150.

Authors: Thambi, Nithya, Phuah, Jia Yao, Staupe, Ryan P, Tobias, Lori M, Cao, Yu, McKelvey, Troy, Railkar, Radha A, Aliprantis, Antonios O, Arriola, Carmen Sofia, Maas, Brian M, Vora, Kalpit A

Source: Journal of Infectious Diseases; Mar2025, Vol. 231 Issue 3, pe488-e496, 9p

Subject Terms: CLINICAL trial registries, ENZYME-linked immunosorbent assay, RESPIRATORY syncytial virus, INFANTS, TITERS

A Phase 1b/2a Trial of a Half-life Extended Respiratory Syncytial Virus Neutralizing Antibody, Clesrovimab, in Healthy Preterm and Full-term Infants.

Authors: Madhi, Shabir A, Simões, Eric A F, Acevedo, Armando, Pizarro, Jose M Novoa, Shepard, Julie S, Railkar, Radha A, Cao, Xin, Maas, Brian M, Zang, Xiaowei, Krick, Andrea, Roadcap, Brad, Vora, Kalpit A, Aliprantis, Antonios O, Lee, Andrew W, Sinha, Anushua

Source: Journal of Infectious Diseases; Mar2025, Vol. 231 Issue 3, pe478-e487, 10p

Subject Terms: RESPIRATORY syncytial virus infections, RESPIRATORY syncytial virus, VIRAL antibodies, RESPIRATORY infections, CHIMERIC proteins

Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice

Authors: Cavazzoni, Cecilia B., Hanson, Benjamin L., Podestà, Manuel A., Bechu, Elsa D., Clement, Rachel L., Zhang, Hengcheng, Daccache, Joe, Reyes-Robles, Tamara, Hett, Erik C., Vora, Kalpit A., Fadeyi, Olugbeminiyi O., Oslund, Rob C., Hazuda, Daria J., Sage, Peter T.

Source: In Cell Reports 22 February 2022 38(8)

Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis

Authors: Maas, Brian M., Lommerse, Jos, Plock, Nele, Railkar, Radha A., Cheung, S.Y. Amy, Caro, Luzelena, Chen, Jingxian, Liu, Wen, Zhang, Ying, Huang, Qinlei, Gao, Wei, Qin, Li, Meng, Jie, Witjes, Han, Schindler, Emilie, Guiastrennec, Benjamin, Bellanti, Francesco, Spellman, Daniel S., Roadcap, Brad, Kalinova, Mariya, Fok-Seang, Juin, Catchpole, Andrew P., Espeseth, Amy S., Stoch, S. Aubrey, Lai, Eseng, Vora, Kalpit A., Aliprantis, Antonios O., Sachs, Jeffrey R.

Source: In EBioMedicine November 2021 73

Development of a microneutralization assay for HSV-2

Authors: Horton, Melanie S. ^*, Minnier, Michael, Cosmi, Scott, Cox, Kara, Galli, Jennifer, Peters, Jessica, Sullivan, Nicole, Squadroni, Brian, Tang, Aimin, Fridman, Arthur, Wang, Dai, Chen, Zhifeng, Vora, Kalpit A.

Source: In Journal of Virological Methods November 2021 297

Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection

Authors: Rouers, Angeline, Chng, Melissa Hui Yen, Lee, Bernett, Rajapakse, Menaka P., Kaur, Kaval, Toh, Ying Xiu, Sathiakumar, Durgalakshmi, Loy, Thomas, Thein, Tun-Linn, Lim, Vanessa W.X., Singhal, Amit, Yeo, Tsin Wen, Leo, Yee-Sin, Vora, Kalpit A., Casimiro, Danilo, Lim, Bing, Tucker-Kellogg, Lisa, Rivino, Laura, Newell, Evan W., Fink, Katja

Source: In Cell Reports Medicine 18 May 2021 2(5)

Anti-Idiotypic Antibody as a Booster Vaccine Against Respiratory Syncytial Virus.

Authors: Mukhopadhyay, Shreya, Manolaridis, Ioannis, Warren, Christopher, Tang, Aimin, O'Donnell, Gregory, Luo, Bin, Staupe, Ryan P., Vora, Kalpit A., Chen, Zhifeng

Source: Vaccines; Jan2025, Vol. 13 Issue 1, p35, 18p

Subject Terms: CLINICAL trials, RESPIRATORY infections in children, RESPIRATORY syncytial virus, BOOSTER vaccines, RESPIRATORY infections

Understanding the immunology of the Zostavax shingles vaccine

Authors: Sullivan, Nicole L, Eberhardt, Christiane S, Wieland, Andreas, Vora, Kalpit A, Pulendran, Bali, Ahmed, Rafi

Source: In Current Opinion in Immunology August 2019 59:25-30

Development and application of a higher throughput RSV plaque assay by immunofluorescent imaging

Authors: Wen, Zhiyun, Citron, Mike, Bett, Andrew J., Espeseth, Amy S., Vora, Kalpit A., Zhang, Lan, DiStefano, Daniel J.

Source: In Journal of Virological Methods January 2019 263:88-95

An Essential Role for BAFF in the Normal Development of B Cells through a BCMA-Independent Pathway

Authors: Schiemann, Barbara, Gommerman, Jennifer L., Vora, Kalpit, Cachero, Teresa G., Shulga-Morskaya, Svetlana, Dobles, Max, Frew, Erica, Scott, Martin L.

Source: Science, 2001 Sep . 293(5537), 2111-2114.

Access URL: https://www.jstor.org/stable/3084566

BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

Authors: Thompson, Jeffrey S., Bixler, Sarah A., Qian, Fang, Vora, Kalpit, Scott, Martin L., Cachero, Teresa G., Hession, Catherine, Schneider, Pascal, Sizing, Irene D., Mullen, Colleen, Strauch, Kathy, Zafari, Mohammad, Benjamin, Christopher D., Tschopp, Jurg, Browning, Jeffrey L., Ambrose, Christine

Source: Science, 2001 Sep . 293(5537), 2108-2111.

Access URL: https://www.jstor.org/stable/3084565

Metabolic Phenotypes of Response to Vaccination in Humans

Authors: Li, Shuzhao, Sullivan, Nicole L., Rouphael, Nadine, Yu, Tianwei, Banton, Sophia, Maddur, Mohan S., McCausland, Megan, Chiu, Christopher, Canniff, Jennifer, Dubey, Sheri, Liu, Ken, Tran, ViLinh, Hagan, Thomas, Duraisingham, Sai, Wieland, Andreas, Mehta, Aneesh K., Whitaker, Jennifer A., Subramaniam, Shankar, Jones, Dean P., Sette, Alessandro, Vora, Kalpit, Weinberg, Adriana, Mulligan, Mark J., Nakaya, Helder I., Levin, Myron, Ahmed, Rafi, Pulendran, Bali

Source: In Cell 18 May 2017 169(5):862-877

A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens

Authors: Swaminathan, Gokul, Thoryk, Elizabeth A., Cox, Kara S., Meschino, Steven, Dubey, Sheri A., Vora, Kalpit A., Celano, Robert, Gindy, Marian, Casimiro, Danilo R., Bett, Andrew J.

Source: In Vaccine 2 January 2016 34(1):110-119

Identification and Quantification of a Pneumococcal Cell Wall Polysaccharide by Antibody-Enhanced Chromatography Assay.

Authors: Deng, James Z., Chen, Zhifeng, Small, James, Yuan, Yue, Cox, Kara, Tang, Aimin, Roman, Jeanette, Guan, Liming, Feller, Katrina, Ansbro, Frances, Vora, Kalpit

Source: Vaccines; May2024, Vol. 12 Issue 5, p469, 12p

Subject Terms: POLYSACCHARIDES, PNEUMOCOCCAL vaccines, CHROMATOGRAPHIC analysis, MONOCLONAL antibodies, IMMUNE response

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities

Authors: Gray, Peter M., Forrest, Gail, Wisniewski, Thomas, Porter, Gene, Freed, Daniel C., DeMartino, Julie A., Zaller, Dennis M., Guo, Zhiqiang, Leone, Joseph, Fu, Tong-Ming, Vora, Kalpit A.

Source: In Cellular Immunology July-August 2012 278(1-2):113-119

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

Authors: Baugh, Mark, Black, Darcey, Westwood, Paul, Kinghorn, Emma, McGregor, Kieran, Bruin, John, Hamilton, William, Dempster, Maureen, Claxton, Christopher, Cai, Jiaqiang, Bennett, Jonathan, Long, Clive, Mckinnon, Heather, Vink, Paul, Hoed, Leontien den, Gorecka, Monika, Vora, Kalpit, Grant, Ethan, Percival, M. David, Boots, A. Mieke H., van Lierop, Marie-José

Source: In Journal of Autoimmunity May 2011 36(3-4):201-209

Phage-derived anti-idiotype and anti-YTE antibodies in development of MK-1654 pharmacokinetic and immune response assays.

Authors: Li, April, Swanson, Michael, Sullivan, Nicole, Homan, Ying, Nahas, Debbie, Mukhopadhyay, Shreya, Li, Hualin Helen, Cao, Yu, Xu, Weifeng, Tang, Huaping, Vora, Kalpit A, Chen, Zhifeng

Source: Bioanalysis; Aug2023, Vol. 15 Issue 16, p1049-1067, 18p

Novel Human Acidic Mammalian Chitinase and Use Thereof