Altered shear stress of blood flow causes plasma membrane damage in endothelial cells

Authors: Nikita Raj, Chang Pan, Ann Marleen Starke, Anna L. L. Matos, Oliver Soehnlein, Volker Gerke

Source: Blood Vessels, Thrombosis & Hemostasis, Vol 2, Iss 1, Pp 100040- (2025)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2950327224000408; https://doaj.org/toc/2950-3272

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Chemigenetic Ca2+ indicators report elevated Ca2+ levels in endothelial Weibel-Palade bodies.

Authors: Julian Terglane, Nicole Mertes, Sarah Weischer, Thomas Zobel, Kai Johnsson, Volker Gerke

Source: PLoS ONE, Vol 20, Iss 1, p e0316854 (2025)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d85ab8527b064d6d884104dac1914e1c

Membrane Tension Regulation is Required for Wound Repair

Authors: Nikita Raj, Martin S. Weiß, Bart E. Vos, Sarah Weischer, Frauke Brinkmann, Timo Betz, Britta Trappmann, Volker Gerke

Source: Advanced Science, Vol 11, Iss 48, Pp n/a-n/a (2024)

Subject Terms: Ca2+, cellular tension, clathrin‐mediated endocytosis, plasma membrane resealing, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/d4f526dc59e54ebe92f09959bceae0cc

RhoGDI1 regulates cell-cell junctions in polarized epithelial cells

Authors: Nicolina Wibbe, Tim Steinbacher, Frederik Tellkamp, Niklas Beckmann, Frauke Brinkmann, Manuel Stecher, Volker Gerke, Carien M. Niessen, Klaus Ebnet

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: ARHGDIA, epithelial barrier, contact inhibition of locomotion, JAM-A, RhoGDI1, tight junction, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1279723/full; https://doaj.org/toc/2296-634X

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Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

Authors: Volker Gerke, Felicity N. E. Gavins, Michael Geisow, Thomas Grewal, Jyoti K. Jaiswal, Jesper Nylandsted, Ursula Rescher

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0372b0d39f0048d4a7ebd22615898ab9

Evoked Weibel‐Palade Body Exocytosis Modifies the Endothelial Cell Surface by Releasing a Substrate‐Selective Phosphodiesterase

Authors: Johannes Naß, Julian Terglane, Dagmar Zeuschner, Volker Gerke

Source: Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)

Subject Terms: calcium, complement, GPI anchor, inflammation, secretion, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/925af5699cd448a886c87e868c414711

Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Authors: Eva-Maria Thüring, Christian Hartmann, Janesha C. Maddumage, Airah Javorsky, Birgitta E. Michels, Volker Gerke, Lawrence Banks, Patrick O. Humbert, Marc Kvansakul, Klaus Ebnet

Source: Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/1f98da77c25844a090ea916faeec5541

P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2

Authors: Jonas Goretzko, Inga Pauels, Nicole Heitzig, Katharina Thomas, Marina Kardell, Johannes Naß, Einar Kleinhans Krogsaeter, Sebastian Schloer, Barbara Spix, Anna Lívia Linard Matos, Charlotte Leser, Tristan Wegner, Frank Glorius, Franz Bracher, Volker Gerke, Jan Rossaint, Christian Grimm, Ursula Rescher

Source: Cell Reports, Vol 42, Iss 12, Pp 113501- (2023)

Subject Terms: CP: Immunology, CP: Cell biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723015139; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/743e166b584b4ba9a9ee505a123e92b3

Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage

Authors: Nikita Raj, Lilo Greune, Martin Kahms, Karina Mildner, Rico Franzkoch, Olympia Ekaterini Psathaki, Thomas Zobel, Dagmar Zeuschner, Jürgen Klingauf, Volker Gerke

Source: Advanced Science, Vol 10, Iss 13, Pp n/a-n/a (2023)

Subject Terms: calcium, endosomal fusion, membrane wounds, plasma membrane resealing, VAMP2, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/aa493a636a924d8e9c05972c84759dcb

Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes

Authors: Antonella Russo, Hendrik Schürmann, Matthias Brandt, Katja Scholz, Anna Livia L. Matos, David Grill, Julian Revenstorff, Maximilian Rembrink, Meike von Wulffen, Lena Fischer‐Riepe, Peter J. Hanley, Hans Häcker, Monika Prünster, Francisco Sánchez‐Madrid, Sven Hermann, Luisa Klotz, Volker Gerke, Timo Betz, Thomas Vogl, Johannes Roth

Source: Advanced Science, Vol 9, Iss 36, Pp n/a-n/a (2022)

Subject Terms: alarmin, calprotectin, CD69, MRP8/MRP14, migration, S100A8/S100A9 tetramer, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/436a845c56a94e71958ce48320f05a72

Editorial: Cell compartments and intracellular trafficking of lipids and proteins: Impact on biomedicine

Authors: Silvana Zanlungo, Carlos Enrich, Volker Gerke, Emily R. Eden, María Isabel Colombo

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: Endosomes, lysosomes, membrane contact sites, lysosome-related organelles, cholesterol, lysosomal storage diseases, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.1087214/full; https://doaj.org/toc/2296-634X

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Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment

Authors: Mariel F. Schwietzer, Sonja Thölmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Eva-Maria Thüring, M. Alexander Schmidt, Volker Gerke, Klaus Ebnet

Source: iScience, Vol 25, Iss 10, Pp 105144- (2022)

Subject Terms: Cell biology, Functional aspects of cell biology, Cancer, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S258900422201416X; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/ed020878c79f4eba8d15a34bc2bef83b

CHIMs are versatile cholesterol analogs mimicking and visualizing cholesterol behavior in lipid bilayers and cells

Authors: Anna L. L. Matos, Fabian Keller, Tristan Wegner, Carla Elizabeth Cadena del Castillo, David Grill, Sergej Kudruk, Anne Spang, Frank Glorius, Andreas Heuer, Volker Gerke

Source: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/6b36ae3d947f489d9b59bc1192d85ba4

The resealing factor S100A11 interacts with annexins and extended synaptotagmin-1 in the course of plasma membrane wound repair

Authors: Arsila P. K. Ashraf, Volker Gerke

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: calcium-binding proteins, cell damage, plasma membrane resealing, extended synaptotagmin, laser ablation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.968164/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/305b7ce4da1c4873b44610b7bbbf8acd

Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells

Authors: Klaus Ebnet, Volker Gerke

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: apico-basal membrane polarity, Rab small GTPase, Rho small GTPase, tight junctions, vesicle transport, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.948013/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/e0a940c3dcb54c6daa6145b0362000df

The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria

Authors: Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama, Klaus Ebnet

Source: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-17 (2020)

Subject Terms: Adhesion molecule, Cell-cell adhesion, JAM, Kidney epithelium, SYNJ2BP, TMIGD1, Cytology, QH573-671

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12860-020-00274-1; https://doaj.org/toc/2661-8850

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Human endothelial cells display a rapid tensional stress increase in response to tumor necrosis factor-α.

Authors: Matthias Brandt, Volker Gerke, Timo Betz

Source: PLoS ONE, Vol 17, Iss 6, p e0270197 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1041dd112f5147c0bc9a9ec645aa48ce

Acidification of endothelial Weibel-Palade bodies is mediated by the vacuolar-type H+-ATPase.

Authors: Julian Terglane, Dirk Menche, Volker Gerke

Source: PLoS ONE, Vol 17, Iss 6, p e0270299 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/dcdb365efb704dadbc050a8df909d1a2

Weibel Palade Bodies: Unique Secretory Organelles of Endothelial Cells that Control Blood Vessel Homeostasis

Authors: Johannes Naß, Julian Terglane, Volker Gerke

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: calcium, exocytosis, lysosome-related organelle, secretory organelles, hemostasis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.813995/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/dfb8472f0bf9493f93e432dd0fbefb77

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine

Authors: Sebastian Schloer, Linda Brunotte, Jonas Goretzko, Angeles Mecate-Zambrano, Nadia Korthals, Volker Gerke, Stephan Ludwig, Ursula Rescher

Source: Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2245-2255 (2020)

Subject Terms: SARS-CoV-2, IAV, FIASMA, fluoxetine, viral entry, endolysosomal interference, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/bcf82b4bf73a42dcb504646c60eb279b