Potentiating antibody-dependent killing of cancers with CAR T cells secreting CD47-SIRPα checkpoint blocker

Authors: Dacek, Megan M., Kurtz, Keifer G., Wallisch, Patrick, Pierre, Stephanie A., Khayat, Shireen, Bourne, Christopher M., Gardner, Thomas J., Vogt, Kristen C., Aquino, Nica, Younes, Anas, Scheinberg, David A.

Source: In Blood 20 April 2023 141(16):2003-2015

Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity.

Authors: Vogt, Kristen C.^1,2,3, Silberman, Pedro C.^1,2,4, Qianqian Lin^1,2,5, Han, James E.¹, Laflin, Amy⁶, Gellineau, Hendryck A.¹, Heller, Daniel A.^1,2,3,4, Scheinberg, David A.^1,2,3,4 scheinbd@mskcc.org

Source: Science Advances. 1/24/2025, Vol. 11 Issue 4, p1-16. 16p.

Subject Terms: *SYNTHETIC receptors, *TUMOR antigens, *CHIMERIC antigen receptors, *TUMOR-infiltrating immune cells, *CANCER cells, *T cells

Scope and efficacy of the broad-spectrum topical antiseptic choline geranate.

Authors: Greene, Joshua R., Merrett, Kahla L., Heyert, Alexanndra J., Simmons, Lucas F., Migliori, Camille M., Vogt, Kristen C., Castro, Rebeca S., Phillips, Paul D., Baker, Joseph L., Lindberg, Gerrick E., Fox, David T., Del Sesto, Rico E., Koppisch, Andrew T.

Source: PLoS ONE; 9/17/2019, Vol. 14 Issue 9, p1-22, 22p

Subject Terms: BACTERIAL cell walls, ENTEROCOCCUS, ENTEROCOCCUS faecium, STAPHYLOCOCCUS aureus, BIOMEDICAL materials, KLEBSIELLA pneumoniae, FOSFOMYCIN

Targeted Cellular Micropharmacies: Cells Engineered for Localized Drug Delivery.

Authors: Gardner, Thomas J., Bourne, Christopher M., Dacek, Megan M., Kurtz, Keifer, Malviya, Manish, Peraro, Leila, Silberman, Pedro C., Vogt, Kristen C., Unti, Mildred J., Brentjens, Renier, Scheinberg, David

Source: Cancers; Aug2020, Vol. 12 Issue 8, p2175-2175, 1p

Subject Terms: BIOMEDICAL engineering, CELL receptors, IMMUNOTHERAPY, T cells, TISSUE engineering