A de novo missense variant in GABRA4 alters receptor function in an epileptic and neurodevelopmental phenotype

Authors: Vogel, Florian D., Krenn, Martin, Westphal, Dominik S., Graf, Elisabeth, Wagner, Matias, Leiz, Steffen, Koniuszewski, Filip, Augé‐Stock, Maximilian, Kramer, Georg, Scholze, Petra, Ernst, Margot

Source: Epilepsia. 63(4):e35-e41

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154931063.0x000001&indx=1&recIds=ETOCvdc_100154931063.0x000001

Tricyclic antipsychotics and antidepressants can inhibit α5‐containing GABAA receptors by two distinct mechanisms

Authors: Bampali, Konstantina, Koniuszewski, Filip, Silva, Luca L., Rehman, Sabah, Vogel, Florian D., Seidel, Thomas, Scholze, Petra, Zirpel, Florian, Garon, Arthur, Langer, Thierry, Willeit, Matthäus, Ernst, Margot

Source: British journal of pharmacology. 179(14):3675-3692

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153632908.0x000001&indx=1&recIds=ETOCvdc_100153632908.0x000001

De novo variants in GABRA4are associated with a neurological phenotype including developmental delay, behavioral abnormalities and epilepsy

Authors: Sajan, Samin A., Gradisch, Ralph, Vogel, Florian D., Coffey, Alison J., Salyakina, Daria, Soler, Diana, Jayakar, Parul, Jayakar, Anuj, Bianconi, Simona E., Cooper, Annina H., Liu, Shuxi, William, Nancy, Benkel-Herrenbrück, Ira, Maiwald, Robert, Heller, Corina, Biskup, Saskia, Leiz, Steffen, Westphal, Dominik S., Wagner, Matias, Clarke, Amy, Stockner, Thomas, Ernst, Margot, Kesari, Akanchha, Krenn, Martin

Source: European Journal of Human Genetics: EJHG; August 2024, Vol. 32 Issue: 8 p912-919, 8p

GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach.

Authors: Bampali, Konstantina, Koniuszewski, Filip, Vogel, Florian D., Fabjan, Jure, Andronis, Christos, Lekka, Eftychia, Virvillis, Vassilis, Seidel, Thomas, Delaunois, Annie, Royer, Leandro, Rolf, Michael G., Giuliano, Chiara, Traebert, Martin, Roussignol, Gautier, Fric-Bordat, Magali, Mazelin-Winum, Ludmilla, Bryant, Sharon D., Langer, Thierry, Ernst, Margot

Source: Cell Biology & Toxicology; Dec2023, Vol. 39 Issue 6, p2793-2819, 27p

Subject Terms: LIGAND-gated ion channels, SEIZURES (Medicine), BINDING sites, CENTRAL nervous system, DRUG development

Navigating the complex landscape of benzodiazepine- and Z-drug diversity: insights from comprehensive FDA adverse event reporting system analysis and beyond.

Authors: Koniuszewski, Filip, Vogel, Florian D., Dajić, Irena, Seidel, Thomas, Kunze, Markus, Willeit, Matthäus, Ernst, Margot

Source: Frontiers in Psychiatry; 2023, p01-23, 23p

Subject Terms: SYSTEM analysis, BINDING sites, PHARMACODYNAMICS, INDIVIDUAL differences, FLUMAZENIL, ANESTHETICS

Company/Entity: UNITED States. Food & Drug Administration

Tricyclic antipsychotics and antidepressants can inhibit α5‐containing GABAA receptors by two distinct mechanisms.

Authors: Bampali, Konstantina, Koniuszewski, Filip, Silva, Luca L., Rehman, Sabah, Vogel, Florian D., Seidel, Thomas, Scholze, Petra, Zirpel, Florian, Garon, Arthur, Langer, Thierry, Willeit, Matthäus, Ernst, Margot

Source: British Journal of Pharmacology; Jul2022, Vol. 179 Issue 14, p3675-3692, 18p, 2 Diagrams, 4 Graphs

Subject Terms: GABA receptors, TRICYCLIC antidepressants, MOLECULAR structure, ANTIPSYCHOTIC agents, ANTIDEPRESSANTS, XENOPUS laevis