Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins

Authors: Kathryn E. Carnazza, Lauren E. Komer, Ying Xue Xie, André Pineda, Juan Antonio Briano, Virginia Gao, Yoonmi Na, Trudy Ramlall, Vladimir L. Buchman, David Eliezer, Manu Sharma, Jacqueline Burré

Source: Cell Reports, Vol 43, Iss 5, Pp 114280- (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724006089; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/92f1178b930f40d6a128c73a29fb7909

Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein

Authors: Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/795dea3b15b941688aa5f281361c1332

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive 'low footprint' genetic knockout of alpha-synuclein

Authors: Valeria V. Goloborshcheva, Kirill D. Chaprov, Ekaterina V. Teterina, Ruslan Ovchinnikov, Vladimir L. Buchman

Source: Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)

Subject Terms: Dopaminergic neurons, Substantia nigra, Striatum, Alpha-synuclein, Null mutant mice, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13041-020-00613-5; https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/f10c55045fcf4e8f86795bb214ab0f18

Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS

Authors: Haiyan An, Camille Rabesahala de Meritens, Vladimir L. Buchman, Tatyana A. Shelkovnikova

Source: Molecular Brain, Vol 13, Iss 1, Pp 1-4 (2020)

Subject Terms: Fused in sarcoma, FUS, Amyotrophic lateral sclerosis, ALS, Frameshift mutation, Frameshift peptide, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13041-020-00618-0; https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/63fa847acb0744858ed38a40f978c4a8

ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity

Authors: Haiyan An, Gioana Litscher, Naruaki Watanabe, Wenbin Wei, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova

Source: Neurobiology of Disease, Vol 162, Iss , Pp 105585- (2022)

Subject Terms: FUS, ALS, Stress granule, RNP granule, FUS aggregate, hnRNPA3, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S096999612100334X; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/5d63137f0a32465ab65af9032e87e214

Loss of the Synuclein Family Members Differentially Affects Baseline- and Apomorphine-Associated EEG Determinants in Single-, Double- and Triple-Knockout Mice

Authors: Vasily Vorobyov, Alexander Deev, Iuliia Sukhanova, Olga Morozova, Zoya Oganesyan, Kirill Chaprov, Vladimir L. Buchman

Source: Biomedicines, Vol 10, Iss 12, p 3128 (2022)

Subject Terms: synucleins, dopamine, electroencephalogram, frequency spectrum, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/12/3128; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/924cb432252141c9a9fb269cec4024de

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

Authors: Haiyan An, Lucy Skelt, Antonietta Notaro, J. Robin Highley, Archa H. Fox, Vincenzo La Bella, Vladimir L. Buchman, Tatyana A. Shelkovnikova

Source: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)

Subject Terms: Amyotrophic lateral sclerosis (ALS), Fused in sarcoma (FUS), NEAT1, Paraspeckle, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-019-0658-x; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/4f6970050ae14e91903ae256f98aa4a0

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

Authors: Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman

Source: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-17 (2018)

Subject Terms: ALS, TDP-43, Paraspeckle, NEAT1, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13024-018-0263-7; https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/32909fe494c245dd9eff4f5d0cc93bdf

Toward a Disease-Modifying Therapy of Alpha-Synucleinopathies: New Molecules and New Approaches Came into the Limelight

Authors: Matthew Upcott, Kirill D. Chaprov, Vladimir L. Buchman

Source: Molecules, Vol 26, Iss 23, p 7351 (2021)

Subject Terms: alpha-synuclein, therapeutic/therapy, biomarker, rodent models, Parkinson’s disease, translational research, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/23/7351; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/d9a9a59bc6094892aa12321aa5d44fdc

Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis

Authors: Tatyana A. Shelkovnikova, Haiyan An, Lucy Skelt, John S. Tregoning, Ian R. Humphreys, Vladimir L. Buchman

Source: Cell Reports, Vol 29, Iss 13, Pp 4496-4508.e4 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719315943; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/44b362b201e6491bbd5c03b86903760f

Triple-Knockout, Synuclein-Free Mice Display Compromised Lipid Pattern

Authors: Irina A. Guschina, Natalia Ninkina, Andrei Roman, Mikhail V. Pokrovskiy, Vladimir L. Buchman

Source: Molecules, Vol 26, Iss 11, p 3078 (2021)

Subject Terms: synucleins, triple-knockout mouse model, phospholipids, non-polar lipids, fatty acids, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/11/3078; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/39454c56edaf4a6d979390defac52a68

Synuclein Deficiency Results in Age-Related Respiratory and Cardiovascular Dysfunctions in Mice

Authors: Patrick S. Hosford, Natalia Ninkina, Vladimir L. Buchman, Jeffrey C. Smith, Nephtali Marina, Shahriar SheikhBahaei

Source: Brain Sciences, Vol 10, Iss 9, p 583 (2020)

Subject Terms: aged mouse, baroreflex, hypoxia, hypercapnia, Parkinson’s disease, synuclein, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/10/9/583; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/6ce6a6308b2c44c1bcccb101ee746cff

CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene

Authors: Tatiana V. Egorova, Evgenia D. Zotova, Denis A. Reshetov, Anna V. Polikarpova, Svetlana G. Vassilieva, Dmitry V. Vlodavets, Alexey A. Gavrilov, Sergey V. Ulianov, Vladimir L. Buchman, Alexei V. Deykin

Source: Disease Models & Mechanisms, Vol 12, Iss 4 (2019)

Subject Terms: Exon skipping, Muscle degeneration, New deletion, Genome editing, DMD, Mouse model, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/12/4/dmm037655; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/316b1ecf089f4dba993bcc8630736791

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis

Authors: Owen M. Peters, Steven Millership, Tatyana A. Shelkovnikova, Ileana Soto, Lora Keeling, Anthony Hann, Nicholas Marsh-Armstrong, Vladimir L. Buchman, Natalia Ninkina

Source: Neurobiology of Disease, Vol 48, Iss 1, Pp 124-131 (2012)

Subject Terms: Neurodegeneration, ALS, Neurofilament, Aggregation, Motor neuron, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996112002318; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/32924db1ff434670bdb95f2f99cccca2

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