Development of chimeric MrNV virus-like particles capable of binding to SARS-CoV-2-susceptible cells and reducing infection by pseudovirus variants

Authors: Supawich Boonkua, Orawan Thongsum, Purimpuch Soongnart, Rueangtip Chantunmapitak, Somkid Jaranathummakul, Kitima Srisanga, Somluk Asuvapongpatana, Patompon Wongtrakoongate, Wattana Weerachatyanukul, Atthaboon Watthammawut, Monsicha Somrit

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Subject Terms: Virus-like particle, Macrobrachium rosenbergii nodavirus (MrNV), Nanotechnology, Genetic modification, SARS-CoV-2, Recombinant capsid protein, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/574de8d917634199b8afdc58bf8fec59

Safety and immunogenicity of the SARS-CoV-2 LYB001 RBD-based VLP vaccine (CHO cell) phase 1 in Chinese adults: a randomized, double-blind, positive-parallel-controlled study

Authors: Rong Tang, Ying Zeng, Yu Zhou, Qi Liang, Wei Kang, Zhonghua Yang, Xiaoxiang Zheng, Xia Zang, Hongxing Pan, Jing Jin, Fengcai Zhu

Source: Expert Review of Vaccines, Vol 23, Iss 1, Pp 498-509 (2024)

Subject Terms: COVID-19 vaccine, recombinant protein, virus-like particle (VLP), safety, tolerance, immunogenicity, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/1476-0584; https://doaj.org/toc/1744-8395

Access URL: https://doaj.org/article/37e9274838794de8853f72ec7ac8733e

Foot-and-mouth disease virus-like particle vaccine incorporating dominant T and B cell epitopes: enhanced immune response in piglets with CD154 molecules

Authors: Yuwan Li, Weijun Zeng, Xinni Niu, Zhongmao Yuan, Shurou Li, Jinru Lin, Kaiyuan Xie, Zixiang Zhu, Lin Yi, Hongxing Ding, Mingqiu Zhao, Shuangqi Fan, Jinding Chen

Source: Frontiers in Veterinary Science, Vol 12 (2025)

Subject Terms: foot-and-mouth disease virus (FMDV), virus-like particle vaccine (VLP), CD154, T and B cell epitopes, ADDomer, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fvets.2025.1540102/full; https://doaj.org/toc/2297-1769

Access URL: https://doaj.org/article/43f081e5cf164016a031b88cf0c4b720

Multifaceted virus-like particles: Navigating towards broadly effective influenza A virus vaccines

Authors: Jaffar Ali Muhamad Norizwan, Wen Siang Tan

Source: Current Research in Microbial Sciences, Vol 8, Iss , Pp 100317- (2025)

Subject Terms: Virus-like particle, Influenza A virus, Vaccine, Conserved antigens, Pain-free, Production system, Microbiology, QR1-502, Genetics, QH426-470

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666517424001007; https://doaj.org/toc/2666-5174

Access URL: https://doaj.org/article/929a171c05a745cb84f4d8218f94ab6c

Lipid A-modified Escherichia coli can produce porcine parvovirus virus-like particles with high immunogenicity and minimal endotoxin activity

Authors: Xuegang Shen, Yong-Bo Yang, Yanfei Gao, Shujie Wang, Haiwei Wang, Mingxia Sun, Fandan Meng, Yan-Dong Tang, Yabin Tu, Qingke Kong, Tong-Qing An, Xue-Hui Cai

Source: Microbial Cell Factories, Vol 23, Iss 1, Pp 1-13 (2024)

Subject Terms: Porcine parvovirus, Virus-like particle, Minimal endotoxin activity, Escherichia coli, Lipid A, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2859

Access URL: https://doaj.org/article/76b5aab8e71349bea27177c50301c830

Leveraging T cell-specific fusogenicity of HIV for in vivo mRNA delivery to produce human CAR-T cells

Authors: Wang, Yue ^{1, 5}, Yang, Min ^{1, 5}, Zhang, Bao-Yue ¹, Zhao, Gui ¹, Zhou, Shi-Kun ¹, Lu, Zi-Dong ², Xu, Cong-Fei ^{1, 3, 4, ∗}, Wang, Jun ^{1, 3, 4, 6, 7, ∗∗}

Source: In Cell Biomaterials 25 March 2025 1(2)

Chromatography media and purification processes for complex and super-large biomolecules: A review

Authors: Zhao, Lan ^{a, b}, Ma, Guanghui ^{a, b, ⁎}

Source: In Journal of Chromatography A 15 March 2025 1744

A phase I/II study of CpG/alum-adjuvanted mammalian-derived quadruple antigen carrying virus-like particle COVID-19 vaccine

Authors: Yilmaz, Ismail Cem ^{a, c, 1}, Ipekoglu, Emre Mert ^{c, 1}, Golcuklu, Berfu Saraydar ^{b, 1}, Bildik, Tugce ^{b, 1}, Aksoy, Aslı Gulce Bartan ^{b, 1}, Evcili, Irem ^{a, b}, Turay, Nilsu ^a, Surucu, Naz ^c, Bulbul, Artun ^b, Guvencli, Nese ^c, Yildirim, Muzaffer ^a, Canavar Yildirim, Tugce ^{a, b}, Atalay, Yagmur Aydin ^c, Abras, Irem ^b, Ceylan, Yasemin ^b, Ozsurekci, Yasemin ^{a, d}, Tigen, Elif Tukenmez ^e, Korten, Volkan ^e, Gursel, Mayda ^{a, ⁎}, Gursel, Ihsan ^{a, ⁎}

Source: In Vaccine 7 March 2025 49

Competition propels, rather than limits, the success of low-affinity B cells in the germinal center response

Authors: Li, Runhan ^{1, 4}, Bao, Keyan ^{2, 4}, Liu, Can ³, Ma, Xuejing ^{1, 3}, Hua, Zhaolin ^{1, 3, ∗}, Zhu, Ping ^{1, 2, 3, ∗∗}, Hou, Baidong ^{1, 3, 5, ∗∗∗}

Source: In Cell Reports 25 February 2025 44(2)

Design and evaluation of a multi-epitope HIV-1 vaccine based on human parvovirus virus-like particles

Authors: Pérez-Saucedo, David ^a, Castro-Perea, Nancy Vanessa ^b, Ruíz-Cruz, Antonio ^a, Bustos-Jaimes, Ismael ^c, Viveros-Rogel, Mónica ^d, Huerta-Hernández, Leonor ^e, Moreno-Fierros, Leticia ^{a, ⁎}

Source: In Vaccine 25 January 2025 45

Broadly cross-reactive immune responses in chickens immunized with chimeric virus-like particles of nodavirus displaying the M2e originated from avian and human influenza A viruses

Authors: Thian, Bernard Yi Zhe ^{a, 1}, Fatimah, Mohd Nasir Nurul ^{a, 1}, Wong, Chuan Loo ^{a, b}, Ong, Hui Kian ^c, Mariatulqabtiah, Abdul Razak ^{d, e}, Ho, Kok Lian ^c, Omar, Abdul Rahman ^{e, f}, Tan, Wen Siang ^{a, ⁎}

Source: In Developmental and Comparative Immunology January 2025 162

IAPSM’s Position Paper on the Human Papilloma Virus (HPV) Vaccine for Adult Immunization in India

Authors: Ranjitha S. Shetty, Anuradha Nadda, Muralidhar Tambe, Abhishek Raut, Kapil Goel, Chythra R. Rao, Aprajita Mehta, Pankaj Bhardwaj, Madhu Gupta, Veena G Kamath

Source: Indian Journal of Community Medicine, Vol 49, Iss Suppl 2, Pp S125-S131 (2024)

Subject Terms: cervical cancer, hpv, immunogenicity, vaccine, virus-like-particle, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/ijcm.ijcm_738_24; https://doaj.org/toc/0970-0218; https://doaj.org/toc/1998-3581

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A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage

Authors: Dexin Kong, Yanjuan He, Jiaxin Wang, Lanyan Chi, Xiang Ao, Hejia Ye, Weihong Qiu, Xiutong Zhu, Ming Liao, Huiying Fan

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: H5N1, virus-like particle, adjuvant, vaccine dose, neutralizing antibodies, cross-protection, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/a2b63d3eaf4a472e99cdee6b5f31b497

A nucleoside-modified mRNA vaccine forming rabies virus-like particle elicits strong cellular and humoral immune responses against rabies virus infection in mice

Authors: Jie Liu, Jie Sun, Xue Ding, Wenhao Liu, Yipeng Wang, Zihan Wang, Hanyu Peng, Yong Zhang, Weiheng Su, Chunlai Jiang

Source: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

Subject Terms: Rabies virus, mRNA vaccine, glycoprotein, prefusion conformation, virus-like particle, germinal centre, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/65037c0fa4f64e178d0ed14000594e3c

Cell-targeted gene modification by delivery of CRISPR-Cas9 ribonucleoprotein complexes in pseudotyped lentivirus-derived nanoparticles

Authors: Ian Helstrup Nielsen, Anne Bruun Rovsing, Jacob Hørlück Janns, Emil Aagaard Thomsen, Albert Ruzo, Andreas Bøggild, Frederikke Nedergaard, Charlotte Thornild Møller, Thomas Boesen, Søren Egedal Degn, Jagesh V. Shah, Jacob Giehm Mikkelsen

Source: Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102318- (2024)

Subject Terms: Delivery, LVNP, Gag, virus-like particle, VLP, CRISPR-Cas9, pseudotyping, cell-targeted gene modification, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253124002051; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/5b0da4b8e2504d17b7dca8efcfd345d5

A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicityResearch in context

Authors: Yuhan Li, Xianwen Zhang, Wanbo Tai, Xinyu Zhuang, Huicheng Shi, Shumin Liao, Xinyang Yu, Rui Mei, Xingzhao Chen, Yanhong Huang, Yubin Liu, Jianying Liu, Yang Liu, Yibin Zhu, Penghua Wang, Mingyao Tian, Guocan Yu, Liang Li, Gong Cheng

Source: EBioMedicine, Vol 110, Iss , Pp 105437- (2024)

Subject Terms: SARS-CoV-2, High-frequency mutations, Spike variants, Virus entry, Virus-like particle mRNA vaccine, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004730; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/30828ee07f364a019c79b0ea962e961b

Semi-automated diagnostic system and severe fever with thrombocytopenia syndrome (SFTS) viral RNA reference materials encapsulated in virus-like particles for on-site diagnosis of SFTS

Authors: Roh, Yeonjeong ^{a, 1}, Baek, Yujin ^{a, b, 1}, Kim, Myoung Gyu ^a, Koo, Bonhan ^a, Seo, Ramin ^c, Lee, Joonseok ^d, Jung, Seungwon ^e, Kim, Sang Kyung ^e, Bae, Moonsuk ^f, Lee, Chang-Seop ^g, Kim, Il-Hwan ^{b, ⁎}, Shin, Yong ^{a, ⁎}

Source: In Sensors and Actuators: B. Chemical 15 June 2025 433

Two-dimensional size exclusion reversed-phase liquid chromatography for quantitative analysis of L1 proteins in complex vaccine matrices

Authors: Arcinas, Arthur J. ^{a, ⁎}, Larson, Eli J. ^b, Buchhalter, Eric P. ^a, Dunn, Zachary D. ^b, Wang, Heather ^b, Singh, Andrew N. ^b, Barrientos, Rodell C. ^b, Ukaegbu, Ophelia ^b, Mukherjee, Malini ^a, Appiah-Amponsah, Emmanuel ^a, Regalado, Erik L. ^b

Source: In Journal of Chromatography A 10 May 2025 1748

A VLP vaccine platform comprising the core protein of hepatitis B virus with N-terminal antigen capture

Authors: Fatema, Kaniz ¹, Snowden, Joseph S. ¹, Watson, Alexander, Sherry, Lee, Ranson, Neil A., Stonehouse, Nicola J. ^⁎, Rowlands, David J. ^⁎

Source: In International Journal of Biological Macromolecules May 2025 305 Part 2

A systematic approach for scalable purification of virus-like particles

Authors: Park, Enoch Y. ^{a, b, ⁎}, Minkner, Robert ^{b, 1}

Source: In Protein Expression and Purification April 2025 228