The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.

Authors: Irene Fasciani, Francesco Petragnano, Ziming Wang, Ruairidh Edwards, Narasimha Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria E Terzenidou, Jacopo Di Gregorio, Cristina Pellegrini, Silvano Santini, Anna R Taddei, Bärbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin J Lohse, Paolo Annibale, Roberto Maggio

Source: PLoS Biology, Vol 22, Iss 4, p e3002582 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/55337ca4f8c84555b649a08804c2bd5c

Protein Stability Regulation in Osteosarcoma: The Ubiquitin-like Modifications and Glycosylation as Mediators of Tumor Growth and as Targets for Therapy

Authors: Jacopo Di Gregorio, Laura Di Giuseppe, Sara Terreri, Michela Rossi, Giulia Battafarano, Olivia Pagliarosi, Vincenzo Flati, Andrea Del Fattore

Source: Cells, Vol 13, Iss 6, p 537 (2024)

Subject Terms: cancer, osteosarcoma, post-translational modifications, ubiquitination, NEDDylation, SUMOylation, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/6/537; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/5580a65d10ff4f8bb494924e1d203093

Mitochondrial and metabolic alterations in cancer cells

Authors: Jacopo Di Gregorio, Sabrina Petricca, Roberto Iorio, Elena Toniato, Vincenzo Flati

Source: European Journal of Cell Biology, Vol 101, Iss 3, Pp 151225- (2022)

Subject Terms: Metabolism, Cancer, Mitochondria, Fatty acids, Amino acids, OXPHOS, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0171933522000280; https://doaj.org/toc/0171-9335

Access URL: https://doaj.org/article/5bbde54b4ecb4e6a8bc4af0d594f1282

Anti-Obesity and Anti-Inflammatory Effects of Novel Carvacrol Derivatives on 3T3-L1 and WJ-MSCs Cells

Authors: Ivana Cacciatore, Sonia Spalletta, Annalisa Di Rienzo, Vincenzo Flati, Erika Fornasari, Laura Pierdomenico, Piero Del Boccio, Silvia Valentinuzzi, Erica Costantini, Elena Toniato, Stefano Martinotti, Carmela Conte, Antonio Di Stefano, Iole Robuffo

Source: Pharmaceuticals, Vol 16, Iss 3, p 340 (2023)

Subject Terms: adipogenesis, anti-inflammatory drugs, carvacrol, obesity, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/3/340; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/cf678bff4bc14b73ac2165405fd2fc1c

mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening

Authors: Annamaria Tisi, Dyan Ramekers, Vincenzo Flati, Huib Versnel, Rita Maccarone

Source: Biomedicines, Vol 10, Iss 11, p 2935 (2022)

Subject Terms: mTOR, organ of Corti, hearing loss, neurotrophins, hair cells, supporting cells, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/11/2935; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/4b7515fb4af9464c80f26ce0ca590b81

Editorial: The Dynamic Interplay Between Nutrition, Autophagy and Cell Metabolism

Authors: Vincenzo Flati, Giovanni Corsetti, Salvatore Papa

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: autophagy, cell metabolism, nutrients and energy, cancer, inflammation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.684049/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/2578efb8871b4edc96ad1ea45361fd0f

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders

Authors: Jacopo Di Gregorio, Iole Robuffo, Sonia Spalletta, Giulia Giambuzzi, Vincenzo De Iuliis, Elena Toniato, Stefano Martinotti, Pio Conti, Vincenzo Flati

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: EMT, fibrosis, autophagy, inflammation, TGF-β, SMADs, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2020.607483/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/2d0cfd462ae745d29e81c95336fbae44

Antioxidant Properties of Cerium Oxide Nanoparticles Prevent Retinal Neovascular Alterations In Vitro and In Vivo

Authors: Annamaria Tisi, Fanny Pulcini, Giulia Carozza, Vincenzo Mattei, Vincenzo Flati, Maurizio Passacantando, Cinzia Antognelli, Rita Maccarone, Simona Delle Monache

Source: Antioxidants, Vol 11, Iss 6, p 1133 (2022)

Subject Terms: oxidative stress, wet AMD, VEGF, RPE, cerium oxide nanoparticles, ARPE-19, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/6/1133; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/13119376de6946f1a10f4367d679561a

Nanoceria Particles Are an Eligible Candidate to Prevent Age-Related Macular Degeneration by Inhibiting Retinal Pigment Epithelium Cell Death and Autophagy Alterations

Authors: Annamaria Tisi, Vincenzo Flati, Simona Delle Monache, Luca Lozzi, Maurizio Passacantando, Rita Maccarone

Source: Cells, Vol 9, Iss 7, p 1617 (2020)

Subject Terms: nanomedicine, nanoceria, retinal pigment epithelium, light damage, autophagy, atrophic AMD, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/7/1617; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/f65c4424211c4b82a18a9b5d442352e8

Body Weight Loss and Tissue Wasting in Late Middle-Aged Mice on Slightly Imbalanced Essential/Non-essential Amino Acids Diet

Authors: Giovanni Corsetti, Evasio Pasini, Claudia Romano, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Vincenzo Flati, Francesco S. Dioguardi

Source: Frontiers in Medicine, Vol 5 (2018)

Subject Terms: aging, nutrition, diet, muscle atrophy, body wasting, food choice, Medicine (General), R5-920

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fmed.2018.00136/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/ae29573021fc4961ba549d726824bcf3

Carvacrol reduces adipogenic differentiation by modulating autophagy and ChREBP expression.

Authors: Sonia Spalletta, Vincenzo Flati, Elena Toniato, Jacopo Di Gregorio, Antonio Marino, Laura Pierdomenico, Marco Marchisio, Gabriella D'Orazi, Ivana Cacciatore, Iole Robuffo

Source: PLoS ONE, Vol 13, Iss 11, p e0206894 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6231630?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6a0deaacf95f499cb34c426daebff1bb

Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis.

Authors: Jacopo Di Gregorio, Roberta Sferra, Silvia Speca, Antonella Vetuschi, Caroline Dubuquoy, Pierre Desreumaux, Simona Pompili, Loredana Cristiano, Eugenio Gaudio, Vincenzo Flati, Giovanni Latella

Source: PLoS ONE, Vol 12, Iss 2, p e0171093 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5313173?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/564d16f4f6fb409f9578eeaa512ec36d

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Authors: Vincenzo De Iuliis, author¹, Sebastiano Ursi, author¹, Alfonso Pennelli, author², Marika Caruso, author², Sabrina Capodifoglio, author², Antonio Marino, author¹, Vincenzo Flati, author³, Gianfranco Vitullo, author¹, Elena Toniato, author², Iole Robuffo, author⁴, Stefano Martinotti, author^{1, 2}

Source: Journal of Visualized Experiments. (146)

Availability: http://www.jove.com/video/57289