Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levelsResearch in context

Authors: Aoife Murray, Gillian Gough, Ana Cindrić, Frano Vučković, David Koschut, Vincenzo Borelli, Dražen J. Petrović, Ana Bekavac, Ante Plećaš, Valentina Hribljan, Reinhard Brunmeir, Julija Jurić, Maja Pučić-Baković, Anita Slana, Helena Deriš, Azra Frkatović, Jűrgen Groet, Niamh L. O’Brien, Hong Yu Chen, Yee Jie Yeap, Frederic Delom, Steven Havlicek, Luke Gammon, Sarah Hamburg, Carla Startin, Hana D’Souza, Dinko Mitrečić, Mijana Kero, Ljubica Odak, Božo Krušlin, Željka Krsnik, Ivica Kostović, Jia Nee Foo, Yuin-Han Loh, Norris Ray Dunn, Susana de la Luna, Tim Spector, Ingeborg Barišić, Michael S.C. Thomas, Andre Strydom, Claudio Franceschi, Gordan Lauc, Jasminka Krištić, Ivan Alić, Dean Nižetić

Source: EBioMedicine, Vol 94, Iss , Pp 104692- (2023)

Subject Terms: Down syndrome, Down syndrome critical region, Chromosome 21, Ageing, DYRK1A, DYRK1A inhibitors, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423002578; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/fccbd6f8ccf04865a74224623e30be79

N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters.

Authors: Roberto Testa, Valerie Vanhooren, Anna Rita Bonfigli, Massimo Boemi, Fabiola Olivieri, Antonio Ceriello, Stefano Genovese, Liana Spazzafumo, Vincenzo Borelli, Maria Giulia Bacalini, Stefano Salvioli, Paolo Garagnani, Sylviane Dewaele, Claude Libert, Claudio Franceschi

Source: PLoS ONE, Vol 10, Iss 3, p e0119983 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4368037?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e5a05f60b170468dacde5aa11d6a9342