Private, public, and bottled drinking water: Shared contaminant-mixture exposures and effects challenge

Authors: Bradley, Paul M. ^{a, ⁎}, Romanok, Kristin M. ^b, Smalling, Kelly L. ^b, Gordon, Stephanie E. ^c, Huffman, Bradley J. ^a, Paul Friedman, Katie ^d, Villeneuve, Daniel L. ^e, Blackwell, Brett R. ^{e, 1}, Fitzpatrick, Suzanne C. ^f, Focazio, Michael J. ^{g, 2}, Medlock-Kakaley, Elizabeth ^d, Meppelink, Shannon M. ^h, Navas–Acien, Ana ⁱ, Nigra, Anne E. ⁱ, Schreiner, Molly L. ^b

Source: In Environment International January 2025 195

The thyroid hormone system disrupting potential of resorcinol in fish

Authors: Van Dingenen, Imke ^a, Andersen, Emma ^b, Volz, Sina ^b, Christiansen, Monica ^b, Novák, Jiří ^c, Haigis, Ann-Cathrin ^a, Stacy, Emma ^d, Blackwell, Brett R. ^d, Villeneuve, Daniel L. ^d, Vergauwen, Lucia ^a, Hilscherová, Klára ^c, Holbech, Henrik ^b, Knapen, Dries ^{a, ⁎}

Source: In Ecotoxicology and Environmental Safety 1 October 2024 284

AOP Report: Aryl Hydrocarbon Receptor Activation Leads to Early–Life Stage Mortality via Sox9 Repression‐Induced Craniofacial and Cardiac Malformations

Authors: Shankar, Prarthana, Villeneuve, Daniel L.

Source: Environmental toxicology and chemistry. 42(10):2063-2077

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194587648.0x000001&indx=1&recIds=ETOCvdc_100194587648.0x000001

A framework for prioritizing contaminants in retrospective ecological assessments: Application in the Milwaukee Estuary (Milwaukee, WI)

Authors: Maloney, Erin M., Villeneuve, Daniel L., Blackwell, Brett R., Vitense, Kelsey, Corsi, Steven R., Pronschinske, Matthew A., Jensen, Kathleen M., Ankley, Gerald T.

Source: Integrated environmental assessment and management. 19(5):1276-1296

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194612753.0x000001&indx=1&recIds=ETOCvdc_100194612753.0x000001

AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male‐Biased Sex Ratio and Population Decline in Fish

Authors: Ankley, Gerald T., Santana‐Rodriguez, Kelvin, Jensen, Kathleen M., Miller, David H., Villeneuve, Daniel L.

Source: Environmental toxicology and chemistry. 42(4):747-756

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192721843.0x000001&indx=1&recIds=ETOCvdc_100192721843.0x000001

Evaluation of Complex Mixture Toxicity in the Milwaukee Estuary (WI, USA) Using Whole‐Mixture and Component‐Based Evaluation Methods

Authors: Maloney, Erin M., Villeneuve, Daniel L., Jensen, Kathleen M., Blackwell, Brett R., Kahl, Michael D., Poole, Shane T., Vitense, Kelsey, Feifarek, David J., Patlewicz, Grace, Dean, Kendra, Tilton, Charlene, Randolph, Eric C., Cavallin, Jenna E., LaLone, Carlie A., Blatz, Donovan, Schaupp, Christopher M., Ankley, Gerald T.

Source: Environmental toxicology and chemistry. 42(6):1229-1256

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184409959.0x000001&indx=1&recIds=ETOCvdc_100184409959.0x000001

Pesticide Prioritization by Potential Biological Effects in Tributaries of the Laurentian Great Lakes

Authors: Oliver, Samantha K., Corsi, Steven R., Baldwin, Austin K., Nott, Michele A., Ankley, Gerald T., Blackwell, Brett R., Villeneuve, Daniel L., Hladik, Michelle L., Kolpin, Dana W., Loken, Luke, DeCicco, Laura A., Meyer, Michael T., Loftin, Keith A.

Source: Environmental toxicology and chemistry. 42(2):367-384

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182011634.0x000001&indx=1&recIds=ETOCvdc_100182011634.0x000001

Prioritizing Pesticides of Potential Concern and Identifying Potential Mixture Effects in Great Lakes Tributaries Using Passive Samplers

Authors: Loken, Luke C., Corsi, Steven R., Alvarez, David A., Ankley, Gerald T., Baldwin, Austin K., Blackwell, Brett R., De Cicco, Laura A., Nott, Michele A., Oliver, Samantha K., Villeneuve, Daniel L.

Source: Environmental toxicology and chemistry. 42(2):340-366

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182011518.0x000001&indx=1&recIds=ETOCvdc_100182011518.0x000001

Verification of In Vivo Estrogenic Activity for Four Per- and Polyfluoroalkyl Substances (PFAS) Identified as Estrogen Receptor Agonists via New Approach Methodologies

Authors: Villeneuve, Daniel L., Blackwell, Brett R., Cavallin, Jenna E., Collins, Jacob, Hoang, John X., Hofer, Rachel N., Houck, Keith A., Jensen, Kathleen M., Kahl, Michael D., Kutsi, Robin N.

Source: Environmental science & technology. 57(9):3794-3803

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631933062&indx=1&recIds=ETOCRN631933062

Case Study in 21st‐Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo

Authors: Villeneuve, Daniel L., Blackwell, Brett R., Blanksma, Chad A., Cavallin, Jenna E., Cheng, Wan‐Yun, Conolly, Rory B., Conrow, Kendra, Feifarek, David J., Heinis, Larry J., Jensen, Kathleen M., Kahl, Michael D., Milsk, Rebecca Y., Poole, Shane T., Randolph, Eric C., Saari, Travis W., Watanabe, Karen H., Ankley, Gerald T.

Source: Environmental toxicology and chemistry. 42(1):100-116

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170814896.0x000001&indx=1&recIds=ETOCvdc_100170814896.0x000001

Leveraging ToxCast data and protein sequence conservation to complement aquatic life criteria derivation

Authors: Schaupp, Christopher M., LaLone, Carlie A., Blackwell, Brett R., Ankley, Gerald T., Villeneuve, Daniel L.

Source: Integrated environmental assessment and management. 19(1):224-238

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169991713.0x000001&indx=1&recIds=ETOCvdc_100169991713.0x000001

Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish

Authors: Van Dingenen, Imke, Vergauwen, Lucia, Haigis, Ann-Cathrin, Blackwell, Brett R., Stacy, Emma, Villeneuve, Daniel L., Knapen, Dries

Source: In Aquatic Toxicology August 2023 261

Putative adverse outcome pathway development based on physiological responses of female fathead minnows to model estrogen versus androgen receptor agonists

Authors: Morshead, Mackenzie L., Jensen, Kathleen M., Ankley, Gerald T., Vliet, Sara, LaLone, Carlie A., Aller, Alejandro Vidales, Watanabe, Karen H., Villeneuve, Daniel L.

Source: In Aquatic Toxicology August 2023 261

Pilot testing and optimization of a larval fathead minnow high throughput transcriptomics assay

Authors: Villeneuve, Daniel L., Le, Michelle, Hazemi, Monique, Biales, Adam, Bencic, David C., Bush, Kendra, Flick, Robert, Martinson, John, Morshead, Mackenzie, Rodriguez, Kelvin Santana, Vitense, Kelsey, Flynn, Kevin

Source: In Current Research in Toxicology 2023 4

Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish- and mammalian-based assays.

Authors: Jankowski, Mark D, Carpenter, Amy F, Harrill, Joshua A, Harris, Felix R, Hill, Bridgett, Labiosa, Rochelle, Makarov, Sergei S, Martinović-Weigelt, Dalma, Nyffeler, Jo, Padilla, Stephanie, Shafer, Timothy J, Smeltz, Marci G, Villeneuve, Daniel L

Source: Toxicological Sciences; Apr2025, Vol. 204 Issue 2, p198-217, 20p

Transcriptomic response of an algal species (Raphidocelis subcapitata) exposed to 22 per- and polyfluoroalkyl substances.

Authors: Flynn, Kevin M, Bush, Kendra, Cavallin, Jenna, Hazemi, Monique, Kasparek, Alex, Schumann, Peter, Villeneuve, Daniel L

Source: Environmental Toxicology & Chemistry; Apr2025, Vol. 44 Issue 4, p995-1006, 12p

Effects of a novel estrogenic perfluoroalkyl substance on reproductive endocrinology and function in the fathead minnow (Pimephales promelas).

Authors: Ankley, Gerald T, Jensen, Kathleen M, Cavallin, Jenna E, Baettig, Camille, Balgooyen, Sarah, Blackwell, Brett R, Blanksma, Chad A, Collins, Jacob, Ellman, Michael, Hoang, John, Kahl, Michael D, Santana-Rodriguez, Kelvin, Schaupp, Christopher M, Stacy, Emma, Villeneuve, Daniel L

Source: Environmental Toxicology & Chemistry; Mar2025, Vol. 44 Issue 3, p786-801, 16p

Subject Terms: FLUOROALKYL compounds, FATHEAD minnow, GENE expression, STEROID synthesis, ENDOCRINE disruptors, OVARIAN follicle

Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network

Authors: Spînu, Nicoleta, Cronin, Mark T.D., Lao, Junpeng, Bal-Price, Anna, Campia, Ivana, Enoch, Steven J., Madden, Judith C., Mora Lagares, Liadys, Novič, Marjana, Pamies, David, Scholz, Stefan, Villeneuve, Daniel L., Worth, Andrew P.

Source: In Computational Toxicology February 2022 21

Towards a qAOP framework for predictive toxicology - Linking data to decisions

Authors: Paini, Alicia, Campia, Ivana, Cronin, Mark T.D., Asturiol, David, Ceriani, Lidia, Exner, Thomas E., Gao, Wang, Gomes, Caroline, Kruisselbrink, Johannes, Martens, Marvin, Meek, M.E. Bette, Pamies, David, Pletz, Julia, Scholz, Stefan, Schüttler, Andreas, Spînu, Nicoleta, Villeneuve, Daniel L., Wittwehr, Clemens, Worth, Andrew, Luijten, Mirjam

Source: In Computational Toxicology February 2022 21

Effects of Metformin and its Metabolite Guanylurea on Fathead Minnow (Pimephales promelas) Reproduction

Authors: Blackwell, Brett R., Ankley, Gerald T., Biales, Adam D., Cavallin, Jenna E., Cole, Alexander R., Collette, Timothy W., Ekman, Drew R., Hofer, Rachel N., Huang, Weichun, Jensen, Kathleen M., Kahl, Michael D., Kittelson, Ashley R., Romano, Shannon N., See, Mary Jean, Teng, Quincy, Tilton, Charlene B., Villeneuve, Daniel L.

Source: Environmental toxicology and chemistry. 41(11):2708-2720

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163061189.0x000001&indx=1&recIds=ETOCvdc_100163061189.0x000001