Molecular mechanisms promoting long-term cytopenia after BCMA CAR-T therapy in multiple myeloma

Authors: Palacios-Berraquero, Maria Luisa, Rodriguez-Marquez, Paula, Calleja-Cervantes, Maria Erendira, Berastegui, Nerea, Zabaleta, Aintzane, Burgos, Leire, Alignani, Diego, San Martin-Uriz, Patxi, Vilas-Zornoza, Amaia, Rodriguez-Diaz, Saray, Inoges, Susana, Lopez-Diaz de Cerio, Ascensión, Huerga, Sofia, Tamariz, Esteban, Rifon, Jose, Alfonso-Pierola, Ana, Lasarte, Juan Jose, Paiva, Bruno, Hernaez, Mikel, Rodriguez-Otero, Paula, San-Miguel, Jesus, Ezponda, Teresa, Rodriguez-Madoz, Juan Roberto, Prosper, Felipe

Source: In Blood Advances 12 November 2024 8(21):5479-5492

Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures

Authors: Moya-Jódar, Marta, Ullate-Agote, Asier, Barlabé, Paula, Rodríguez-Madoz, Juan Roberto, Abizanda, Gloria, Barreda, Carolina, Carvajal-Vergara, Xonia, Vilas-Zornoza, Amaia, Romero, Juan Pablo, Garate, Leire, Agirre, Xabier, Coppiello, Giulia, Prósper, Felipe, Aranguren, Xabier L.

Source: In Stem Cell Reports 10 January 2023 18(1):64-80

In vivo CRISPR-Cas9 inhibition of hepatic LDH as treatment of primary hyperoxaluria

Authors: Martinez-Turrillas, Rebeca, Martin-Mallo, Angel, Rodriguez-Diaz, Saray, Zapata-Linares, Natalia, Rodriguez-Marquez, Paula, San Martin-Uriz, Patxi, Vilas-Zornoza, Amaia, Calleja-Cervantes, María E., Salido, Eduardo, Prosper, Felipe, Rodriguez-Madoz, Juan R.

Source: In Molecular Therapy - Methods & Clinical Development 9 June 2022 25:137-146

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

Authors: Garreta, Elena, Prado, Patricia, Stanifer, Megan L., Monteil, Vanessa, Marco, Andrés, Ullate-Agote, Asier, Moya-Rull, Daniel, Vilas-Zornoza, Amaia, Tarantino, Carolina, Romero, Juan Pablo, Jonsson, Gustav, Oria, Roger, Leopoldi, Alexandra, Hagelkruys, Astrid, Gallo, Maria, González, Federico, Domingo-Pedrol, Pere, Gavaldà, Aleix, del Pozo, Carmen Hurtado, Hasan Ali, Omar, Ventura-Aguiar, Pedro, Campistol, Josep María, Prosper, Felipe, Mirazimi, Ali, Boulant, Steeve, Penninger, Josef M., Montserrat, Nuria

Source: In Cell Metabolism 7 June 2022 34(6):857-873

Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

Authors: Goicoechea, Ibai, Puig, Noemi, Cedena, Maria-Teresa, Burgos, Leire, Cordón, Lourdes, Vidriales, María-Belén, Flores-Montero, Juan, Gutierrez, Norma C., Calasanz, Maria-Jose, Ramos, Maria-Luisa Martin, Lara-Astiaso, David, Vilas-Zornoza, Amaia, Alignani, Diego, Rodriguez, Idoia, Sarvide, Sarai, Alameda, Daniel, Garcés, Juan José, Rodriguez, Sara, Fresquet, Vicente, Celay, Jon, Garcia-Sanz, Ramón, Martinez-Lopez, Joaquin, Oriol, Albert, Rios, Rafael, Martin-Sanchez, Jesus, Martinez-Martinez, Rafael, Sarra, Josep, Hernandez, Miguel-Teodoro, de la Rubia, Javier, Krsnik, Isabel, Moraleda, Jose-Maria, Palomera, Luis, Bargay, Joan, Martinez-Climent, Jose-Angel, Orfao, Alberto, Rosiñol, Laura, Mateos, Maria-Victoria, Lahuerta, Juan-José, Blade, Joan, San Miguel, Jesús, Paiva, Bruno ^*

Source: In Blood 7 January 2021 137(1):49-60

Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma

Authors: Perez, Cristina ^{1, *}, Botta, Cirino ^{1, 2, *}, Zabaleta, Aintzane ¹, Puig, Noemi ³, Cedena, Maria-Teresa ⁴, Goicoechea, Ibai ¹, Alameda, Daniel ¹, San José-Eneriz, Edurne ¹, Merino, Juana ¹, Rodríguez-Otero, Paula ¹, Maia, Catarina ¹, Alignani, Diego ¹, Maiso, Patricia ¹, Manrique, Irene ¹, Lara-Astiaso, David ¹, Vilas-Zornoza, Amaia ¹, Sarvide, Sarai ¹, Riillo, Caterina ⁵, Rossi, Marco ⁵, Rosiñol, Laura ⁶, Oriol, Albert ⁷, Blanchard, María-Jesús ⁸, Rios, Rafael ⁹, Sureda, Anna ¹⁰, Martin, Jesus ¹¹, Martinez, Rafael ¹², Bargay, Joan ¹³, de la Rubia, Javier ^{14, 15}, Hernandez, Miguel-Teodoro ¹⁶, Martinez-Lopez, Joaquin ⁴, Orfao, Alberto ^{3, 17, 18, 19}, Agirre, Xabier ¹, Prosper, Felipe ¹, Mateos, Maria-Victoria ³, Lahuerta, Juan-José ⁴, Blade, Joan ⁶, San-Miguel, Jesús F. ¹, Paiva, Bruno ^{1, 1}

Source: In Blood 9 July 2020 136(2):199-209

Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis.

Authors: Garreta, Elena, Moya‐Rull, Daniel, Marco, Andrés, Amato, Gaia, Ullate‐Agote, Asier, Tarantino, Carolina, Gallo, Maria, Esporrín‐Ubieto, David, Centeno, Alberto, Vilas‐Zornoza, Amaia, Mestre, Rafael, Kalil, María, Gorroñogoitia, Izar, Zaldua, Ane Miren, Sanchez, Samuel, Izquierdo Reyes, Laura, Fernández‐Santos, María Eugenia, Prosper, Felipe, Montserrat, Nuria

Source: Advanced Materials; 8/22/2024, Vol. 36 Issue 34, p1-15, 15p

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia.

Authors: San José-Enériz, Edurne, Gimenez-Camino, Naroa, Rabal, Obdulia, Garate, Leire, Miranda, Estibaliz, Gómez-Echarte, Nahia, García, Fernando, Charalampopoulou, Stella, Sáez, Elena, Vilas-Zornoza, Amaia, San Martín-Uriz, Patxi, Valcárcel, Luis V., Barrena, Naroa, Alignani, Diego, Tamariz-Amador, Luis Esteban, Pérez-Ruiz, Ana, Hilscher, Sebastian, Schutkowski, Mike, Alfonso-Pierola, Ana, Martinez-Calle, Nicolás

Source: Nature Communications; 7/2/2024, Vol. 15 Issue 1, p1-23, 23p

Subject Terms: ACUTE myeloid leukemia, ACUTE promyelocytic leukemia, HISTONE deacetylase inhibitors, TRANSCRIPTION factors

A community effort to track commercial single-cell and spatial ’omic technologies and business trends.

Authors: De Jonghe, Joachim, Opzoomer, James W., Vilas-Zornoza, Amaia, Crane, Peter, Nilges, Benedikt S., Vicari, Marco, Lee, Hower, Lara-Astiaso, David, Gross, Torsten, Morf, Jörg, Schneider, Kim, Cudini, Juliana, Ramos-Mucci, Lorenzo, Mooijman, Dylan, Tiklová, Katarína, Salas, Sergio Marco, Langseth, Christoffer Mattsson, Kashikar, Nachiket D., Roberts, Charles E. S., Carrami, Eli M.

Source: Nature Biotechnology; Jul2024, Vol. 42 Issue 7, p1017-1023, 7p

Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide.

Authors: Serrano, Guillermo, Berastegui, Nerea, Díaz-Mazkiaran, Aintzane, García-Olloqui, Paula, Rodriguez-Res, Carmen, Huerga-Dominguez, Sofia, Ainciburu, Marina, Vilas-Zornoza, Amaia, Martin-Uriz, Patxi San, Aguirre-Ruiz, Paula, Ullate-Agote, Asier, Ariceta, Beñat, Lamo-Espinosa, Jose-Maria, Acha, Pamela, Calvete, Oriol, Jimenez, Tamara, Molero, Antonieta, Montoro, Maria Julia, Díez-Campelo, Maria, Valcarcel, David

Source: Nature Communications; 6/20/2024, Vol. 15 Issue 1, p1-17, 17p

Subject Terms: MYELODYSPLASTIC syndromes, LENALIDOMIDE, PROGENITOR cells, GENE regulatory networks, CD34 antigen

Identification of Molecular Mechanisms Governing CAR-T Cell Response in MM Patients Using Single Cell Transcriptomics

Authors: Jordana-Urriza, Lorea ^*, Serrano, Guillermo ^*, Calleja-Cervantes, Maria Erendira ^*, San Martin-Uriz, Patxi ^*, Vilas-Zornoza, Amaia ^*, Ullate-Agote, Asier ^*, Zabaleta, Aintzane ^*, Alignani, Diego ^*, Lozano, Teresa ^*, Cabañas, Valentin ^*, Navarro-Bailón, Almudena ^*, Oliver-Caldes, Aina ^*, Español-Rego, Marta ^*, Pascal, Mariona ^*, Juan, Manel ^*, Urbano-Ispizua, Álvaro, Reguera, Juan Luis ^*, Moraleda, Jose Maria ^*, Mateos, Maria-Victoria, Sanchez-Guijo, Fermin ^*, Alfonso Pierola, Ana ^*, Rifón Roca, José J. ^*, Rodríguez-Otero, Paula ^*, Fernandez de Larrea, Carlos, Paiva, Bruno ^*, Inogés, Susana ^*, López-Diaz de Cerio, Ascensión ^*, Lasarte, Juan Jose ^*, San-Miguel, Jesús, Rodriguez-Madoz, Juan Roberto ^*, Hernáez, Mikel ^*, Prósper, Felipe ^*

Source: In Blood 15 November 2022 140 Supplement 1:7366-7368

BCMA CAR-T Cell Phenotype and Functionality Is Affected By Disease Stage of Multiple Myeloma Patients

Authors: Martin-Mallo, Angel ^*, Calleja-Cervantes, Maria Erendira ^*, San Martin-Uriz, Patxi ^*, Vilas-Zornoza, Amaia ^*, Zabaleta, Aintzane ^*, Alignani, Diego ^*, Rodríguez-Márquez, Paula ^*, Rodríguez-Diaz, Saray ^*, Martínez-Turrillas, Rebeca ^*, Jauregui, Patricia ^*, Calviño, Cristina ^*, Palacios-Berraquero, Maria Luisa ^*, Ceballos, Candela ^*, Illarramendi Esteban, Jorge ^*, Gabaldon Limas, Diana Gisell ^*, Viguria, Maria Cruz ^*, Redondo, Ana Margarita ^*, Juan, Manel ^*, Urbano-Ispizua, Álvaro, Fernandez de Larrea, Carlos, Rodríguez-Otero, Paula ^*, Rifon Roca, Jose J. ^*, Alfonso Pierola, Ana ^*, Lozano, Teresa ^*, Lasarte, Juan Jose ^*, Paiva, Bruno ^*, Inogés, Susana ^*, López-Diaz de Cerio, Ascensión ^*, San-Miguel, Jesús, Rodriguez-Madoz, Juan Roberto ^*, Prósper, Felipe ^*

Source: In Blood 15 November 2022 140 Supplement 1:12708-12710

Characterization of Transcriptional Alterations Leading to Aberrant Myeloid Differentiation in Myelodysplastic Syndromes

Authors: Diaz-Mazkiaran, Aintzane ^*, De la Fuente, Jesús ^*, Serrano, Guillermo ^*, Garcia-Olloqui, Paula ^*, Berastegui, Nerea ^*, Ainciburu, Marina ^*, Alfonso Pierola, Ana ^*, Vilas-Zornoza, Amaia ^*, San Martin-Uriz, Patxi ^*, Lamo De Espinosa, Jose Maria ^*, San Julián, Mikel ^*, Acha, Pamela ^*, Solé, Francesc, Jimenez, Tamara ^*, López Cadenas, Félix ^*, Diez-Campelo, Maria ^*, Molero, Antonieta ^*, Montoro, Maria Julia ^*, Valcarcel, David ^*, Ezponda, Teresa ^*, Hernáez, Mikel ^*, Prosper, Felipe ^*

Source: In Blood 15 November 2022 140 Supplement 1:5852-5854

Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML

Authors: Rio-Machin, Ana ^*, Bewicke-Copley, Findlay, Zheng, Jiexin ^*, Casado Izquierdo, Pedro ^*, Miettinen, Juho J. ^*, Khan, Naeem ^*, Demeulemeester, Jonas ^*, Krizsán, Szilvia ^*, Middleton, Christopher ^*, Benkwitz-Bedford, Sam ^*, Saad, Joseph ^*, Vilas-Zornoza, Amaia ^*, Ezponda, Teresa ^*, Grey, William ^*, Lavallée, Vincent-Philippe ^*, Nolin-Lapalme, Alexis ^*, Miraki-Moud, Farideh ^*, Matthews, Janet ^*, Grantham, Marianne ^*, Colm, Ryan J ^*, Bond, Jonathan ^*, Di Bella, Doriana ^*, Wennerberg, Krister ^*, Parsons, Alun ^*, Zeng, Andy G.X., Armes, Hannah ^*, Close, Karina ^*, Kaya, Fadimana ^*, Rouault-Pierre, Kevin ^*, Gribben, John G., Prosper, Felipe ^*, Cavenagh, James, Dick, John E., Freeman, Sylvie D, Van Loo, Peter ^*, Bödör, Csaba ^*, Sauvageau, Guy, Porkka, Kimmo ^*, Heckman, Caroline A., Wang, Jun ^*, Cazier, Jean-Baptiste ^*, Taussig, David ^*, Bonnet, Dominique, Cutillas, Pedro ^*, Fitzgibbon, Jude ^*

Source: In Blood 15 November 2022 140 Supplement 1:1030-1032

IBCL-541 A Comprehensive Single-Cell Multi-Omic Analysis to Depict the Biological Heterogeneity of Follicular and Large B-Cell Lymphomas

Authors: Huerga-Domínguez, Sofía, Ariceta, Beñat, Aguirre-Ruiz, Paula, San, Patxi, Sarvide, Sarai, López-Janeiro, Álvaro, Alignani, Diego, López-López, Aintzane, Muiños-López, Emma, Abengozar, Marta, Browne, Santiago, Figueroa, Rocío, Grande, Carlos, Roa, Sergio, Roberto Rodríguez-Madoz, Juan, Vilas-Zornoza, Amaia, Prósper, Felipe, Canales, Miguel

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2024 24 Supplement 1:S502-S502

A Comprehensive Single-Cell Multi-Omic Analysis to Depict the Biological Heterogeneity of Follicular and Large B-Cell Lymphomas

Authors: Huerga-Domínguez, Sofía, Ariceta, Beñat, Aguirre-Ruiz, Paula, San Martín-Uriz, Patxi, Sarvide, Sarai, López-Janeiro, Álvaro, Alignani, Diego, López-López, Aintzane, Muiños-López, Emma, Abengozar, Marta, Browne, Santiago, Figueroa, Rocío, Grande, Carlos, Roa, Sergio, Roberto Rodríguez-Madoz, Juan, Vilas-Zornoza, Amaia, Prósper, Felipe, Canales, Miguel

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2024 24 Supplement 1:S224-S224

Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development

Authors: Alameda, Daniel ^*, Goicoechea, Ibai ^*, Vicari, Marco ^*, Arriazu, Elena, Nevone, Alice, Rodriguez, Sara, Lasa, Marta, Puig, Noemi, Cedena, Maria Teresa, Alignani, Diego, Garate, Sonia, Lara-Astiaso, David, Vilas-Zornoza, Amaia, Sarvide, Sarai, Ocio, Enrique M., Lecumberri, Ramon, Garcia de Coca, Alfonso, Labrador, Jorge, Gonzalez, Maria-Esther, Palomera, Luis, Gironella, Mercedes, Cabañas, Valentin, Casanova, Maria, Oriol, Albert, Krsnik, Isabel, Perez-Montaña, Albert, de la Rubia, Javier, de la Puerta, Jose-Enrique, de Arriba, Felipe, Fazio, Vito Michele, Martinez-Lopez, Joaquin, Lahuerta, Juan-Jose, Mateos, Maria-Victoria, Odero, Maria-Dolores, Prosper, Felipe, Weiner, Assaf, Amit, Ido, Nuvolone, Mario, San Miguel, Jesus F., Paiva, Bruno ^*

Source: In Blood 28 October 2021 138(17):1583-1589

The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary CD4 T cells.

Authors: Perucho, Laura, Icardi, Laura, Di Simone, Elisabetta, Basso, Veronica, Agresti, Alessandra, Vilas Zornoza, Amaia, Lozano, Teresa, Prosper, Felipe, Lasarte, Juan José, Mondino, Anna

Source: EMBO Reports; May2023, Vol. 24 Issue 5, p1-14, 14p

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution.

Authors: Ainciburu, Marina, Ezponda, Teresa, Berastegui, Nerea, Alfonso-Pierola, Ana, Vilas-Zornoza, Amaia, Martin-Uriz, Patxi San, Alignani, Diego, Lamo-Espinosa, Jose, San-Julian, Mikel, Jiménez-Solas, Tamara, Lopez, Felix, Muntion, Sandra, Sanchez-Guijo, Fermin, Molero, Antonieta, Montoro, Julia, Serrano, Guillermo, Diaz-Mazkiaran, Aintzane, Lasaga, Miren, Gomez-Cabrero, David, Diez-Campelo, Maria

Source: eLife; 2/7/2023, p1-28, 28p

The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes.

Authors: Berastegui, Nerea, Ainciburu, Marina, Romero, Juan P., Garcia-Olloqui, Paula, Alfonso-Pierola, Ana, Philippe, Céline, Vilas-Zornoza, Amaia, San Martin-Uriz, Patxi, Ruiz-Hernández, Raquel, Abarrategi, Ander, Ordoñez, Raquel, Alignani, Diego, Sarvide, Sarai, Castro-Labrador, Laura, Lamo-Espinosa, José M., San-Julian, Mikel, Jimenez, Tamara, López-Cadenas, Félix, Muntion, Sandra, Sanchez-Guijo, Fermin

Source: Nature Communications; 12/9/2022, Vol. 13 Issue 1, p1-17, 17p

Subject Terms: MYELODYSPLASTIC syndromes, TRANSCRIPTION factors, HEMATOPOIETIC stem cells, BLOOD cells, OLDER people, HEMATOPOIESIS