Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state

Authors: Fahad Paryani, Ji-Sun Kwon, Christopher W. Ng, Kelly Jakubiak, Nacoya Madden, Kenneth Ofori, Alice Tang, Hong Lu, Shengnan Xia, Juncheng Li, Aayushi Mahajan, Shawn M. Davidson, Anna O. Basile, Caitlin McHugh, Jean Paul Vonsattel, Richard Hickman, Michael C. Zody, David E. Housman, James E. Goldman, Andrew S. Yoo, Vilas Menon, Osama Al-Dalahmah

Source: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8951e53b83a446a78dbb4875a502960b

G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults

Authors: Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett

Source: Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/db373cb64bd548c290a7761d99ec2353

An integrated toolkit for human microglia functional genomics

Authors: Imdadul Haq, Jason C. Ngo, Nainika Roy, Richard L. Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K. Soni, Xuebing Wu, David A. Bennett, Vilas Menon, Marta Olah, Falak Sher

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-29 (2024)

Subject Terms: Neurodegenerative diseases, Microglia, iPSC-derived microglia (iMG), Functional genomics, CRISPR, Chromatin accessibility (ATAC-Seq), Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/1c0632afbc3d446a9b3d14a09b0120e1

Corrigendum: Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment

Authors: Jason Mares, Ana Paula Costa, William J. Dartora, Krista M. Wartchow, Artur Lazarian, David A. Bennett, Tal Nuriel, Vilas Menon, Laura Beth J. McIntire

Source: Frontiers in Aging Neuroscience, Vol 16 (2024)

Subject Terms: lipidomics, lipid metabolism, Alzheimer's disease, ROSMAP, ApoE, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1480818/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/5fa08c15bfa74a22abac9724831821ac

INPP5D regulates inflammasome activation in human microglia

Authors: Vicky Chou, Richard V. Pearse, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioglu, Masashi Fujita, Seeley B. Fancher, Alina Sigalov, Courtney R. Benoit, Hyo Lee, Matti Lam, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Vilas Menon, Tracy L. Young-Pearse

Source: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9e3d8cd8d32347f6b00af0ac1594f3b7

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease

Authors: Hyun-Sik Yang, Ling Teng, Daniel Kang, Vilas Menon, Tian Ge, Hilary K. Finucane, Aaron P. Schultz, Michael Properzi, Hans-Ulrich Klein, Lori B. Chibnik, Julie A. Schneider, David A. Bennett, Timothy J. Hohman, Richard P. Mayeux, Keith A. Johnson, Philip L. De Jager, Reisa A. Sperling

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0e512e3890b148e388c778ba58f1e579

Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment

Authors: Jason Mares, Ana Paula Costa, William J. Dartora, Krista M. Wartchow, Artur Lazarian, David A. Bennett, Tal Nuriel, Vilas Menon, Laura Beth J. McIntire

Source: Frontiers in Aging Neuroscience, Vol 16 (2024)

Subject Terms: lipidomics, lipid metabolism, Alzheimer’s disease, ROSMAP, ApoE, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1419253/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/2cfa0c832486466fb01aece9affa2ea5

New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop

Authors: Maria A. Telpoukhovskaia, Thomas J. Murdy, Olivia J. Marola, Kevin Charland, Michael MacLean, Tain Luquez, Alexandra M. Lish, Sarah Neuner, Amy Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J. Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J. Van Eldik, Paul R. Territo, Gareth R. Howell, Gregory W. Carter, Kristen M. S. O'Connell, Catherine C. Kaczorowski, the 2022 JAX CADR Workshop

Source: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/2352-8737

Access URL: https://doaj.org/article/cf95533f4c0f4321bd855f02582741fa

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states

Authors: Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54

Focused Ultrasound-Mediated Blood–Brain Barrier Opening Best Promotes Neuroimmunomodulation through Brain Macrophage Redistribution

Authors: Alina R. Kline-Schoder, Rebecca L. Noel, Hemali Phatnani, Vilas Menon, Elisa E. Konofagou

Source: Neuroglia, Vol 4, Iss 2, Pp 141-157 (2023)

Subject Terms: microglia, central nervous system-associated macrophages, ultrasound, blood–brain barrier, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.mdpi.com/2571-6980/4/2/10; https://doaj.org/toc/2571-6980

Access URL: https://doaj.org/article/6e289fd197fc4c61a08e80d6cf232bfb

53 Inducing immune response with FLASH and conventional radiation in diffuse midline glioma (DMG)

Authors: Xu Zhang, Zhiguo Zhang, Raul Rabadan, Peter Canoll, Claire Vanpouille-Box, Hanna Minns, Oscar Padilla, Hong-Jian Wei, Robyn D Gartrell, Andrea Webster-Carrion, Masih Tazhibi, Nicholas McQuillan, Matthew Gallitto, Rebecca Yeh, Tom Hei, Luca Szalontay, Jovana Pavisic, Guy Garty, James Garvin, Vilas Menon, Marta Olah, Cheng-Chia Wu

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/a99f5d9f84394dd9a7b25cbed6dd61d0

St18 specifies globus pallidus projection neuron identity in MGE lineage

Authors: Luke F. Nunnelly, Melissa Campbell, Dylan I. Lee, Patrick Dummer, Guoqiang Gu, Vilas Menon, Edmund Au

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eb988cb6137b40b0a9e120f9a79a74f7

Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

Authors: Ryan G. Lim, Osama Al-Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Richard A. Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu Michael, Nicolette McClure, Xena E. Flowers, Jean Paul Vonsattel, Shawn Davidson, Vilas Menon, Vivek Swarup, Ernest Fraenkel, James E. Goldman, Leslie M. Thompson

Source: Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3ad164ee693049358f658929a36c0698

Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease

Authors: Tain Luquez, Pallavi Gaur, Ivy M Kosater, Matti Lam, Dylan I Lee, Jason Mares, Fahad Paryani, Archana Yadav, Vilas Menon

Source: Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)

Subject Terms: Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/2205b184395e4aa3ac7b698efb752721

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

Authors: Hyo Lee, Aimee J. Aylward, Richard V. Pearse, II, Alexandra M. Lish, Yi-Chen Hsieh, Zachary M. Augur, Courtney R. Benoit, Vicky Chou, Allison Knupp, Cheryl Pan, Srilakshmi Goberdhan, Duc M. Duong, Nicholas T. Seyfried, David A. Bennett, Mariko F. Taga, Kevin Huynh, Matthias Arnold, Peter J. Meikle, Philip L. De Jager, Vilas Menon, Jessica E. Young, Tracy L. Young-Pearse

Source: Cell Reports, Vol 42, Iss 8, Pp 112994- (2023)

Subject Terms: CP: Neuroscience, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723010057; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/911ab12d4ed045b69c2a0c7474867a7a

An immune response characterizes early Alzheimer’s disease pathology and subjective cognitive impairment in hydrocephalus biopsies

Authors: Wenrui Huang, Anne Marie Bartosch, Harrison Xiao, Suvrajit Maji, Elliot H. H. Youth, Xena Flowers, Sandra Leskinen, Zeljko Tomljanovic, Gail Iodice, Deborah Boyett, Eleonora Spinazzi, Vilas Menon, Robert A. McGovern, Guy M. McKhann, Andrew F. Teich

Source: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/43b5c7a214414bc4bb15263806a47f08

A harmonized atlas of mouse spinal cord cell types and their spatial organization

Authors: Daniel E. Russ, Ryan B. Patterson Cross, Li Li, Stephanie C. Koch, Kaya J. E. Matson, Archana Yadav, Mor R. Alkaslasi, Dylan I. Lee, Claire E. Le Pichon, Vilas Menon, Ariel J. Levine

Source: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2245175ca2a449b38653689a6a9924c8

A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

Authors: Tanya Grancharova, Kaytlyn A. Gerbin, Alexander B. Rosenberg, Charles M. Roco, Joy E. Arakaki, Colette M. DeLizo, Stephanie Q. Dinh, Rory M. Donovan-Maiye, Matthew Hirano, Angelique M. Nelson, Joyce Tang, Julie A. Theriot, Calysta Yan, Vilas Menon, Sean P. Palecek, Georg Seelig, Ruwanthi N. Gunawardane

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d4fb933e376547c486f87bcf5fd17339

Molecular correlates of muscle spindle and Golgi tendon organ afferents

Authors: Katherine M. Oliver, Danny M. Florez-Paz, Tudor Constantin Badea, George Z. Mentis, Vilas Menon, Joriene C. de Nooij

Source: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1a25f8a076bf42029aa7c592d7e11206

Selecting single cell clustering parameter values using subsampling-based robustness metrics

Authors: Ryan B. Patterson-Cross, Ariel J. Levine, Vilas Menon

Source: BMC Bioinformatics, Vol 22, Iss 1, Pp 1-13 (2021)

Subject Terms: Single cell RNAseq, Parameter selection, Clustering, Resolution, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2105

Access URL: https://doaj.org/article/b84d380938f047e4b749af13974c5eae